PubMed:11356303 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11356303","sourcedb":"PubMed","sourceid":"11356303","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11356303","text":"Matrix metalloproteinase inhibitor KB-R7785 attenuates brain damage resulting from permanent focal cerebral ischemia in mice.\nMatrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix. MMP-9 and MMP-2 have been implicated in brain injury formation. The authors examined the effect of MMP inhibitor KB-R7785 on brain infarct formation resulting from permanent focal cerebral ischemia in mice. Ischemia was induced by intraluminal middle cerebral artery occlusion (MCAO) in mice under halothane anesthesia. Zymography was conducted to measure the MMPs activity in ischemic brain tissues. Injection of KB-R7785 (100 mg/kg) 30 min before MCAO significantly decreased both MMP-9 activity and infarct volume determined at 24 h. In addition, KB-R7785 injected twice at 1 and 4.5 h after MCAO significantly decreased infarct volume. These results indicate that KB-R7785 has a protective efficacy against focal cerebral ischemia, and our data provide further evidence that MMP-9 contributes to brain infarct formation.","tracks":[{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":0,"end":34},"obj":"CHEBI:50664"},{"id":"T3","span":{"begin":7,"end":34},"obj":"P29695"},{"id":"T4","span":{"begin":7,"end":34},"obj":"P01077"},{"id":"T5","span":{"begin":7,"end":34},"obj":"Q9DGI0"},{"id":"T2","span":{"begin":7,"end":34},"obj":"GO:0008191"},{"id":"T7","span":{"begin":35,"end":39},"obj":"CVCL_M096"},{"id":"T8","span":{"begin":35,"end":43},"obj":"C107086"},{"id":"T9","span":{"begin":35,"end":43},"obj":"C107086"},{"id":"T10","span":{"begin":55,"end":60},"obj":"UBERON:6110636"},{"id":"T11","span":{"begin":55,"end":60},"obj":"UBERON:0000955"},{"id":"T12","span":{"begin":99,"end":116},"obj":"D002545"},{"id":"T13","span":{"begin":99,"end":116},"obj":"D002545"},{"id":"T17","span":{"begin":120,"end":124},"obj":"D051379"},{"id":"T19","span":{"begin":120,"end":124},"obj":"10095"},{"id":"T16","span":{"begin":120,"end":124},"obj":"PR:000005054"},{"id":"T18","span":{"begin":120,"end":124},"obj":"O89094"},{"id":"T20","span":{"begin":133,"end":151},"obj":"D045726"},{"id":"T21","span":{"begin":153,"end":157},"obj":"D020782"},{"id":"T22","span":{"begin":163,"end":182},"obj":"D010447"},{"id":"T24","span":{"begin":204,"end":224},"obj":"GO:0031012"},{"id":"T25","span":{"begin":218,"end":224},"obj":"UBERON:0027368"},{"id":"T26","span":{"begin":226,"end":229},"obj":"CHEBI:340824"},{"id":"T29","span":{"begin":226,"end":229},"obj":"CHEBI:59761"},{"id":"T30","span":{"begin":226,"end":231},"obj":"PR:P50282"},{"id":"T31","span":{"begin":226,"end":231},"obj":"PR:P14780"},{"id":"T32","span":{"begin":226,"end":231},"obj":"P14780"},{"id":"T33","span":{"begin":226,"end":231},"obj":"PR:P41245"},{"id":"T34","span":{"begin":226,"end":231},"obj":"P41246"},{"id":"T35","span":{"begin":226,"end":231},"obj":"P41245"},{"id":"T36","span":{"begin":226,"end":231},"obj":"PR:P52176"},{"id":"T37","span":{"begin":226,"end":231},"obj":"P50282"},{"id":"T39","span":{"begin":226,"end":231},"obj":"PR:000010491"},{"id":"T40","span":{"begin":226,"end":231},"obj":"P52176"},{"id":"T41","span":{"begin":226,"end":231},"obj":"O18733"},{"id":"T38","span":{"begin":226,"end":231},"obj":"GO:0004229"},{"id":"T42","span":{"begin":236,"end":239},"obj":"CHEBI:340824"},{"id":"T45","span":{"begin":236,"end":239},"obj":"CHEBI:59761"},{"id":"T46","span":{"begin":236,"end":241},"obj":"PR:P08253"},{"id":"T47","span":{"begin":236,"end":241},"obj":"Q9GLE5"},{"id":"T48","span":{"begin":236,"end":241},"obj":"P08253"},{"id":"T49","span":{"begin":236,"end":241},"obj":"Q90611"},{"id":"T51","span":{"begin":236,"end":241},"obj":"PR:Q8MPP3"},{"id":"T52","span":{"begin":236,"end":241},"obj":"P33436"},{"id":"T53","span":{"begin":236,"end":241},"obj":"PR:Q90611"},{"id":"T54","span":{"begin":236,"end":241},"obj":"PR:P33436"},{"id":"T55","span":{"begin":236,"end":241},"obj":"PR:000010479"},{"id":"T56","span":{"begin":236,"end":241},"obj":"PR:P33434"},{"id":"T57","span":{"begin":236,"end":241},"obj":"P33434"},{"id":"T58","span":{"begin":236,"end":241},"obj":"P50757"},{"id":"T50","span":{"begin":236,"end":241},"obj":"GO:0004228"},{"id":"T59","span":{"begin":266,"end":271},"obj":"UBERON:6110636"},{"id":"T60","span":{"begin":266,"end":271},"obj":"UBERON:0000955"},{"id":"T61","span":{"begin":266,"end":278},"obj":"D001930"},{"id":"T62","span":{"begin":266,"end":278},"obj":"D001930"},{"id":"T63","span":{"begin":279,"end":288},"obj":"GO:0009058"},{"id":"T66","span":{"begin":325,"end":328},"obj":"PR:O04529"},{"id":"T64","span":{"begin":325,"end":328},"obj":"CHEBI:340824"},{"id":"T67","span":{"begin":325,"end":328},"obj":"CHEBI:59761"},{"id":"T65","span":{"begin":325,"end":328},"obj":"GO:0004235"},{"id":"T68","span":{"begin":329,"end":338},"obj":"CHEBI:35222"},{"id":"T69","span":{"begin":339,"end":343},"obj":"CVCL_M096"},{"id":"T70","span":{"begin":339,"end":347},"obj":"C107086"},{"id":"T71","span":{"begin":339,"end":347},"obj":"C107086"},{"id":"T72","span":{"begin":351,"end":356},"obj":"UBERON:6110636"},{"id":"T73","span":{"begin":351,"end":356},"obj":"UBERON:0000955"},{"id":"T74","span":{"begin":351,"end":364},"obj":"D020520"},{"id":"T75","span":{"begin":351,"end":364},"obj":"D020520"},{"id":"T78","span":{"begin":365,"end":374},"obj":"GO:0009058"},{"id":"T79","span":{"begin":406,"end":423},"obj":"D002545"},{"id":"T80","span":{"begin":406,"end":423},"obj":"D002545"},{"id":"T84","span":{"begin":427,"end":431},"obj":"D051379"},{"id":"T86","span":{"begin":427,"end":431},"obj":"10095"},{"id":"T83","span":{"begin":427,"end":431},"obj":"PR:000005054"},{"id":"T85","span":{"begin":427,"end":431},"obj":"O89094"},{"id":"T87","span":{"begin":433,"end":441},"obj":"D007511"},{"id":"T88","span":{"begin":433,"end":441},"obj":"D007511"},{"id":"T89","span":{"begin":470,"end":492},"obj":"UBERON:0001627"},{"id":"T90","span":{"begin":470,"end":502},"obj":"D020244"},{"id":"T91","span":{"begin":470,"end":502},"obj":"D020244"},{"id":"T96","span":{"begin":513,"end":517},"obj":"PR:000005054"},{"id":"T98","span":{"begin":513,"end":517},"obj":"O89094"},{"id":"T97","span":{"begin":513,"end":517},"obj":"D051379"},{"id":"T99","span":{"begin":513,"end":517},"obj":"10095"},{"id":"T100","span":{"begin":524,"end":533},"obj":"D006221"},{"id":"T101","span":{"begin":524,"end":533},"obj":"CHEBI:5615"},{"id":"T102","span":{"begin":524,"end":533},"obj":"D006221"},{"id":"T103","span":{"begin":586,"end":590},"obj":"D020782"},{"id":"T104","span":{"begin":612,"end":617},"obj":"UBERON:6110636"},{"id":"T105","span":{"begin":612,"end":617},"obj":"UBERON:0000955"},{"id":"T106","span":{"begin":627,"end":636},"obj":"1649574"},{"id":"T107","span":{"begin":640,"end":644},"obj":"CVCL_M096"},{"id":"T108","span":{"begin":640,"end":648},"obj":"C107086"},{"id":"T109","span":{"begin":640,"end":648},"obj":"C107086"},{"id":"T110","span":{"begin":664,"end":667},"obj":"CVCL_E777"},{"id":"T111","span":{"begin":709,"end":712},"obj":"CHEBI:340824"},{"id":"T114","span":{"begin":709,"end":712},"obj":"CHEBI:59761"},{"id":"T115","span":{"begin":709,"end":714},"obj":"PR:P50282"},{"id":"T116","span":{"begin":709,"end":714},"obj":"PR:P14780"},{"id":"T117","span":{"begin":709,"end":714},"obj":"P14780"},{"id":"T118","span":{"begin":709,"end":714},"obj":"PR:P41245"},{"id":"T119","span":{"begin":709,"end":714},"obj":"P41246"},{"id":"T120","span":{"begin":709,"end":714},"obj":"P41245"},{"id":"T121","span":{"begin":709,"end":714},"obj":"PR:P52176"},{"id":"T122","span":{"begin":709,"end":714},"obj":"P50282"},{"id":"T124","span":{"begin":709,"end":714},"obj":"PR:000010491"},{"id":"T125","span":{"begin":709,"end":714},"obj":"P52176"},{"id":"T126","span":{"begin":709,"end":714},"obj":"O18733"},{"id":"T123","span":{"begin":709,"end":714},"obj":"GO:0004229"},{"id":"T127","span":{"begin":728,"end":735},"obj":"D007238"},{"id":"T128","span":{"begin":728,"end":735},"obj":"D007238"},{"id":"T130","span":{"begin":757,"end":761},"obj":"CVCL_8262"},{"id":"T131","span":{"begin":776,"end":780},"obj":"CVCL_M096"},{"id":"T132","span":{"begin":776,"end":784},"obj":"C107086"},{"id":"T133","span":{"begin":776,"end":784},"obj":"C107086"},{"id":"T161","span":{"begin":850,"end":857},"obj":"D007238"},{"id":"T162","span":{"begin":850,"end":857},"obj":"D007238"},{"id":"T163","span":{"begin":894,"end":898},"obj":"CVCL_M096"},{"id":"T164","span":{"begin":894,"end":902},"obj":"C107086"},{"id":"T165","span":{"begin":894,"end":902},"obj":"C107086"},{"id":"T166","span":{"begin":943,"end":960},"obj":"D002545"},{"id":"T167","span":{"begin":943,"end":960},"obj":"D002545"},{"id":"T170","span":{"begin":1005,"end":1008},"obj":"CHEBI:340824"},{"id":"T173","span":{"begin":1005,"end":1008},"obj":"CHEBI:59761"},{"id":"T174","span":{"begin":1005,"end":1010},"obj":"PR:P50282"},{"id":"T175","span":{"begin":1005,"end":1010},"obj":"PR:P14780"},{"id":"T176","span":{"begin":1005,"end":1010},"obj":"P14780"},{"id":"T177","span":{"begin":1005,"end":1010},"obj":"PR:P41245"},{"id":"T178","span":{"begin":1005,"end":1010},"obj":"P41246"},{"id":"T179","span":{"begin":1005,"end":1010},"obj":"P41245"},{"id":"T180","span":{"begin":1005,"end":1010},"obj":"PR:P52176"},{"id":"T181","span":{"begin":1005,"end":1010},"obj":"P50282"},{"id":"T183","span":{"begin":1005,"end":1010},"obj":"PR:000010491"},{"id":"T184","span":{"begin":1005,"end":1010},"obj":"P52176"},{"id":"T185","span":{"begin":1005,"end":1010},"obj":"O18733"},{"id":"T182","span":{"begin":1005,"end":1010},"obj":"GO:0004229"},{"id":"T186","span":{"begin":1026,"end":1031},"obj":"UBERON:6110636"},{"id":"T187","span":{"begin":1026,"end":1031},"obj":"UBERON:0000955"},{"id":"T188","span":{"begin":1026,"end":1039},"obj":"D020520"},{"id":"T189","span":{"begin":1026,"end":1039},"obj":"D020520"},{"id":"T192","span":{"begin":1040,"end":1049},"obj":"GO:0009058"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":125},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":126,"end":225},"obj":"DRI_Approach"},{"id":"T3","span":{"begin":226,"end":289},"obj":"DRI_Background"},{"id":"T4","span":{"begin":290,"end":432},"obj":"DRI_Background"},{"id":"T5","span":{"begin":433,"end":545},"obj":"DRI_Background"},{"id":"T6","span":{"begin":546,"end":626},"obj":"DRI_Background"},{"id":"T7","span":{"begin":627,"end":865},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":866,"end":1050},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"c_corpus","color":"#93c6ec","default":true},{"id":"UseCases_ArguminSci_Discourse","color":"#e0ec93"}]}]}}