PMC:7795966 / 3243-3821 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795966","sourcedb":"PMC","sourceid":"7795966","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795966","text":"As critically ill patients are often found to form methemoglobin (MetHb) [8,9,10] and carboxyhemoglobin (COHb) [11,12], MetHb and COHb formation might also be relevant in case of COVID-19. MetHb is formed when the ferrous iron (Fe2+) of the heme group of hemoglobin (Hb) is oxidized to ferric iron (Fe3+). The ferric iron of MetHb is unable to bind oxygen (O2). Thus, the O2 dissociation curve is left-shifted, making it more difficult to release O2 and to provide proper tissue oxygenation. 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