PubMed:20053629 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":74},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":75,"end":291},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":292,"end":482},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":483,"end":702},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":703,"end":978},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":74},"obj":"Sentence"},{"id":"T2","span":{"begin":75,"end":291},"obj":"Sentence"},{"id":"T3","span":{"begin":292,"end":482},"obj":"Sentence"},{"id":"T4","span":{"begin":483,"end":702},"obj":"Sentence"},{"id":"T5","span":{"begin":703,"end":978},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":74},"obj":"Sentence"},{"id":"T2","span":{"begin":75,"end":291},"obj":"Sentence"},{"id":"T3","span":{"begin":292,"end":482},"obj":"Sentence"},{"id":"T4","span":{"begin":483,"end":702},"obj":"Sentence"},{"id":"T5","span":{"begin":703,"end":978},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":220,"end":225},"obj":"HP_0002664"},{"id":"T2","span":{"begin":351,"end":356},"obj":"HP_0002664"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":226,"end":231},"obj":"FMAID:169002"},{"id":"_T2","span":{"begin":226,"end":231},"obj":"FMAID:68646"},{"id":"_T3","span":{"begin":357,"end":362},"obj":"FMAID:169002"},{"id":"_T4","span":{"begin":357,"end":362},"obj":"FMAID:68646"},{"id":"_T5","span":{"begin":450,"end":462},"obj":"FMAID:201611"},{"id":"_T6","span":{"begin":457,"end":462},"obj":"FMAID:68646"},{"id":"_T7","span":{"begin":457,"end":462},"obj":"FMAID:169002"},{"id":"_T8","span":{"begin":616,"end":621},"obj":"FMAID:169002"},{"id":"_T9","span":{"begin":616,"end":621},"obj":"FMAID:68646"},{"id":"_T10","span":{"begin":912,"end":918},"obj":"FMAID:178661"},{"id":"_T11","span":{"begin":952,"end":957},"obj":"FMAID:169002"},{"id":"_T12","span":{"begin":952,"end":957},"obj":"FMAID:68646"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":510,"end":523},"obj":"http://www.uniprot.org/uniprot/Q7KYX7"},{"id":"T2","span":{"begin":588,"end":597},"obj":"http://www.uniprot.org/uniprot/P42574"},{"id":"T3","span":{"begin":852,"end":864},"obj":"http://www.uniprot.org/uniprot/O43451"},{"id":"T4","span":{"begin":852,"end":864},"obj":"http://www.uniprot.org/uniprot/Q2M2H8"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":510,"end":523},"obj":"http://www.uniprot.org/uniprot/P70343"},{"id":"T2","span":{"begin":588,"end":597},"obj":"http://www.uniprot.org/uniprot/P70677"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":226,"end":231},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T2","span":{"begin":357,"end":362},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T3","span":{"begin":457,"end":462},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T4","span":{"begin":616,"end":621},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T5","span":{"begin":670,"end":673},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/9596"},{"id":"T6","span":{"begin":952,"end":957},"obj":"http://purl.bioontology.org/ontology/STY/T025"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":199,"end":208},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T2","span":{"begin":199,"end":208},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T3","span":{"begin":483,"end":492},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T4","span":{"begin":483,"end":492},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T5","span":{"begin":576,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0004197"},{"id":"T6","span":{"begin":576,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0097153"},{"id":"T7","span":{"begin":576,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0006919"},{"id":"T8","span":{"begin":927,"end":938},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T9","span":{"begin":932,"end":938},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T10","span":{"begin":943,"end":948},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T11","span":{"begin":943,"end":957},"obj":"http://purl.obolibrary.org/obo/GO_0008219"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":226,"end":231},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":357,"end":362},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":457,"end":462},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4","span":{"begin":616,"end":621},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5","span":{"begin":927,"end":931},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":670,"end":673},"obj":"http://purl.obolibrary.org/obo/GO_0022623"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":708,"end":713},"obj":"http://edamontology.org/topic_3678"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":450,"end":456},"obj":"http://edamontology.org/operation_3435"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":220,"end":225},"obj":"Disease"},{"id":"T2","span":{"begin":351,"end":356},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":220,"end":225},"obj":"Phenotype"},{"id":"T2","span":{"begin":351,"end":356},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002664"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":220,"end":231},"obj":"Cell"},{"id":"T2","span":{"begin":351,"end":362},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0001063"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0001063"}],"text":"The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.\nD-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer. Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic. Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK. This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin."}