PubMed:10791221 JSON TXT

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PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":145,"end":169},"obj":"HP_0001402"},{"id":"T2","span":{"begin":206,"end":230},"obj":"HP_0001402"},{"id":"T3","span":{"begin":245,"end":269},"obj":"HP_0001402"},{"id":"T4","span":{"begin":409,"end":434},"obj":"HP_0001402"}],"text":"Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.\nBACKGROUND/AIMS: The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested. The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.\nMETHODOLOGY: Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of: 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically. Immunohistochemical studies were also performed using the antibodies against p53 protein.\nRESULTS: Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors. Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components. B-HCC tended to be less differentiated than C-HCC (P \u003c 0.05). Adenomatous hyperplasia was detected in only 2 cases of C-HCC. Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P \u003c 0.05). The prognosis of the 14 minute hepatocellular carcinomas varied considerably. Immunohistochemically, some tumor cells were positive for p53 in 3 cases.\nCONCLUSIONS: Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy."}

PubCasesHPO

{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":145,"end":169},"obj":"HP:0001402"},{"id":"TI1","span":{"begin":66,"end":91},"obj":"HP:0001402"},{"id":"AB2","span":{"begin":206,"end":230},"obj":"HP:0001402"},{"id":"AB3","span":{"begin":245,"end":269},"obj":"HP:0001402"},{"id":"AB4","span":{"begin":409,"end":434},"obj":"HP:0001402"},{"id":"AB5","span":{"begin":516,"end":541},"obj":"HP:0001402"},{"id":"AB6","span":{"begin":587,"end":611},"obj":"HP:0001402"},{"id":"AB7","span":{"begin":615,"end":624},"obj":"HP:0012115"},{"id":"AB8","span":{"begin":685,"end":709},"obj":"HP:0001402"},{"id":"AB9","span":{"begin":713,"end":722},"obj":"HP:0012115"},{"id":"AB10","span":{"begin":970,"end":994},"obj":"HP:0001402"},{"id":"AB11","span":{"begin":1102,"end":1127},"obj":"HP:0001402"},{"id":"AB12","span":{"begin":1449,"end":1474},"obj":"HP:0001402"},{"id":"AB13","span":{"begin":1755,"end":1779},"obj":"HP:0001402"},{"id":"AB14","span":{"begin":1815,"end":1839},"obj":"HP:0001402"},{"id":"AB15","span":{"begin":1979,"end":2004},"obj":"HP:0001402"}],"text":"Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.\nBACKGROUND/AIMS: The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested. The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.\nMETHODOLOGY: Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of: 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically. Immunohistochemical studies were also performed using the antibodies against p53 protein.\nRESULTS: Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors. Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components. B-HCC tended to be less differentiated than C-HCC (P \u003c 0.05). Adenomatous hyperplasia was detected in only 2 cases of C-HCC. Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P \u003c 0.05). The prognosis of the 14 minute hepatocellular carcinomas varied considerably. Immunohistochemically, some tumor cells were positive for p53 in 3 cases.\nCONCLUSIONS: Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy."}

PubCasesORDO

{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":145,"end":169},"obj":"ORDO:88673"},{"id":"TI1","span":{"begin":66,"end":91},"obj":"ORDO:88673"},{"id":"AB2","span":{"begin":206,"end":230},"obj":"ORDO:88673"},{"id":"AB3","span":{"begin":245,"end":269},"obj":"ORDO:88673"},{"id":"AB4","span":{"begin":409,"end":434},"obj":"ORDO:88673"},{"id":"AB5","span":{"begin":516,"end":541},"obj":"ORDO:88673"},{"id":"AB6","span":{"begin":587,"end":611},"obj":"ORDO:88673"},{"id":"AB7","span":{"begin":664,"end":667},"obj":"ORDO:88673"},{"id":"AB8","span":{"begin":685,"end":709},"obj":"ORDO:88673"},{"id":"AB9","span":{"begin":761,"end":764},"obj":"ORDO:88673"},{"id":"AB10","span":{"begin":970,"end":994},"obj":"ORDO:88673"},{"id":"AB11","span":{"begin":1102,"end":1127},"obj":"ORDO:88673"},{"id":"AB12","span":{"begin":1190,"end":1193},"obj":"ORDO:88673"},{"id":"AB13","span":{"begin":1234,"end":1237},"obj":"ORDO:88673"},{"id":"AB14","span":{"begin":1308,"end":1311},"obj":"ORDO:88673"},{"id":"AB15","span":{"begin":1388,"end":1391},"obj":"ORDO:88673"},{"id":"AB16","span":{"begin":1402,"end":1405},"obj":"ORDO:88673"},{"id":"AB17","span":{"begin":1449,"end":1474},"obj":"ORDO:88673"},{"id":"AB18","span":{"begin":1755,"end":1779},"obj":"ORDO:88673"},{"id":"AB19","span":{"begin":1815,"end":1839},"obj":"ORDO:88673"},{"id":"AB20","span":{"begin":1854,"end":1857},"obj":"ORDO:88673"},{"id":"AB21","span":{"begin":1906,"end":1909},"obj":"ORDO:88673"},{"id":"AB22","span":{"begin":1954,"end":1957},"obj":"ORDO:88673"},{"id":"AB23","span":{"begin":1979,"end":2004},"obj":"ORDO:88673"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.\nBACKGROUND/AIMS: The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested. The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.\nMETHODOLOGY: Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of: 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically. Immunohistochemical studies were also performed using the antibodies against p53 protein.\nRESULTS: Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors. Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components. B-HCC tended to be less differentiated than C-HCC (P \u003c 0.05). Adenomatous hyperplasia was detected in only 2 cases of C-HCC. Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P \u003c 0.05). The prognosis of the 14 minute hepatocellular carcinomas varied considerably. Immunohistochemically, some tumor cells were positive for p53 in 3 cases.\nCONCLUSIONS: Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1324,"end":1329},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.\nBACKGROUND/AIMS: The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested. The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.\nMETHODOLOGY: Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of: 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically. Immunohistochemical studies were also performed using the antibodies against p53 protein.\nRESULTS: Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors. Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components. B-HCC tended to be less differentiated than C-HCC (P \u003c 0.05). Adenomatous hyperplasia was detected in only 2 cases of C-HCC. Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P \u003c 0.05). The prognosis of the 14 minute hepatocellular carcinomas varied considerably. Immunohistochemically, some tumor cells were positive for p53 in 3 cases.\nCONCLUSIONS: Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy."}

performance-test

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1324,"end":1329},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.\nBACKGROUND/AIMS: The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested. The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.\nMETHODOLOGY: Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of: 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically. Immunohistochemical studies were also performed using the antibodies against p53 protein.\nRESULTS: Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors. Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components. B-HCC tended to be less differentiated than C-HCC (P \u003c 0.05). Adenomatous hyperplasia was detected in only 2 cases of C-HCC. Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P \u003c 0.05). The prognosis of the 14 minute hepatocellular carcinomas varied considerably. Immunohistochemically, some tumor cells were positive for p53 in 3 cases.\nCONCLUSIONS: Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy."}