PubMed:11118434
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 215-221 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T2 | 235-241 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T3 | 340-351 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T4 | 355-364 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
| T6 | 372-378 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T7 | 490-493 | Glycan_Motif | denotes | SM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD |
| T8 | 541-547 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T9 | 551-557 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T10 | 598-603 | Glycan_Motif | denotes | core1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T11 | 976-982 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T12 | 1052-1055 | Glycan_Motif | denotes | SM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD |
| T13 | 1121-1124 | Glycan_Motif | denotes | SM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD |
| T14 | 1214-1220 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T15 | 1297-1300 | Glycan_Motif | denotes | SM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD |
| T16 | 1435-1441 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-154 | Sentence | denotes | The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. |
| T2 | 155-248 | Sentence | denotes | In breast cancer, the O-glycans added to the MUC1 mucin are core 1- rather than core 2-based. |
| T3 | 249-502 | Sentence | denotes | We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid to galactose in the core 1 substrate, is key to this switch in MUC1 glycosylation that results in the expression of the cancer-associated SM3 epitope. |
| T4 | 503-668 | Sentence | denotes | Of the three enzymes known to convert core 1 to core 2, by the addition of GlcNAc to GalNAc in core1 C2GnT1 is the dominant enzyme expressed in normal breast tissue. |
| T5 | 669-797 | Sentence | denotes | Expression of C2GnT1 is low or absent in around 50% of breast cancers, whereas expression of ST3Gal-I is consistently increased. |
| T6 | 798-874 | Sentence | denotes | Mapping of ST3Gal-I and C2GnT1 within the Golgi pathway showed some overlap. |
| T7 | 875-1064 | Sentence | denotes | To examine functional competition, the enzymes were overexpressed in T47D cells, which normally make core 1-based structures, have no detectable C2GnT1 activity and express the SM3 epitope. |
| T8 | 1065-1232 | Sentence | denotes | Overexpression of C2GnT1 resulted in loss of binding of SM3 to MUC1, accompanied by a decrease in the GalNAc/GlcNAc ratio, indicative of a switch to core 2 structures. |
| T9 | 1233-1362 | Sentence | denotes | Transfection of a C2GnT1 expressing line with ST3Gal-I restored SM3 binding and reduced GlcNAc incorporation into MUC1 O-glycans. |
| T10 | 1363-1535 | Sentence | denotes | Thus, even when C2GnT1 is expressed, the O-glycans added to MUC1 become core 1-dominated structures, provided expression of ST3Gal-I is increased as it is in breast cancer. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 215-221 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T2 | 340-351 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
| T3 | 355-364 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
| T4 | 355-364 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
| T5 | 372-378 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T6 | 490-493 | https://glytoucan.org/Structures/Glycans/G20044TD | denotes | SM3 |
| T7 | 541-547 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T8 | 598-603 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core1 |
| T9 | 976-982 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T10 | 1052-1055 | https://glytoucan.org/Structures/Glycans/G20044TD | denotes | SM3 |
| T11 | 1121-1124 | https://glytoucan.org/Structures/Glycans/G20044TD | denotes | SM3 |
| T12 | 1297-1300 | https://glytoucan.org/Structures/Glycans/G20044TD | denotes | SM3 |
| T13 | 1435-1441 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 490-493 | http://www.glycoepitope.jp/epitopes/EP0079 | denotes | SM3 |
| T2 | 1052-1055 | http://www.glycoepitope.jp/epitopes/EP0079 | denotes | SM3 |
| T3 | 1121-1124 | http://www.glycoepitope.jp/epitopes/EP0079 | denotes | SM3 |
| T4 | 1297-1300 | http://www.glycoepitope.jp/epitopes/EP0079 | denotes | SM3 |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 578-584 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 1174-1180 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 1321-1327 | chem:24139 | denotes | GlcNAc |
CoMAGC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1487-1495 | Gene | denotes | ST3Gal-I |
| E1 | 1473-1483 | Gene_expression | denotes | expression |
| E2 | 1499-1508 | Positive_regulation | denotes | increased |
| T2 | 1521-1534 | breast cancer | denotes | breast cancer |
| R1 | T1 | E1 | themeOf | ST3Gal-I,expression |
| R2 | E1 | E2 | themeOf | expression,increased |
| R3 | T1 | T2 | CGE-increased | ST3Gal-I,breast cancer |
| R4 | T1 | T2 | CCS-normalTOcancer | ST3Gal-I,breast cancer |
| R5 | T1 | T2 | PT-observation | ST3Gal-I,breast cancer |
| R3 | T1 | T2 | IGE-unchanged | ST3Gal-I,breast cancer |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 121-126 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 158-171 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T3 | 472-478 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T4 | 724-738 | Disease | denotes | breast cancers | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T5 | 1521-1534 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 215-221 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T2 | 235-241 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T3 | 372-378 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T4 | 490-493 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
| T5 | 541-547 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T6 | 551-557 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T7 | 588-594 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T8 | 976-982 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T9 | 1052-1055 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
| T10 | 1121-1124 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
| T11 | 1167-1173 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T12 | 1214-1220 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T13 | 1297-1300 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
| T14 | 1435-1441 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 121-126 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 158-171 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 472-478 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 724-738 | Phenotype | denotes | breast cancers | HP:0003002 |
| T5 | 1521-1534 | Phenotype | denotes | breast cancer | HP:0003002 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 121-126 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 158-171 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T3 | 472-478 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T4 | 724-738 | Disease | denotes | breast cancers | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T5 | 1521-1534 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 158-164 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 654-660 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T3 | 661-667 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T4 | 724-730 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T5 | 840-845 | Body_part | denotes | Golgi | http://purl.obolibrary.org/obo/GO_0005794 |
| T6 | 1521-1527 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
Glycosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 490-493 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
| T2 | 1052-1055 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
| T3 | 1121-1124 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
| T4 | 1297-1300 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 158-164 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 654-660 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T3 | 661-667 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T4 | 724-730 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T5 | 840-845 | Body_part | denotes | Golgi | http://purl.obolibrary.org/obo/GO_0005794 |
| T6 | 1521-1527 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 121-126 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 158-171 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 472-478 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 724-738 | Phenotype | denotes | breast cancers | HP:0003002 |
| T5 | 1521-1534 | Phenotype | denotes | breast cancer | HP:0003002 |