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PMC:7796041 / 26167-27737 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
792 107-111 Gene denotes IL-6 Gene:3569
793 946-950 Gene denotes IL-6 Gene:3569
794 0-8 Species denotes Patients Tax:9606
795 509-517 Species denotes patients Tax:9606
796 954-962 Species denotes patients Tax:9606
797 1344-1351 Species denotes patient Tax:9606
798 387-393 Chemical denotes oxygen MESH:D010100
799 599-605 Chemical denotes oxygen MESH:D010100
800 14-25 Disease denotes arrhythmias MESH:D001145
801 113-130 Disease denotes Myocardial injury MESH:D009202
802 134-142 Disease denotes COVID-19 MESH:C000657245
803 265-275 Disease denotes arrhythmia MESH:D001145
804 536-558 Disease denotes cardiovascular disease MESH:D002318
805 632-642 Disease denotes arrhythmia MESH:D001145
806 663-680 Disease denotes myocardial injury MESH:D009202
807 684-692 Disease denotes ischemia MESH:D007511
808 743-765 Disease denotes cardiovascular disease MESH:D002318
809 968-979 Disease denotes arrhythmias MESH:D001145
810 998-1006 Disease denotes COVID-19 MESH:C000657245
811 1082-1101 Disease denotes respiratory failure MESH:D012131
812 1106-1123 Disease denotes myocardial injury MESH:D009202
813 1223-1233 Disease denotes arrhythmia MESH:D001145

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T186 14-25 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T187 265-275 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T188 536-558 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T189 632-642 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T190 743-765 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T191 968-979 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T192 1082-1101 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T193 1223-1233 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T214 0-112 Sentence denotes Patients with arrhythmias during hospitalization showed elevated cardiac biomarkers and elevated levels of IL-6.
T215 113-249 Sentence denotes Myocardial injury in COVID-19 has been reported by multiple studies, however, the underlying mechanisms have yet to be elucidated [2,4].
T216 250-487 Sentence denotes In our cohort, arrhythmia itself may have promoted a more pronounced increase in hsTNT and NTproBNP by an additional shift in myocardial oxygen demand under a restricted respiratory function and by increasing atrial and ventricular load.
T217 488-643 Sentence denotes In particular, among patients with pre-existent cardiovascular disease a myocardial supply-demand-imbalance of oxygen may become evident during arrhythmia.
T218 644-860 Sentence denotes On the other hand, myocardial injury or ischemia-especially in the light of a higher prevalence of cardiovascular disease in this subgroup-may have exerted proarrhythmic effects in addition to the inflammatory state.
T219 861-994 Sentence denotes Such additional inflammatory influences are implicated by the pronounced increase in IL-6 in patients with arrhythmias in our cohort.
T220 995-1129 Sentence denotes In COVID-19 a state of hyperinflammation is commonly observed and correlates with both respiratory failure and myocardial injury [27].
T221 1130-1360 Sentence denotes Based on our observations, it may additionally constitute a risk factor for the incidence of arrhythmia but distinct molecular mechanisms have yet to be investigated in experimental studies and larger, prospective patient cohorts.
T222 1361-1466 Sentence denotes Estimating optimal cut-off values is associated with uncertainty and is affected by the study population.
T223 1467-1570 Sentence denotes Therefore, the calculated cut-offs for the biomarkers in this study should be interpreted with caution.