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PubMed:12145192 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 120-123 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 120-123 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 481-484 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 481-484 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 653-656 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 653-656 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 857-860 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 857-860 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 962-965 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 962-965 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1029-1032 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1029-1032 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1125-1128 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1125-1128 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1336-1339 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1336-1339 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 1386-1389 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 1386-1389 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 1632-1635 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T20 1632-1635 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 120-123 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 481-484 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 653-656 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 857-860 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T9 962-965 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T11 1029-1032 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T13 1125-1128 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T15 1336-1339 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T17 1386-1389 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T19 1632-1635 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-132 Sentence denotes Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.
TextSentencer_T2 133-248 Sentence denotes Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function.
TextSentencer_T3 249-391 Sentence denotes Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lactone forms.
TextSentencer_T4 392-732 Sentence denotes The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.
TextSentencer_T5 733-927 Sentence denotes Specific inhibition of EGF-dependent receptor tyrosine phosphorylation was observed by HK1-ceramide 2 at 25 microM, whereas GM3 showed a comparable inhibition at eightfold higher concentrations.
TextSentencer_T6 928-1111 Sentence denotes In cells exposed to low pH, where GM3 is thought to form its lactone to a higher extent, addition of GM3 showed no further inhibitory effect on EGF-dependent receptor phosphorylation.
TextSentencer_T7 1112-1212 Sentence denotes Similarly to GM3, HK1-ceramide 2 does not affect binding of (125)I-EGF to the cell surface receptor.
TextSentencer_T8 1213-1340 Sentence denotes EGF-dependent growth of KB cells was also found to be inhibited by HK1-ceramide 2 at much lower concentrations compared to GM3.
TextSentencer_T9 1341-1636 Sentence denotes In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3.
T1 0-132 Sentence denotes Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.
T2 133-248 Sentence denotes Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function.
T3 249-391 Sentence denotes Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lactone forms.
T4 392-732 Sentence denotes The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.
T5 733-927 Sentence denotes Specific inhibition of EGF-dependent receptor tyrosine phosphorylation was observed by HK1-ceramide 2 at 25 microM, whereas GM3 showed a comparable inhibition at eightfold higher concentrations.
T6 928-1111 Sentence denotes In cells exposed to low pH, where GM3 is thought to form its lactone to a higher extent, addition of GM3 showed no further inhibitory effect on EGF-dependent receptor phosphorylation.
T7 1112-1212 Sentence denotes Similarly to GM3, HK1-ceramide 2 does not affect binding of (125)I-EGF to the cell surface receptor.
T8 1213-1340 Sentence denotes EGF-dependent growth of KB cells was also found to be inhibited by HK1-ceramide 2 at much lower concentrations compared to GM3.
T9 1341-1636 Sentence denotes In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3.
T1 0-132 Sentence denotes Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.
T2 133-248 Sentence denotes Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function.
T3 249-391 Sentence denotes Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lactone forms.
T4 392-732 Sentence denotes The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.
T5 733-927 Sentence denotes Specific inhibition of EGF-dependent receptor tyrosine phosphorylation was observed by HK1-ceramide 2 at 25 microM, whereas GM3 showed a comparable inhibition at eightfold higher concentrations.
T6 928-1111 Sentence denotes In cells exposed to low pH, where GM3 is thought to form its lactone to a higher extent, addition of GM3 showed no further inhibitory effect on EGF-dependent receptor phosphorylation.
T7 1112-1212 Sentence denotes Similarly to GM3, HK1-ceramide 2 does not affect binding of (125)I-EGF to the cell surface receptor.
T8 1213-1340 Sentence denotes EGF-dependent growth of KB cells was also found to be inhibited by HK1-ceramide 2 at much lower concentrations compared to GM3.
T9 1341-1636 Sentence denotes In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 120-123 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 120-123 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 481-484 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 481-484 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 653-656 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 653-656 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 857-860 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 857-860 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 962-965 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 962-965 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1029-1032 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1029-1032 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1125-1128 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1125-1128 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1336-1339 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1336-1339 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 1386-1389 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 1386-1389 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 1632-1635 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T20 1632-1635 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 45-53 FMAID:86471 denotes and cell
_T2 45-53 FMAID:200932 denotes and cell
_T3 108-119 FMAID:82816 denotes ganglioside
_T4 108-119 FMAID:196811 denotes ganglioside
_T5 133-145 FMAID:196811 denotes Gangliosides
_T6 133-145 FMAID:82816 denotes Gangliosides
_T7 296-301 FMAID:68646 denotes cells
_T8 296-301 FMAID:169002 denotes cells
_T9 303-314 FMAID:196811 denotes ganglosides
_T10 303-314 FMAID:82816 denotes ganglosides
_T11 469-480 FMAID:82816 denotes ganglioside
_T12 469-480 FMAID:196811 denotes ganglioside
_T13 537-544 FMAID:93687 denotes ovarial
_T14 537-544 FMAID:7209 denotes ovarial
_T15 571-576 FMAID:169002 denotes cells
_T16 571-576 FMAID:68646 denotes cells
_T17 577-585 FMAID:86471 denotes and cell
_T18 577-585 FMAID:200932 denotes and cell
_T19 631-636 FMAID:68646 denotes cells
_T20 631-636 FMAID:169002 denotes cells
_T21 779-787 FMAID:82768 denotes tyrosine
_T22 779-787 FMAID:196757 denotes tyrosine
_T23 841-847 FMAID:165145 denotes microM
_T24 928-936 FMAID:84785 denotes In cells
_T25 928-936 FMAID:199054 denotes In cells
_T26 931-936 FMAID:68646 denotes cells
_T27 931-936 FMAID:169002 denotes cells
_T28 1190-1202 FMAID:212684 denotes cell surface
_T29 1190-1202 FMAID:200942 denotes cell surface
_T30 1195-1202 FMAID:146300 denotes surface
_T31 1195-1202 FMAID:50594 denotes surface
_T32 1240-1245 FMAID:68646 denotes cells
_T33 1240-1245 FMAID:169002 denotes cells
_T34 1514-1522 FMAID:82768 denotes tyrosine
_T35 1514-1522 FMAID:196757 denotes tyrosine
_T36 1563-1568 FMAID:169002 denotes cells
_T37 1563-1568 FMAID:68646 denotes cells
_T38 1614-1619 FMAID:169002 denotes cells
_T39 1614-1619 FMAID:68646 denotes cells
_T40 1614-1628 FMAID:226227 denotes cells compared

uniprot-human

Id Subject Object Predicate Lexical cue
T1 14-17 http://www.uniprot.org/uniprot/P01133 denotes EGF
T2 513-516 http://www.uniprot.org/uniprot/P01133 denotes EGF
T3 756-759 http://www.uniprot.org/uniprot/P01133 denotes EGF
T4 1072-1075 http://www.uniprot.org/uniprot/P01133 denotes EGF
T5 1179-1182 http://www.uniprot.org/uniprot/P01133 denotes EGF
T6 1213-1216 http://www.uniprot.org/uniprot/P01133 denotes EGF
T7 1447-1450 http://www.uniprot.org/uniprot/P01133 denotes EGF
T8 1500-1503 http://www.uniprot.org/uniprot/P01133 denotes EGF
T9 488-511 http://www.uniprot.org/uniprot/P01133 denotes epidermal growth factor
T10 71-74 http://www.uniprot.org/uniprot/Q9NNZ5 denotes HK1
T11 672-675 http://www.uniprot.org/uniprot/Q9NNZ5 denotes HK1
T12 820-823 http://www.uniprot.org/uniprot/Q9NNZ5 denotes HK1
T13 1130-1133 http://www.uniprot.org/uniprot/Q9NNZ5 denotes HK1
T14 1280-1283 http://www.uniprot.org/uniprot/Q9NNZ5 denotes HK1
T15 1405-1408 http://www.uniprot.org/uniprot/Q9NNZ5 denotes HK1
T16 183-205 http://www.uniprot.org/uniprot/Q9NZT4 denotes growth factor receptor
T17 183-205 http://www.uniprot.org/uniprot/Q9UIH8 denotes growth factor receptor
T18 183-205 http://www.uniprot.org/uniprot/Q9GZX1 denotes growth factor receptor
T19 488-511 http://www.uniprot.org/uniprot/Q9GZX1 denotes epidermal growth factor
T20 183-205 http://www.uniprot.org/uniprot/P08581 denotes growth factor receptor
T21 1190-1211 http://www.uniprot.org/uniprot/Q9UKJ1 denotes cell surface receptor
T22 1190-1211 http://www.uniprot.org/uniprot/Q9UKJ0 denotes cell surface receptor

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 14-17 http://www.uniprot.org/uniprot/P01132 denotes EGF
T2 513-516 http://www.uniprot.org/uniprot/P01132 denotes EGF
T3 756-759 http://www.uniprot.org/uniprot/P01132 denotes EGF
T4 1072-1075 http://www.uniprot.org/uniprot/P01132 denotes EGF
T5 1179-1182 http://www.uniprot.org/uniprot/P01132 denotes EGF
T6 1213-1216 http://www.uniprot.org/uniprot/P01132 denotes EGF
T7 1447-1450 http://www.uniprot.org/uniprot/P01132 denotes EGF
T8 1500-1503 http://www.uniprot.org/uniprot/P01132 denotes EGF
T9 488-511 http://www.uniprot.org/uniprot/P01132 denotes epidermal growth factor
T10 71-74 http://www.uniprot.org/uniprot/Q99N14 denotes HK1
T11 672-675 http://www.uniprot.org/uniprot/Q99N14 denotes HK1
T12 820-823 http://www.uniprot.org/uniprot/Q99N14 denotes HK1
T13 1130-1133 http://www.uniprot.org/uniprot/Q99N14 denotes HK1
T14 1280-1283 http://www.uniprot.org/uniprot/Q99N14 denotes HK1
T15 1405-1408 http://www.uniprot.org/uniprot/Q99N14 denotes HK1

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 230-247 http://purl.bioontology.org/ontology/STY/T043 denotes cellular function
T2 296-301 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 556-565 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinoma
T4 571-576 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 618-627 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinoma
T6 631-636 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 931-936 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 1240-1245 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 1563-1568 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 1614-1619 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 18-44 http://purl.obolibrary.org/obo/GO_0048260 denotes mediated receptor activity
T2 27-53 http://purl.obolibrary.org/obo/GO_0032393 denotes receptor activity and cell
T3 27-53 http://purl.obolibrary.org/obo/GO_0032394 denotes receptor activity and cell
T4 27-53 http://purl.obolibrary.org/obo/GO_0032395 denotes receptor activity and cell
T5 36-53 http://purl.obolibrary.org/obo/GO_0001775 denotes activity and cell
T6 36-67 http://purl.obolibrary.org/obo/GO_0030890 denotes activity and cell proliferation
T7 36-67 http://purl.obolibrary.org/obo/GO_0050679 denotes activity and cell proliferation
T8 36-67 http://purl.obolibrary.org/obo/GO_0050798 denotes activity and cell proliferation
T9 36-67 http://purl.obolibrary.org/obo/GO_0070668 denotes activity and cell proliferation
T10 36-67 http://purl.obolibrary.org/obo/GO_1904075 denotes activity and cell proliferation
T11 36-67 http://purl.obolibrary.org/obo/GO_1904899 denotes activity and cell proliferation
T12 36-67 http://purl.obolibrary.org/obo/GO_0008284 denotes activity and cell proliferation
T13 36-67 http://purl.obolibrary.org/obo/GO_1904197 denotes activity and cell proliferation
T14 49-67 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T15 71-74 http://purl.obolibrary.org/obo/GO_0004673 denotes HK1
T16 672-675 http://purl.obolibrary.org/obo/GO_0004673 denotes HK1
T17 820-823 http://purl.obolibrary.org/obo/GO_0004673 denotes HK1
T18 1130-1133 http://purl.obolibrary.org/obo/GO_0004673 denotes HK1
T19 1280-1283 http://purl.obolibrary.org/obo/GO_0004673 denotes HK1
T20 1405-1408 http://purl.obolibrary.org/obo/GO_0004673 denotes HK1
T21 183-189 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T22 498-504 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T23 586-592 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T24 1227-1233 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T25 1601-1607 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T26 230-238 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T27 518-527 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T28 581-592 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T29 788-803 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T30 1095-1110 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T31 1523-1538 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation

GO-MF

Id Subject Object Predicate Lexical cue
T1 14-17 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T2 513-516 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T3 756-759 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T4 1072-1075 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T5 1179-1182 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T6 1213-1216 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T7 1447-1450 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T8 1500-1503 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T9 1587-1590 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T10 27-53 http://purl.obolibrary.org/obo/GO_0003823 denotes receptor activity and cell
T11 27-53 http://purl.obolibrary.org/obo/GO_0050839 denotes receptor activity and cell
T12 183-205 http://purl.obolibrary.org/obo/GO_0070851 denotes growth factor receptor
T13 1161-1168 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T14 1161-1168 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T15 1161-1168 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T16 1161-1168 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 49-53 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 581-585 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 296-301 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 571-576 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 631-636 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 931-936 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1240-1245 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 1563-1568 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9 1614-1619 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 1190-1202 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 407-412 http://edamontology.org/topic_3678 denotes study
T2 531-536 http://edamontology.org/topic_2815 denotes human
T3 596-601 http://edamontology.org/topic_2815 denotes human

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 266-268 http://edamontology.org/format_1997 denotes pH
T2 912-926 http://edamontology.org/data_2140 denotes concentrations
T3 952-954 http://edamontology.org/format_1997 denotes pH
T4 1309-1323 http://edamontology.org/data_2140 denotes concentrations

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 290-295 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 545-565 Disease denotes epidermoid carcinoma http://purl.obolibrary.org/obo/MONDO_0005096
T3 607-627 Disease denotes epidermoid carcinoma http://purl.obolibrary.org/obo/MONDO_0005096

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 290-295 Phenotype denotes tumor HP:0002664
T2 556-565 Phenotype denotes carcinoma HP:0030731
T3 618-627 Phenotype denotes carcinoma HP:0030731

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 120-123 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 481-484 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 653-656 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 857-860 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 962-965 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1029-1032 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1125-1128 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1336-1339 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 1386-1389 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 1632-1635 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 290-295 Phenotype denotes tumor HP:0002664
T2 556-565 Phenotype denotes carcinoma HP:0030731
T3 618-627 Phenotype denotes carcinoma HP:0030731

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 290-295 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 545-565 Disease denotes epidermoid carcinoma http://purl.obolibrary.org/obo/MONDO_0005096
T3 607-627 Disease denotes epidermoid carcinoma http://purl.obolibrary.org/obo/MONDO_0005096

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 531-536 OrganismTaxon denotes human 9606
T2 596-601 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 290-301 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 488-504 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-132 Sentence denotes Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.
TextSentencer_T2 133-248 Sentence denotes Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function.
TextSentencer_T3 249-391 Sentence denotes Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lactone forms.
TextSentencer_T4 392-732 Sentence denotes The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.
TextSentencer_T5 733-927 Sentence denotes Specific inhibition of EGF-dependent receptor tyrosine phosphorylation was observed by HK1-ceramide 2 at 25 microM, whereas GM3 showed a comparable inhibition at eightfold higher concentrations.
TextSentencer_T6 928-1111 Sentence denotes In cells exposed to low pH, where GM3 is thought to form its lactone to a higher extent, addition of GM3 showed no further inhibitory effect on EGF-dependent receptor phosphorylation.
TextSentencer_T7 1112-1212 Sentence denotes Similarly to GM3, HK1-ceramide 2 does not affect binding of (125)I-EGF to the cell surface receptor.
TextSentencer_T8 1213-1340 Sentence denotes EGF-dependent growth of KB cells was also found to be inhibited by HK1-ceramide 2 at much lower concentrations compared to GM3.
TextSentencer_T9 1341-1636 Sentence denotes In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3.
T1 0-132 Sentence denotes Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.
T2 133-248 Sentence denotes Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function.
T3 249-391 Sentence denotes Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lactone forms.
T4 392-732 Sentence denotes The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.
T5 733-927 Sentence denotes Specific inhibition of EGF-dependent receptor tyrosine phosphorylation was observed by HK1-ceramide 2 at 25 microM, whereas GM3 showed a comparable inhibition at eightfold higher concentrations.
T6 928-1111 Sentence denotes In cells exposed to low pH, where GM3 is thought to form its lactone to a higher extent, addition of GM3 showed no further inhibitory effect on EGF-dependent receptor phosphorylation.
T7 1112-1212 Sentence denotes Similarly to GM3, HK1-ceramide 2 does not affect binding of (125)I-EGF to the cell surface receptor.
T8 1213-1340 Sentence denotes EGF-dependent growth of KB cells was also found to be inhibited by HK1-ceramide 2 at much lower concentrations compared to GM3.
T9 1341-1636 Sentence denotes In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3.
T1 0-132 Sentence denotes Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.
T2 133-248 Sentence denotes Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function.
T3 249-391 Sentence denotes Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lactone forms.
T4 392-732 Sentence denotes The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.
T5 733-927 Sentence denotes Specific inhibition of EGF-dependent receptor tyrosine phosphorylation was observed by HK1-ceramide 2 at 25 microM, whereas GM3 showed a comparable inhibition at eightfold higher concentrations.
T6 928-1111 Sentence denotes In cells exposed to low pH, where GM3 is thought to form its lactone to a higher extent, addition of GM3 showed no further inhibitory effect on EGF-dependent receptor phosphorylation.
T7 1112-1212 Sentence denotes Similarly to GM3, HK1-ceramide 2 does not affect binding of (125)I-EGF to the cell surface receptor.
T8 1213-1340 Sentence denotes EGF-dependent growth of KB cells was also found to be inhibited by HK1-ceramide 2 at much lower concentrations compared to GM3.
T9 1341-1636 Sentence denotes In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.
T2 133-248 Sentence denotes Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function.
T3 249-391 Sentence denotes Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lactone forms.
T4 392-732 Sentence denotes The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.
T5 733-927 Sentence denotes Specific inhibition of EGF-dependent receptor tyrosine phosphorylation was observed by HK1-ceramide 2 at 25 microM, whereas GM3 showed a comparable inhibition at eightfold higher concentrations.
T6 928-1111 Sentence denotes In cells exposed to low pH, where GM3 is thought to form its lactone to a higher extent, addition of GM3 showed no further inhibitory effect on EGF-dependent receptor phosphorylation.
T7 1112-1212 Sentence denotes Similarly to GM3, HK1-ceramide 2 does not affect binding of (125)I-EGF to the cell surface receptor.
T8 1213-1340 Sentence denotes EGF-dependent growth of KB cells was also found to be inhibited by HK1-ceramide 2 at much lower concentrations compared to GM3.
T9 1341-1636 Sentence denotes In conclusion, our results indicate that the GM3 lactone analog HK1-ceramide 2 is a specific inhibitor of EGF receptor function and is more potent in reducing EGF-dependent tyrosine phosphorylation of the receptor in A431 cells and in inhibiting EGF-dependent growth of KB cells compared to GM3.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 120-123 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 481-484 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 653-656 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 857-860 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 962-965 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1029-1032 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1125-1128 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1336-1339 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 1386-1389 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 1632-1635 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 531-536 OrganismTaxon denotes human 9606
T2 596-601 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 488-504 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 290-301 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063