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UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-125 DRI_Challenge denotes Matrix metalloproteinase inhibitor KB-R7785 attenuates brain damage resulting from permanent focal cerebral ischemia in mice.
T2 126-225 DRI_Approach denotes Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix.
T3 226-289 DRI_Background denotes MMP-9 and MMP-2 have been implicated in brain injury formation.
T4 290-432 DRI_Background denotes The authors examined the effect of MMP inhibitor KB-R7785 on brain infarct formation resulting from permanent focal cerebral ischemia in mice.
T5 433-545 DRI_Background denotes Ischemia was induced by intraluminal middle cerebral artery occlusion (MCAO) in mice under halothane anesthesia.
T6 546-626 DRI_Background denotes Zymography was conducted to measure the MMPs activity in ischemic brain tissues.
T7 627-865 DRI_Outcome denotes Injection of KB-R7785 (100 mg/kg) 30 min before MCAO significantly decreased both MMP-9 activity and infarct volume determined at 24 h. In addition, KB-R7785 injected twice at 1 and 4.5 h after MCAO significantly decreased infarct volume.
T8 866-1050 DRI_Outcome denotes These results indicate that KB-R7785 has a protective efficacy against focal cerebral ischemia, and our data provide further evidence that MMP-9 contributes to brain infarct formation.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-34 CHEBI:50664 denotes Matrix metalloproteinase inhibitor
T3 7-34 P29695 denotes metalloproteinase inhibitor
T4 7-34 P01077 denotes metalloproteinase inhibitor
T5 7-34 Q9DGI0 denotes metalloproteinase inhibitor
T2 7-34 GO:0008191 denotes metalloproteinase inhibitor
T7 35-39 CVCL_M096 denotes KB-R
T8 35-43 C107086 denotes KB-R7785
T9 35-43 C107086 denotes KB-R7785
T10 55-60 UBERON:6110636 denotes brain
T11 55-60 UBERON:0000955 denotes brain
T12 99-116 D002545 denotes cerebral ischemia
T13 99-116 D002545 denotes cerebral ischemia
T17 120-124 D051379 denotes mice
T19 120-124 10095 denotes mice
T16 120-124 PR:000005054 denotes mice
T18 120-124 O89094 denotes mice
T20 133-151 D045726 denotes metalloproteinases
T21 153-157 D020782 denotes MMPs
T22 163-182 D010447 denotes proteolytic enzymes
T24 204-224 GO:0031012 denotes extracellular matrix
T25 218-224 UBERON:0027368 denotes matrix
T26 226-229 CHEBI:340824 denotes MMP
T29 226-229 CHEBI:59761 denotes MMP
T30 226-231 PR:P50282 denotes MMP-9
T31 226-231 PR:P14780 denotes MMP-9
T32 226-231 P14780 denotes MMP-9
T33 226-231 PR:P41245 denotes MMP-9
T34 226-231 P41246 denotes MMP-9
T35 226-231 P41245 denotes MMP-9
T36 226-231 PR:P52176 denotes MMP-9
T37 226-231 P50282 denotes MMP-9
T39 226-231 PR:000010491 denotes MMP-9
T40 226-231 P52176 denotes MMP-9
T41 226-231 O18733 denotes MMP-9
T38 226-231 GO:0004229 denotes MMP-9
T42 236-239 CHEBI:340824 denotes MMP
T45 236-239 CHEBI:59761 denotes MMP
T46 236-241 PR:P08253 denotes MMP-2
T47 236-241 Q9GLE5 denotes MMP-2
T48 236-241 P08253 denotes MMP-2
T49 236-241 Q90611 denotes MMP-2
T51 236-241 PR:Q8MPP3 denotes MMP-2
T52 236-241 P33436 denotes MMP-2
T53 236-241 PR:Q90611 denotes MMP-2
T54 236-241 PR:P33436 denotes MMP-2
T55 236-241 PR:000010479 denotes MMP-2
T56 236-241 PR:P33434 denotes MMP-2
T57 236-241 P33434 denotes MMP-2
T58 236-241 P50757 denotes MMP-2
T50 236-241 GO:0004228 denotes MMP-2
T59 266-271 UBERON:6110636 denotes brain
T60 266-271 UBERON:0000955 denotes brain
T61 266-278 D001930 denotes brain injury
T62 266-278 D001930 denotes brain injury
T63 279-288 GO:0009058 denotes formation
T66 325-328 PR:O04529 denotes MMP
T64 325-328 CHEBI:340824 denotes MMP
T67 325-328 CHEBI:59761 denotes MMP
T65 325-328 GO:0004235 denotes MMP
T68 329-338 CHEBI:35222 denotes inhibitor
T69 339-343 CVCL_M096 denotes KB-R
T70 339-347 C107086 denotes KB-R7785
T71 339-347 C107086 denotes KB-R7785
T72 351-356 UBERON:6110636 denotes brain
T73 351-356 UBERON:0000955 denotes brain
T74 351-364 D020520 denotes brain infarct
T75 351-364 D020520 denotes brain infarct
T78 365-374 GO:0009058 denotes formation
T79 406-423 D002545 denotes cerebral ischemia
T80 406-423 D002545 denotes cerebral ischemia
T84 427-431 D051379 denotes mice
T86 427-431 10095 denotes mice
T83 427-431 PR:000005054 denotes mice
T85 427-431 O89094 denotes mice
T87 433-441 D007511 denotes Ischemia
T88 433-441 D007511 denotes Ischemia
T89 470-492 UBERON:0001627 denotes middle cerebral artery
T90 470-502 D020244 denotes middle cerebral artery occlusion
T91 470-502 D020244 denotes middle cerebral artery occlusion
T96 513-517 PR:000005054 denotes mice
T98 513-517 O89094 denotes mice
T97 513-517 D051379 denotes mice
T99 513-517 10095 denotes mice
T100 524-533 D006221 denotes halothane
T101 524-533 CHEBI:5615 denotes halothane
T102 524-533 D006221 denotes halothane
T103 586-590 D020782 denotes MMPs
T104 612-617 UBERON:6110636 denotes brain
T105 612-617 UBERON:0000955 denotes brain
T106 627-636 1649574 denotes Injection
T107 640-644 CVCL_M096 denotes KB-R
T108 640-648 C107086 denotes KB-R7785
T109 640-648 C107086 denotes KB-R7785
T110 664-667 CVCL_E777 denotes min
T111 709-712 CHEBI:340824 denotes MMP
T114 709-712 CHEBI:59761 denotes MMP
T115 709-714 PR:P50282 denotes MMP-9
T116 709-714 PR:P14780 denotes MMP-9
T117 709-714 P14780 denotes MMP-9
T118 709-714 PR:P41245 denotes MMP-9
T119 709-714 P41246 denotes MMP-9
T120 709-714 P41245 denotes MMP-9
T121 709-714 PR:P52176 denotes MMP-9
T122 709-714 P50282 denotes MMP-9
T124 709-714 PR:000010491 denotes MMP-9
T125 709-714 P52176 denotes MMP-9
T126 709-714 O18733 denotes MMP-9
T123 709-714 GO:0004229 denotes MMP-9
T127 728-735 D007238 denotes infarct
T128 728-735 D007238 denotes infarct
T130 757-761 CVCL_8262 denotes 24 h
T131 776-780 CVCL_M096 denotes KB-R
T132 776-784 C107086 denotes KB-R7785
T133 776-784 C107086 denotes KB-R7785
T161 850-857 D007238 denotes infarct
T162 850-857 D007238 denotes infarct
T163 894-898 CVCL_M096 denotes KB-R
T164 894-902 C107086 denotes KB-R7785
T165 894-902 C107086 denotes KB-R7785
T166 943-960 D002545 denotes cerebral ischemia
T167 943-960 D002545 denotes cerebral ischemia
T170 1005-1008 CHEBI:340824 denotes MMP
T173 1005-1008 CHEBI:59761 denotes MMP
T174 1005-1010 PR:P50282 denotes MMP-9
T175 1005-1010 PR:P14780 denotes MMP-9
T176 1005-1010 P14780 denotes MMP-9
T177 1005-1010 PR:P41245 denotes MMP-9
T178 1005-1010 P41246 denotes MMP-9
T179 1005-1010 P41245 denotes MMP-9
T180 1005-1010 PR:P52176 denotes MMP-9
T181 1005-1010 P50282 denotes MMP-9
T183 1005-1010 PR:000010491 denotes MMP-9
T184 1005-1010 P52176 denotes MMP-9
T185 1005-1010 O18733 denotes MMP-9
T182 1005-1010 GO:0004229 denotes MMP-9
T186 1026-1031 UBERON:6110636 denotes brain
T187 1026-1031 UBERON:0000955 denotes brain
T188 1026-1039 D020520 denotes brain infarct
T189 1026-1039 D020520 denotes brain infarct
T192 1040-1049 GO:0009058 denotes formation