PMC:7799378 / 15422-16207 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7799378","sourcedb":"PMC","sourceid":"7799378","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7799378","text":"G6PD may play an important role in viral infection [9–11,85]. Lack of G6PD promotes cytopathic effects and viral replication. G6PD-deficient cells are susceptible to viral infection, such as coronavirus, dengue virus, and enterovirus [9,85,86]. During human coronavirus 229E or enterovirus 71 infections in G6PD-deficient human lung fibroblasts and epithelial cells, HSCARG, a NADPH sensor, and a negative NF-κB regulator is up-regulated. Knockdown of HSCARG activates NF-κB and induces downstream antiviral gene expression, including TNF-α and MX1 [10]. Downregulation of HSCARG decreases viral gene expression, while the upregulation of HSCARG increases viral replication. 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