PMC:7652766 / 53586-54245 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T262","span":{"begin":0,"end":146},"obj":"Sentence"},{"id":"T263","span":{"begin":147,"end":291},"obj":"Sentence"},{"id":"T264","span":{"begin":292,"end":659},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Polyfunctional CD4+ T cells are characterized by the expression of activation markers as well as their capacity to produce IFN-γ, IL-2, and TNF-α. These cells have been linked to an excellent response against viral infections and during the development of immunity by vaccination (185, 186). Even though COVID-19 patients have shown an increase in the expression of molecules related to T CD4+ activation, such as CD69, CD38, and CD44, molecules related to their function, such as intracellular IFN-γ, IL-2, and TNF-α, are reduced, especially in individuals with a more severe stage of the disease (9, 170), indicating an impairment of polyfunctional T cells."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2060","span":{"begin":15,"end":18},"obj":"Gene"},{"id":"2061","span":{"begin":123,"end":128},"obj":"Gene"},{"id":"2062","span":{"begin":130,"end":134},"obj":"Gene"},{"id":"2063","span":{"begin":140,"end":145},"obj":"Gene"},{"id":"2064","span":{"begin":389,"end":392},"obj":"Gene"},{"id":"2065","span":{"begin":414,"end":418},"obj":"Gene"},{"id":"2066","span":{"begin":420,"end":424},"obj":"Gene"},{"id":"2067","span":{"begin":430,"end":434},"obj":"Gene"},{"id":"2068","span":{"begin":495,"end":500},"obj":"Gene"},{"id":"2069","span":{"begin":502,"end":506},"obj":"Gene"},{"id":"2070","span":{"begin":512,"end":517},"obj":"Gene"},{"id":"2071","span":{"begin":112,"end":114},"obj":"Gene"},{"id":"2072","span":{"begin":313,"end":321},"obj":"Species"},{"id":"2073","span":{"begin":563,"end":564},"obj":"Gene"},{"id":"2074","span":{"begin":209,"end":225},"obj":"Disease"},{"id":"2075","span":{"begin":304,"end":312},"obj":"Disease"}],"attributes":[{"id":"A2060","pred":"tao:has_database_id","subj":"2060","obj":"Gene:920"},{"id":"A2061","pred":"tao:has_database_id","subj":"2061","obj":"Gene:3458"},{"id":"A2062","pred":"tao:has_database_id","subj":"2062","obj":"Gene:3558"},{"id":"A2063","pred":"tao:has_database_id","subj":"2063","obj":"Gene:7124"},{"id":"A2064","pred":"tao:has_database_id","subj":"2064","obj":"Gene:920"},{"id":"A2065","pred":"tao:has_database_id","subj":"2065","obj":"Gene:969"},{"id":"A2066","pred":"tao:has_database_id","subj":"2066","obj":"Gene:952"},{"id":"A2067","pred":"tao:has_database_id","subj":"2067","obj":"Gene:960"},{"id":"A2068","pred":"tao:has_database_id","subj":"2068","obj":"Gene:3458"},{"id":"A2069","pred":"tao:has_database_id","subj":"2069","obj":"Gene:3558"},{"id":"A2070","pred":"tao:has_database_id","subj":"2070","obj":"Gene:7124"},{"id":"A2071","pred":"tao:has_database_id","subj":"2071","obj":"Gene:6999"},{"id":"A2072","pred":"tao:has_database_id","subj":"2072","obj":"Tax:9606"},{"id":"A2073","pred":"tao:has_database_id","subj":"2073","obj":"Gene:351"},{"id":"A2074","pred":"tao:has_database_id","subj":"2074","obj":"MESH:D001102"},{"id":"A2075","pred":"tao:has_database_id","subj":"2075","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Polyfunctional CD4+ T cells are characterized by the expression of activation markers as well as their capacity to produce IFN-γ, IL-2, and TNF-α. These cells have been linked to an excellent response against viral infections and during the development of immunity by vaccination (185, 186). Even though COVID-19 patients have shown an increase in the expression of molecules related to T CD4+ activation, such as CD69, CD38, and CD44, molecules related to their function, such as intracellular IFN-γ, IL-2, and TNF-α, are reduced, especially in individuals with a more severe stage of the disease (9, 170), indicating an impairment of polyfunctional T cells."}