PubMed:18674790 / 0-563 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/18674790","sourcedb":"PubMed","sourceid":"18674790","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/18674790","text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we 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