PMC:7652766 / 89740-90398 JSONTXT

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Analyses of molecular dynamics and structure-guided drug-binding have suggested an efficiency of arbidol at blocking or hampering the trimerization of the SARS-CoV-2 spike glycoprotein, in addition to inhibiting virus-cell interactions, which supports the potential use of arbidol to treat COVID-19 (315).","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T438","span":{"begin":0,"end":217},"obj":"Sentence"},{"id":"T439","span":{"begin":218,"end":352},"obj":"Sentence"},{"id":"T440","span":{"begin":353,"end":658},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T438","pred":"source","obj":"LitCovid-sentences"},{"subj":"T439","pred":"source","obj":"LitCovid-sentences"},{"subj":"T440","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3268","span":{"begin":634,"end":636},"obj":"Gene"},{"id":"3269","span":{"begin":551,"end":553},"obj":"Gene"},{"id":"3270","span":{"begin":304,"end":306},"obj":"Gene"},{"id":"3271","span":{"begin":148,"end":156},"obj":"Species"},{"id":"3272","span":{"begin":508,"end":518},"obj":"Species"},{"id":"3273","span":{"begin":313,"end":322},"obj":"Species"},{"id":"3274","span":{"begin":242,"end":243},"obj":"Gene"},{"id":"3275","span":{"begin":171,"end":172},"obj":"Gene"},{"id":"3276","span":{"begin":110,"end":111},"obj":"Gene"},{"id":"3277","span":{"begin":50,"end":69},"obj":"Chemical"},{"id":"3278","span":{"begin":75,"end":82},"obj":"Chemical"},{"id":"3279","span":{"begin":197,"end":216},"obj":"Chemical"},{"id":"3280","span":{"begin":218,"end":225},"obj":"Chemical"},{"id":"3281","span":{"begin":227,"end":237},"obj":"Chemical"},{"id":"3282","span":{"begin":450,"end":457},"obj":"Chemical"},{"id":"3283","span":{"begin":626,"end":633},"obj":"Chemical"},{"id":"3284","span":{"begin":139,"end":147},"obj":"Disease"},{"id":"3285","span":{"begin":643,"end":651},"obj":"Disease"}],"attributes":[{"id":"A3268","pred":"tao:has_database_id","subj":"3268","obj":"Gene:6999"},{"id":"A3269","pred":"tao:has_database_id","subj":"3269","obj":"Gene:6999"},{"id":"A3270","pred":"tao:has_database_id","subj":"3270","obj":"Gene:6999"},{"id":"A3271","pred":"tao:has_database_id","subj":"3271","obj":"Tax:9606"},{"id":"A3272","pred":"tao:has_database_id","subj":"3272","obj":"Tax:2697049"},{"id":"A3273","pred":"tao:has_database_id","subj":"3273","obj":"Tax:11309"},{"id":"A3274","pred":"tao:has_database_id","subj":"3274","obj":"Gene:351"},{"id":"A3275","pred":"tao:has_database_id","subj":"3275","obj":"Gene:351"},{"id":"A3276","pred":"tao:has_database_id","subj":"3276","obj":"Gene:351"},{"id":"A3277","pred":"tao:has_database_id","subj":"3277","obj":"MESH:C558899"},{"id":"A3278","pred":"tao:has_database_id","subj":"3278","obj":"MESH:C086979"},{"id":"A3279","pred":"tao:has_database_id","subj":"3279","obj":"MESH:C558899"},{"id":"A3280","pred":"tao:has_database_id","subj":"3280","obj":"MESH:C086979"},{"id":"A3281","pred":"tao:has_database_id","subj":"3281","obj":"MESH:C086979"},{"id":"A3282","pred":"tao:has_database_id","subj":"3282","obj":"MESH:C086979"},{"id":"A3283","pred":"tao:has_database_id","subj":"3283","obj":"MESH:C086979"},{"id":"A3284","pred":"tao:has_database_id","subj":"3284","obj":"MESH:C000657245"},{"id":"A3285","pred":"tao:has_database_id","subj":"3285","obj":"MESH:C000657245"},{"subj":"3268","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3269","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3270","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3271","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3272","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3273","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3274","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3275","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3276","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3277","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3278","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3279","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3280","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3281","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3282","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3283","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3284","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3285","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#93ecab","default":true},{"id":"LitCovid-PubTator","color":"#ec9395"}]}]}}