PubMed:11118434 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11118434","sourcedb":"PubMed","sourceid":"11118434","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11118434","text":"The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.\nIn breast cancer, the O-glycans added to the MUC1 mucin are core 1- rather than core 2-based. We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid to galactose in the core 1 substrate, is key to this switch in MUC1 glycosylation that results in the expression of the cancer-associated SM3 epitope. Of the three enzymes known to convert core 1 to core 2, by the addition of GlcNAc to GalNAc in core1 C2GnT1 is the dominant enzyme expressed in normal breast tissue. Expression of C2GnT1 is low or absent in around 50% of breast cancers, whereas expression of ST3Gal-I is consistently increased. Mapping of ST3Gal-I and C2GnT1 within the Golgi pathway showed some overlap. To examine functional competition, the enzymes were overexpressed in T47D cells, which normally make core 1-based structures, have no detectable C2GnT1 activity and express the SM3 epitope. Overexpression of C2GnT1 resulted in loss of binding of SM3 to MUC1, accompanied by a decrease in the GalNAc/GlcNAc ratio, indicative of a switch to core 2 structures. Transfection of a C2GnT1 expressing line with ST3Gal-I restored SM3 binding and reduced GlcNAc incorporation into MUC1 O-glycans. Thus, even when C2GnT1 is expressed, the O-glycans added to MUC1 become core 1-dominated structures, provided expression of ST3Gal-I is increased as it is in breast cancer.","tracks":[{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":215,"end":221},"obj":"Glycan_Motif"},{"id":"T2","span":{"begin":235,"end":241},"obj":"Glycan_Motif"},{"id":"T3","span":{"begin":340,"end":351},"obj":"Glycan_Motif"},{"id":"T4","span":{"begin":355,"end":364},"obj":"Glycan_Motif"},{"id":"T6","span":{"begin":372,"end":378},"obj":"Glycan_Motif"},{"id":"T7","span":{"begin":490,"end":493},"obj":"Glycan_Motif"},{"id":"T8","span":{"begin":541,"end":547},"obj":"Glycan_Motif"},{"id":"T9","span":{"begin":551,"end":557},"obj":"Glycan_Motif"},{"id":"T10","span":{"begin":598,"end":603},"obj":"Glycan_Motif"},{"id":"T11","span":{"begin":976,"end":982},"obj":"Glycan_Motif"},{"id":"T12","span":{"begin":1052,"end":1055},"obj":"Glycan_Motif"},{"id":"T13","span":{"begin":1121,"end":1124},"obj":"Glycan_Motif"},{"id":"T14","span":{"begin":1214,"end":1220},"obj":"Glycan_Motif"},{"id":"T15","span":{"begin":1297,"end":1300},"obj":"Glycan_Motif"},{"id":"T16","span":{"begin":1435,"end":1441},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO"},{"id":"A2","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO"},{"id":"A3","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"},{"id":"A4","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT"},{"id":"A5","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE"},{"id":"A6","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO"},{"id":"A7","pred":"image","subj":"T7","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD"},{"id":"A8","pred":"image","subj":"T8","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO"},{"id":"A9","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO"},{"id":"A10","pred":"image","subj":"T10","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO"},{"id":"A11","pred":"image","subj":"T11","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO"},{"id":"A12","pred":"image","subj":"T12","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD"},{"id":"A13","pred":"image","subj":"T13","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD"},{"id":"A14","pred":"image","subj":"T14","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO"},{"id":"A15","pred":"image","subj":"T15","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD"},{"id":"A16","pred":"image","subj":"T16","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO"},{"subj":"T1","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T3","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T4","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T6","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T7","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T8","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T9","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T10","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T11","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T12","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T13","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T14","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T15","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"},{"subj":"T16","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Image"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":154},"obj":"Sentence"},{"id":"T2","span":{"begin":155,"end":248},"obj":"Sentence"},{"id":"T3","span":{"begin":249,"end":502},"obj":"Sentence"},{"id":"T4","span":{"begin":503,"end":668},"obj":"Sentence"},{"id":"T5","span":{"begin":669,"end":797},"obj":"Sentence"},{"id":"T6","span":{"begin":798,"end":874},"obj":"Sentence"},{"id":"T7","span":{"begin":875,"end":1064},"obj":"Sentence"},{"id":"T8","span":{"begin":1065,"end":1232},"obj":"Sentence"},{"id":"T9","span":{"begin":1233,"end":1362},"obj":"Sentence"},{"id":"T10","span":{"begin":1363,"end":1535},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"}]},{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":215,"end":221},"obj":"https://glytoucan.org/Structures/Glycans/G00031MO"},{"id":"T2","span":{"begin":340,"end":351},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T3","span":{"begin":355,"end":364},"obj":"https://glytoucan.org/Structures/Glycans/G65889KE"},{"id":"T4","span":{"begin":355,"end":364},"obj":"https://glytoucan.org/Structures/Glycans/G68158BT"},{"id":"T5","span":{"begin":372,"end":378},"obj":"https://glytoucan.org/Structures/Glycans/G00031MO"},{"id":"T6","span":{"begin":490,"end":493},"obj":"https://glytoucan.org/Structures/Glycans/G20044TD"},{"id":"T7","span":{"begin":541,"end":547},"obj":"https://glytoucan.org/Structures/Glycans/G00031MO"},{"id":"T8","span":{"begin":598,"end":603},"obj":"https://glytoucan.org/Structures/Glycans/G00031MO"},{"id":"T9","span":{"begin":976,"end":982},"obj":"https://glytoucan.org/Structures/Glycans/G00031MO"},{"id":"T10","span":{"begin":1052,"end":1055},"obj":"https://glytoucan.org/Structures/Glycans/G20044TD"},{"id":"T11","span":{"begin":1121,"end":1124},"obj":"https://glytoucan.org/Structures/Glycans/G20044TD"},{"id":"T12","span":{"begin":1297,"end":1300},"obj":"https://glytoucan.org/Structures/Glycans/G20044TD"},{"id":"T13","span":{"begin":1435,"end":1441},"obj":"https://glytoucan.org/Structures/Glycans/G00031MO"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T2","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T3","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T4","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T5","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T6","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T7","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T8","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T9","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T10","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T11","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T12","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"},{"subj":"T13","pred":"source","obj":"GlyCosmos6-Glycan-Motif-Structure"}]},{"project":"Glycosmos6-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":490,"end":493},"obj":"http://www.glycoepitope.jp/epitopes/EP0079"},{"id":"T2","span":{"begin":1052,"end":1055},"obj":"http://www.glycoepitope.jp/epitopes/EP0079"},{"id":"T3","span":{"begin":1121,"end":1124},"obj":"http://www.glycoepitope.jp/epitopes/EP0079"},{"id":"T4","span":{"begin":1297,"end":1300},"obj":"http://www.glycoepitope.jp/epitopes/EP0079"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-GlycoEpitope"},{"subj":"T2","pred":"source","obj":"Glycosmos6-GlycoEpitope"},{"subj":"T3","pred":"source","obj":"Glycosmos6-GlycoEpitope"},{"subj":"T4","pred":"source","obj":"Glycosmos6-GlycoEpitope"}]},{"project":"NGLY1-deficiency","denotations":[{"id":"PD-NGLY1-deficiency-B_T1","span":{"begin":578,"end":584},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T2","span":{"begin":1174,"end":1180},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T3","span":{"begin":1321,"end":1327},"obj":"chem:24139"}],"namespaces":[{"prefix":"hgnc","uri":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:"},{"prefix":"omim","uri":"https://www.omim.org/entry/"},{"prefix":"chem","uri":"https://pubchem.ncbi.nlm.nih.gov/compound/"}],"attributes":[{"subj":"PD-NGLY1-deficiency-B_T1","pred":"source","obj":"NGLY1-deficiency"},{"subj":"PD-NGLY1-deficiency-B_T2","pred":"source","obj":"NGLY1-deficiency"},{"subj":"PD-NGLY1-deficiency-B_T3","pred":"source","obj":"NGLY1-deficiency"}]},{"project":"CoMAGC","denotations":[{"id":"T1","span":{"begin":1487,"end":1495},"obj":"Gene"},{"id":"E1","span":{"begin":1473,"end":1483},"obj":"Gene_expression"},{"id":"E2","span":{"begin":1499,"end":1508},"obj":"Positive_regulation"},{"id":"T2","span":{"begin":1521,"end":1534},"obj":"breast cancer"}],"relations":[{"id":"R1","pred":"themeOf","subj":"T1","obj":"E1"},{"id":"R2","pred":"themeOf","subj":"E1","obj":"E2"},{"id":"R3","pred":"CGE-increased","subj":"T1","obj":"T2"},{"id":"R4","pred":"CCS-normalTOcancer","subj":"T1","obj":"T2"},{"id":"R5","pred":"PT-observation","subj":"T1","obj":"T2"},{"id":"R3","pred":"IGE-unchanged","subj":"T1","obj":"T2"}],"attributes":[{"subj":"T1","pred":"source","obj":"CoMAGC"},{"subj":"E1","pred":"source","obj":"CoMAGC"},{"subj":"E2","pred":"source","obj":"CoMAGC"},{"subj":"T2","pred":"source","obj":"CoMAGC"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":121,"end":126},"obj":"Disease"},{"id":"T2","span":{"begin":158,"end":171},"obj":"Disease"},{"id":"T3","span":{"begin":472,"end":478},"obj":"Disease"},{"id":"T4","span":{"begin":724,"end":738},"obj":"Disease"},{"id":"T5","span":{"begin":1521,"end":1534},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T5","pred":"source","obj":"mondo_disease"}]},{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":215,"end":221},"obj":"Glycan"},{"id":"T2","span":{"begin":235,"end":241},"obj":"Glycan"},{"id":"T3","span":{"begin":372,"end":378},"obj":"Glycan"},{"id":"T4","span":{"begin":490,"end":493},"obj":"Glycan"},{"id":"T5","span":{"begin":541,"end":547},"obj":"Glycan"},{"id":"T6","span":{"begin":551,"end":557},"obj":"Glycan"},{"id":"T7","span":{"begin":976,"end":982},"obj":"Glycan"},{"id":"T8","span":{"begin":1052,"end":1055},"obj":"Glycan"},{"id":"T9","span":{"begin":1121,"end":1124},"obj":"Glycan"},{"id":"T10","span":{"begin":1214,"end":1220},"obj":"Glycan"},{"id":"T11","span":{"begin":1297,"end":1300},"obj":"Glycan"},{"id":"T12","span":{"begin":1435,"end":1441},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A13","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"https://glycosmos.org/glycans/show/G00033MO"},{"id":"A14","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A15","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"https://glycosmos.org/glycans/show/G20044TD"},{"id":"A16","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD"},{"id":"A5","pred":"glycosmos_id","subj":"T5","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A17","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A6","pred":"glycosmos_id","subj":"T6","obj":"https://glycosmos.org/glycans/show/G00033MO"},{"id":"A18","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO"},{"id":"A7","pred":"glycosmos_id","subj":"T7","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A19","pred":"image","subj":"T7","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A8","pred":"glycosmos_id","subj":"T8","obj":"https://glycosmos.org/glycans/show/G20044TD"},{"id":"A20","pred":"image","subj":"T8","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD"},{"id":"A9","pred":"glycosmos_id","subj":"T9","obj":"https://glycosmos.org/glycans/show/G20044TD"},{"id":"A21","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD"},{"id":"A10","pred":"glycosmos_id","subj":"T10","obj":"https://glycosmos.org/glycans/show/G00033MO"},{"id":"A22","pred":"image","subj":"T10","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO"},{"id":"A11","pred":"glycosmos_id","subj":"T11","obj":"https://glycosmos.org/glycans/show/G20044TD"},{"id":"A23","pred":"image","subj":"T11","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD"},{"id":"A12","pred":"glycosmos_id","subj":"T12","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A24","pred":"image","subj":"T12","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"subj":"T1","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T2","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T3","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T4","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T5","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T6","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T7","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T8","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T9","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T10","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T11","pred":"source","obj":"GlyCosmos15-Glycan"},{"subj":"T12","pred":"source","obj":"GlyCosmos15-Glycan"}]},{"project":"Glycosmos15-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":490,"end":493},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"},{"id":"T2","span":{"begin":1052,"end":1055},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"},{"id":"T3","span":{"begin":1121,"end":1124},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"},{"id":"T4","span":{"begin":1297,"end":1300},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"}],"attributes":[{"id":"A1","pred":"glycoepitope_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0079"},{"id":"A2","pred":"glycoepitope_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0079"},{"id":"A3","pred":"glycoepitope_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0079"},{"id":"A4","pred":"glycoepitope_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/EP0079"},{"subj":"T1","pred":"source","obj":"Glycosmos15-GlycoEpitope"},{"subj":"T2","pred":"source","obj":"Glycosmos15-GlycoEpitope"},{"subj":"T3","pred":"source","obj":"Glycosmos15-GlycoEpitope"},{"subj":"T4","pred":"source","obj":"Glycosmos15-GlycoEpitope"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":158,"end":164},"obj":"Body_part"},{"id":"T2","span":{"begin":654,"end":660},"obj":"Body_part"},{"id":"T3","span":{"begin":661,"end":667},"obj":"Body_part"},{"id":"T4","span":{"begin":724,"end":730},"obj":"Body_part"},{"id":"T5","span":{"begin":840,"end":845},"obj":"Body_part"},{"id":"T6","span":{"begin":1521,"end":1527},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/GO_0005794"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T6","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"GlyCosmos15-HP","denotations":[{"id":"T1","span":{"begin":121,"end":126},"obj":"Phenotype"},{"id":"T2","span":{"begin":158,"end":171},"obj":"Phenotype"},{"id":"T3","span":{"begin":472,"end":478},"obj":"Phenotype"},{"id":"T4","span":{"begin":724,"end":738},"obj":"Phenotype"},{"id":"T5","span":{"begin":1521,"end":1534},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0003002"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0002664"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0003002"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"HP:0003002"},{"subj":"T1","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T2","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T3","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T4","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T5","pred":"source","obj":"GlyCosmos15-HP"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"GlyCosmos6-Glycan-Motif-Image","color":"#ec93ad","default":true},{"id":"sentences","color":"#93c7ec"},{"id":"GlyCosmos6-Glycan-Motif-Structure","color":"#e1ec93"},{"id":"Glycosmos6-GlycoEpitope","color":"#dd93ec"},{"id":"NGLY1-deficiency","color":"#93ecc3"},{"id":"CoMAGC","color":"#eca993"},{"id":"mondo_disease","color":"#9396ec"},{"id":"GlyCosmos15-Glycan","color":"#b0ec93"},{"id":"Glycosmos15-GlycoEpitope","color":"#ec93ca"},{"id":"Anatomy-UBERON","color":"#93e5ec"},{"id":"GlyCosmos15-HP","color":"#ecd993"}]}]}}