PMC:7799378 / 15422-16207
Annnotations
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"635","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"636","span":{"begin":70,"end":74},"obj":"Gene"},{"id":"637","span":{"begin":367,"end":373},"obj":"Gene"},{"id":"638","span":{"begin":406,"end":411},"obj":"Gene"},{"id":"639","span":{"begin":452,"end":458},"obj":"Gene"},{"id":"640","span":{"begin":469,"end":474},"obj":"Gene"},{"id":"641","span":{"begin":535,"end":540},"obj":"Gene"},{"id":"642","span":{"begin":545,"end":548},"obj":"Gene"},{"id":"643","span":{"begin":639,"end":645},"obj":"Gene"},{"id":"644","span":{"begin":695,"end":699},"obj":"Gene"},{"id":"645","span":{"begin":756,"end":762},"obj":"Gene"},{"id":"646","span":{"begin":771,"end":776},"obj":"Gene"},{"id":"647","span":{"begin":191,"end":202},"obj":"Species"},{"id":"648","span":{"begin":204,"end":216},"obj":"Species"},{"id":"649","span":{"begin":252,"end":274},"obj":"Species"},{"id":"650","span":{"begin":278,"end":292},"obj":"Species"},{"id":"651","span":{"begin":322,"end":327},"obj":"Species"},{"id":"652","span":{"begin":222,"end":233},"obj":"Species"},{"id":"653","span":{"begin":573,"end":579},"obj":"Gene"},{"id":"654","span":{"begin":377,"end":382},"obj":"Gene"},{"id":"655","span":{"begin":35,"end":50},"obj":"Disease"},{"id":"656","span":{"begin":126,"end":140},"obj":"Disease"},{"id":"657","span":{"begin":166,"end":181},"obj":"Disease"},{"id":"658","span":{"begin":293,"end":303},"obj":"Disease"},{"id":"659","span":{"begin":307,"end":321},"obj":"Disease"}],"attributes":[{"id":"A635","pred":"tao:has_database_id","subj":"635","obj":"Gene:2539"},{"id":"A636","pred":"tao:has_database_id","subj":"636","obj":"Gene:2539"},{"id":"A637","pred":"tao:has_database_id","subj":"637","obj":"Gene:57407"},{"id":"A638","pred":"tao:has_database_id","subj":"638","obj":"Gene:4790"},{"id":"A639","pred":"tao:has_database_id","subj":"639","obj":"Gene:57407"},{"id":"A640","pred":"tao:has_database_id","subj":"640","obj":"Gene:4790"},{"id":"A641","pred":"tao:has_database_id","subj":"641","obj":"Gene:7124"},{"id":"A642","pred":"tao:has_database_id","subj":"642","obj":"Gene:4599"},{"id":"A643","pred":"tao:has_database_id","subj":"643","obj":"Gene:57407"},{"id":"A644","pred":"tao:has_database_id","subj":"644","obj":"Gene:2539"},{"id":"A645","pred":"tao:has_database_id","subj":"645","obj":"Gene:57407"},{"id":"A646","pred":"tao:has_database_id","subj":"646","obj":"Gene:4790"},{"id":"A647","pred":"tao:has_database_id","subj":"647","obj":"Tax:11118"},{"id":"A648","pred":"tao:has_database_id","subj":"648","obj":"Tax:12637"},{"id":"A649","pred":"tao:has_database_id","subj":"649","obj":"Tax:11137"},{"id":"A650","pred":"tao:has_database_id","subj":"650","obj":"Tax:39054"},{"id":"A651","pred":"tao:has_database_id","subj":"651","obj":"Tax:9606"},{"id":"A652","pred":"tao:has_database_id","subj":"652","obj":"Tax:39054"},{"id":"A653","pred":"tao:has_database_id","subj":"653","obj":"Gene:57407"},{"id":"A654","pred":"tao:has_database_id","subj":"654","obj":"Gene:1666"},{"id":"A655","pred":"tao:has_database_id","subj":"655","obj":"MESH:D001102"},{"id":"A656","pred":"tao:has_database_id","subj":"656","obj":"MESH:D005955"},{"id":"A657","pred":"tao:has_database_id","subj":"657","obj":"MESH:D001102"},{"id":"A658","pred":"tao:has_database_id","subj":"658","obj":"MESH:D007239"},{"id":"A659","pred":"tao:has_database_id","subj":"659","obj":"MESH:D005955"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"G6PD may play an important role in viral infection [9–11,85]. Lack of G6PD promotes cytopathic effects and viral replication. G6PD-deficient cells are susceptible to viral infection, such as coronavirus, dengue virus, and enterovirus [9,85,86]. During human coronavirus 229E or enterovirus 71 infections in G6PD-deficient human lung fibroblasts and epithelial cells, HSCARG, a NADPH sensor, and a negative NF-κB regulator is up-regulated. Knockdown of HSCARG activates NF-κB and induces downstream antiviral gene expression, including TNF-α and MX1 [10]. Downregulation of HSCARG decreases viral gene expression, while the upregulation of HSCARG increases viral replication. This indicates that G6PD activity determines the anti-viral response mediated by HSCARG and the NF-κB pathway."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T130","span":{"begin":0,"end":61},"obj":"Sentence"},{"id":"T131","span":{"begin":62,"end":125},"obj":"Sentence"},{"id":"T132","span":{"begin":126,"end":244},"obj":"Sentence"},{"id":"T133","span":{"begin":245,"end":438},"obj":"Sentence"},{"id":"T134","span":{"begin":439,"end":554},"obj":"Sentence"},{"id":"T135","span":{"begin":555,"end":674},"obj":"Sentence"},{"id":"T136","span":{"begin":675,"end":785},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"G6PD may play an important role in viral infection [9–11,85]. Lack of G6PD promotes cytopathic effects and viral replication. G6PD-deficient cells are susceptible to viral infection, such as coronavirus, dengue virus, and enterovirus [9,85,86]. During human coronavirus 229E or enterovirus 71 infections in G6PD-deficient human lung fibroblasts and epithelial cells, HSCARG, a NADPH sensor, and a negative NF-κB regulator is up-regulated. Knockdown of HSCARG activates NF-κB and induces downstream antiviral gene expression, including TNF-α and MX1 [10]. Downregulation of HSCARG decreases viral gene expression, while the upregulation of HSCARG increases viral replication. This indicates that G6PD activity determines the anti-viral response mediated by HSCARG and the NF-κB pathway."}