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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-10 CL:0000057 denotes Fibroblast
T2 11-21 CL:0000182 denotes hepatocyte
T4 11-35 Q9BH09 denotes hepatocyte growth factor
T6 11-35 PR:000008534 denotes hepatocyte growth factor
T7 11-35 Q08048 denotes hepatocyte growth factor
T8 11-35 Q867B7 denotes hepatocyte growth factor
T9 11-35 Q76BS1 denotes hepatocyte growth factor
T10 11-35 P17945 denotes hepatocyte growth factor
T12 11-35 P14210 denotes hepatocyte growth factor
T5 11-35 D017228 denotes hepatocyte growth factor
T11 11-35 D017228 denotes hepatocyte growth factor
T3 11-35 GO:0005171 denotes hepatocyte growth factor
T18 57-62 D006801 denotes human
T19 63-87 D018270 denotes mammary ductal carcinoma
T20 63-87 D018270 denotes mammary ductal carcinoma
T23 71-95 D002285 denotes ductal carcinoma in situ
T24 71-95 D002285 denotes ductal carcinoma in situ
T29 113-123 CL:0000182 denotes hepatocyte
T31 113-137 Q9BH09 denotes hepatocyte growth factor
T33 113-137 PR:000008534 denotes hepatocyte growth factor
T34 113-137 Q08048 denotes hepatocyte growth factor
T35 113-137 Q867B7 denotes hepatocyte growth factor
T36 113-137 Q76BS1 denotes hepatocyte growth factor
T37 113-137 P17945 denotes hepatocyte growth factor
T39 113-137 P14210 denotes hepatocyte growth factor
T32 113-137 D017228 denotes hepatocyte growth factor
T38 113-137 D017228 denotes hepatocyte growth factor
T30 113-137 GO:0005171 denotes hepatocyte growth factor
T45 139-142 PR:Q08048 denotes HGF
T46 139-142 PR:P17945 denotes HGF
T47 139-142 PR:000008534 denotes HGF
T49 139-142 PR:P14210 denotes HGF
T48 139-142 135300 denotes HGF
T56 198-201 SO:0001442 denotes Met
T50 198-201 PR:P16056 denotes Met
T52 198-201 PR:P97523 denotes Met
T54 198-201 PR:000014144 denotes Met
T57 198-201 PR:Q8CH25 denotes Met
T51 198-201 CHEBI:16044 denotes Met
T53 198-201 CHEBI:16643 denotes Met
T55 198-201 CHEBI:49037 denotes Met
T58 198-201 CHEBI:49038 denotes Met
T59 198-201 CHEBI:16811 denotes Met
T60 253-263 GO:0065007 denotes regulation
T61 267-272 D009369 denotes tumor
T62 267-272 D009369 denotes tumor
T63 267-277 CL:0001063 denotes tumor cell
T64 273-287 GO:0016477 denotes cell migration
T65 306-316 SO:1000009 denotes transition
T68 334-358 D002285 denotes ductal carcinoma in situ
T69 334-358 D002285 denotes ductal carcinoma in situ
T75 360-364 CVCL_5552 denotes DCIS
T74 360-364 D002285 denotes DCIS
T76 360-364 D002285 denotes DCIS
T77 378-384 UBERON:0000310 denotes breast
T78 378-394 D001943 denotes breast carcinoma
T79 378-394 D001943 denotes breast carcinoma
T82 460-477 GO:0005604 denotes basement membrane
T83 460-477 UBERON:0005769 denotes basement membrane
T87 500-503 PR:Q08048 denotes HGF
T88 500-503 PR:P17945 denotes HGF
T89 500-503 PR:000008534 denotes HGF
T91 500-503 PR:P14210 denotes HGF
T90 500-503 135300 denotes HGF
T93 579-583 CVCL_5552 denotes DCIS
T92 579-583 D002285 denotes DCIS
T94 579-583 D002285 denotes DCIS
T96 666-683 UBERON:0005769 denotes basement membrane
T95 666-683 GO:0005604 denotes basement membrane
T100 712-717 D006801 denotes human
T102 718-722 CVCL_5552 denotes DCIS
T101 718-722 D002285 denotes DCIS
T103 718-722 D002285 denotes DCIS
T105 735-745 CVCL_5552 denotes MCF10.DCIS
T106 741-745 D002285 denotes DCIS
T108 741-745 D002285 denotes DCIS
T109 750-756 CVCL_3421 denotes SUM102
T111 854-858 CVCL_5552 denotes DCIS
T110 854-858 D002285 denotes DCIS
T112 854-858 D002285 denotes DCIS
T113 933-936 PR:Q08048 denotes HGF
T114 933-936 PR:P17945 denotes HGF
T115 933-936 PR:000008534 denotes HGF
T117 933-936 PR:P14210 denotes HGF
T116 933-936 135300 denotes HGF
T119 986-990 CVCL_5552 denotes DCIS
T118 986-990 D002285 denotes DCIS
T120 986-990 D002285 denotes DCIS
T127 1058-1061 SO:0001442 denotes Met
T121 1058-1061 PR:P16056 denotes Met
T123 1058-1061 PR:P97523 denotes Met
T125 1058-1061 PR:000014144 denotes Met
T128 1058-1061 PR:Q8CH25 denotes Met
T122 1058-1061 CHEBI:16044 denotes Met
T124 1058-1061 CHEBI:16643 denotes Met
T126 1058-1061 CHEBI:49037 denotes Met
T129 1058-1061 CHEBI:49038 denotes Met
T130 1058-1061 CHEBI:16811 denotes Met
T131 1067-1085 D017077 denotes conditioned medium
T132 1091-1094 PR:Q08048 denotes HGF
T133 1091-1094 PR:P17945 denotes HGF
T134 1091-1094 PR:000008534 denotes HGF
T136 1091-1094 PR:P14210 denotes HGF
T135 1091-1094 135300 denotes HGF
T137 1137-1140 PR:Q08048 denotes HGF
T138 1137-1140 PR:P17945 denotes HGF
T139 1137-1140 PR:000008534 denotes HGF
T141 1137-1140 PR:P14210 denotes HGF
T140 1137-1140 135300 denotes HGF
T143 1169-1173 CVCL_5552 denotes DCIS
T142 1169-1173 D002285 denotes DCIS
T144 1169-1173 D002285 denotes DCIS
T145 1217-1228 GO:0009056 denotes degradation
T147 1232-1240 2714 denotes collagen
T148 1232-1240 D003094 denotes collagen
T149 1232-1240 CHEBI:3815 denotes collagen
T146 1232-1240 GO:0005202 denotes collagen
T150 1255-1264 GO:0046903 denotes secretion
T151 1255-1264 UBERON:0000456 denotes secretion
T153 1268-1304 P06869 denotes urokinase-type plasminogen activator
T154 1268-1304 P29598 denotes urokinase-type plasminogen activator
T155 1268-1304 Q5RF29 denotes urokinase-type plasminogen activator
T157 1268-1304 P04185 denotes urokinase-type plasminogen activator
T158 1268-1304 PR:000012826 denotes urokinase-type plasminogen activator
T159 1268-1304 Q8MHY7 denotes urokinase-type plasminogen activator
T160 1268-1304 P00749 denotes urokinase-type plasminogen activator
T161 1268-1304 Q05589 denotes urokinase-type plasminogen activator
T163 1268-1304 P16227 denotes urokinase-type plasminogen activator
T164 1268-1304 P15120 denotes urokinase-type plasminogen activator
T162 1268-1304 D014568 denotes urokinase-type plasminogen activator
T156 1268-1304 GO:0008243 denotes urokinase-type plasminogen activator
T185 1381-1384 PR:Q08048 denotes HGF
T186 1381-1384 PR:P17945 denotes HGF
T187 1381-1384 PR:000008534 denotes HGF
T189 1381-1384 PR:P14210 denotes HGF
T188 1381-1384 135300 denotes HGF
T191 1433-1443 CVCL_5552 denotes MCF10.DCIS
T192 1439-1443 D002285 denotes DCIS
T194 1439-1443 D002285 denotes DCIS
T195 1458-1494 D016513 denotes severe combined immunodeficient mice
T196 1490-1494 PR:000005054 denotes mice
T198 1490-1494 O89094 denotes mice
T200 1527-1530 PR:Q08048 denotes HGF
T201 1527-1530 PR:P17945 denotes HGF
T202 1527-1530 PR:000008534 denotes HGF
T204 1527-1530 PR:P14210 denotes HGF
T203 1527-1530 135300 denotes HGF
T211 1533-1536 SO:0001442 denotes Met
T205 1533-1536 PR:P16056 denotes Met
T207 1533-1536 PR:P97523 denotes Met
T209 1533-1536 PR:000014144 denotes Met
T212 1533-1536 PR:Q8CH25 denotes Met
T206 1533-1536 CHEBI:16044 denotes Met
T208 1533-1536 CHEBI:16643 denotes Met
T210 1533-1536 CHEBI:49037 denotes Met
T213 1533-1536 CHEBI:49038 denotes Met
T214 1533-1536 CHEBI:16811 denotes Met
T215 1537-1546 GO:0023052 denotes signaling
T217 1583-1587 CVCL_5552 denotes DCIS
T216 1583-1587 D002285 denotes DCIS
T218 1583-1587 D002285 denotes DCIS
T219 1607-1617 SO:1000009 denotes transition
T220 1630-1640 D002277 denotes carcinomas
T221 1630-1640 D002277 denotes carcinomas
T222 1748-1753 D009369 denotes tumor
T223 1748-1753 D009369 denotes tumor

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 97-301 DRI_Challenge denotes Stromal-derived hepatocyte growth factor (HGF) acting through its specific proto-oncogene receptor c-Met has been suggested to play a paracrine role in the regulation of tumor cell migration and invasion.
T2 302-478 DRI_Background denotes The transition from preinvasive ductal carcinoma in situ (DCIS) to invasive breast carcinoma is marked by infiltration of stromal fibroblasts and the loss of basement membrane.
T3 479-757 DRI_Background denotes We hypothesized that HGF produced by the infiltrating fibroblasts may alter proteolytic pathways in DCIS cells, and, to study this hypothesis, established three-dimensional reconstituted basement membrane overlay cocultures with two human DCIS cell lines, MCF10.DCIS and SUM102.
T4 758-914 DRI_Background denotes Both cell lines formed large dysplastic structures in three-dimensional cultures that resembled DCIS in vivo and occasionally developed invasive outgrowths.
T5 915-1041 DRI_Outcome denotes In coculture with HGF-secreting mammary fibroblasts, the percentage of DCIS structures with invasive outgrowths was increased.
T6 1042-1322 DRI_Outcome denotes Activation of c-Met with conditioned medium from HGF-secreting fibroblasts or with recombinant HGF increased the percentage of DCIS structures with invasive outgrowths, their degradation of collagen IV, and their secretion of urokinase-type plasminogen activator and its receptor.
T7 1323-1495 DRI_Outcome denotes In agreement with the in vitro findings, coinjection with HGF-secreting fibroblasts increased invasiveness of MCF10.DCIS xenografts in severe combined immunodeficient mice.
T8 1496-1793 DRI_Outcome denotes Our study shows that paracrine HGF/c-Met signaling between fibroblasts and preinvasive DCIS cells enhances the transition to invasive carcinomas and suggests that three-dimensional cocultures are appropriate models for testing therapeutics that target tumor microenvironment-enhanced invasiveness.