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PubMed:20053629 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-74 Sentence denotes The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.
TextSentencer_T2 75-291 Sentence denotes D-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer.
TextSentencer_T3 292-482 Sentence denotes Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic.
TextSentencer_T4 483-702 Sentence denotes Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK.
TextSentencer_T5 703-978 Sentence denotes This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin.
T1 0-74 Sentence denotes The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.
T2 75-291 Sentence denotes D-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer.
T3 292-482 Sentence denotes Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic.
T4 483-702 Sentence denotes Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK.
T5 703-978 Sentence denotes This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin.
T1 0-74 Sentence denotes The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine.
T2 75-291 Sentence denotes D-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as apoptosis inducer on tumor cells of different origin, in contrast to its natural enantiomer.
T3 292-482 Sentence denotes Although D-(-)-4 exhibited a proapoptotic activity towards tumor cells at level lower than the chemotherapeutic agent, SN38, it was less proapoptotic towards normal cells and less cytotoxic.
T4 483-702 Sentence denotes Apoptosis induced by D-(-)-4 was caspase-dependent, as shown by the increased expression and activity of caspase-3 and -8 in treated cells, and by inhibition following treatment with the pan caspase inhibitor, ZVAD-FMK.
T5 703-978 Sentence denotes This study highlighted how a natural iminosugar alkaloid and its synthetic enantiomer, which were simply known for their inhibition against a fungal glucoamylase, could behave in a complete different way when tested towards cell growth and death of cells of different origin.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 220-225 HP_0002664 denotes tumor
T2 351-356 HP_0002664 denotes tumor

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 226-231 FMAID:169002 denotes cells
_T2 226-231 FMAID:68646 denotes cells
_T3 357-362 FMAID:169002 denotes cells
_T4 357-362 FMAID:68646 denotes cells
_T5 450-462 FMAID:201611 denotes normal cells
_T6 457-462 FMAID:68646 denotes cells
_T7 457-462 FMAID:169002 denotes cells
_T8 616-621 FMAID:169002 denotes cells
_T9 616-621 FMAID:68646 denotes cells
_T10 912-918 FMAID:178661 denotes tested
_T11 952-957 FMAID:169002 denotes cells
_T12 952-957 FMAID:68646 denotes cells

uniprot-human

Id Subject Object Predicate Lexical cue
T1 510-523 http://www.uniprot.org/uniprot/Q7KYX7 denotes 4 was caspase
T2 588-597 http://www.uniprot.org/uniprot/P42574 denotes caspase-3
T3 852-864 http://www.uniprot.org/uniprot/O43451 denotes glucoamylase
T4 852-864 http://www.uniprot.org/uniprot/Q2M2H8 denotes glucoamylase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 510-523 http://www.uniprot.org/uniprot/P70343 denotes 4 was caspase
T2 588-597 http://www.uniprot.org/uniprot/P70677 denotes caspase-3

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 226-231 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 357-362 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 457-462 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 616-621 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 670-673 http://purl.bioontology.org/ontology/NCBITAXON/9596 denotes pan
T6 952-957 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 199-208 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T2 199-208 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T3 483-492 http://purl.obolibrary.org/obo/GO_0006915 denotes Apoptosis
T4 483-492 http://purl.obolibrary.org/obo/GO_0097194 denotes Apoptosis
T5 576-595 http://purl.obolibrary.org/obo/GO_0004197 denotes activity of caspase
T6 576-595 http://purl.obolibrary.org/obo/GO_0097153 denotes activity of caspase
T7 576-595 http://purl.obolibrary.org/obo/GO_0006919 denotes activity of caspase
T8 927-938 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T9 932-938 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T10 943-948 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T11 943-957 http://purl.obolibrary.org/obo/GO_0008219 denotes death of cells

GO-CC

Id Subject Object Predicate Lexical cue
T1 226-231 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 357-362 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 457-462 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 616-621 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 927-931 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 670-673 http://purl.obolibrary.org/obo/GO_0022623 denotes pan

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 708-713 http://edamontology.org/topic_3678 denotes study

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 450-456 http://edamontology.org/operation_3435 denotes normal

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 220-225 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 351-356 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 220-225 Phenotype denotes tumor HP:0002664
T2 351-356 Phenotype denotes tumor HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 220-231 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T2 351-362 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063