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PubMed:10791221 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-92 Sentence denotes Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.
TextSentencer_T2 93-109 Sentence denotes BACKGROUND/AIMS:
TextSentencer_T3 110-327 Sentence denotes The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested.
TextSentencer_T4 328-486 Sentence denotes The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.
TextSentencer_T5 487-499 Sentence denotes METHODOLOGY:
TextSentencer_T6 500-583 Sentence denotes Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of:
TextSentencer_T7 584-849 Sentence denotes 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically.
TextSentencer_T8 850-939 Sentence denotes Immunohistochemical studies were also performed using the antibodies against p53 protein.
TextSentencer_T9 940-948 Sentence denotes RESULTS:
TextSentencer_T10 949-1062 Sentence denotes Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors.
TextSentencer_T11 1063-1187 Sentence denotes Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components.
TextSentencer_T12 1188-1249 Sentence denotes B-HCC tended to be less differentiated than C-HCC (P < 0.05).
TextSentencer_T13 1250-1312 Sentence denotes Adenomatous hyperplasia was detected in only 2 cases of C-HCC.
TextSentencer_T14 1313-1417 Sentence denotes Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P < 0.05).
TextSentencer_T15 1418-1495 Sentence denotes The prognosis of the 14 minute hepatocellular carcinomas varied considerably.
TextSentencer_T16 1496-1569 Sentence denotes Immunohistochemically, some tumor cells were positive for p53 in 3 cases.
TextSentencer_T17 1570-1582 Sentence denotes CONCLUSIONS:
TextSentencer_T18 1583-2053 Sentence denotes Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy.
T1 0-92 Sentence denotes Clinicopathological characteristics of surgically resected minute hepatocellular carcinomas.
T2 93-109 Sentence denotes BACKGROUND/AIMS:
T3 110-327 Sentence denotes The multistep development of overt hepatocellular carcinoma from very well-differentiated early hepatocellular carcinoma, and of early hepatocellular carcinoma from adenomatous hyperplasia has been strongly suggested.
T4 328-486 Sentence denotes The clinicopathologic and immunohistochemical characteristics of solitary minute hepatocellular carcinomas smaller than 1 cm in size have yet to be clarified.
T5 487-499 Sentence denotes METHODOLOGY:
T6 500-583 Sentence denotes Fourteen minute hepatocellular carcinomas were divided into 2 groups consisting of:
T7 584-849 Sentence denotes 1) hepatocellular carcinoma of hepatitis B surface antigen positive patients (B-HCC) (n = 5), and 2) hepatocellular carcinoma of hepatitis C virus antibody positive patients (C-HCC) (n = 9), then they were all analyzed histopathologically and clinicopathologically.
T8 850-939 Sentence denotes Immunohistochemical studies were also performed using the antibodies against p53 protein.
T9 940-948 Sentence denotes RESULTS:
T10 949-1062 Sentence denotes Six of the 14 minute hepatocellular carcinoma were demonstrated to be moderately or poorly differentiated tumors.
T11 1063-1187 Sentence denotes Among the 8 well-differentiated minute hepatocellular carcinomas, 2 tumors already contained less differentiated components.
T12 1188-1249 Sentence denotes B-HCC tended to be less differentiated than C-HCC (P < 0.05).
T13 1250-1312 Sentence denotes Adenomatous hyperplasia was detected in only 2 cases of C-HCC.
T14 1313-1417 Sentence denotes Small cell liver dysplasia was detected significantly more frequently in C-HCC than in B-HCC (P < 0.05).
T15 1418-1495 Sentence denotes The prognosis of the 14 minute hepatocellular carcinomas varied considerably.
T16 1496-1569 Sentence denotes Immunohistochemically, some tumor cells were positive for p53 in 3 cases.
T17 1570-1582 Sentence denotes CONCLUSIONS:
T18 1583-2053 Sentence denotes Our study suggests that 1) the multistep carcinogenesis through adenomatous hyperplasia may not be so frequent, 2) De novo carcinogenesis from not only well-differentiated hepatocellular carcinoma, but also from less differentiated hepatocellular carcinoma, especially B-HCC, may be present, 3) the carcinogenesis in the B-HCC cases may behave differently from that in C-HCC cases, and 4) minute hepatocellular carcinomas demonstrate varying prognoses after hepatectomy.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 145-169 HP_0001402 denotes hepatocellular carcinoma
T2 206-230 HP_0001402 denotes hepatocellular carcinoma
T3 245-269 HP_0001402 denotes hepatocellular carcinoma
T4 409-434 HP_0001402 denotes hepatocellular carcinomas

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 145-169 HP:0001402 denotes hepatocellular carcinoma
TI1 66-91 HP:0001402 denotes hepatocellular carcinomas
AB2 206-230 HP:0001402 denotes hepatocellular carcinoma
AB3 245-269 HP:0001402 denotes hepatocellular carcinoma
AB4 409-434 HP:0001402 denotes hepatocellular carcinomas
AB5 516-541 HP:0001402 denotes hepatocellular carcinomas
AB6 587-611 HP:0001402 denotes hepatocellular carcinoma
AB7 615-624 HP:0012115 denotes hepatitis
AB8 685-709 HP:0001402 denotes hepatocellular carcinoma
AB9 713-722 HP:0012115 denotes hepatitis
AB10 970-994 HP:0001402 denotes hepatocellular carcinoma
AB11 1102-1127 HP:0001402 denotes hepatocellular carcinomas
AB12 1449-1474 HP:0001402 denotes hepatocellular carcinomas
AB13 1755-1779 HP:0001402 denotes hepatocellular carcinoma
AB14 1815-1839 HP:0001402 denotes hepatocellular carcinoma
AB15 1979-2004 HP:0001402 denotes hepatocellular carcinomas

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 145-169 ORDO:88673 denotes hepatocellular carcinoma
TI1 66-91 ORDO:88673 denotes hepatocellular carcinomas
AB2 206-230 ORDO:88673 denotes hepatocellular carcinoma
AB3 245-269 ORDO:88673 denotes hepatocellular carcinoma
AB4 409-434 ORDO:88673 denotes hepatocellular carcinomas
AB5 516-541 ORDO:88673 denotes hepatocellular carcinomas
AB6 587-611 ORDO:88673 denotes hepatocellular carcinoma
AB7 664-667 ORDO:88673 denotes HCC
AB8 685-709 ORDO:88673 denotes hepatocellular carcinoma
AB9 761-764 ORDO:88673 denotes HCC
AB10 970-994 ORDO:88673 denotes hepatocellular carcinoma
AB11 1102-1127 ORDO:88673 denotes hepatocellular carcinomas
AB12 1190-1193 ORDO:88673 denotes HCC
AB13 1234-1237 ORDO:88673 denotes HCC
AB14 1308-1311 ORDO:88673 denotes HCC
AB15 1388-1391 ORDO:88673 denotes HCC
AB16 1402-1405 ORDO:88673 denotes HCC
AB17 1449-1474 ORDO:88673 denotes hepatocellular carcinomas
AB18 1755-1779 ORDO:88673 denotes hepatocellular carcinoma
AB19 1815-1839 ORDO:88673 denotes hepatocellular carcinoma
AB20 1854-1857 ORDO:88673 denotes HCC
AB21 1906-1909 ORDO:88673 denotes HCC
AB22 1954-1957 ORDO:88673 denotes HCC
AB23 1979-2004 ORDO:88673 denotes hepatocellular carcinomas

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1324-1329 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1324-1329 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver