PMC:7795966 / 3243-3821 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"123","span":{"begin":51,"end":64},"obj":"Gene"},{"id":"124","span":{"begin":66,"end":71},"obj":"Gene"},{"id":"125","span":{"begin":325,"end":330},"obj":"Gene"},{"id":"126","span":{"begin":509,"end":514},"obj":"Gene"},{"id":"127","span":{"begin":189,"end":194},"obj":"Gene"},{"id":"128","span":{"begin":120,"end":125},"obj":"Gene"},{"id":"129","span":{"begin":18,"end":26},"obj":"Species"},{"id":"130","span":{"begin":214,"end":226},"obj":"Chemical"},{"id":"131","span":{"begin":228,"end":232},"obj":"Chemical"},{"id":"132","span":{"begin":286,"end":297},"obj":"Chemical"},{"id":"133","span":{"begin":299,"end":303},"obj":"Chemical"},{"id":"134","span":{"begin":310,"end":321},"obj":"Chemical"},{"id":"135","span":{"begin":349,"end":355},"obj":"Chemical"},{"id":"136","span":{"begin":357,"end":359},"obj":"Chemical"},{"id":"137","span":{"begin":372,"end":374},"obj":"Chemical"},{"id":"138","span":{"begin":447,"end":449},"obj":"Chemical"},{"id":"139","span":{"begin":553,"end":555},"obj":"Chemical"},{"id":"140","span":{"begin":3,"end":17},"obj":"Disease"},{"id":"141","span":{"begin":179,"end":187},"obj":"Disease"}],"attributes":[{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"Gene:3048"},{"id":"A124","pred":"tao:has_database_id","subj":"124","obj":"Gene:3048"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"Gene:3048"},{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"Gene:3048"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"Gene:3048"},{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"Gene:3048"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"Tax:9606"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"MESH:D010100"},{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"MESH:D010100"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"MESH:D010100"},{"id":"A138","pred":"tao:has_database_id","subj":"138","obj":"MESH:D010100"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"MESH:D010100"},{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"MESH:D016638"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"As critically ill patients are often found to form methemoglobin (MetHb) [8,9,10] and carboxyhemoglobin (COHb) [11,12], MetHb and COHb formation might also be relevant in case of COVID-19. MetHb is formed when the ferrous iron (Fe2+) of the heme group of hemoglobin (Hb) is oxidized to ferric iron (Fe3+). The ferric iron of MetHb is unable to bind oxygen (O2). Thus, the O2 dissociation curve is left-shifted, making it more difficult to release O2 and to provide proper tissue oxygenation. The formation of MetHb also results in less Hb available for O2 binding and transport."}

{"project":"LitCovid-sentences","denotations":[{"id":"T20","span":{"begin":0,"end":188},"obj":"Sentence"},{"id":"T21","span":{"begin":189,"end":305},"obj":"Sentence"},{"id":"T22","span":{"begin":306,"end":361},"obj":"Sentence"},{"id":"T23","span":{"begin":362,"end":491},"obj":"Sentence"},{"id":"T24","span":{"begin":492,"end":578},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As critically ill patients are often found to form methemoglobin (MetHb) [8,9,10] and carboxyhemoglobin (COHb) [11,12], MetHb and COHb formation might also be relevant in case of COVID-19. MetHb is formed when the ferrous iron (Fe2+) of the heme group of hemoglobin (Hb) is oxidized to ferric iron (Fe3+). The ferric iron of MetHb is unable to bind oxygen (O2). Thus, the O2 dissociation curve is left-shifted, making it more difficult to release O2 and to provide proper tissue oxygenation. The formation of MetHb also results in less Hb available for O2 binding and transport."}