PMC:7652766 / 89740-90398 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T438","span":{"begin":0,"end":217},"obj":"Sentence"},{"id":"T439","span":{"begin":218,"end":352},"obj":"Sentence"},{"id":"T440","span":{"begin":353,"end":658},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Deng et al. (312) have studied the association of lopinavir/ritonavir with arbidol treatment and demonstrated a significant improvement in COVID-19 patients compared with a group treated only with lopinavir/ritonavir. Arbidol (umifenovir) is a broad-spectrum antiviral and immunomodulatory compound used to treat influenza and many other viruses (314). Analyses of molecular dynamics and structure-guided drug-binding have suggested an efficiency of arbidol at blocking or hampering the trimerization of the SARS-CoV-2 spike glycoprotein, in addition to inhibiting virus-cell interactions, which supports the potential use of arbidol to treat COVID-19 (315)."}

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