PubMed:1520341 JSON TXT

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jnlpba-st-training

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":36,"end":40},"obj":"protein"},{"id":"T2","span":{"begin":42,"end":52},"obj":"protein"},{"id":"T3","span":{"begin":58,"end":85},"obj":"protein"},{"id":"T4","span":{"begin":89,"end":108},"obj":"cell_type"},{"id":"T5","span":{"begin":123,"end":142},"obj":"cell_type"},{"id":"T6","span":{"begin":206,"end":227},"obj":"protein"},{"id":"T7","span":{"begin":262,"end":282},"obj":"protein"},{"id":"T8","span":{"begin":284,"end":288},"obj":"protein"},{"id":"T9","span":{"begin":314,"end":324},"obj":"protein"},{"id":"T10","span":{"begin":377,"end":401},"obj":"protein"},{"id":"T11","span":{"begin":403,"end":408},"obj":"protein"},{"id":"T12","span":{"begin":412,"end":417},"obj":"protein"},{"id":"T13","span":{"begin":442,"end":446},"obj":"protein"},{"id":"T14","span":{"begin":451,"end":461},"obj":"protein"},{"id":"T15","span":{"begin":521,"end":565},"obj":"DNA"},{"id":"T16","span":{"begin":609,"end":623},"obj":"RNA"},{"id":"T17","span":{"begin":695,"end":709},"obj":"RNA"},{"id":"T18","span":{"begin":769,"end":778},"obj":"protein"},{"id":"T19","span":{"begin":878,"end":882},"obj":"protein"},{"id":"T20","span":{"begin":887,"end":897},"obj":"protein"},{"id":"T21","span":{"begin":947,"end":961},"obj":"protein"}],"text":"Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes.\nTreatment of human B lymphocytes with an optimal concentration of okadaic acid, an inhibitor of phosphatases 1 and 2A, resulted in the induction of the transcription factor, AP-1 and a marked increase in NF-kappa B levels. In contrast, no effect on the levels of the octamer binding proteins, Oct-1 or Oct-2, were found. Since both AP-1 and NF-kappa B have been reported to be important in the induction of the tumor necrosis factor-alpha (TNF-alpha) gene we examined the effects of okadaic acid on TNF-alpha mRNA levels. Treatment with okadaic acid resulted in a striking increase in TNF-alpha mRNA transcripts within 1 h of stimulation and large amounts of TNF-alpha were released into the culture media. Although okadaic acid provides a potent inductive signal for AP-1 and NF-kappa B it did not induce either B cell proliferation or immunoglobulin secretion."}

genia-medco-coref

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":12},"obj":"NP"},{"id":"C2","span":{"begin":36,"end":40},"obj":"NP"},{"id":"C3","span":{"begin":42,"end":52},"obj":"NP"},{"id":"C4","span":{"begin":58,"end":85},"obj":"NP"},{"id":"C5","span":{"begin":89,"end":108},"obj":"NP"},{"id":"C6","span":{"begin":123,"end":142},"obj":"NP"},{"id":"C7","span":{"begin":176,"end":188},"obj":"NP"},{"id":"C8","span":{"begin":190,"end":227},"obj":"NP"},{"id":"C9","span":{"begin":258,"end":282},"obj":"NP"},{"id":"C10","span":{"begin":284,"end":288},"obj":"NP"},{"id":"C11","span":{"begin":314,"end":324},"obj":"NP"},{"id":"C12","span":{"begin":373,"end":401},"obj":"NP"},{"id":"C13","span":{"begin":403,"end":417},"obj":"NP"},{"id":"C14","span":{"begin":442,"end":446},"obj":"NP"},{"id":"C15","span":{"begin":451,"end":461},"obj":"NP"},{"id":"C16","span":{"begin":521,"end":560},"obj":"NP"},{"id":"C17","span":{"begin":593,"end":605},"obj":"NP"},{"id":"C18","span":{"begin":609,"end":618},"obj":"NP"},{"id":"C19","span":{"begin":647,"end":659},"obj":"NP"},{"id":"C20","span":{"begin":695,"end":704},"obj":"NP"},{"id":"C21","span":{"begin":769,"end":778},"obj":"NP"},{"id":"C22","span":{"begin":826,"end":838},"obj":"NP"},{"id":"C23","span":{"begin":878,"end":882},"obj":"NP"},{"id":"C24","span":{"begin":887,"end":897},"obj":"NP"},{"id":"C25","span":{"begin":898,"end":900},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R2","pred":"coref-ident","subj":"C7","obj":"C1"},{"id":"R3","pred":"coref-appos","subj":"C8","obj":"C7"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C2"},{"id":"R5","pred":"coref-appos","subj":"C10","obj":"C9"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C3"},{"id":"R7","pred":"coref-appos","subj":"C13","obj":"C12"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C10"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C11"},{"id":"R10","pred":"coref-ident","subj":"C16","obj":"C4"},{"id":"R11","pred":"coref-ident","subj":"C17","obj":"C7"},{"id":"R12","pred":"coref-ident","subj":"C18","obj":"C16"},{"id":"R13","pred":"coref-ident","subj":"C19","obj":"C17"},{"id":"R14","pred":"coref-ident","subj":"C20","obj":"C18"},{"id":"R15","pred":"coref-ident","subj":"C21","obj":"C20"},{"id":"R16","pred":"coref-ident","subj":"C22","obj":"C19"},{"id":"R17","pred":"coref-ident","subj":"C23","obj":"C14"},{"id":"R18","pred":"coref-ident","subj":"C24","obj":"C15"},{"id":"R19","pred":"coref-pron","subj":"C25","obj":"C22"}],"text":"Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes.\nTreatment of human B lymphocytes with an optimal concentration of okadaic acid, an inhibitor of phosphatases 1 and 2A, resulted in the induction of the transcription factor, AP-1 and a marked increase in NF-kappa B levels. In contrast, no effect on the levels of the octamer binding proteins, Oct-1 or Oct-2, were found. Since both AP-1 and NF-kappa B have been reported to be important in the induction of the tumor necrosis factor-alpha (TNF-alpha) gene we examined the effects of okadaic acid on TNF-alpha mRNA levels. Treatment with okadaic acid resulted in a striking increase in TNF-alpha mRNA transcripts within 1 h of stimulation and large amounts of TNF-alpha were released into the culture media. Although okadaic acid provides a potent inductive signal for AP-1 and NF-kappa B it did not induce either B cell proliferation or immunoglobulin secretion."}

semrep-sample

pubmed-sentences-benchmark

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":109},"obj":"Sentence"},{"id":"S2","span":{"begin":110,"end":332},"obj":"Sentence"},{"id":"S3","span":{"begin":333,"end":430},"obj":"Sentence"},{"id":"S4","span":{"begin":431,"end":631},"obj":"Sentence"},{"id":"S5","span":{"begin":632,"end":816},"obj":"Sentence"},{"id":"S6","span":{"begin":817,"end":972},"obj":"Sentence"}],"text":"Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes.\nTreatment of human B lymphocytes with an optimal concentration of okadaic acid, an inhibitor of phosphatases 1 and 2A, resulted in the induction of the transcription factor, AP-1 and a marked increase in NF-kappa B levels. In contrast, no effect on the levels of the octamer binding proteins, Oct-1 or Oct-2, were found. Since both AP-1 and NF-kappa B have been reported to be important in the induction of the tumor necrosis factor-alpha (TNF-alpha) gene we examined the effects of okadaic acid on TNF-alpha mRNA levels. Treatment with okadaic acid resulted in a striking increase in TNF-alpha mRNA transcripts within 1 h of stimulation and large amounts of TNF-alpha were released into the culture media. Although okadaic acid provides a potent inductive signal for AP-1 and NF-kappa B it did not induce either B cell proliferation or immunoglobulin secretion."}

GENIAcorpus

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":12},"obj":"other_organic_compound"},{"id":"T2","span":{"begin":36,"end":40},"obj":"protein_molecule"},{"id":"T3","span":{"begin":42,"end":52},"obj":"protein_molecule"},{"id":"T4","span":{"begin":58,"end":85},"obj":"protein_molecule"},{"id":"T5","span":{"begin":89,"end":108},"obj":"cell_type"},{"id":"T6","span":{"begin":123,"end":142},"obj":"cell_type"},{"id":"T7","span":{"begin":176,"end":188},"obj":"other_organic_compound"},{"id":"T8","span":{"begin":262,"end":282},"obj":"protein_family_or_group"},{"id":"T9","span":{"begin":284,"end":288},"obj":"protein_molecule"},{"id":"T10","span":{"begin":314,"end":324},"obj":"protein_molecule"},{"id":"T11","span":{"begin":377,"end":401},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":403,"end":408},"obj":"protein_molecule"},{"id":"T13","span":{"begin":412,"end":417},"obj":"protein_molecule"},{"id":"T14","span":{"begin":442,"end":446},"obj":"protein_molecule"},{"id":"T15","span":{"begin":451,"end":461},"obj":"protein_molecule"},{"id":"T16","span":{"begin":521,"end":548},"obj":"protein_molecule"},{"id":"T17","span":{"begin":593,"end":605},"obj":"other_organic_compound"},{"id":"T18","span":{"begin":609,"end":623},"obj":"RNA_molecule"},{"id":"T19","span":{"begin":647,"end":659},"obj":"other_organic_compound"},{"id":"T20","span":{"begin":695,"end":709},"obj":"RNA_molecule"},{"id":"T21","span":{"begin":769,"end":778},"obj":"protein_molecule"},{"id":"T22","span":{"begin":802,"end":815},"obj":"other_name"},{"id":"T23","span":{"begin":826,"end":838},"obj":"other_organic_compound"},{"id":"T24","span":{"begin":878,"end":882},"obj":"protein_molecule"},{"id":"T25","span":{"begin":887,"end":897},"obj":"protein_molecule"},{"id":"T26","span":{"begin":923,"end":943},"obj":"other_name"},{"id":"T27","span":{"begin":947,"end":961},"obj":"protein_family_or_group"}],"text":"Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes.\nTreatment of human B lymphocytes with an optimal concentration of okadaic acid, an inhibitor of phosphatases 1 and 2A, resulted in the induction of the transcription factor, AP-1 and a marked increase in NF-kappa B levels. In contrast, no effect on the levels of the octamer binding proteins, Oct-1 or Oct-2, were found. Since both AP-1 and NF-kappa B have been reported to be important in the induction of the tumor necrosis factor-alpha (TNF-alpha) gene we examined the effects of okadaic acid on TNF-alpha mRNA levels. Treatment with okadaic acid resulted in a striking increase in TNF-alpha mRNA transcripts within 1 h of stimulation and large amounts of TNF-alpha were released into the culture media. Although okadaic acid provides a potent inductive signal for AP-1 and NF-kappa B it did not induce either B cell proliferation or immunoglobulin secretion."}

metamap-sample