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PubMed:17056596 JSONTXT

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Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 332-338 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T2 427-440 Cell denotes naïve T-cells http://purl.obolibrary.org/obo/CL:0000898
T3 639-645 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T4 1408-1414 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084

LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
12 156-162 ChemicalEntity denotes Ca(2+) MESH:D000069285
13 221-227 ChemicalEntity denotes Ca(2+) MESH:D000069285
14 483-489 ChemicalEntity denotes Ca(2+) MESH:D000069285
15 561-567 ChemicalEntity denotes Ca(2+) MESH:D000069285
16 622-628 ChemicalEntity denotes Ca(2+) MESH:D000069285
17 766-772 ChemicalEntity denotes Ca(2+) MESH:D000069285
18 836-842 ChemicalEntity denotes Ca(2+) MESH:D000069285
19 1000-1006 ChemicalEntity denotes Ca(2+) MESH:D000069285
20 1050-1056 ChemicalEntity denotes Ca(2+) MESH:D000069285
21 1112-1118 ChemicalEntity denotes Ca(2+) MESH:D000069285
22 1262-1268 ChemicalEntity denotes Ca(2+) MESH:D000069285
23 1391-1397 ChemicalEntity denotes Ca(2+) MESH:D000069285

sentences

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane.
T2 128-210 Sentence denotes A rise of the intracellular Ca(2+) concentration has multiple signaling functions.
T3 211-468 Sentence denotes Sustained Ca(2+) influx across plasma membrane through calcium release-activated calcium (CRAC) channels is required for T-cell development in the thymus, gene transcription, and proliferation and differentiation of naïve T-cells into armed effectors cells.
T4 469-575 Sentence denotes Intracellular Ca(2+) signals are shaped by mitochondria, which function as a highly dynamic Ca(2+) buffer.
T5 576-668 Sentence denotes However, the precise role of mitochondria for Ca(2+)-dependent T-cell activation is unknown.
T6 669-872 Sentence denotes Here we have shown that mitochondria are translocated to the plasma membrane as a consequence of Ca(2+) influx and that this directed movement is essential to sustain Ca(2+) influx through CRAC channels.
T7 873-1127 Sentence denotes The decreased distance between mitochondria and the plasma membrane enabled mitochondria to take up large amounts of inflowing Ca(2+) at the plasma membrane, thereby preventing Ca(2+)-dependent inactivation of CRAC channels and sustaining Ca(2+) signals.
T8 1128-1277 Sentence denotes Inhibition of kinesin-dependent mitochondrial movement along microtubules abolished mitochondrial translocation and reduced sustained Ca(2+) signals.
T9 1278-1426 Sentence denotes Our results show how a directed movement of mitochondria is used to control important cellular functions such as Ca(2+)-dependent T-cell activation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 358-364 http://purl.obolibrary.org/obo/MAT_0000080 denotes thymus

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1160-1173 HP_0001427 denotes mitochondrial
T2 1212-1225 HP_0001427 denotes mitochondrial

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 358-364 OrganismTaxon denotes thymus 49990

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 111-126 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T2 142-155 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T3 242-257 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T4 332-338 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T5 358-364 Body_part denotes thymus http://purl.obolibrary.org/obo/UBERON_0002370
T6 469-482 Body_part denotes Intracellular http://purl.obolibrary.org/obo/GO_0005622
T7 639-645 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T8 730-745 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T9 925-940 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T10 1014-1029 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T11 1189-1201 Body_part denotes microtubules http://purl.obolibrary.org/obo/GO_0005874
T12 1408-1414 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 358-364 Body_part denotes thymus http://purl.obolibrary.org/obo/MAT_0000080