PubMed:16377754 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/16377754","sourcedb":"PubMed","sourceid":"16377754","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/16377754","text":"A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates.\nWithin cells, dermatan sulfate (DS) and heparan sulfate (HS) are degraded in two steps. The initial endohydrolysis of these polysaccharides is followed by the sequential action of lysosomal exoenzymes to reduce the resulting oligosaccharides to monosaccharides and inorganic sulfate. Mucopolysaccharidosis (MPS) type II is a lysosomal storage disorder caused by a deficiency of the exoenzyme iduronate-2-sulfatase (I2S). Consequently, partially degraded fragments of DS and HS have been shown to accumulate in the lysosomes of affected cells and are excreted in the urine. Di- to hexadecasaccharides, isolated from the urine of a MPS II patient using anion exchange and gel filtration chromatography, were identified using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). These oligosaccharides were shown to have non-reducing terminal iduronate-2-sulfate residues by digestion with recombinant I2S. A pattern of growing oligosaccharide chains composed of alternating uronic acid and N-acetylhexosamine residues was identified and suggested to originate from DS. A series of oligosaccharides consisting of hexosamine/N-acetylhexosamine alternating with uronic acid residues was also identified and on the basis of the presence of unacetylated hexosamine; these oligosaccharides are proposed to derive from HS. The presence of both odd and even-length oligosaccharides suggests both endo-beta-glucuronidase and endo-N-acetylhexosaminidase activities toward both glycosaminoglycans. Furthermore, the putative HS oligosaccharide structures identified indicate that heparanase activities are directed toward regions of both low and high sulfation, while the N-acetylhexosaminidase activity acted only in regions of low sulfation in this polysaccharide.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":108,"end":195},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":196,"end":391},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":392,"end":528},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":529,"end":680},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":681,"end":892},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":893,"end":1020},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1021,"end":1183},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1184,"end":1430},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1431,"end":1601},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1602,"end":1869},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"T2","span":{"begin":108,"end":195},"obj":"Sentence"},{"id":"T3","span":{"begin":196,"end":391},"obj":"Sentence"},{"id":"T4","span":{"begin":392,"end":528},"obj":"Sentence"},{"id":"T5","span":{"begin":529,"end":680},"obj":"Sentence"},{"id":"T6","span":{"begin":681,"end":892},"obj":"Sentence"},{"id":"T7","span":{"begin":893,"end":1020},"obj":"Sentence"},{"id":"T8","span":{"begin":1021,"end":1183},"obj":"Sentence"},{"id":"T9","span":{"begin":1184,"end":1430},"obj":"Sentence"},{"id":"T10","span":{"begin":1431,"end":1601},"obj":"Sentence"},{"id":"T11","span":{"begin":1602,"end":1869},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"T2","span":{"begin":108,"end":195},"obj":"Sentence"},{"id":"T3","span":{"begin":196,"end":391},"obj":"Sentence"},{"id":"T4","span":{"begin":392,"end":528},"obj":"Sentence"},{"id":"T5","span":{"begin":529,"end":680},"obj":"Sentence"},{"id":"T6","span":{"begin":681,"end":892},"obj":"Sentence"},{"id":"T7","span":{"begin":893,"end":1020},"obj":"Sentence"},{"id":"T8","span":{"begin":1021,"end":1183},"obj":"Sentence"},{"id":"T9","span":{"begin":1184,"end":1430},"obj":"Sentence"},{"id":"T10","span":{"begin":1431,"end":1601},"obj":"Sentence"},{"id":"T11","span":{"begin":1602,"end":1869},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":148,"end":163},"obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"T2","span":{"begin":165,"end":167},"obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"T3","span":{"begin":582,"end":584},"obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"T4","span":{"begin":1427,"end":1429},"obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"T5","span":{"begin":1628,"end":1630},"obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-GlycoEpitope"},{"subj":"T2","pred":"source","obj":"Glycosmos6-GlycoEpitope"},{"subj":"T3","pred":"source","obj":"Glycosmos6-GlycoEpitope"},{"subj":"T4","pred":"source","obj":"Glycosmos6-GlycoEpitope"},{"subj":"T5","pred":"source","obj":"Glycosmos6-GlycoEpitope"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":674,"end":679},"obj":"http://purl.obolibrary.org/obo/MAT_0000058"},{"id":"T2","span":{"begin":727,"end":732},"obj":"http://purl.obolibrary.org/obo/MAT_0000058"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":392,"end":413},"obj":"HP_0008155"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"ICD10","denotations":[{"id":"T1","span":{"begin":392,"end":413},"obj":"http://purl.bioontology.org/ontology/ICD10/E76.3"}],"attributes":[{"subj":"T1","pred":"source","obj":"ICD10"}]},{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":140,"end":142},"obj":"http://www.uniprot.org/uniprot/P49366"},{"id":"T2","span":{"begin":575,"end":577},"obj":"http://www.uniprot.org/uniprot/P49366"},{"id":"T3","span":{"begin":1180,"end":1182},"obj":"http://www.uniprot.org/uniprot/P49366"},{"id":"T4","span":{"begin":881,"end":884},"obj":"http://www.uniprot.org/uniprot/P19957"},{"id":"T5","span":{"begin":885,"end":887},"obj":"http://www.uniprot.org/uniprot/Q99707"},{"id":"T6","span":{"begin":888,"end":890},"obj":"http://www.uniprot.org/uniprot/Q99707"},{"id":"T7","span":{"begin":1508,"end":1526},"obj":"http://www.uniprot.org/uniprot/P08236"},{"id":"T8","span":{"begin":1683,"end":1693},"obj":"http://www.uniprot.org/uniprot/Q9Y251"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-human"},{"subj":"T2","pred":"source","obj":"uniprot-human"},{"subj":"T3","pred":"source","obj":"uniprot-human"},{"subj":"T4","pred":"source","obj":"uniprot-human"},{"subj":"T5","pred":"source","obj":"uniprot-human"},{"subj":"T6","pred":"source","obj":"uniprot-human"},{"subj":"T7","pred":"source","obj":"uniprot-human"},{"subj":"T8","pred":"source","obj":"uniprot-human"}]},{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":885,"end":887},"obj":"http://www.uniprot.org/uniprot/A6H5Y3"},{"id":"T2","span":{"begin":888,"end":890},"obj":"http://www.uniprot.org/uniprot/A6H5Y3"},{"id":"T3","span":{"begin":1508,"end":1526},"obj":"http://www.uniprot.org/uniprot/P12265"},{"id":"T4","span":{"begin":1683,"end":1693},"obj":"http://www.uniprot.org/uniprot/Q6YGZ1"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-mouse"},{"subj":"T2","pred":"source","obj":"uniprot-mouse"},{"subj":"T3","pred":"source","obj":"uniprot-mouse"},{"subj":"T4","pred":"source","obj":"uniprot-mouse"}]},{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":115,"end":120},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T2","span":{"begin":644,"end":649},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T3","span":{"begin":935,"end":938},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/604139"},{"id":"T4","span":{"begin":1508,"end":1512},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T5","span":{"begin":1508,"end":1512},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T2","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T3","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T4","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T5","pred":"source","obj":"GlycoBiology-NCBITAXON"}]},{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":98,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T2","span":{"begin":131,"end":138},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T3","span":{"begin":156,"end":163},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T4","span":{"begin":383,"end":390},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T5","span":{"begin":969,"end":976},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T6","span":{"begin":1754,"end":1763},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T7","span":{"begin":1836,"end":1845},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T8","span":{"begin":173,"end":181},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T9","span":{"begin":553,"end":561},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T10","span":{"begin":443,"end":450},"obj":"http://purl.obolibrary.org/obo/GO_0051235"},{"id":"T11","span":{"begin":443,"end":450},"obj":"http://purl.obolibrary.org/obo/GO_0035732"},{"id":"T12","span":{"begin":500,"end":521},"obj":"http://purl.obolibrary.org/obo/GO_0004423"},{"id":"T13","span":{"begin":658,"end":666},"obj":"http://purl.obolibrary.org/obo/GO_0007588"},{"id":"T14","span":{"begin":674,"end":679},"obj":"http://purl.obolibrary.org/obo/GO_0060073"},{"id":"T15","span":{"begin":727,"end":732},"obj":"http://purl.obolibrary.org/obo/GO_0060073"},{"id":"T16","span":{"begin":765,"end":773},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T17","span":{"begin":989,"end":998},"obj":"http://purl.obolibrary.org/obo/GO_0007586"},{"id":"T18","span":{"begin":1536,"end":1569},"obj":"http://purl.obolibrary.org/obo/GO_0004563"},{"id":"T19","span":{"begin":1775,"end":1806},"obj":"http://purl.obolibrary.org/obo/GO_0004563"},{"id":"T20","span":{"begin":1683,"end":1704},"obj":"http://purl.obolibrary.org/obo/GO_0030305"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-BP"},{"subj":"T2","pred":"source","obj":"GO-BP"},{"subj":"T3","pred":"source","obj":"GO-BP"},{"subj":"T4","pred":"source","obj":"GO-BP"},{"subj":"T5","pred":"source","obj":"GO-BP"},{"subj":"T6","pred":"source","obj":"GO-BP"},{"subj":"T7","pred":"source","obj":"GO-BP"},{"subj":"T8","pred":"source","obj":"GO-BP"},{"subj":"T9","pred":"source","obj":"GO-BP"},{"subj":"T10","pred":"source","obj":"GO-BP"},{"subj":"T11","pred":"source","obj":"GO-BP"},{"subj":"T12","pred":"source","obj":"GO-BP"},{"subj":"T13","pred":"source","obj":"GO-BP"},{"subj":"T14","pred":"source","obj":"GO-BP"},{"subj":"T15","pred":"source","obj":"GO-BP"},{"subj":"T16","pred":"source","obj":"GO-BP"},{"subj":"T17","pred":"source","obj":"GO-BP"},{"subj":"T18","pred":"source","obj":"GO-BP"},{"subj":"T19","pred":"source","obj":"GO-BP"},{"subj":"T20","pred":"source","obj":"GO-BP"}]},{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":115,"end":120},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":644,"end":649},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":288,"end":297},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T4","span":{"begin":433,"end":442},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T5","span":{"begin":622,"end":631},"obj":"http://purl.obolibrary.org/obo/GO_0005764"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-CC"},{"subj":"T2","pred":"source","obj":"GO-CC"},{"subj":"T3","pred":"source","obj":"GO-CC"},{"subj":"T4","pred":"source","obj":"GO-CC"},{"subj":"T5","pred":"source","obj":"GO-CC"}]},{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":674,"end":679},"obj":"http://purl.obolibrary.org/obo/UBERON_0001088"},{"id":"T2","span":{"begin":727,"end":732},"obj":"http://purl.obolibrary.org/obo/UBERON_0001088"}],"attributes":[{"subj":"T1","pred":"source","obj":"UBERON-AE"},{"subj":"T2","pred":"source","obj":"UBERON-AE"}]},{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":27,"end":35},"obj":"http://edamontology.org/topic_0602"},{"id":"T2","span":{"begin":288,"end":297},"obj":"http://edamontology.org/topic_0616"},{"id":"T3","span":{"begin":433,"end":442},"obj":"http://edamontology.org/topic_0616"},{"id":"T4","span":{"begin":622,"end":631},"obj":"http://edamontology.org/topic_0616"},{"id":"T5","span":{"begin":862,"end":879},"obj":"http://edamontology.org/topic_0134"},{"id":"T6","span":{"begin":862,"end":879},"obj":"http://edamontology.org/topic_3520"},{"id":"T7","span":{"begin":948,"end":956},"obj":"http://edamontology.org/topic_0749"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-topics"},{"subj":"T2","pred":"source","obj":"EDAM-topics"},{"subj":"T3","pred":"source","obj":"EDAM-topics"},{"subj":"T4","pred":"source","obj":"EDAM-topics"},{"subj":"T5","pred":"source","obj":"EDAM-topics"},{"subj":"T6","pred":"source","obj":"EDAM-topics"},{"subj":"T7","pred":"source","obj":"EDAM-topics"}]},{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":27,"end":35},"obj":"http://edamontology.org/data_2600"},{"id":"T2","span":{"begin":353,"end":368},"obj":"http://edamontology.org/data_2746"},{"id":"T3","span":{"begin":814,"end":824},"obj":"http://edamontology.org/data_2611"},{"id":"T4","span":{"begin":814,"end":824},"obj":"http://edamontology.org/data_0842"},{"id":"T5","span":{"begin":862,"end":879},"obj":"http://edamontology.org/data_3147"},{"id":"T6","span":{"begin":862,"end":879},"obj":"http://edamontology.org/data_2536"},{"id":"T7","span":{"begin":977,"end":985},"obj":"http://edamontology.org/data_1756"},{"id":"T8","span":{"begin":1124,"end":1132},"obj":"http://edamontology.org/data_1756"},{"id":"T9","span":{"begin":1124,"end":1147},"obj":"http://edamontology.org/data_0994"},{"id":"T10","span":{"begin":1137,"end":1147},"obj":"http://edamontology.org/data_0842"},{"id":"T11","span":{"begin":1137,"end":1147},"obj":"http://edamontology.org/data_2611"},{"id":"T12","span":{"begin":1286,"end":1294},"obj":"http://edamontology.org/data_1756"},{"id":"T13","span":{"begin":1286,"end":1314},"obj":"http://edamontology.org/data_0994"},{"id":"T14","span":{"begin":1304,"end":1314},"obj":"http://edamontology.org/data_2611"},{"id":"T15","span":{"begin":1304,"end":1314},"obj":"http://edamontology.org/data_0842"},{"id":"T16","span":{"begin":1647,"end":1657},"obj":"http://edamontology.org/data_0883"},{"id":"T17","span":{"begin":1647,"end":1668},"obj":"http://edamontology.org/data_3035"},{"id":"T18","span":{"begin":1647,"end":1668},"obj":"http://edamontology.org/data_1071"},{"id":"T19","span":{"begin":1658,"end":1668},"obj":"http://edamontology.org/data_0842"},{"id":"T20","span":{"begin":1658,"end":1668},"obj":"http://edamontology.org/data_2611"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-DFO"},{"subj":"T2","pred":"source","obj":"EDAM-DFO"},{"subj":"T3","pred":"source","obj":"EDAM-DFO"},{"subj":"T4","pred":"source","obj":"EDAM-DFO"},{"subj":"T5","pred":"source","obj":"EDAM-DFO"},{"subj":"T6","pred":"source","obj":"EDAM-DFO"},{"subj":"T7","pred":"source","obj":"EDAM-DFO"},{"subj":"T8","pred":"source","obj":"EDAM-DFO"},{"subj":"T9","pred":"source","obj":"EDAM-DFO"},{"subj":"T10","pred":"source","obj":"EDAM-DFO"},{"subj":"T11","pred":"source","obj":"EDAM-DFO"},{"subj":"T12","pred":"source","obj":"EDAM-DFO"},{"subj":"T13","pred":"source","obj":"EDAM-DFO"},{"subj":"T14","pred":"source","obj":"EDAM-DFO"},{"subj":"T15","pred":"source","obj":"EDAM-DFO"},{"subj":"T16","pred":"source","obj":"EDAM-DFO"},{"subj":"T17","pred":"source","obj":"EDAM-DFO"},{"subj":"T18","pred":"source","obj":"EDAM-DFO"},{"subj":"T19","pred":"source","obj":"EDAM-DFO"},{"subj":"T20","pred":"source","obj":"EDAM-DFO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16377754-3#108#129#gene3423","span":{"begin":500,"end":521},"obj":"gene3423"},{"id":"16377754-3#131#134#gene3423","span":{"begin":523,"end":526},"obj":"gene3423"},{"id":"16377754-3#0#21#diseaseC0026703","span":{"begin":392,"end":413},"obj":"diseaseC0026703"},{"id":"16377754-3#23#26#diseaseC0026703","span":{"begin":415,"end":418},"obj":"diseaseC0026703"},{"id":"16377754-3#0#21#diseaseC0026703","span":{"begin":392,"end":413},"obj":"diseaseC0026703"},{"id":"16377754-3#23#26#diseaseC0026703","span":{"begin":415,"end":418},"obj":"diseaseC0026703"},{"id":"16377754-3#41#67#diseaseC0085078","span":{"begin":433,"end":459},"obj":"diseaseC0085078"}],"relations":[{"id":"108#129#gene34230#21#diseaseC0026703","pred":"associated_with","subj":"16377754-3#108#129#gene3423","obj":"16377754-3#0#21#diseaseC0026703"},{"id":"108#129#gene342323#26#diseaseC0026703","pred":"associated_with","subj":"16377754-3#108#129#gene3423","obj":"16377754-3#23#26#diseaseC0026703"},{"id":"108#129#gene34230#21#diseaseC0026703","pred":"associated_with","subj":"16377754-3#108#129#gene3423","obj":"16377754-3#0#21#diseaseC0026703"},{"id":"108#129#gene342323#26#diseaseC0026703","pred":"associated_with","subj":"16377754-3#108#129#gene3423","obj":"16377754-3#23#26#diseaseC0026703"},{"id":"108#129#gene342341#67#diseaseC0085078","pred":"associated_with","subj":"16377754-3#108#129#gene3423","obj":"16377754-3#41#67#diseaseC0085078"},{"id":"131#134#gene34230#21#diseaseC0026703","pred":"associated_with","subj":"16377754-3#131#134#gene3423","obj":"16377754-3#0#21#diseaseC0026703"},{"id":"131#134#gene342323#26#diseaseC0026703","pred":"associated_with","subj":"16377754-3#131#134#gene3423","obj":"16377754-3#23#26#diseaseC0026703"},{"id":"131#134#gene34230#21#diseaseC0026703","pred":"associated_with","subj":"16377754-3#131#134#gene3423","obj":"16377754-3#0#21#diseaseC0026703"},{"id":"131#134#gene342323#26#diseaseC0026703","pred":"associated_with","subj":"16377754-3#131#134#gene3423","obj":"16377754-3#23#26#diseaseC0026703"},{"id":"131#134#gene342341#67#diseaseC0085078","pred":"associated_with","subj":"16377754-3#131#134#gene3423","obj":"16377754-3#41#67#diseaseC0085078"}],"attributes":[{"subj":"16377754-3#108#129#gene3423","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"16377754-3#131#134#gene3423","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"16377754-3#0#21#diseaseC0026703","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"16377754-3#23#26#diseaseC0026703","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"16377754-3#0#21#diseaseC0026703","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"16377754-3#23#26#diseaseC0026703","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"16377754-3#41#67#diseaseC0085078","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":674,"end":679},"obj":"http://purl.obolibrary.org/obo/MAT_0000058"},{"id":"T2","span":{"begin":727,"end":732},"obj":"http://purl.obolibrary.org/obo/MAT_0000058"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T2","pred":"source","obj":"GlycoBiology-MAT"}]},{"project":"GlycoBiology-Motifs","denotations":[{"id":"T1","span":{"begin":89,"end":106},"obj":"http://rdf.glycoinfo.org/glycan/G00019MO"},{"id":"T2","span":{"begin":122,"end":138},"obj":"http://rdf.glycoinfo.org/glycan/G00019MO"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-Motifs"},{"subj":"T2","pred":"source","obj":"GlycoBiology-Motifs"}]},{"project":"GlycoBiology-Epitope","denotations":[{"id":"PD-GlycoEpitope-B_T1","span":{"begin":148,"end":163},"obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"attributes":[{"subj":"PD-GlycoEpitope-B_T1","pred":"source","obj":"GlycoBiology-Epitope"}]},{"project":"GlyTouCan-IUPAC","denotations":[{"id":"GlycanIUPAC_T1","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G02780QX\""},{"id":"GlycanIUPAC_T2","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G18425DX\""},{"id":"GlycanIUPAC_T3","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G18630JE\""},{"id":"GlycanIUPAC_T4","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G01004IT\""},{"id":"GlycanIUPAC_T5","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G87301QZ\""},{"id":"GlycanIUPAC_T6","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G39790GW\""},{"id":"GlycanIUPAC_T7","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G42928BB\""},{"id":"GlycanIUPAC_T8","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G51134HC\""},{"id":"GlycanIUPAC_T9","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G68183GR\""},{"id":"GlycanIUPAC_T10","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G46883FA\""},{"id":"GlycanIUPAC_T11","span":{"begin":935,"end":938},"obj":"\"http://rdf.glycoinfo.org/glycan/G54702VY\""}],"attributes":[{"subj":"GlycanIUPAC_T1","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T2","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T3","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T4","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T5","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T6","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T7","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T8","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T9","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T10","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T11","pred":"source","obj":"GlyTouCan-IUPAC"}]},{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":674,"end":679},"obj":"http://purl.obolibrary.org/obo/UBERON_0001088"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":727,"end":732},"obj":"http://purl.obolibrary.org/obo/UBERON_0001088"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":500,"end":521},"obj":"gene:3423"},{"id":"T1","span":{"begin":392,"end":413},"obj":"disease:C0026703"},{"id":"T2","span":{"begin":500,"end":521},"obj":"gene:3423"},{"id":"T3","span":{"begin":415,"end":418},"obj":"disease:C0026703"},{"id":"T4","span":{"begin":500,"end":521},"obj":"gene:3423"},{"id":"T5","span":{"begin":433,"end":459},"obj":"disease:C0085078"},{"id":"T6","span":{"begin":523,"end":526},"obj":"gene:3423"},{"id":"T7","span":{"begin":392,"end":413},"obj":"disease:C0026703"},{"id":"T8","span":{"begin":523,"end":526},"obj":"gene:3423"},{"id":"T9","span":{"begin":415,"end":418},"obj":"disease:C0026703"},{"id":"T10","span":{"begin":523,"end":526},"obj":"gene:3423"},{"id":"T11","span":{"begin":433,"end":459},"obj":"disease:C0085078"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":674,"end":679},"obj":"Body_part"},{"id":"T2","span":{"begin":727,"end":732},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000058"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000058"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":1452,"end":1455},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0010865"},{"subj":"T1","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":392,"end":413},"obj":"Disease"},{"id":"T2","span":{"begin":415,"end":418},"obj":"Disease"},{"id":"T3","span":{"begin":433,"end":459},"obj":"Disease"},{"id":"T4","span":{"begin":738,"end":744},"obj":"Disease"},{"id":"T5","span":{"begin":738,"end":741},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0019249"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0019249"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0002561"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0010674"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0019249"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T5","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":745,"end":752},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":622,"end":631},"obj":"Body_part"},{"id":"T2","span":{"begin":674,"end":679},"obj":"Body_part"},{"id":"T3","span":{"begin":727,"end":732},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001088"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001088"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#a4ec93","default":true},{"id":"Glycosmos6-GlycoEpitope","color":"#ec93be"},{"id":"Glycosmos6-MAT","color":"#93d8ec"},{"id":"PubmedHPO","color":"#ece693"},{"id":"ICD10","color":"#cb93ec"},{"id":"uniprot-human","color":"#93ecb1"},{"id":"uniprot-mouse","color":"#ec9793"},{"id":"GlycoBiology-NCBITAXON","color":"#93a8ec"},{"id":"GO-BP","color":"#c2ec93"},{"id":"GO-CC","color":"#ec93dc"},{"id":"UBERON-AE","color":"#93ece2"},{"id":"EDAM-topics","color":"#ecc893"},{"id":"EDAM-DFO","color":"#ae93ec"},{"id":"DisGeNET5_gene_disease","color":"#93ec94"},{"id":"GlycoBiology-MAT","color":"#ec93ac"},{"id":"GlycoBiology-Motifs","color":"#93c6ec"},{"id":"GlycoBiology-Epitope","color":"#e0ec93"},{"id":"GlyTouCan-IUPAC","color":"#de93ec"},{"id":"performance-test","color":"#93ecc4"},{"id":"DisGeNET","color":"#ecaa93"},{"id":"Anatomy-MAT","color":"#9395ec"},{"id":"HP-phenotype","color":"#afec93"},{"id":"mondo_disease","color":"#ec93ca"},{"id":"NCBITAXON","color":"#93e4ec"},{"id":"Anatomy-UBERON","color":"#ecda93"}]}]}}