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PubMed:17823124 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-172 Sentence denotes Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
T2 173-351 Sentence denotes Type I interferon gene induction relies on IKK-related kinase TBK1 and IKKepsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways.
T3 352-436 Sentence denotes The scaffold proteins that assemble these kinase complexes are poorly characterized.
T4 437-633 Sentence denotes We show here that TANK/ITRAF is required for the TBK1- and IKKepsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex.
T5 634-737 Sentence denotes Moreover, TANK is dispensable for the early phase of double-stranded RNA-mediated IRF3 phosphorylation.
T6 738-1012 Sentence denotes Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity.
T7 1013-1369 Sentence denotes Thus, we have identified TANK as a scaffold protein that assembles some but not all IRF3/7-phosphorylating TBK1-IKKepsilon complexes and demonstrated that these kinases possess two functions, namely the phosphorylation of both IRF3/7 and TANK as well as the recruitment of an E3 ligase for Lys(63)-linked polyubiquitination of their scaffold protein, TANK.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 77-81 Protein denotes TBK1
T2 82-92 Protein denotes IKKepsilon
T3 160-164 Protein denotes TANK
T4 165-171 Protein denotes I-TRAF
T5 235-239 Protein denotes TBK1
T6 244-254 Protein denotes IKKepsilon
T7 284-288 Protein denotes IRF3
T8 289-290 Protein denotes 7
T9 455-459 Protein denotes TANK
T10 460-465 Protein denotes ITRAF
T11 486-490 Protein denotes TBK1
T12 496-506 Protein denotes IKKepsilon
T13 516-520 Protein denotes IRF3
T14 521-522 Protein denotes 7
T15 608-613 Protein denotes TRAF3
T16 644-648 Protein denotes TANK
T17 716-720 Protein denotes IRF3
T18 753-757 Protein denotes TANK
T19 787-791 Protein denotes TBK1
T20 792-802 Protein denotes IKKepsilon
T21 886-890 Protein denotes TBK1
T22 891-901 Protein denotes IKKepsilon
T23 980-984 Protein denotes TBK1
T24 985-995 Protein denotes IKKepsilon
T25 1038-1042 Protein denotes TANK
T26 1097-1101 Protein denotes IRF3
T27 1102-1103 Protein denotes 7
T28 1120-1124 Protein denotes TBK1
T29 1125-1135 Protein denotes IKKepsilon
T30 1240-1244 Protein denotes IRF3
T31 1245-1246 Protein denotes 7
T32 1251-1255 Protein denotes TANK
T33 1364-1368 Protein denotes TANK

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 173-179 Cell denotes Type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138