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PubMed:11118434 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 215-221 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T2 235-241 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T3 340-351 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 355-364 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T6 372-378 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T7 490-493 Glycan_Motif denotes SM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD
T8 541-547 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T9 551-557 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T10 598-603 Glycan_Motif denotes core1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T11 976-982 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T12 1052-1055 Glycan_Motif denotes SM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD
T13 1121-1124 Glycan_Motif denotes SM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD
T14 1214-1220 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T15 1297-1300 Glycan_Motif denotes SM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD
T16 1435-1441 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-154 Sentence denotes The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.
T2 155-248 Sentence denotes In breast cancer, the O-glycans added to the MUC1 mucin are core 1- rather than core 2-based.
T3 249-502 Sentence denotes We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid to galactose in the core 1 substrate, is key to this switch in MUC1 glycosylation that results in the expression of the cancer-associated SM3 epitope.
T4 503-668 Sentence denotes Of the three enzymes known to convert core 1 to core 2, by the addition of GlcNAc to GalNAc in core1 C2GnT1 is the dominant enzyme expressed in normal breast tissue.
T5 669-797 Sentence denotes Expression of C2GnT1 is low or absent in around 50% of breast cancers, whereas expression of ST3Gal-I is consistently increased.
T6 798-874 Sentence denotes Mapping of ST3Gal-I and C2GnT1 within the Golgi pathway showed some overlap.
T7 875-1064 Sentence denotes To examine functional competition, the enzymes were overexpressed in T47D cells, which normally make core 1-based structures, have no detectable C2GnT1 activity and express the SM3 epitope.
T8 1065-1232 Sentence denotes Overexpression of C2GnT1 resulted in loss of binding of SM3 to MUC1, accompanied by a decrease in the GalNAc/GlcNAc ratio, indicative of a switch to core 2 structures.
T9 1233-1362 Sentence denotes Transfection of a C2GnT1 expressing line with ST3Gal-I restored SM3 binding and reduced GlcNAc incorporation into MUC1 O-glycans.
T10 1363-1535 Sentence denotes Thus, even when C2GnT1 is expressed, the O-glycans added to MUC1 become core 1-dominated structures, provided expression of ST3Gal-I is increased as it is in breast cancer.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 215-221 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T2 340-351 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 355-364 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T4 355-364 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T5 372-378 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T6 490-493 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM3
T7 541-547 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T8 598-603 https://glytoucan.org/Structures/Glycans/G00031MO denotes core1
T9 976-982 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T10 1052-1055 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM3
T11 1121-1124 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM3
T12 1297-1300 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM3
T13 1435-1441 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 490-493 http://www.glycoepitope.jp/epitopes/EP0079 denotes SM3
T2 1052-1055 http://www.glycoepitope.jp/epitopes/EP0079 denotes SM3
T3 1121-1124 http://www.glycoepitope.jp/epitopes/EP0079 denotes SM3
T4 1297-1300 http://www.glycoepitope.jp/epitopes/EP0079 denotes SM3

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 578-584 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 1174-1180 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 1321-1327 chem:24139 denotes GlcNAc

CoMAGC

Id Subject Object Predicate Lexical cue
T1 1487-1495 Gene denotes ST3Gal-I
E1 1473-1483 Gene_expression denotes expression
E2 1499-1508 Positive_regulation denotes increased
T2 1521-1534 breast cancer denotes breast cancer
R1 T1 E1 themeOf ST3Gal-I,expression
R2 E1 E2 themeOf expression,increased
R3 T1 T2 CGE-increased ST3Gal-I,breast cancer
R4 T1 T2 CCS-normalTOcancer ST3Gal-I,breast cancer
R5 T1 T2 PT-observation ST3Gal-I,breast cancer
R3 T1 T2 IGE-unchanged ST3Gal-I,breast cancer

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 215-221 Glycan denotes core 1
T2 235-241 Glycan denotes core 2
T3 372-378 Glycan denotes core 1
T4 490-493 Glycan denotes SM3
T5 541-547 Glycan denotes core 1
T6 551-557 Glycan denotes core 2
T7 588-594 Glycan denotes GalNAc
T8 598-603 Glycan denotes core1
T9 976-982 Glycan denotes core 1
T10 1052-1055 Glycan denotes SM3
T11 1121-1124 Glycan denotes SM3
T12 1167-1173 Glycan denotes GalNAc
T13 1214-1220 Glycan denotes core 2
T14 1297-1300 Glycan denotes SM3
T15 1435-1441 Glycan denotes core 1

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 121-126 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 158-171 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 472-478 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 724-738 Disease denotes breast cancers http://purl.obolibrary.org/obo/MONDO_0007254
T5 1521-1534 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

Glycosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 490-493 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes SM3 http://www.glycoepitope.jp/epitopes/EP0079
T2 1052-1055 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes SM3 http://www.glycoepitope.jp/epitopes/EP0079
T3 1121-1124 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes SM3 http://www.glycoepitope.jp/epitopes/EP0079
T4 1297-1300 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes SM3 http://www.glycoepitope.jp/epitopes/EP0079

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 158-164 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 654-660 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 661-667 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T4 724-730 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 840-845 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T6 1521-1527 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 121-126 Phenotype denotes tumor HP:0002664
T2 158-171 Phenotype denotes breast cancer HP:0003002
T3 472-478 Phenotype denotes cancer HP:0002664
T4 724-738 Phenotype denotes breast cancers HP:0003002
T5 1521-1534 Phenotype denotes breast cancer HP:0003002