PMC:7784830 / 11980-13945 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"209","span":{"begin":155,"end":162},"obj":"Chemical"},{"id":"210","span":{"begin":349,"end":354},"obj":"Chemical"},{"id":"211","span":{"begin":605,"end":610},"obj":"Chemical"},{"id":"212","span":{"begin":888,"end":893},"obj":"Chemical"},{"id":"213","span":{"begin":1553,"end":1558},"obj":"Chemical"},{"id":"214","span":{"begin":494,"end":497},"obj":"Disease"},{"id":"215","span":{"begin":941,"end":966},"obj":"Disease"},{"id":"216","span":{"begin":1273,"end":1276},"obj":"Disease"},{"id":"217","span":{"begin":1342,"end":1348},"obj":"Disease"}],"attributes":[{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"MESH:D011108"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"MESH:D014867"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"MESH:D014867"},{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"MESH:D014867"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"MESH:D014867"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"MESH:C537262"},{"id":"A215","pred":"tao:has_database_id","subj":"215","obj":"MESH:C537262"},{"id":"A216","pred":"tao:has_database_id","subj":"216","obj":"MESH:C537262"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"MESH:D009369"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 2. Antiviral drugs formulated as ODFs.\nDrug name – technique employed to load to ODFs Reason for choosing the drug or API to formulate as an ODFs Polymer Plasticizer Method Key highlight(s) Ref.\nHerpetrione (HPE) – extracted from Herpetospermum caudigerum.HPE nanoparticles were prepared using sodium dodecyl sulfate and PVP K-30 Poor water solubility and low bioavailability Hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), and l-hydroxypropyl cellulose (HPC) PEG-400 Solvent casting method (SCM) Studies established that ODFs are suitable for delivery of poorly water-soluble drugsSCM is modified to prepare drug nanosuspensionOral bioavailability of HPE nanoparticles was higher when compared HPE coarse suspension [62]\nHerpetrione (HPE)Nanoparticles were prepared and optimized using the Box–Behnken design response surface methodology Poor water solubility and low bioavailability HPMC, MCC, L-HPC PEG-400 SCM ODFs formulation of HPE nanoparticles was successfully optimized using the Box–Behnken design response surface methodology [63]\nCidofovirNanoparticles were prepared using poly(ethylene glycol)–polycaprolactone (PEG-PCL) To achieve its controlled release and also due to its wide spectrum anti-viral activity HPC a Printed using inkjet printer Combination of complexed anti cancer drug (Paclitaxel) and complexed anti viral drug (Cidofovir) were printed onto ODFsMechanical properties of film were enhanced due to drug printing [64,65]\nAcyclovir – solid dispersion was prepared Poor water solubility and low bioavailability HPMC Glycerol SCM Oral administration of ODFs of acyclovir instead of intravenous route of administration [66]\nEntecavir (single or multi-layered ODFs) Low dose − 0.5–1 mg per day Starch, carrageenan, pullulan and many others Acetyl triethyl citrate or propylene glycol or citrate ester or triacetin SCM Multi-layered ODFs were disclosed [67]\na Nothing found."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T3","span":{"begin":1342,"end":1348},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Table 2. Antiviral drugs formulated as ODFs.\nDrug name – technique employed to load to ODFs Reason for choosing the drug or API to formulate as an ODFs Polymer Plasticizer Method Key highlight(s) Ref.\nHerpetrione (HPE) – extracted from Herpetospermum caudigerum.HPE nanoparticles were prepared using sodium dodecyl sulfate and PVP K-30 Poor water solubility and low bioavailability Hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), and l-hydroxypropyl cellulose (HPC) PEG-400 Solvent casting method (SCM) Studies established that ODFs are suitable for delivery of poorly water-soluble drugsSCM is modified to prepare drug nanosuspensionOral bioavailability of HPE nanoparticles was higher when compared HPE coarse suspension [62]\nHerpetrione (HPE)Nanoparticles were prepared and optimized using the Box–Behnken design response surface methodology Poor water solubility and low bioavailability HPMC, MCC, L-HPC PEG-400 SCM ODFs formulation of HPE nanoparticles was successfully optimized using the Box–Behnken design response surface methodology [63]\nCidofovirNanoparticles were prepared using poly(ethylene glycol)–polycaprolactone (PEG-PCL) To achieve its controlled release and also due to its wide spectrum anti-viral activity HPC a Printed using inkjet printer Combination of complexed anti cancer drug (Paclitaxel) and complexed anti viral drug (Cidofovir) were printed onto ODFsMechanical properties of film were enhanced due to drug printing [64,65]\nAcyclovir – solid dispersion was prepared Poor water solubility and low bioavailability HPMC Glycerol SCM Oral administration of ODFs of acyclovir instead of intravenous route of administration [66]\nEntecavir (single or multi-layered ODFs) Low dose − 0.5–1 mg per day Starch, carrageenan, pullulan and many others Acetyl triethyl citrate or propylene glycol or citrate ester or triacetin SCM Multi-layered ODFs were disclosed [67]\na Nothing found."}

{"project":"LitCovid-sentences","denotations":[{"id":"T102","span":{"begin":0,"end":8},"obj":"Sentence"},{"id":"T103","span":{"begin":10,"end":45},"obj":"Sentence"},{"id":"T104","span":{"begin":46,"end":207},"obj":"Sentence"},{"id":"T105","span":{"begin":208,"end":764},"obj":"Sentence"},{"id":"T106","span":{"begin":765,"end":1090},"obj":"Sentence"},{"id":"T107","span":{"begin":1091,"end":1504},"obj":"Sentence"},{"id":"T108","span":{"begin":1505,"end":1709},"obj":"Sentence"},{"id":"T109","span":{"begin":1710,"end":1947},"obj":"Sentence"},{"id":"T110","span":{"begin":1948,"end":1965},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 2. Antiviral drugs formulated as ODFs.\nDrug name – technique employed to load to ODFs Reason for choosing the drug or API to formulate as an ODFs Polymer Plasticizer Method Key highlight(s) Ref.\nHerpetrione (HPE) – extracted from Herpetospermum caudigerum.HPE nanoparticles were prepared using sodium dodecyl sulfate and PVP K-30 Poor water solubility and low bioavailability Hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), and l-hydroxypropyl cellulose (HPC) PEG-400 Solvent casting method (SCM) Studies established that ODFs are suitable for delivery of poorly water-soluble drugsSCM is modified to prepare drug nanosuspensionOral bioavailability of HPE nanoparticles was higher when compared HPE coarse suspension [62]\nHerpetrione (HPE)Nanoparticles were prepared and optimized using the Box–Behnken design response surface methodology Poor water solubility and low bioavailability HPMC, MCC, L-HPC PEG-400 SCM ODFs formulation of HPE nanoparticles was successfully optimized using the Box–Behnken design response surface methodology [63]\nCidofovirNanoparticles were prepared using poly(ethylene glycol)–polycaprolactone (PEG-PCL) To achieve its controlled release and also due to its wide spectrum anti-viral activity HPC a Printed using inkjet printer Combination of complexed anti cancer drug (Paclitaxel) and complexed anti viral drug (Cidofovir) were printed onto ODFsMechanical properties of film were enhanced due to drug printing [64,65]\nAcyclovir – solid dispersion was prepared Poor water solubility and low bioavailability HPMC Glycerol SCM Oral administration of ODFs of acyclovir instead of intravenous route of administration [66]\nEntecavir (single or multi-layered ODFs) Low dose − 0.5–1 mg per day Starch, carrageenan, pullulan and many others Acetyl triethyl citrate or propylene glycol or citrate ester or triacetin SCM Multi-layered ODFs were disclosed [67]\na Nothing found."}