PubMed:14707489 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/14707489","sourcedb":"PubMed","sourceid":"14707489","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/14707489","text":"Synthesis of a targeting drug for antifibrosis of liver; a conjugate for delivering glycyrrhetin to hepatic stellate cells.\nThe neoglycoproteins that consist of human serum albumin (HSA) modified with mannose 6-phosphate ([M6P]x-HSA) were synthesized, and they showed high binding property to hepatic stellate cells (HSC) by immunohistochemical analysis. In addition, an increased substitution (X) of 6-phosphated mannose (M6P) was associated with an increased accumulation in HSC. So the [M6P]x-HSA might be a carrier to deliver drugs to HSC. The antifibrotic drug, glycyrrhetin, was chosen to conjugate to M6P(26)-HSA. The result suggests there were 6 approximately 7 glycyrrhetin molecules having been conjugated to the carrier. Targeting glycyrrhetin to HSC might reduce its adverse affects and increase the efficacy.","tracks":[{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":201,"end":208},"obj":"Glycan_Motif"},{"id":"T2","span":{"begin":414,"end":421},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"},{"id":"A2","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"},{"subj":"T1","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"}]},{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":201,"end":208},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T2","span":{"begin":414,"end":421},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":124,"end":354},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":355,"end":481},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":482,"end":543},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":544,"end":620},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":621,"end":731},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":732,"end":821},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T2","span":{"begin":124,"end":354},"obj":"Sentence"},{"id":"T3","span":{"begin":355,"end":481},"obj":"Sentence"},{"id":"T4","span":{"begin":482,"end":543},"obj":"Sentence"},{"id":"T5","span":{"begin":544,"end":620},"obj":"Sentence"},{"id":"T6","span":{"begin":621,"end":731},"obj":"Sentence"},{"id":"T7","span":{"begin":732,"end":821},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":50,"end":55},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":182,"end":185},"obj":"Disease"},{"id":"T2","span":{"begin":229,"end":232},"obj":"Disease"},{"id":"T3","span":{"begin":496,"end":499},"obj":"Disease"},{"id":"T4","span":{"begin":616,"end":619},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0011848"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0011848"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0011848"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0011848"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":50,"end":55},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":161,"end":166},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":50,"end":55},"obj":"Body_part"},{"id":"T2","span":{"begin":100,"end":122},"obj":"Body_part"},{"id":"T3","span":{"begin":293,"end":315},"obj":"Body_part"},{"id":"T4","span":{"begin":317,"end":320},"obj":"Body_part"},{"id":"T5","span":{"begin":477,"end":480},"obj":"Body_part"},{"id":"T6","span":{"begin":539,"end":542},"obj":"Body_part"},{"id":"T7","span":{"begin":758,"end":761},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000632"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000632"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000632"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000632"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0000632"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000632"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T6","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T7","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"Glycosmos15-CL","denotations":[{"id":"T1","span":{"begin":100,"end":122},"obj":"Cell"},{"id":"T2","span":{"begin":293,"end":315},"obj":"Cell"},{"id":"T3","span":{"begin":317,"end":320},"obj":"Cell"},{"id":"T4","span":{"begin":477,"end":480},"obj":"Cell"},{"id":"T5","span":{"begin":539,"end":542},"obj":"Cell"},{"id":"T6","span":{"begin":758,"end":761},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000632"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000632"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000632"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000632"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000632"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000632"},{"subj":"T1","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T2","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T3","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T4","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T5","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T6","pred":"source","obj":"Glycosmos15-CL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"GlyCosmos6-Glycan-Motif-Image","color":"#a5ec93","default":true},{"id":"GlyCosmos6-Glycan-Motif-Structure","color":"#ec93bf"},{"id":"sentences","color":"#93d9ec"},{"id":"Glycosmos6-MAT","color":"#ece493"},{"id":"mondo_disease","color":"#ca93ec"},{"id":"Anatomy-MAT","color":"#93ecb0"},{"id":"NCBITAXON","color":"#ec9693"},{"id":"Anatomy-UBERON","color":"#93a9ec"},{"id":"Glycosmos15-CL","color":"#c3ec93"}]}]}}