PubMed:10426995 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10426995","sourcedb":"PubMed","sourceid":"10426995","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10426995","text":"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.\nThe generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. 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