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PMC:7784830 / 11980-13945 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
209 155-162 Chemical denotes Polymer MESH:D011108
210 349-354 Chemical denotes water MESH:D014867
211 605-610 Chemical denotes water MESH:D014867
212 888-893 Chemical denotes water MESH:D014867
213 1553-1558 Chemical denotes water MESH:D014867
214 494-497 Disease denotes HPC MESH:C537262
215 941-966 Disease denotes L-HPC PEG-400 SCM ODFs MESH:C537262
216 1273-1276 Disease denotes HPC MESH:C537262
217 1342-1348 Disease denotes cancer MESH:D009369

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 1342-1348 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T102 0-8 Sentence denotes Table 2.
T103 10-45 Sentence denotes Antiviral drugs formulated as ODFs.
T104 46-207 Sentence denotes Drug name – technique employed to load to ODFs Reason for choosing the drug or API to formulate as an ODFs Polymer Plasticizer Method Key highlight(s) Ref.
T105 208-764 Sentence denotes Herpetrione (HPE) – extracted from Herpetospermum caudigerum.HPE nanoparticles were prepared using sodium dodecyl sulfate and PVP K-30 Poor water solubility and low bioavailability Hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), and l-hydroxypropyl cellulose (HPC) PEG-400 Solvent casting method (SCM) Studies established that ODFs are suitable for delivery of poorly water-soluble drugsSCM is modified to prepare drug nanosuspensionOral bioavailability of HPE nanoparticles was higher when compared HPE coarse suspension [62]
T106 765-1090 Sentence denotes Herpetrione (HPE)Nanoparticles were prepared and optimized using the Box–Behnken design response surface methodology Poor water solubility and low bioavailability HPMC, MCC, L-HPC PEG-400 SCM ODFs formulation of HPE nanoparticles was successfully optimized using the Box–Behnken design response surface methodology [63]
T107 1091-1504 Sentence denotes CidofovirNanoparticles were prepared using poly(ethylene glycol)–polycaprolactone (PEG-PCL) To achieve its controlled release and also due to its wide spectrum anti-viral activity HPC a Printed using inkjet printer Combination of complexed anti cancer drug (Paclitaxel) and complexed anti viral drug (Cidofovir) were printed onto ODFsMechanical properties of film were enhanced due to drug printing [64,65]
T108 1505-1709 Sentence denotes Acyclovir – solid dispersion was prepared Poor water solubility and low bioavailability HPMC Glycerol SCM Oral administration of ODFs of acyclovir instead of intravenous route of administration [66]
T109 1710-1947 Sentence denotes Entecavir (single or multi-layered ODFs) Low dose − 0.5–1 mg per day Starch, carrageenan, pullulan and many others Acetyl triethyl citrate or propylene glycol or citrate ester or triacetin SCM Multi-layered ODFs were disclosed [67]
T110 1948-1965 Sentence denotes a Nothing found.