PMC:7652766 / 53586-54245 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T262	0-146	Sentence	denotes	Polyfunctional CD4+ T cells are characterized by the expression of activation markers as well as their capacity to produce IFN-γ, IL-2, and TNF-α.
T263	147-291	Sentence	denotes	These cells have been linked to an excellent response against viral infections and during the development of immunity by vaccination (185, 186).
T264	292-659	Sentence	denotes	Even though COVID-19 patients have shown an increase in the expression of molecules related to T CD4+ activation, such as CD69, CD38, and CD44, molecules related to their function, such as intracellular IFN-γ, IL-2, and TNF-α, are reduced, especially in individuals with a more severe stage of the disease (9, 170), indicating an impairment of polyfunctional T cells.

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
2060	15-18	Gene	denotes	CD4	Gene:920
2061	123-128	Gene	denotes	IFN-γ	Gene:3458
2062	130-134	Gene	denotes	IL-2	Gene:3558
2063	140-145	Gene	denotes	TNF-α	Gene:7124
2064	389-392	Gene	denotes	CD4	Gene:920
2065	414-418	Gene	denotes	CD69	Gene:969
2066	420-424	Gene	denotes	CD38	Gene:952
2067	430-434	Gene	denotes	CD44	Gene:960
2068	495-500	Gene	denotes	IFN-γ	Gene:3458
2069	502-506	Gene	denotes	IL-2	Gene:3558
2070	512-517	Gene	denotes	TNF-α	Gene:7124
2071	112-114	Gene	denotes	to	Gene:6999
2072	313-321	Species	denotes	patients	Tax:9606
2073	563-564	Gene	denotes	a	Gene:351
2074	209-225	Disease	denotes	viral infections	MESH:D001102
2075	304-312	Disease	denotes	COVID-19	MESH:C000657245