PMC:7795966 / 3243-3821 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
123	51-64	Gene	denotes	methemoglobin	Gene:3048
124	66-71	Gene	denotes	MetHb	Gene:3048
125	325-330	Gene	denotes	MetHb	Gene:3048
126	509-514	Gene	denotes	MetHb	Gene:3048
127	189-194	Gene	denotes	MetHb	Gene:3048
128	120-125	Gene	denotes	MetHb	Gene:3048
129	18-26	Species	denotes	patients	Tax:9606
130	214-226	Chemical	denotes	ferrous iron
131	228-232	Chemical	denotes	Fe2+
132	286-297	Chemical	denotes	ferric iron
133	299-303	Chemical	denotes	Fe3+
134	310-321	Chemical	denotes	ferric iron
135	349-355	Chemical	denotes	oxygen	MESH:D010100
136	357-359	Chemical	denotes	O2	MESH:D010100
137	372-374	Chemical	denotes	O2	MESH:D010100
138	447-449	Chemical	denotes	O2	MESH:D010100
139	553-555	Chemical	denotes	O2	MESH:D010100
140	3-17	Disease	denotes	critically ill	MESH:D016638
141	179-187	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue
T20	0-188	Sentence	denotes	As critically ill patients are often found to form methemoglobin (MetHb) [8,9,10] and carboxyhemoglobin (COHb) [11,12], MetHb and COHb formation might also be relevant in case of COVID-19.
T21	189-305	Sentence	denotes	MetHb is formed when the ferrous iron (Fe2+) of the heme group of hemoglobin (Hb) is oxidized to ferric iron (Fe3+).
T22	306-361	Sentence	denotes	The ferric iron of MetHb is unable to bind oxygen (O2).
T23	362-491	Sentence	denotes	Thus, the O2 dissociation curve is left-shifted, making it more difficult to release O2 and to provide proper tissue oxygenation.
T24	492-578	Sentence	denotes	The formation of MetHb also results in less Hb available for O2 binding and transport.