PubMed:10791221
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10791221","sourcedb":"PubMed","sourceid":"10791221","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10791221","text":"Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.\nBACKGROUND/AIMS: The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested. The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.\nMETHODOLOGY: Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of: 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically. Immunohistochemical studies were also performed using the antibodies against p53 protein.\nRESULTS: Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors. Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components. B-HCC tended to be less differentiated than C-HCC (P \u003c 0.05). Adenomatous hyperplasia was detected in only 2 cases of C-HCC. Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P \u003c 0.05). The prognosis of the 14 minute hepatocellular carcinomas varied considerably. Immunohistochemically, some tumor cells were positive for p53 in 3 cases.\nCONCLUSIONS: Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":93,"end":109},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":110,"end":327},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":328,"end":486},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":487,"end":499},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":500,"end":583},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":584,"end":849},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":850,"end":939},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":940,"end":948},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":949,"end":1062},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1063,"end":1187},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1188,"end":1249},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1250,"end":1312},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1313,"end":1417},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":1418,"end":1495},"obj":"Sentence"},{"id":"TextSentencer_T16","span":{"begin":1496,"end":1569},"obj":"Sentence"},{"id":"TextSentencer_T17","span":{"begin":1570,"end":1582},"obj":"Sentence"},{"id":"TextSentencer_T18","span":{"begin":1583,"end":2053},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T2","span":{"begin":93,"end":109},"obj":"Sentence"},{"id":"T3","span":{"begin":110,"end":327},"obj":"Sentence"},{"id":"T4","span":{"begin":328,"end":486},"obj":"Sentence"},{"id":"T5","span":{"begin":487,"end":499},"obj":"Sentence"},{"id":"T6","span":{"begin":500,"end":583},"obj":"Sentence"},{"id":"T7","span":{"begin":584,"end":849},"obj":"Sentence"},{"id":"T8","span":{"begin":850,"end":939},"obj":"Sentence"},{"id":"T9","span":{"begin":940,"end":948},"obj":"Sentence"},{"id":"T10","span":{"begin":949,"end":1062},"obj":"Sentence"},{"id":"T11","span":{"begin":1063,"end":1187},"obj":"Sentence"},{"id":"T12","span":{"begin":1188,"end":1249},"obj":"Sentence"},{"id":"T13","span":{"begin":1250,"end":1312},"obj":"Sentence"},{"id":"T14","span":{"begin":1313,"end":1417},"obj":"Sentence"},{"id":"T15","span":{"begin":1418,"end":1495},"obj":"Sentence"},{"id":"T16","span":{"begin":1496,"end":1569},"obj":"Sentence"},{"id":"T17","span":{"begin":1570,"end":1582},"obj":"Sentence"},{"id":"T18","span":{"begin":1583,"end":2053},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T13","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T14","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T15","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T16","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T17","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T18","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"},{"subj":"T16","pred":"source","obj":"sentences"},{"subj":"T17","pred":"source","obj":"sentences"},{"subj":"T18","pred":"source","obj":"sentences"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":145,"end":169},"obj":"HP_0001402"},{"id":"T2","span":{"begin":206,"end":230},"obj":"HP_0001402"},{"id":"T3","span":{"begin":245,"end":269},"obj":"HP_0001402"},{"id":"T4","span":{"begin":409,"end":434},"obj":"HP_0001402"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]},{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":145,"end":169},"obj":"HP:0001402"},{"id":"TI1","span":{"begin":66,"end":91},"obj":"HP:0001402"},{"id":"AB2","span":{"begin":206,"end":230},"obj":"HP:0001402"},{"id":"AB3","span":{"begin":245,"end":269},"obj":"HP:0001402"},{"id":"AB4","span":{"begin":409,"end":434},"obj":"HP:0001402"},{"id":"AB5","span":{"begin":516,"end":541},"obj":"HP:0001402"},{"id":"AB6","span":{"begin":587,"end":611},"obj":"HP:0001402"},{"id":"AB7","span":{"begin":615,"end":624},"obj":"HP:0012115"},{"id":"AB8","span":{"begin":685,"end":709},"obj":"HP:0001402"},{"id":"AB9","span":{"begin":713,"end":722},"obj":"HP:0012115"},{"id":"AB10","span":{"begin":970,"end":994},"obj":"HP:0001402"},{"id":"AB11","span":{"begin":1102,"end":1127},"obj":"HP:0001402"},{"id":"AB12","span":{"begin":1449,"end":1474},"obj":"HP:0001402"},{"id":"AB13","span":{"begin":1755,"end":1779},"obj":"HP:0001402"},{"id":"AB14","span":{"begin":1815,"end":1839},"obj":"HP:0001402"},{"id":"AB15","span":{"begin":1979,"end":2004},"obj":"HP:0001402"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"TI1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"},{"subj":"AB3","pred":"source","obj":"PubCasesHPO"},{"subj":"AB4","pred":"source","obj":"PubCasesHPO"},{"subj":"AB5","pred":"source","obj":"PubCasesHPO"},{"subj":"AB6","pred":"source","obj":"PubCasesHPO"},{"subj":"AB7","pred":"source","obj":"PubCasesHPO"},{"subj":"AB8","pred":"source","obj":"PubCasesHPO"},{"subj":"AB9","pred":"source","obj":"PubCasesHPO"},{"subj":"AB10","pred":"source","obj":"PubCasesHPO"},{"subj":"AB11","pred":"source","obj":"PubCasesHPO"},{"subj":"AB12","pred":"source","obj":"PubCasesHPO"},{"subj":"AB13","pred":"source","obj":"PubCasesHPO"},{"subj":"AB14","pred":"source","obj":"PubCasesHPO"},{"subj":"AB15","pred":"source","obj":"PubCasesHPO"}]},{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":145,"end":169},"obj":"ORDO:88673"},{"id":"TI1","span":{"begin":66,"end":91},"obj":"ORDO:88673"},{"id":"AB2","span":{"begin":206,"end":230},"obj":"ORDO:88673"},{"id":"AB3","span":{"begin":245,"end":269},"obj":"ORDO:88673"},{"id":"AB4","span":{"begin":409,"end":434},"obj":"ORDO:88673"},{"id":"AB5","span":{"begin":516,"end":541},"obj":"ORDO:88673"},{"id":"AB6","span":{"begin":587,"end":611},"obj":"ORDO:88673"},{"id":"AB7","span":{"begin":664,"end":667},"obj":"ORDO:88673"},{"id":"AB8","span":{"begin":685,"end":709},"obj":"ORDO:88673"},{"id":"AB9","span":{"begin":761,"end":764},"obj":"ORDO:88673"},{"id":"AB10","span":{"begin":970,"end":994},"obj":"ORDO:88673"},{"id":"AB11","span":{"begin":1102,"end":1127},"obj":"ORDO:88673"},{"id":"AB12","span":{"begin":1190,"end":1193},"obj":"ORDO:88673"},{"id":"AB13","span":{"begin":1234,"end":1237},"obj":"ORDO:88673"},{"id":"AB14","span":{"begin":1308,"end":1311},"obj":"ORDO:88673"},{"id":"AB15","span":{"begin":1388,"end":1391},"obj":"ORDO:88673"},{"id":"AB16","span":{"begin":1402,"end":1405},"obj":"ORDO:88673"},{"id":"AB17","span":{"begin":1449,"end":1474},"obj":"ORDO:88673"},{"id":"AB18","span":{"begin":1755,"end":1779},"obj":"ORDO:88673"},{"id":"AB19","span":{"begin":1815,"end":1839},"obj":"ORDO:88673"},{"id":"AB20","span":{"begin":1854,"end":1857},"obj":"ORDO:88673"},{"id":"AB21","span":{"begin":1906,"end":1909},"obj":"ORDO:88673"},{"id":"AB22","span":{"begin":1954,"end":1957},"obj":"ORDO:88673"},{"id":"AB23","span":{"begin":1979,"end":2004},"obj":"ORDO:88673"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesORDO"},{"subj":"TI1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB2","pred":"source","obj":"PubCasesORDO"},{"subj":"AB3","pred":"source","obj":"PubCasesORDO"},{"subj":"AB4","pred":"source","obj":"PubCasesORDO"},{"subj":"AB5","pred":"source","obj":"PubCasesORDO"},{"subj":"AB6","pred":"source","obj":"PubCasesORDO"},{"subj":"AB7","pred":"source","obj":"PubCasesORDO"},{"subj":"AB8","pred":"source","obj":"PubCasesORDO"},{"subj":"AB9","pred":"source","obj":"PubCasesORDO"},{"subj":"AB10","pred":"source","obj":"PubCasesORDO"},{"subj":"AB11","pred":"source","obj":"PubCasesORDO"},{"subj":"AB12","pred":"source","obj":"PubCasesORDO"},{"subj":"AB13","pred":"source","obj":"PubCasesORDO"},{"subj":"AB14","pred":"source","obj":"PubCasesORDO"},{"subj":"AB15","pred":"source","obj":"PubCasesORDO"},{"subj":"AB16","pred":"source","obj":"PubCasesORDO"},{"subj":"AB17","pred":"source","obj":"PubCasesORDO"},{"subj":"AB18","pred":"source","obj":"PubCasesORDO"},{"subj":"AB19","pred":"source","obj":"PubCasesORDO"},{"subj":"AB20","pred":"source","obj":"PubCasesORDO"},{"subj":"AB21","pred":"source","obj":"PubCasesORDO"},{"subj":"AB22","pred":"source","obj":"PubCasesORDO"},{"subj":"AB23","pred":"source","obj":"PubCasesORDO"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1324,"end":1329},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"}]},{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1324,"end":1329},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#b093ec","default":true},{"id":"PubmedHPO","color":"#93ec96"},{"id":"PubCasesHPO","color":"#ec93a9"},{"id":"PubCasesORDO","color":"#93c3ec"},{"id":"UBERON-AE","color":"#ddec93"},{"id":"performance-test","color":"#e193ec"}]}]}}