PMC:7647877 / 62535-63164 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7647877","sourcedb":"PMC","sourceid":"7647877","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7647877","text":"Protects cell membranes from damage caused by free radicals and ↑ the integrity of epithelial barriers\n↑ NK cell cytotoxic activity; ↓ PGE2 production by macrophages (thus indirectly protecting T-cell function)\nImportant fat-soluble antioxidant that hinders the chain reaction induced by free radicals (chain-breaking effect) and protects cells against them; ↑ IL-2 production; ↓ production of PGE2 (indirectly protecting T-cell function)\n↑ Lymphocyte proliferation and T-cell-mediated functions; ↑ Th1 response; ↓ Th2 response; helps to form effective immune synapses between Th cells; ↑ proportion of antigen-experienced memory","divisions":[{"label":"p","span":{"begin":0,"end":102}},{"label":"p","span":{"begin":103,"end":210}},{"label":"p","span":{"begin":211,"end":438}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T717","span":{"begin":9,"end":23},"obj":"Body_part"},{"id":"T718","span":{"begin":9,"end":13},"obj":"Body_part"},{"id":"T719","span":{"begin":105,"end":112},"obj":"Body_part"},{"id":"T720","span":{"begin":108,"end":112},"obj":"Body_part"},{"id":"T721","span":{"begin":154,"end":165},"obj":"Body_part"},{"id":"T722","span":{"begin":196,"end":200},"obj":"Body_part"},{"id":"T723","span":{"begin":339,"end":344},"obj":"Body_part"},{"id":"T724","span":{"begin":361,"end":365},"obj":"Body_part"},{"id":"T725","span":{"begin":361,"end":363},"obj":"Body_part"},{"id":"T726","span":{"begin":424,"end":428},"obj":"Body_part"},{"id":"T727","span":{"begin":441,"end":451},"obj":"Body_part"},{"id":"T728","span":{"begin":472,"end":476},"obj":"Body_part"},{"id":"T729","span":{"begin":560,"end":568},"obj":"Body_part"},{"id":"T730","span":{"begin":580,"end":585},"obj":"Body_part"}],"attributes":[{"id":"A717","pred":"fma_id","subj":"T717","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A718","pred":"fma_id","subj":"T718","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A719","pred":"fma_id","subj":"T719","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A720","pred":"fma_id","subj":"T720","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A721","pred":"fma_id","subj":"T721","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A722","pred":"fma_id","subj":"T722","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A723","pred":"fma_id","subj":"T723","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A724","pred":"fma_id","subj":"T724","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A725","pred":"fma_id","subj":"T725","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A726","pred":"fma_id","subj":"T726","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A727","pred":"fma_id","subj":"T727","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A728","pred":"fma_id","subj":"T728","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A729","pred":"fma_id","subj":"T729","obj":"http://purl.org/sig/ont/fma/fma67408"},{"id":"A730","pred":"fma_id","subj":"T730","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T717","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T718","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T719","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T720","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T721","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T722","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T723","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T724","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T725","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T726","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T727","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T728","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T729","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T730","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T793","span":{"begin":9,"end":13},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T794","span":{"begin":14,"end":23},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T795","span":{"begin":83,"end":93},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T796","span":{"begin":105,"end":112},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T797","span":{"begin":123,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T798","span":{"begin":194,"end":200},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T799","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T800","span":{"begin":339,"end":344},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T801","span":{"begin":361,"end":365},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T802","span":{"begin":422,"end":428},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T803","span":{"begin":470,"end":476},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T804","span":{"begin":580,"end":585},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T793","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T794","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T795","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T796","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T797","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T798","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T799","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T800","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T801","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T802","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T803","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T804","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T53066","span":{"begin":51,"end":59},"obj":"Chemical"},{"id":"T40363","span":{"begin":135,"end":139},"obj":"Chemical"},{"id":"T16390","span":{"begin":233,"end":244},"obj":"Chemical"},{"id":"T30136","span":{"begin":293,"end":301},"obj":"Chemical"},{"id":"T19059","span":{"begin":361,"end":363},"obj":"Chemical"},{"id":"T53264","span":{"begin":394,"end":398},"obj":"Chemical"},{"id":"T87984","span":{"begin":577,"end":579},"obj":"Chemical"},{"id":"T201","span":{"begin":603,"end":610},"obj":"Chemical"}],"attributes":[{"id":"A87027","pred":"chebi_id","subj":"T53066","obj":"http://purl.obolibrary.org/obo/CHEBI_26519"},{"id":"A12204","pred":"chebi_id","subj":"T40363","obj":"http://purl.obolibrary.org/obo/CHEBI_15551"},{"id":"A41720","pred":"chebi_id","subj":"T16390","obj":"http://purl.obolibrary.org/obo/CHEBI_22586"},{"id":"A6145","pred":"chebi_id","subj":"T30136","obj":"http://purl.obolibrary.org/obo/CHEBI_26519"},{"id":"A74234","pred":"chebi_id","subj":"T19059","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A88672","pred":"chebi_id","subj":"T19059","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A67308","pred":"chebi_id","subj":"T53264","obj":"http://purl.obolibrary.org/obo/CHEBI_15551"},{"id":"A93283","pred":"chebi_id","subj":"T87984","obj":"http://purl.obolibrary.org/obo/CHEBI_33385"},{"id":"A70768","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"subj":"T53066","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40363","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T16390","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T30136","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19059","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T53264","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T87984","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T295","span":{"begin":361,"end":376},"obj":"http://purl.obolibrary.org/obo/GO_0032623"},{"id":"T296","span":{"begin":441,"end":465},"obj":"http://purl.obolibrary.org/obo/GO_0046651"},{"id":"T297","span":{"begin":623,"end":629},"obj":"http://purl.obolibrary.org/obo/GO_0007613"}],"attributes":[{"subj":"T295","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T384","span":{"begin":103,"end":210},"obj":"Sentence"},{"id":"T385","span":{"begin":211,"end":438},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T384","pred":"source","obj":"LitCovid-sentences"},{"subj":"T385","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1448","span":{"begin":361,"end":365},"obj":"Gene"}],"attributes":[{"id":"A1448","pred":"tao:has_database_id","subj":"1448","obj":"Gene:3558"},{"subj":"1448","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9693ec","default":true},{"id":"LitCovid-PD-CLO","color":"#aaec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93c4"},{"id":"LitCovid-PD-GO-BP","color":"#93deec"},{"id":"LitCovid-sentences","color":"#ece093"},{"id":"LitCovid-PubTator","color":"#c693ec"}]}]}}