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Id Subject Object Predicate Lexical cue
T1 53-59 UBERON:0027368 denotes matrix
T2 60-86 GO:0008237 denotes metalloproteinase activity
T3 95-109 GO:0016477 denotes cell migration
T5 114-134 GO:0031012 denotes extracellular matrix
T6 128-134 UBERON:0027368 denotes matrix
T7 171-177 UBERON:0001630 denotes muscle
T8 171-177 UBERON:0005090 denotes muscle
T9 194-206 GO:0031099 denotes regeneration
T10 263-271 CL:0000056 denotes myoblast
T11 263-281 GO:0051451 denotes myoblast migration
T12 335-343 CVCL_0188 denotes C(2)C(12
T13 339-343 P51525 denotes C(12
T16 339-343 CHEBI:87146 denotes C(12
T18 345-353 CL:0000056 denotes myoblast
T19 453-459 UBERON:0027368 denotes matrix
T20 453-478 D020782 denotes matrix metalloproteinases
T22 480-484 D020782 denotes MMPs
T23 520-528 CVCL_0188 denotes C(2)C(12
T24 524-528 P51525 denotes C(12
T27 524-528 CHEBI:87146 denotes C(12
T29 565-574 32630 denotes synthetic
T30 565-602 C075190 denotes synthetic metalloproteinase inhibitor
T31 565-602 C075190 denotes synthetic metalloproteinase inhibitor
T33 575-602 P29695 denotes metalloproteinase inhibitor
T34 575-602 P01077 denotes metalloproteinase inhibitor
T35 575-602 Q9DGI0 denotes metalloproteinase inhibitor
T32 575-602 GO:0008191 denotes metalloproteinase inhibitor
T37 604-608 C080985 denotes BB94
T38 604-608 C080985 denotes BB94
T39 610-620 C080985 denotes Batimastat
T40 610-620 C080985 denotes Batimastat
T41 673-677 C080985 denotes BB94
T42 673-677 C080985 denotes BB94
T45 703-711 CVCL_0188 denotes C(2)C(12
T46 707-711 P51525 denotes C(12
T49 707-711 CHEBI:87146 denotes C(12
T68 761-764 PR:O04529 denotes MMP
T66 761-764 CHEBI:340824 denotes MMP
T69 761-764 CHEBI:59761 denotes MMP
T67 761-764 GO:0004235 denotes MMP
T70 798-806 CL:0000056 denotes myoblast
T71 798-816 GO:0051451 denotes myoblast migration
T72 884-888 D020782 denotes MMPs
T73 906-914 CVCL_0188 denotes C(2)C(12
T74 910-914 P51525 denotes C(12
T77 910-914 CHEBI:87146 denotes C(12
T79 933-936 Q41249 denotes PCR
T80 933-936 O66148 denotes PCR
T81 933-936 Q59987 denotes PCR
T82 933-936 Q01289 denotes PCR
T83 933-936 O80333 denotes PCR
T84 933-936 P15904 denotes PCR
T85 933-936 Q9SDT1 denotes PCR
T86 933-936 Q39617 denotes PCR
T89 980-983 PR:O04529 denotes MMP
T87 980-983 CHEBI:340824 denotes MMP
T90 980-983 CHEBI:59761 denotes MMP
T88 980-983 GO:0004235 denotes MMP
T93 984-988 SO:0000234 denotes mRNA
T91 984-988 D012333 denotes mRNA
T92 984-988 CHEBI:33699 denotes mRNA
T94 1007-1015 CVCL_0188 denotes C(2)C(12
T95 1011-1015 P51525 denotes C(12
T98 1011-1015 CHEBI:87146 denotes C(12
T100 1062-1066 D020782 denotes MMPs
T101 1120-1127 4716 denotes gelatin
T102 1120-1127 D005780 denotes gelatin
T103 1120-1127 CHEBI:5291 denotes gelatin
T104 1164-1167 CHEBI:340824 denotes MMP
T107 1164-1167 CHEBI:59761 denotes MMP
T108 1164-1168 PR:P08253 denotes MMP2
T109 1164-1168 Q9GLE5 denotes MMP2
T110 1164-1168 P08253 denotes MMP2
T111 1164-1168 Q90611 denotes MMP2
T113 1164-1168 PR:Q8MPP3 denotes MMP2
T114 1164-1168 P33436 denotes MMP2
T115 1164-1168 PR:Q90611 denotes MMP2
T116 1164-1168 PR:P33436 denotes MMP2
T117 1164-1168 PR:000010479 denotes MMP2
T118 1164-1168 PR:P33434 denotes MMP2
T119 1164-1168 P33434 denotes MMP2
T120 1164-1168 P50757 denotes MMP2
T112 1164-1168 GO:0004228 denotes MMP2
T123 1170-1182 P08253 denotes gelatinase A
T124 1170-1182 Q90611 denotes gelatinase A
T126 1170-1182 PR:000010479 denotes gelatinase A
T127 1170-1182 P33436 denotes gelatinase A
T128 1170-1182 P33434 denotes gelatinase A
T129 1170-1182 P50757 denotes gelatinase A
T125 1170-1182 D020778 denotes gelatinase A
T130 1181-1186 CVCL_3453 denotes A, 72
T131 1184-1210 Q9GLE5 denotes 72-kDa type IV collagenase
T132 1184-1210 P08253 denotes 72-kDa type IV collagenase
T133 1184-1210 Q90611 denotes 72-kDa type IV collagenase
T135 1184-1210 PR:000010479 denotes 72-kDa type IV collagenase
T136 1184-1210 P33436 denotes 72-kDa type IV collagenase
T137 1184-1210 P33434 denotes 72-kDa type IV collagenase
T138 1184-1210 P50757 denotes 72-kDa type IV collagenase
T134 1184-1210 D020778 denotes 72-kDa type IV collagenase
T140 1199-1210 58939 denotes collagenase
T167 1216-1219 CVCL_2501 denotes MT1
T152 1216-1219 GO:0047152 denotes MT1
T161 1216-1219 GO:0043791 denotes MT1
T170 1216-1219 GO:0043834 denotes MT1
T186 1216-1223 Q9XT90 denotes MT1-MMP
T187 1216-1223 P50281 denotes MT1-MMP
T188 1216-1223 Q9GLE4 denotes MT1-MMP
T189 1216-1223 PR:000010474 denotes MT1-MMP
T190 1216-1223 Q10739 denotes MT1-MMP
T191 1216-1223 Q95220 denotes MT1-MMP
T193 1216-1223 P53690 denotes MT1-MMP
T192 1216-1223 D053511 denotes MT1-MMP
T196 1220-1223 GO:0004235 denotes MMP
T199 1284-1287 CHEBI:340824 denotes MMP
T202 1284-1287 CHEBI:59761 denotes MMP
T203 1284-1288 PR:P08253 denotes MMP2
T204 1284-1288 Q9GLE5 denotes MMP2
T205 1284-1288 P08253 denotes MMP2
T206 1284-1288 Q90611 denotes MMP2
T208 1284-1288 PR:Q8MPP3 denotes MMP2
T209 1284-1288 P33436 denotes MMP2
T210 1284-1288 PR:Q90611 denotes MMP2
T211 1284-1288 PR:P33436 denotes MMP2
T212 1284-1288 PR:000010479 denotes MMP2
T213 1284-1288 PR:P33434 denotes MMP2
T214 1284-1288 P33434 denotes MMP2
T215 1284-1288 P50757 denotes MMP2
T207 1284-1288 GO:0004228 denotes MMP2
T216 1338-1351 GO:0005576 denotes extracellular
T217 1398-1401 CHEBI:340824 denotes MMP
T220 1398-1401 CHEBI:59761 denotes MMP
T221 1398-1402 PR:P50282 denotes MMP9
T222 1398-1402 PR:P14780 denotes MMP9
T223 1398-1402 P14780 denotes MMP9
T224 1398-1402 PR:P41245 denotes MMP9
T225 1398-1402 P41246 denotes MMP9
T226 1398-1402 P41245 denotes MMP9
T227 1398-1402 PR:P52176 denotes MMP9
T228 1398-1402 P50282 denotes MMP9
T230 1398-1402 PR:000010491 denotes MMP9
T231 1398-1402 P52176 denotes MMP9
T232 1398-1402 O18733 denotes MMP9
T229 1398-1402 GO:0004229 denotes MMP9
T236 1404-1416 P14780 denotes gelatinase B
T237 1404-1416 P41246 denotes gelatinase B
T238 1404-1416 P41245 denotes gelatinase B
T239 1404-1416 P50282 denotes gelatinase B
T240 1404-1416 PR:000010491 denotes gelatinase B
T241 1404-1416 P52176 denotes gelatinase B
T242 1404-1416 O18733 denotes gelatinase B
T235 1404-1416 D020780 denotes gelatinase B
T243 1415-1420 CVCL_4115 denotes B, 92
T245 1418-1444 P14780 denotes 92-kDa type IV collagenase
T246 1418-1444 P41246 denotes 92-kDa type IV collagenase
T247 1418-1444 P41245 denotes 92-kDa type IV collagenase
T248 1418-1444 P50282 denotes 92-kDa type IV collagenase
T249 1418-1444 PR:000010491 denotes 92-kDa type IV collagenase
T250 1418-1444 P52176 denotes 92-kDa type IV collagenase
T251 1418-1444 O18733 denotes 92-kDa type IV collagenase
T244 1418-1444 D020780 denotes 92-kDa type IV collagenase
T253 1433-1444 58939 denotes collagenase
T259 1507-1515 GO:0016020 denotes membrane
T258 1507-1515 UBERON:0000094 denotes membrane
T260 1507-1515 UBERON:0000158 denotes membrane
T263 1521-1524 PR:O04529 denotes MMP
T261 1521-1524 CHEBI:340824 denotes MMP
T264 1521-1524 CHEBI:59761 denotes MMP
T262 1521-1524 GO:0004235 denotes MMP
T287 1526-1529 CVCL_2501 denotes MT1
T272 1526-1529 GO:0047152 denotes MT1
T281 1526-1529 GO:0043791 denotes MT1
T290 1526-1529 GO:0043834 denotes MT1
T306 1526-1533 Q9XT90 denotes MT1-MMP
T307 1526-1533 P50281 denotes MT1-MMP
T308 1526-1533 Q9GLE4 denotes MT1-MMP
T309 1526-1533 PR:000010474 denotes MT1-MMP
T310 1526-1533 Q10739 denotes MT1-MMP
T311 1526-1533 Q95220 denotes MT1-MMP
T313 1526-1533 P53690 denotes MT1-MMP
T312 1526-1533 D053511 denotes MT1-MMP
T316 1530-1533 GO:0004235 denotes MMP
T319 1535-1545 SO:0000673 denotes transcript
T320 1571-1579 CVCL_0188 denotes C(2)C(12
T321 1575-1579 P51525 denotes C(12
T324 1575-1579 CHEBI:87146 denotes C(12
T326 1599-1602 CHEBI:340824 denotes MMP
T329 1599-1602 CHEBI:59761 denotes MMP
T330 1599-1603 PR:P08253 denotes MMP2
T331 1599-1603 Q9GLE5 denotes MMP2
T332 1599-1603 P08253 denotes MMP2
T333 1599-1603 Q90611 denotes MMP2
T335 1599-1603 PR:Q8MPP3 denotes MMP2
T336 1599-1603 P33436 denotes MMP2
T337 1599-1603 PR:Q90611 denotes MMP2
T338 1599-1603 PR:P33436 denotes MMP2
T339 1599-1603 PR:000010479 denotes MMP2
T340 1599-1603 PR:P33434 denotes MMP2
T341 1599-1603 P33434 denotes MMP2
T342 1599-1603 P50757 denotes MMP2
T334 1599-1603 GO:0004228 denotes MMP2
T347 1613-1616 SO:0001439 denotes pro
T343 1613-1616 CVCL_N817 denotes pro
T349 1613-1621 C069860 denotes pro-MMP2
T354 1617-1621 PR:P08253 denotes MMP2
T355 1617-1621 Q9GLE5 denotes MMP2
T356 1617-1621 P08253 denotes MMP2
T357 1617-1621 Q90611 denotes MMP2
T359 1617-1621 PR:Q8MPP3 denotes MMP2
T360 1617-1621 P33436 denotes MMP2
T361 1617-1621 PR:Q90611 denotes MMP2
T362 1617-1621 PR:P33436 denotes MMP2
T363 1617-1621 PR:000010479 denotes MMP2
T364 1617-1621 PR:P33434 denotes MMP2
T365 1617-1621 P33434 denotes MMP2
T366 1617-1621 P50757 denotes MMP2
T358 1617-1621 GO:0004228 denotes MMP2
T389 1648-1651 CVCL_2501 denotes MT1
T374 1648-1651 GO:0047152 denotes MT1
T383 1648-1651 GO:0043791 denotes MT1
T392 1648-1651 GO:0043834 denotes MT1
T408 1648-1655 Q9XT90 denotes MT1-MMP
T409 1648-1655 P50281 denotes MT1-MMP
T410 1648-1655 Q9GLE4 denotes MT1-MMP
T411 1648-1655 PR:000010474 denotes MT1-MMP
T412 1648-1655 Q10739 denotes MT1-MMP
T413 1648-1655 Q95220 denotes MT1-MMP
T415 1648-1655 P53690 denotes MT1-MMP
T414 1648-1655 D053511 denotes MT1-MMP
T418 1652-1655 GO:0004235 denotes MMP
T421 1731-1739 CVCL_0188 denotes C(2)C(12
T422 1735-1739 P51525 denotes C(12
T425 1735-1739 CHEBI:87146 denotes C(12
T427 1746-1760 P14894 denotes concanavalin A
T428 1746-1760 P81461 denotes concanavalin A
T429 1746-1760 P02866 denotes concanavalin A
T430 1746-1760 P81460 denotes concanavalin A
T431 1746-1760 D003208 denotes concanavalin A
T454 1805-1808 CVCL_2501 denotes MT1
T439 1805-1808 GO:0047152 denotes MT1
T448 1805-1808 GO:0043791 denotes MT1
T457 1805-1808 GO:0043834 denotes MT1
T473 1805-1812 Q9XT90 denotes MT1-MMP
T474 1805-1812 P50281 denotes MT1-MMP
T475 1805-1812 Q9GLE4 denotes MT1-MMP
T476 1805-1812 PR:000010474 denotes MT1-MMP
T477 1805-1812 Q10739 denotes MT1-MMP
T478 1805-1812 Q95220 denotes MT1-MMP
T480 1805-1812 P53690 denotes MT1-MMP
T479 1805-1812 D053511 denotes MT1-MMP
T483 1809-1812 GO:0004235 denotes MMP
T486 1844-1847 CVCL_N817 denotes pro
T490 1844-1847 SO:0001439 denotes pro
T492 1844-1852 C069860 denotes pro-MMP2
T497 1848-1852 PR:P08253 denotes MMP2
T498 1848-1852 Q9GLE5 denotes MMP2
T499 1848-1852 P08253 denotes MMP2
T500 1848-1852 Q90611 denotes MMP2
T502 1848-1852 PR:Q8MPP3 denotes MMP2
T503 1848-1852 P33436 denotes MMP2
T504 1848-1852 PR:Q90611 denotes MMP2
T505 1848-1852 PR:P33436 denotes MMP2
T506 1848-1852 PR:000010479 denotes MMP2
T507 1848-1852 PR:P33434 denotes MMP2
T508 1848-1852 P33434 denotes MMP2
T509 1848-1852 P50757 denotes MMP2
T501 1848-1852 GO:0004228 denotes MMP2
T510 1934-1937 CHEBI:340824 denotes MMP
T513 1934-1937 CHEBI:59761 denotes MMP
T514 1934-1938 PR:P08253 denotes MMP2
T515 1934-1938 Q9GLE5 denotes MMP2
T516 1934-1938 P08253 denotes MMP2
T517 1934-1938 Q90611 denotes MMP2
T519 1934-1938 PR:Q8MPP3 denotes MMP2
T520 1934-1938 P33436 denotes MMP2
T521 1934-1938 PR:Q90611 denotes MMP2
T522 1934-1938 PR:P33436 denotes MMP2
T523 1934-1938 PR:000010479 denotes MMP2
T524 1934-1938 PR:P33434 denotes MMP2
T525 1934-1938 P33434 denotes MMP2
T526 1934-1938 P50757 denotes MMP2
T518 1934-1938 GO:0004228 denotes MMP2
T527 2001-2006 10090 denotes mouse
T528 2001-2006 D051379 denotes mouse
T529 2043-2046 CHEBI:340824 denotes MMP
T532 2043-2046 CHEBI:59761 denotes MMP
T533 2043-2047 PR:P08253 denotes MMP2
T534 2043-2047 Q9GLE5 denotes MMP2
T535 2043-2047 P08253 denotes MMP2
T536 2043-2047 Q90611 denotes MMP2
T538 2043-2047 PR:Q8MPP3 denotes MMP2
T539 2043-2047 P33436 denotes MMP2
T540 2043-2047 PR:Q90611 denotes MMP2
T541 2043-2047 PR:P33436 denotes MMP2
T542 2043-2047 PR:000010479 denotes MMP2
T543 2043-2047 PR:P33434 denotes MMP2
T544 2043-2047 P33434 denotes MMP2
T545 2043-2047 P50757 denotes MMP2
T537 2043-2047 GO:0004228 denotes MMP2
T568 2052-2055 CVCL_2501 denotes MT1
T553 2052-2055 GO:0047152 denotes MT1
T562 2052-2055 GO:0043791 denotes MT1
T571 2052-2055 GO:0043834 denotes MT1
T587 2052-2059 Q9XT90 denotes MT1-MMP
T588 2052-2059 P50281 denotes MT1-MMP
T589 2052-2059 Q9GLE4 denotes MT1-MMP
T590 2052-2059 PR:000010474 denotes MT1-MMP
T591 2052-2059 Q10739 denotes MT1-MMP
T592 2052-2059 Q95220 denotes MT1-MMP
T594 2052-2059 P53690 denotes MT1-MMP
T593 2052-2059 D053511 denotes MT1-MMP
T597 2056-2059 GO:0004235 denotes MMP
T600 2060-2064 SO:0000704 denotes gene
T601 2084-2092 CVCL_0188 denotes C(2)C(12
T602 2088-2092 P51525 denotes C(12
T605 2088-2092 CHEBI:87146 denotes C(12
T607 2153-2161 CVCL_0188 denotes C(2)C(12
T608 2157-2161 P51525 denotes C(12
T611 2157-2161 CHEBI:87146 denotes C(12
T613 2215-2218 CHEBI:340824 denotes MMP
T616 2215-2218 CHEBI:59761 denotes MMP
T617 2215-2219 PR:P08253 denotes MMP2
T618 2215-2219 Q9GLE5 denotes MMP2
T619 2215-2219 P08253 denotes MMP2
T620 2215-2219 Q90611 denotes MMP2
T622 2215-2219 PR:Q8MPP3 denotes MMP2
T623 2215-2219 P33436 denotes MMP2
T624 2215-2219 PR:Q90611 denotes MMP2
T625 2215-2219 PR:P33436 denotes MMP2
T626 2215-2219 PR:000010479 denotes MMP2
T627 2215-2219 PR:P33434 denotes MMP2
T628 2215-2219 P33434 denotes MMP2
T629 2215-2219 P50757 denotes MMP2
T621 2215-2219 GO:0004228 denotes MMP2
T652 2242-2245 CVCL_2501 denotes MT1
T637 2242-2245 GO:0047152 denotes MT1
T646 2242-2245 GO:0043791 denotes MT1
T655 2242-2245 GO:0043834 denotes MT1
T671 2242-2249 Q9XT90 denotes MT1-MMP
T672 2242-2249 P50281 denotes MT1-MMP
T673 2242-2249 Q9GLE4 denotes MT1-MMP
T674 2242-2249 PR:000010474 denotes MT1-MMP
T675 2242-2249 Q10739 denotes MT1-MMP
T676 2242-2249 Q95220 denotes MT1-MMP
T678 2242-2249 P53690 denotes MT1-MMP
T677 2242-2249 D053511 denotes MT1-MMP
T681 2246-2249 GO:0004235 denotes MMP
T684 2254-2262 CL:0000056 denotes myoblast
T685 2254-2272 GO:0051451 denotes myoblast migration

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-87 DRI_Background denotes In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity.
T2 88-207 DRI_Background denotes Muscle cell migration and extracellular matrix remodeling are essential aspects of muscle development and regeneration.
T3 208-424 DRI_Approach denotes In this study, using a new technique to assess in vivo myoblast migration, we have confirmed previous results showing that the C(2)C(12) myoblast cell line exhibits a higher migratory capacity than primary myoblasts.
T4 425-654 DRI_Approach denotes To test the hypothesis that matrix metalloproteinases (MMPs) are required for the migration of C(2)C(12) myoblasts, we determined whether a synthetic metalloproteinase inhibitor, BB94 (Batimastat), inhibited this process in vivo.
T5 655-754 DRI_Approach denotes Pretreatment with BB94 for 3 days decreased the C(2)C(12) migration at 2 days after cell injection.
T6 755-926 DRI_Approach denotes Since MMP expression is thus necessary for myoblast migration, we have undertaken the identification and characterization of the MMPs expressed by the C(2)C(12) cell line.
T7 927-1027 DRI_Background denotes An RT-PCR assay was used to determine the pattern of MMP mRNA expression by the C(2)C(12) cell line.
T8 1028-1139 DRI_Background denotes The proteolytic activities of the MMPs secreted in the culture medium were also assessed by gelatin zymography.
T9 1140-1364 DRI_Outcome denotes The results showed that MMP2 (gelatinase A, 72-kDa type IV collagenase) and MT1-MMP transcripts were expressed by this cell line; however, only MMP2 was secreted and was able to be activated in the extracellular environment.
T10 1365-1481 DRI_Approach denotes This cell line failed to express MMP9 (gelatinase B, 92-kDa type IV collagenase), stromelysine 2, or stromelysine 3.
T11 1482-1598 DRI_Approach denotes Our observation that the membrane type MMP (MT1-MMP) transcript is also expressed by the C(2)C(12) suggests that the
T12 1599-1611 Token_Label.OUTSIDE denotes MMP2 proform
T13 1612-1656 DRI_Approach denotes (pro-MMP2), may be activated by the MT1-MMP.
T14 1657-1900 DRI_Approach denotes This possibility is supported by our observation that the pretreatment of C(2)C(12) with concanavalin A (which is known to induce the expression of MT1-MMP) resulted in the processing of pro-MMP2 to its mature form, in a dose-dependent manner.
T15 1901-2025 DRI_Background denotes Overexpression and activation of MMP2 in normal myoblasts showed significant increased migration of mouse myoblasts in vivo.
T16 2026-2163 DRI_Approach denotes Our finding that MMP2 and MT1-MMP gene are coexpressed by C(2)C(12) myoblasts could account for the high migratory capacity of C(2)C(12).
T17 2164-2273 DRI_Unspecified denotes Together these results supported the importance of MMP2 and its activation by MT1-MMP for myoblast migration.