PMC:7795966 / 11348-12995
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795966","sourcedb":"PMC","sourceid":"7795966","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795966","text":"Naymagon et al. [18] reported three cases of COVID-19 patients with MetHb measurements. The first case was a 50-year-old SARS-CoV-2 positive man with no medical history presenting with acute hypoxic respiratory failure in the clinic. He received hydroxychloroquine, azithromycin and ceftriaxone, and mechanical ventilation. He showed persistently low SpO2 values despite being mechanically ventilated. MetHb values increased steadily, peaking at 10.6% on day six (Figure 2a). Treatments with methylene blue and ascorbic acid normalized MetHb and his clinical status improved. A genetic analysis of G6PC deficiency was not done. The second case was a 52-year-old SARS-CoV-2 positive morbidly obese man with diabetes mellitus, admitted to the hospital due to acute hypoxic respiratory failure. He received hydroxychloroquine, azithromycin, cefepime, vancomycin, and apixaban, and was mechanically ventilated. A persistently low SpO2 was recognized and testing for MetHb resulted in a value of 22% (Figure 2a). He received methylene blue and ascorbic acid, but his MetHb increased to \u003e30%. After receiving red blood cell transfusion, MetHb decreased to 2.9%. No genetic analysis of G6PD deficiency was performed. The third case was a 54-year-old SARS-CoV-2 positive man with diabetes mellitus admitted to the hospital due to acute hypoxic respiratory failure. He received azithromycin and hydroxychloroquine and was mechanically ventilated. He demonstrated persistent hypoxia and a MetHb of 13.7%. After receiving methylene blue, MetHb did not improve and increased to 18.8%. Shortly after, the patient died. Genetic testing revealed G6PD deficiency.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"435","span":{"begin":536,"end":541},"obj":"Gene"},{"id":"436","span":{"begin":1527,"end":1532},"obj":"Gene"},{"id":"437","span":{"begin":962,"end":967},"obj":"Gene"},{"id":"438","span":{"begin":1479,"end":1484},"obj":"Gene"},{"id":"439","span":{"begin":1131,"end":1136},"obj":"Gene"},{"id":"440","span":{"begin":1062,"end":1067},"obj":"Gene"},{"id":"441","span":{"begin":402,"end":407},"obj":"Gene"},{"id":"442","span":{"begin":68,"end":73},"obj":"Gene"},{"id":"443","span":{"begin":54,"end":62},"obj":"Species"},{"id":"444","span":{"begin":121,"end":131},"obj":"Species"},{"id":"445","span":{"begin":662,"end":672},"obj":"Species"},{"id":"446","span":{"begin":1243,"end":1253},"obj":"Species"},{"id":"447","span":{"begin":1592,"end":1599},"obj":"Species"},{"id":"448","span":{"begin":246,"end":264},"obj":"Chemical"},{"id":"449","span":{"begin":266,"end":278},"obj":"Chemical"},{"id":"450","span":{"begin":283,"end":294},"obj":"Chemical"},{"id":"451","span":{"begin":492,"end":506},"obj":"Chemical"},{"id":"452","span":{"begin":511,"end":524},"obj":"Chemical"},{"id":"453","span":{"begin":804,"end":822},"obj":"Chemical"},{"id":"454","span":{"begin":824,"end":836},"obj":"Chemical"},{"id":"455","span":{"begin":838,"end":846},"obj":"Chemical"},{"id":"456","span":{"begin":848,"end":858},"obj":"Chemical"},{"id":"457","span":{"begin":864,"end":872},"obj":"Chemical"},{"id":"458","span":{"begin":1020,"end":1034},"obj":"Chemical"},{"id":"459","span":{"begin":1039,"end":1052},"obj":"Chemical"},{"id":"460","span":{"begin":1369,"end":1381},"obj":"Chemical"},{"id":"461","span":{"begin":1386,"end":1404},"obj":"Chemical"},{"id":"462","span":{"begin":1511,"end":1525},"obj":"Chemical"},{"id":"463","span":{"begin":45,"end":53},"obj":"Disease"},{"id":"464","span":{"begin":185,"end":218},"obj":"Disease"},{"id":"465","span":{"begin":598,"end":613},"obj":"Disease"},{"id":"466","span":{"begin":691,"end":696},"obj":"Disease"},{"id":"467","span":{"begin":706,"end":723},"obj":"Disease"},{"id":"468","span":{"begin":763,"end":790},"obj":"Disease"},{"id":"469","span":{"begin":1179,"end":1194},"obj":"Disease"},{"id":"470","span":{"begin":1272,"end":1289},"obj":"Disease"},{"id":"471","span":{"begin":1328,"end":1355},"obj":"Disease"},{"id":"472","span":{"begin":1465,"end":1472},"obj":"Disease"},{"id":"473","span":{"begin":1631,"end":1646},"obj":"Disease"}],"attributes":[{"id":"A435","pred":"tao:has_database_id","subj":"435","obj":"Gene:3048"},{"id":"A436","pred":"tao:has_database_id","subj":"436","obj":"Gene:3048"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Gene:3048"},{"id":"A438","pred":"tao:has_database_id","subj":"438","obj":"Gene:3048"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"Gene:3048"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"Gene:3048"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"Gene:3048"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Gene:3048"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Tax:9606"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Tax:2697049"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"Tax:2697049"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"Tax:2697049"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"Tax:9606"},{"id":"A448","pred":"tao:has_database_id","subj":"448","obj":"MESH:D006886"},{"id":"A449","pred":"tao:has_database_id","subj":"449","obj":"MESH:D017963"},{"id":"A450","pred":"tao:has_database_id","subj":"450","obj":"MESH:D002443"},{"id":"A451","pred":"tao:has_database_id","subj":"451","obj":"MESH:D008751"},{"id":"A452","pred":"tao:has_database_id","subj":"452","obj":"MESH:D001205"},{"id":"A453","pred":"tao:has_database_id","subj":"453","obj":"MESH:D006886"},{"id":"A454","pred":"tao:has_database_id","subj":"454","obj":"MESH:D017963"},{"id":"A455","pred":"tao:has_database_id","subj":"455","obj":"MESH:D000077723"},{"id":"A456","pred":"tao:has_database_id","subj":"456","obj":"MESH:D014640"},{"id":"A457","pred":"tao:has_database_id","subj":"457","obj":"MESH:C522181"},{"id":"A458","pred":"tao:has_database_id","subj":"458","obj":"MESH:D008751"},{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"MESH:D001205"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"MESH:D017963"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"MESH:D006886"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"MESH:D008751"},{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"MESH:C000657245"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"MESH:D012120"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"MESH:D007153"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"MESH:D009765"},{"id":"A467","pred":"tao:has_database_id","subj":"467","obj":"MESH:D003920"},{"id":"A468","pred":"tao:has_database_id","subj":"468","obj":"MESH:D012131"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"MESH:D005955"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"MESH:D003920"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"MESH:D012131"},{"id":"A472","pred":"tao:has_database_id","subj":"472","obj":"MESH:D000860"},{"id":"A473","pred":"tao:has_database_id","subj":"473","obj":"MESH:D005955"},{"subj":"435","pred":"source","obj":"LitCovid-PubTator"},{"subj":"436","pred":"source","obj":"LitCovid-PubTator"},{"subj":"437","pred":"source","obj":"LitCovid-PubTator"},{"subj":"438","pred":"source","obj":"LitCovid-PubTator"},{"subj":"439","pred":"source","obj":"LitCovid-PubTator"},{"subj":"440","pred":"source","obj":"LitCovid-PubTator"},{"subj":"441","pred":"source","obj":"LitCovid-PubTator"},{"subj":"442","pred":"source","obj":"LitCovid-PubTator"},{"subj":"443","pred":"source","obj":"LitCovid-PubTator"},{"subj":"444","pred":"source","obj":"LitCovid-PubTator"},{"subj":"445","pred":"source","obj":"LitCovid-PubTator"},{"subj":"446","pred":"source","obj":"LitCovid-PubTator"},{"subj":"447","pred":"source","obj":"LitCovid-PubTator"},{"subj":"448","pred":"source","obj":"LitCovid-PubTator"},{"subj":"449","pred":"source","obj":"LitCovid-PubTator"},{"subj":"450","pred":"source","obj":"LitCovid-PubTator"},{"subj":"451","pred":"source","obj":"LitCovid-PubTator"},{"subj":"452","pred":"source","obj":"LitCovid-PubTator"},{"subj":"453","pred":"source","obj":"LitCovid-PubTator"},{"subj":"454","pred":"source","obj":"LitCovid-PubTator"},{"subj":"455","pred":"source","obj":"LitCovid-PubTator"},{"subj":"456","pred":"source","obj":"LitCovid-PubTator"},{"subj":"457","pred":"source","obj":"LitCovid-PubTator"},{"subj":"458","pred":"source","obj":"LitCovid-PubTator"},{"subj":"459","pred":"source","obj":"LitCovid-PubTator"},{"subj":"460","pred":"source","obj":"LitCovid-PubTator"},{"subj":"461","pred":"source","obj":"LitCovid-PubTator"},{"subj":"462","pred":"source","obj":"LitCovid-PubTator"},{"subj":"463","pred":"source","obj":"LitCovid-PubTator"},{"subj":"464","pred":"source","obj":"LitCovid-PubTator"},{"subj":"465","pred":"source","obj":"LitCovid-PubTator"},{"subj":"466","pred":"source","obj":"LitCovid-PubTator"},{"subj":"467","pred":"source","obj":"LitCovid-PubTator"},{"subj":"468","pred":"source","obj":"LitCovid-PubTator"},{"subj":"469","pred":"source","obj":"LitCovid-PubTator"},{"subj":"470","pred":"source","obj":"LitCovid-PubTator"},{"subj":"471","pred":"source","obj":"LitCovid-PubTator"},{"subj":"472","pred":"source","obj":"LitCovid-PubTator"},{"subj":"473","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T28","span":{"begin":199,"end":218},"obj":"Phenotype"},{"id":"T29","span":{"begin":706,"end":723},"obj":"Phenotype"},{"id":"T30","span":{"begin":771,"end":790},"obj":"Phenotype"},{"id":"T31","span":{"begin":1272,"end":1289},"obj":"Phenotype"},{"id":"T32","span":{"begin":1336,"end":1355},"obj":"Phenotype"},{"id":"T33","span":{"begin":1465,"end":1472},"obj":"Phenotype"}],"attributes":[{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0000819"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0000819"},{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T94","span":{"begin":0,"end":87},"obj":"Sentence"},{"id":"T95","span":{"begin":88,"end":233},"obj":"Sentence"},{"id":"T96","span":{"begin":234,"end":323},"obj":"Sentence"},{"id":"T97","span":{"begin":324,"end":401},"obj":"Sentence"},{"id":"T98","span":{"begin":402,"end":475},"obj":"Sentence"},{"id":"T99","span":{"begin":476,"end":575},"obj":"Sentence"},{"id":"T100","span":{"begin":576,"end":627},"obj":"Sentence"},{"id":"T101","span":{"begin":628,"end":791},"obj":"Sentence"},{"id":"T102","span":{"begin":792,"end":906},"obj":"Sentence"},{"id":"T103","span":{"begin":907,"end":1007},"obj":"Sentence"},{"id":"T104","span":{"begin":1008,"end":1086},"obj":"Sentence"},{"id":"T105","span":{"begin":1087,"end":1155},"obj":"Sentence"},{"id":"T106","span":{"begin":1156,"end":1209},"obj":"Sentence"},{"id":"T107","span":{"begin":1210,"end":1356},"obj":"Sentence"},{"id":"T108","span":{"begin":1357,"end":1437},"obj":"Sentence"},{"id":"T109","span":{"begin":1438,"end":1494},"obj":"Sentence"},{"id":"T110","span":{"begin":1495,"end":1572},"obj":"Sentence"},{"id":"T111","span":{"begin":1573,"end":1605},"obj":"Sentence"},{"id":"T112","span":{"begin":1606,"end":1647},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T94","pred":"source","obj":"LitCovid-sentences"},{"subj":"T95","pred":"source","obj":"LitCovid-sentences"},{"subj":"T96","pred":"source","obj":"LitCovid-sentences"},{"subj":"T97","pred":"source","obj":"LitCovid-sentences"},{"subj":"T98","pred":"source","obj":"LitCovid-sentences"},{"subj":"T99","pred":"source","obj":"LitCovid-sentences"},{"subj":"T100","pred":"source","obj":"LitCovid-sentences"},{"subj":"T101","pred":"source","obj":"LitCovid-sentences"},{"subj":"T102","pred":"source","obj":"LitCovid-sentences"},{"subj":"T103","pred":"source","obj":"LitCovid-sentences"},{"subj":"T104","pred":"source","obj":"LitCovid-sentences"},{"subj":"T105","pred":"source","obj":"LitCovid-sentences"},{"subj":"T106","pred":"source","obj":"LitCovid-sentences"},{"subj":"T107","pred":"source","obj":"LitCovid-sentences"},{"subj":"T108","pred":"source","obj":"LitCovid-sentences"},{"subj":"T109","pred":"source","obj":"LitCovid-sentences"},{"subj":"T110","pred":"source","obj":"LitCovid-sentences"},{"subj":"T111","pred":"source","obj":"LitCovid-sentences"},{"subj":"T112","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93ecad","default":true},{"id":"LitCovid-PD-HP","color":"#ec9393"},{"id":"LitCovid-sentences","color":"#93acec"}]}]}}