PubMed:10426995 JSONTXT

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":88},"obj":"Sentence"},{"id":"S2","span":{"begin":89,"end":256},"obj":"Sentence"},{"id":"S3","span":{"begin":257,"end":396},"obj":"Sentence"},{"id":"S4","span":{"begin":397,"end":568},"obj":"Sentence"},{"id":"S5","span":{"begin":569,"end":732},"obj":"Sentence"},{"id":"S6","span":{"begin":733,"end":846},"obj":"Sentence"}],"text":"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.\nThe generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens."}

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