PubMed:18674790 / 0-563 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":88},"obj":"Sentence"},{"id":"T2","span":{"begin":89,"end":222},"obj":"Sentence"},{"id":"T3","span":{"begin":223,"end":341},"obj":"Sentence"},{"id":"T4","span":{"begin":342,"end":528},"obj":"Sentence"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":24,"end":28},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:10118"},{"id":"A2","pred":"db_id","subj":"T1","obj":"NCBItxid:10116"},{"id":"A3","pred":"db_id","subj":"T1","obj":"NCBItxid:10114"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

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{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":18,"end":23},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":140,"end":147},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":421,"end":434},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":463,"end":467},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":514,"end":519},"obj":"GeneOrGeneProduct"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":18,"end":23},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":33,"end":39},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":65,"end":72},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":140,"end":147},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":318,"end":325},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":421,"end":434},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":457,"end":462},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":463,"end":467},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":479,"end":482},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":514,"end":519},"obj":"GeneOrGeneProduct"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":18,"end":23},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":73,"end":87},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":172,"end":186},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":326,"end":340},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D066126"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D066126"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D066126"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":514,"end":519},"obj":"GeneOrGeneProduct"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":14,"end":17},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":40,"end":49},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0007620"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0000605"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":18,"end":23},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":73,"end":87},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":172,"end":186},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":326,"end":340},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D066126"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D066126"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D066126"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":18,"end":23},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":73,"end":87},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":172,"end":186},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":326,"end":340},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"#label","subj":"T2","obj":"D066126"},{"id":"A3","pred":"#label","subj":"T3","obj":"D066126"},{"id":"A4","pred":"#label","subj":"T4","obj":"D066126"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":53,"end":64},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":112,"end":123},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":125,"end":135},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":306,"end":317},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":421,"end":434},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":479,"end":482},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D004317"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_64816"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_28748"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D004317"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_64816"},{"id":"A6","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_28748"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_28748"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D004317"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_64816"},{"id":"A10","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_28748"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D014280"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_17855"},{"id":"A13","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":24,"end":28},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":190,"end":198},"obj":"OrganismTaxon"}],"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.\nOften, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investiga"}

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