PMC:7796041 / 26167-27737 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"792","span":{"begin":107,"end":111},"obj":"Gene"},{"id":"793","span":{"begin":946,"end":950},"obj":"Gene"},{"id":"794","span":{"begin":0,"end":8},"obj":"Species"},{"id":"795","span":{"begin":509,"end":517},"obj":"Species"},{"id":"796","span":{"begin":954,"end":962},"obj":"Species"},{"id":"797","span":{"begin":1344,"end":1351},"obj":"Species"},{"id":"798","span":{"begin":387,"end":393},"obj":"Chemical"},{"id":"799","span":{"begin":599,"end":605},"obj":"Chemical"},{"id":"800","span":{"begin":14,"end":25},"obj":"Disease"},{"id":"801","span":{"begin":113,"end":130},"obj":"Disease"},{"id":"802","span":{"begin":134,"end":142},"obj":"Disease"},{"id":"803","span":{"begin":265,"end":275},"obj":"Disease"},{"id":"804","span":{"begin":536,"end":558},"obj":"Disease"},{"id":"805","span":{"begin":632,"end":642},"obj":"Disease"},{"id":"806","span":{"begin":663,"end":680},"obj":"Disease"},{"id":"807","span":{"begin":684,"end":692},"obj":"Disease"},{"id":"808","span":{"begin":743,"end":765},"obj":"Disease"},{"id":"809","span":{"begin":968,"end":979},"obj":"Disease"},{"id":"810","span":{"begin":998,"end":1006},"obj":"Disease"},{"id":"811","span":{"begin":1082,"end":1101},"obj":"Disease"},{"id":"812","span":{"begin":1106,"end":1123},"obj":"Disease"},{"id":"813","span":{"begin":1223,"end":1233},"obj":"Disease"}],"attributes":[{"id":"A792","pred":"tao:has_database_id","subj":"792","obj":"Gene:3569"},{"id":"A793","pred":"tao:has_database_id","subj":"793","obj":"Gene:3569"},{"id":"A794","pred":"tao:has_database_id","subj":"794","obj":"Tax:9606"},{"id":"A795","pred":"tao:has_database_id","subj":"795","obj":"Tax:9606"},{"id":"A796","pred":"tao:has_database_id","subj":"796","obj":"Tax:9606"},{"id":"A797","pred":"tao:has_database_id","subj":"797","obj":"Tax:9606"},{"id":"A798","pred":"tao:has_database_id","subj":"798","obj":"MESH:D010100"},{"id":"A799","pred":"tao:has_database_id","subj":"799","obj":"MESH:D010100"},{"id":"A800","pred":"tao:has_database_id","subj":"800","obj":"MESH:D001145"},{"id":"A801","pred":"tao:has_database_id","subj":"801","obj":"MESH:D009202"},{"id":"A802","pred":"tao:has_database_id","subj":"802","obj":"MESH:C000657245"},{"id":"A803","pred":"tao:has_database_id","subj":"803","obj":"MESH:D001145"},{"id":"A804","pred":"tao:has_database_id","subj":"804","obj":"MESH:D002318"},{"id":"A805","pred":"tao:has_database_id","subj":"805","obj":"MESH:D001145"},{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"MESH:D009202"},{"id":"A807","pred":"tao:has_database_id","subj":"807","obj":"MESH:D007511"},{"id":"A808","pred":"tao:has_database_id","subj":"808","obj":"MESH:D002318"},{"id":"A809","pred":"tao:has_database_id","subj":"809","obj":"MESH:D001145"},{"id":"A810","pred":"tao:has_database_id","subj":"810","obj":"MESH:C000657245"},{"id":"A811","pred":"tao:has_database_id","subj":"811","obj":"MESH:D012131"},{"id":"A812","pred":"tao:has_database_id","subj":"812","obj":"MESH:D009202"},{"id":"A813","pred":"tao:has_database_id","subj":"813","obj":"MESH:D001145"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Patients with arrhythmias during hospitalization showed elevated cardiac biomarkers and elevated levels of IL-6. Myocardial injury in COVID-19 has been reported by multiple studies, however, the underlying mechanisms have yet to be elucidated [2,4]. In our cohort, arrhythmia itself may have promoted a more pronounced increase in hsTNT and NTproBNP by an additional shift in myocardial oxygen demand under a restricted respiratory function and by increasing atrial and ventricular load. In particular, among patients with pre-existent cardiovascular disease a myocardial supply-demand-imbalance of oxygen may become evident during arrhythmia. On the other hand, myocardial injury or ischemia-especially in the light of a higher prevalence of cardiovascular disease in this subgroup-may have exerted proarrhythmic effects in addition to the inflammatory state. Such additional inflammatory influences are implicated by the pronounced increase in IL-6 in patients with arrhythmias in our cohort. In COVID-19 a state of hyperinflammation is commonly observed and correlates with both respiratory failure and myocardial injury [27]. Based on our observations, it may additionally constitute a risk factor for the incidence of arrhythmia but distinct molecular mechanisms have yet to be investigated in experimental studies and larger, prospective patient cohorts. Estimating optimal cut-off values is associated with uncertainty and is affected by the study population. Therefore, the calculated cut-offs for the biomarkers in this study should be interpreted with caution."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T186","span":{"begin":14,"end":25},"obj":"Phenotype"},{"id":"T187","span":{"begin":265,"end":275},"obj":"Phenotype"},{"id":"T188","span":{"begin":536,"end":558},"obj":"Phenotype"},{"id":"T189","span":{"begin":632,"end":642},"obj":"Phenotype"},{"id":"T190","span":{"begin":743,"end":765},"obj":"Phenotype"},{"id":"T191","span":{"begin":968,"end":979},"obj":"Phenotype"},{"id":"T192","span":{"begin":1082,"end":1101},"obj":"Phenotype"},{"id":"T193","span":{"begin":1223,"end":1233},"obj":"Phenotype"}],"attributes":[{"id":"A186","pred":"hp_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/HP_0011675"},{"id":"A187","pred":"hp_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/HP_0011675"},{"id":"A188","pred":"hp_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"id":"A189","pred":"hp_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/HP_0011675"},{"id":"A190","pred":"hp_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"id":"A191","pred":"hp_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/HP_0011675"},{"id":"A192","pred":"hp_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A193","pred":"hp_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/HP_0011675"}],"text":"Patients with arrhythmias during hospitalization showed elevated cardiac biomarkers and elevated levels of IL-6. Myocardial injury in COVID-19 has been reported by multiple studies, however, the underlying mechanisms have yet to be elucidated [2,4]. In our cohort, arrhythmia itself may have promoted a more pronounced increase in hsTNT and NTproBNP by an additional shift in myocardial oxygen demand under a restricted respiratory function and by increasing atrial and ventricular load. In particular, among patients with pre-existent cardiovascular disease a myocardial supply-demand-imbalance of oxygen may become evident during arrhythmia. On the other hand, myocardial injury or ischemia-especially in the light of a higher prevalence of cardiovascular disease in this subgroup-may have exerted proarrhythmic effects in addition to the inflammatory state. Such additional inflammatory influences are implicated by the pronounced increase in IL-6 in patients with arrhythmias in our cohort. In COVID-19 a state of hyperinflammation is commonly observed and correlates with both respiratory failure and myocardial injury [27]. Based on our observations, it may additionally constitute a risk factor for the incidence of arrhythmia but distinct molecular mechanisms have yet to be investigated in experimental studies and larger, prospective patient cohorts. Estimating optimal cut-off values is associated with uncertainty and is affected by the study population. Therefore, the calculated cut-offs for the biomarkers in this study should be interpreted with caution."}

{"project":"LitCovid-sentences","denotations":[{"id":"T214","span":{"begin":0,"end":112},"obj":"Sentence"},{"id":"T215","span":{"begin":113,"end":249},"obj":"Sentence"},{"id":"T216","span":{"begin":250,"end":487},"obj":"Sentence"},{"id":"T217","span":{"begin":488,"end":643},"obj":"Sentence"},{"id":"T218","span":{"begin":644,"end":860},"obj":"Sentence"},{"id":"T219","span":{"begin":861,"end":994},"obj":"Sentence"},{"id":"T220","span":{"begin":995,"end":1129},"obj":"Sentence"},{"id":"T221","span":{"begin":1130,"end":1360},"obj":"Sentence"},{"id":"T222","span":{"begin":1361,"end":1466},"obj":"Sentence"},{"id":"T223","span":{"begin":1467,"end":1570},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Patients with arrhythmias during hospitalization showed elevated cardiac biomarkers and elevated levels of IL-6. Myocardial injury in COVID-19 has been reported by multiple studies, however, the underlying mechanisms have yet to be elucidated [2,4]. In our cohort, arrhythmia itself may have promoted a more pronounced increase in hsTNT and NTproBNP by an additional shift in myocardial oxygen demand under a restricted respiratory function and by increasing atrial and ventricular load. In particular, among patients with pre-existent cardiovascular disease a myocardial supply-demand-imbalance of oxygen may become evident during arrhythmia. On the other hand, myocardial injury or ischemia-especially in the light of a higher prevalence of cardiovascular disease in this subgroup-may have exerted proarrhythmic effects in addition to the inflammatory state. Such additional inflammatory influences are implicated by the pronounced increase in IL-6 in patients with arrhythmias in our cohort. In COVID-19 a state of hyperinflammation is commonly observed and correlates with both respiratory failure and myocardial injury [27]. Based on our observations, it may additionally constitute a risk factor for the incidence of arrhythmia but distinct molecular mechanisms have yet to be investigated in experimental studies and larger, prospective patient cohorts. Estimating optimal cut-off values is associated with uncertainty and is affected by the study population. Therefore, the calculated cut-offs for the biomarkers in this study should be interpreted with caution."}