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PubMed:16377754 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-107 Sentence denotes A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates.
TextSentencer_T2 108-195 Sentence denotes Within cells, dermatan sulfate (DS) and heparan sulfate (HS) are degraded in two steps.
TextSentencer_T3 196-391 Sentence denotes The initial endohydrolysis of these polysaccharides is followed by the sequential action of lysosomal exoenzymes to reduce the resulting oligosaccharides to monosaccharides and inorganic sulfate.
TextSentencer_T4 392-528 Sentence denotes Mucopolysaccharidosis (MPS) type II is a lysosomal storage disorder caused by a deficiency of the exoenzyme iduronate-2-sulfatase (I2S).
TextSentencer_T5 529-680 Sentence denotes Consequently, partially degraded fragments of DS and HS have been shown to accumulate in the lysosomes of affected cells and are excreted in the urine.
TextSentencer_T6 681-892 Sentence denotes Di- to hexadecasaccharides, isolated from the urine of a MPS II patient using anion exchange and gel filtration chromatography, were identified using electrospray ionization-tandem mass spectrometry (ESI-MS/MS).
TextSentencer_T7 893-1020 Sentence denotes These oligosaccharides were shown to have non-reducing terminal iduronate-2-sulfate residues by digestion with recombinant I2S.
TextSentencer_T8 1021-1183 Sentence denotes A pattern of growing oligosaccharide chains composed of alternating uronic acid and N-acetylhexosamine residues was identified and suggested to originate from DS.
TextSentencer_T9 1184-1430 Sentence denotes A series of oligosaccharides consisting of hexosamine/N-acetylhexosamine alternating with uronic acid residues was also identified and on the basis of the presence of unacetylated hexosamine; these oligosaccharides are proposed to derive from HS.
TextSentencer_T10 1431-1601 Sentence denotes The presence of both odd and even-length oligosaccharides suggests both endo-beta-glucuronidase and endo-N-acetylhexosaminidase activities toward both glycosaminoglycans.
TextSentencer_T11 1602-1869 Sentence denotes Furthermore, the putative HS oligosaccharide structures identified indicate that heparanase activities are directed toward regions of both low and high sulfation, while the N-acetylhexosaminidase activity acted only in regions of low sulfation in this polysaccharide.
T1 0-107 Sentence denotes A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates.
T2 108-195 Sentence denotes Within cells, dermatan sulfate (DS) and heparan sulfate (HS) are degraded in two steps.
T3 196-391 Sentence denotes The initial endohydrolysis of these polysaccharides is followed by the sequential action of lysosomal exoenzymes to reduce the resulting oligosaccharides to monosaccharides and inorganic sulfate.
T4 392-528 Sentence denotes Mucopolysaccharidosis (MPS) type II is a lysosomal storage disorder caused by a deficiency of the exoenzyme iduronate-2-sulfatase (I2S).
T5 529-680 Sentence denotes Consequently, partially degraded fragments of DS and HS have been shown to accumulate in the lysosomes of affected cells and are excreted in the urine.
T6 681-892 Sentence denotes Di- to hexadecasaccharides, isolated from the urine of a MPS II patient using anion exchange and gel filtration chromatography, were identified using electrospray ionization-tandem mass spectrometry (ESI-MS/MS).
T7 893-1020 Sentence denotes These oligosaccharides were shown to have non-reducing terminal iduronate-2-sulfate residues by digestion with recombinant I2S.
T8 1021-1183 Sentence denotes A pattern of growing oligosaccharide chains composed of alternating uronic acid and N-acetylhexosamine residues was identified and suggested to originate from DS.
T9 1184-1430 Sentence denotes A series of oligosaccharides consisting of hexosamine/N-acetylhexosamine alternating with uronic acid residues was also identified and on the basis of the presence of unacetylated hexosamine; these oligosaccharides are proposed to derive from HS.
T10 1431-1601 Sentence denotes The presence of both odd and even-length oligosaccharides suggests both endo-beta-glucuronidase and endo-N-acetylhexosaminidase activities toward both glycosaminoglycans.
T11 1602-1869 Sentence denotes Furthermore, the putative HS oligosaccharide structures identified indicate that heparanase activities are directed toward regions of both low and high sulfation, while the N-acetylhexosaminidase activity acted only in regions of low sulfation in this polysaccharide.
T1 0-107 Sentence denotes A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates.
T2 108-195 Sentence denotes Within cells, dermatan sulfate (DS) and heparan sulfate (HS) are degraded in two steps.
T3 196-391 Sentence denotes The initial endohydrolysis of these polysaccharides is followed by the sequential action of lysosomal exoenzymes to reduce the resulting oligosaccharides to monosaccharides and inorganic sulfate.
T4 392-528 Sentence denotes Mucopolysaccharidosis (MPS) type II is a lysosomal storage disorder caused by a deficiency of the exoenzyme iduronate-2-sulfatase (I2S).
T5 529-680 Sentence denotes Consequently, partially degraded fragments of DS and HS have been shown to accumulate in the lysosomes of affected cells and are excreted in the urine.
T6 681-892 Sentence denotes Di- to hexadecasaccharides, isolated from the urine of a MPS II patient using anion exchange and gel filtration chromatography, were identified using electrospray ionization-tandem mass spectrometry (ESI-MS/MS).
T7 893-1020 Sentence denotes These oligosaccharides were shown to have non-reducing terminal iduronate-2-sulfate residues by digestion with recombinant I2S.
T8 1021-1183 Sentence denotes A pattern of growing oligosaccharide chains composed of alternating uronic acid and N-acetylhexosamine residues was identified and suggested to originate from DS.
T9 1184-1430 Sentence denotes A series of oligosaccharides consisting of hexosamine/N-acetylhexosamine alternating with uronic acid residues was also identified and on the basis of the presence of unacetylated hexosamine; these oligosaccharides are proposed to derive from HS.
T10 1431-1601 Sentence denotes The presence of both odd and even-length oligosaccharides suggests both endo-beta-glucuronidase and endo-N-acetylhexosaminidase activities toward both glycosaminoglycans.
T11 1602-1869 Sentence denotes Furthermore, the putative HS oligosaccharide structures identified indicate that heparanase activities are directed toward regions of both low and high sulfation, while the N-acetylhexosaminidase activity acted only in regions of low sulfation in this polysaccharide.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 148-163 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T2 165-167 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T3 582-584 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T4 1427-1429 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T5 1628-1630 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 674-679 http://purl.obolibrary.org/obo/MAT_0000058 denotes urine
T2 727-732 http://purl.obolibrary.org/obo/MAT_0000058 denotes urine

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 392-413 HP_0008155 denotes Mucopolysaccharidosis

ICD10

Id Subject Object Predicate Lexical cue
T1 392-413 http://purl.bioontology.org/ontology/ICD10/E76.3 denotes Mucopolysaccharidosis

uniprot-human

Id Subject Object Predicate Lexical cue
T1 140-142 http://www.uniprot.org/uniprot/P49366 denotes DS
T2 575-577 http://www.uniprot.org/uniprot/P49366 denotes DS
T3 1180-1182 http://www.uniprot.org/uniprot/P49366 denotes DS
T4 881-884 http://www.uniprot.org/uniprot/P19957 denotes ESI
T5 885-887 http://www.uniprot.org/uniprot/Q99707 denotes MS
T6 888-890 http://www.uniprot.org/uniprot/Q99707 denotes MS
T7 1508-1526 http://www.uniprot.org/uniprot/P08236 denotes beta-glucuronidase
T8 1683-1693 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 885-887 http://www.uniprot.org/uniprot/A6H5Y3 denotes MS
T2 888-890 http://www.uniprot.org/uniprot/A6H5Y3 denotes MS
T3 1508-1526 http://www.uniprot.org/uniprot/P12265 denotes beta-glucuronidase
T4 1683-1693 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 115-120 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 644-649 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 935-938 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non
T4 1508-1512 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes beta
T5 1508-1512 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes beta

GO-BP

Id Subject Object Predicate Lexical cue
T1 98-106 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfates
T2 131-138 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T3 156-163 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T4 383-390 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T5 969-976 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T6 1754-1763 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T7 1836-1845 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T8 173-181 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T9 553-561 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T10 443-450 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T11 443-450 http://purl.obolibrary.org/obo/GO_0035732 denotes storage
T12 500-521 http://purl.obolibrary.org/obo/GO_0004423 denotes iduronate-2-sulfatase
T13 658-666 http://purl.obolibrary.org/obo/GO_0007588 denotes excreted
T14 674-679 http://purl.obolibrary.org/obo/GO_0060073 denotes urine
T15 727-732 http://purl.obolibrary.org/obo/GO_0060073 denotes urine
T16 765-773 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T17 989-998 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T18 1536-1569 http://purl.obolibrary.org/obo/GO_0004563 denotes N-acetylhexosaminidase activities
T19 1775-1806 http://purl.obolibrary.org/obo/GO_0004563 denotes N-acetylhexosaminidase activity
T20 1683-1704 http://purl.obolibrary.org/obo/GO_0030305 denotes heparanase activities

GO-CC

Id Subject Object Predicate Lexical cue
T1 115-120 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 644-649 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 288-297 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T4 433-442 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T5 622-631 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 674-679 http://purl.obolibrary.org/obo/UBERON_0001088 denotes urine
T2 727-732 http://purl.obolibrary.org/obo/UBERON_0001088 denotes urine

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 27-35 http://edamontology.org/topic_0602 denotes pathways
T2 288-297 http://edamontology.org/topic_0616 denotes lysosomal
T3 433-442 http://edamontology.org/topic_0616 denotes lysosomal
T4 622-631 http://edamontology.org/topic_0616 denotes lysosomes
T5 862-879 http://edamontology.org/topic_0134 denotes mass spectrometry
T6 862-879 http://edamontology.org/topic_3520 denotes mass spectrometry
T7 948-956 http://edamontology.org/topic_0749 denotes terminal

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 27-35 http://edamontology.org/data_2600 denotes pathways
T2 353-368 http://edamontology.org/data_2746 denotes monosaccharides
T3 814-824 http://edamontology.org/data_2611 denotes identified
T4 814-824 http://edamontology.org/data_0842 denotes identified
T5 862-879 http://edamontology.org/data_3147 denotes mass spectrometry
T6 862-879 http://edamontology.org/data_2536 denotes mass spectrometry
T7 977-985 http://edamontology.org/data_1756 denotes residues
T8 1124-1132 http://edamontology.org/data_1756 denotes residues
T9 1124-1147 http://edamontology.org/data_0994 denotes residues was identified
T10 1137-1147 http://edamontology.org/data_0842 denotes identified
T11 1137-1147 http://edamontology.org/data_2611 denotes identified
T12 1286-1294 http://edamontology.org/data_1756 denotes residues
T13 1286-1314 http://edamontology.org/data_0994 denotes residues was also identified
T14 1304-1314 http://edamontology.org/data_2611 denotes identified
T15 1304-1314 http://edamontology.org/data_0842 denotes identified
T16 1647-1657 http://edamontology.org/data_0883 denotes structures
T17 1647-1668 http://edamontology.org/data_3035 denotes structures identified
T18 1647-1668 http://edamontology.org/data_1071 denotes structures identified
T19 1658-1668 http://edamontology.org/data_0842 denotes identified
T20 1658-1668 http://edamontology.org/data_2611 denotes identified

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16377754-3#108#129#gene3423 500-521 gene3423 denotes iduronate-2-sulfatase
16377754-3#131#134#gene3423 523-526 gene3423 denotes I2S
16377754-3#0#21#diseaseC0026703 392-413 diseaseC0026703 denotes Mucopolysaccharidosis
16377754-3#23#26#diseaseC0026703 415-418 diseaseC0026703 denotes MPS
16377754-3#0#21#diseaseC0026703 392-413 diseaseC0026703 denotes Mucopolysaccharidosis
16377754-3#23#26#diseaseC0026703 415-418 diseaseC0026703 denotes MPS
16377754-3#41#67#diseaseC0085078 433-459 diseaseC0085078 denotes lysosomal storage disorder
108#129#gene34230#21#diseaseC0026703 16377754-3#108#129#gene3423 16377754-3#0#21#diseaseC0026703 associated_with iduronate-2-sulfatase,Mucopolysaccharidosis
108#129#gene342323#26#diseaseC0026703 16377754-3#108#129#gene3423 16377754-3#23#26#diseaseC0026703 associated_with iduronate-2-sulfatase,MPS
108#129#gene34230#21#diseaseC0026703 16377754-3#108#129#gene3423 16377754-3#0#21#diseaseC0026703 associated_with iduronate-2-sulfatase,Mucopolysaccharidosis
108#129#gene342323#26#diseaseC0026703 16377754-3#108#129#gene3423 16377754-3#23#26#diseaseC0026703 associated_with iduronate-2-sulfatase,MPS
108#129#gene342341#67#diseaseC0085078 16377754-3#108#129#gene3423 16377754-3#41#67#diseaseC0085078 associated_with iduronate-2-sulfatase,lysosomal storage disorder
131#134#gene34230#21#diseaseC0026703 16377754-3#131#134#gene3423 16377754-3#0#21#diseaseC0026703 associated_with I2S,Mucopolysaccharidosis
131#134#gene342323#26#diseaseC0026703 16377754-3#131#134#gene3423 16377754-3#23#26#diseaseC0026703 associated_with I2S,MPS
131#134#gene34230#21#diseaseC0026703 16377754-3#131#134#gene3423 16377754-3#0#21#diseaseC0026703 associated_with I2S,Mucopolysaccharidosis
131#134#gene342323#26#diseaseC0026703 16377754-3#131#134#gene3423 16377754-3#23#26#diseaseC0026703 associated_with I2S,MPS
131#134#gene342341#67#diseaseC0085078 16377754-3#131#134#gene3423 16377754-3#41#67#diseaseC0085078 associated_with I2S,lysosomal storage disorder

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 674-679 http://purl.obolibrary.org/obo/MAT_0000058 denotes urine
T2 727-732 http://purl.obolibrary.org/obo/MAT_0000058 denotes urine

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 89-106 http://rdf.glycoinfo.org/glycan/G00019MO denotes dermatan sulfates
T2 122-138 http://rdf.glycoinfo.org/glycan/G00019MO denotes dermatan sulfate

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 148-163 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 935-938 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T2 935-938 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T3 935-938 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T4 935-938 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T5 935-938 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T6 935-938 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T7 935-938 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T8 935-938 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T9 935-938 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T10 935-938 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T11 935-938 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 674-679 http://purl.obolibrary.org/obo/UBERON_0001088 denotes urine
PD-UBERON-AE-B_T2 727-732 http://purl.obolibrary.org/obo/UBERON_0001088 denotes urine

DisGeNET

Id Subject Object Predicate Lexical cue
T0 500-521 gene:3423 denotes iduronate-2-sulfatase
T1 392-413 disease:C0026703 denotes Mucopolysaccharidosis
T2 500-521 gene:3423 denotes iduronate-2-sulfatase
T3 415-418 disease:C0026703 denotes MPS
T4 500-521 gene:3423 denotes iduronate-2-sulfatase
T5 433-459 disease:C0085078 denotes lysosomal storage disorder
T6 523-526 gene:3423 denotes I2S
T7 392-413 disease:C0026703 denotes Mucopolysaccharidosis
T8 523-526 gene:3423 denotes I2S
T9 415-418 disease:C0026703 denotes MPS
T10 523-526 gene:3423 denotes I2S
T11 433-459 disease:C0085078 denotes lysosomal storage disorder
R1 T0 T1 associated_with iduronate-2-sulfatase,Mucopolysaccharidosis
R2 T2 T3 associated_with iduronate-2-sulfatase,MPS
R3 T4 T5 associated_with iduronate-2-sulfatase,lysosomal storage disorder
R4 T6 T7 associated_with I2S,Mucopolysaccharidosis
R5 T8 T9 associated_with I2S,MPS
R6 T10 T11 associated_with I2S,lysosomal storage disorder

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 674-679 Body_part denotes urine http://purl.obolibrary.org/obo/MAT_0000058
T2 727-732 Body_part denotes urine http://purl.obolibrary.org/obo/MAT_0000058

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1452-1455 Phenotype denotes odd HP:0010865

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 392-413 Disease denotes Mucopolysaccharidosis http://purl.obolibrary.org/obo/MONDO_0019249
T2 415-418 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249
T3 433-459 Disease denotes lysosomal storage disorder http://purl.obolibrary.org/obo/MONDO_0002561
T4 738-744 Disease denotes MPS II http://purl.obolibrary.org/obo/MONDO_0010674
T5 738-741 Disease denotes MPS http://purl.obolibrary.org/obo/MONDO_0019249

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 745-752 OrganismTaxon denotes patient 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 622-631 Body_part denotes lysosomes http://purl.obolibrary.org/obo/GO_0005764
T2 674-679 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T3 727-732 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088