PubMed:10202178 JSONTXT

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":231},"obj":"Sentence"},{"id":"S2","span":{"begin":232,"end":339},"obj":"Sentence"},{"id":"S3","span":{"begin":340,"end":522},"obj":"Sentence"},{"id":"S4","span":{"begin":523,"end":763},"obj":"Sentence"},{"id":"S5","span":{"begin":764,"end":1199},"obj":"Sentence"},{"id":"S6","span":{"begin":1200,"end":1589},"obj":"Sentence"}],"text":"Differential induction of interferon (IFN)-inducible protein 10 following differentiation of a monocyte, macrophage cell lineage is related to the changes of nuclear proteins bound to IFN stimulus response element and kappaB sites.\nWe examined chemokine gene expression following the differentiation of a monocyte, macrophage cell lineage. The human monoblastic cell line, U937 was differentiated to macrophages by the treatment with either phorbol 12-myristate 13-acetate (PMA), retinoic acid (RA), or vitamin D3 (VitD3). The gene expression of interferon (IFN)-inducible protein 10 (IP-10) (a CXC chemokine) was markedly augmented by the IFNgamma treatment in PMA- or RA-differentiated U937 cells, but only marginally in undifferentiated or VitD3-treated cells. In contrast, another inducible gene expression of monocyte chemotactic protein-1 (a CC chemokine) and the activation of the transcriptional factor (FcRFgamma) bound to the gamma response region were similarly or less abundantly induced by IFNgamma treatment in PMA- or RA-differentiated U937 cells, indicating that increased IP-10 mRNA induction was not due to the augmented ability of the cells to respond to the presence of IFNgamma. Increased expression of IFNgamma-induced IP-10 mRNA following the differentiation of U937 cells was mediated largely by augmented transcriptional activity of the gene and was related to differentiation-dependent changes of the proteins bound to IFN stimulus response element (ISRE) and kB sites, suggesting that these nuclear proteins may determine the IP-10 mRNA inducibility by IFNgamma."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":74,"end":128},"obj":"NP"},{"id":"C2","span":{"begin":184,"end":230},"obj":"NP"},{"id":"C3","span":{"begin":280,"end":338},"obj":"NP"},{"id":"C4","span":{"begin":340,"end":371},"obj":"NP"},{"id":"C5","span":{"begin":373,"end":377},"obj":"NP"},{"id":"C6","span":{"begin":636,"end":698},"obj":"NP"},{"id":"C7","span":{"begin":1003,"end":1061},"obj":"NP"},{"id":"C8","span":{"begin":1190,"end":1198},"obj":"NP"},{"id":"C9","span":{"begin":1285,"end":1295},"obj":"NP"},{"id":"C10","span":{"begin":1445,"end":1494},"obj":"NP"},{"id":"C11","span":{"begin":1580,"end":1588},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-appos","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C4"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C2"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C8"}],"text":"Differential induction of interferon (IFN)-inducible protein 10 following differentiation of a monocyte, macrophage cell lineage is related to the changes of nuclear proteins bound to IFN stimulus response element and kappaB sites.\nWe examined chemokine gene expression following the differentiation of a monocyte, macrophage cell lineage. The human monoblastic cell line, U937 was differentiated to macrophages by the treatment with either phorbol 12-myristate 13-acetate (PMA), retinoic acid (RA), or vitamin D3 (VitD3). The gene expression of interferon (IFN)-inducible protein 10 (IP-10) (a CXC chemokine) was markedly augmented by the IFNgamma treatment in PMA- or RA-differentiated U937 cells, but only marginally in undifferentiated or VitD3-treated cells. In contrast, another inducible gene expression of monocyte chemotactic protein-1 (a CC chemokine) and the activation of the transcriptional factor (FcRFgamma) bound to the gamma response region were similarly or less abundantly induced by IFNgamma treatment in PMA- or RA-differentiated U937 cells, indicating that increased IP-10 mRNA induction was not due to the augmented ability of the cells to respond to the presence of IFNgamma. Increased expression of IFNgamma-induced IP-10 mRNA following the differentiation of U937 cells was mediated largely by augmented transcriptional activity of the gene and was related to differentiation-dependent changes of the proteins bound to IFN stimulus response element (ISRE) and kB sites, suggesting that these nuclear proteins may determine the IP-10 mRNA inducibility by IFNgamma."}

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