PMC:7601109 / 84749-87156
Annnotations
LitCovid-PD-UBERON
{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T164","span":{"begin":409,"end":414},"obj":"Body_part"},{"id":"T165","span":{"begin":1170,"end":1174},"obj":"Body_part"}],"attributes":[{"id":"A164","pred":"uberon_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A165","pred":"uberon_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/UBERON_0000033"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T741","span":{"begin":409,"end":414},"obj":"Body_part"},{"id":"T742","span":{"begin":662,"end":669},"obj":"Body_part"},{"id":"T743","span":{"begin":758,"end":764},"obj":"Body_part"},{"id":"T744","span":{"begin":765,"end":774},"obj":"Body_part"},{"id":"T745","span":{"begin":792,"end":799},"obj":"Body_part"},{"id":"T746","span":{"begin":876,"end":883},"obj":"Body_part"},{"id":"T747","span":{"begin":1058,"end":1079},"obj":"Body_part"},{"id":"T748","span":{"begin":1129,"end":1136},"obj":"Body_part"},{"id":"T749","span":{"begin":1170,"end":1174},"obj":"Body_part"},{"id":"T750","span":{"begin":1293,"end":1300},"obj":"Body_part"},{"id":"T751","span":{"begin":1334,"end":1341},"obj":"Body_part"},{"id":"T752","span":{"begin":1362,"end":1364},"obj":"Body_part"},{"id":"T753","span":{"begin":1366,"end":1377},"obj":"Body_part"},{"id":"T754","span":{"begin":1420,"end":1427},"obj":"Body_part"},{"id":"T755","span":{"begin":1443,"end":1458},"obj":"Body_part"},{"id":"T756","span":{"begin":1468,"end":1474},"obj":"Body_part"},{"id":"T757","span":{"begin":1504,"end":1511},"obj":"Body_part"},{"id":"T758","span":{"begin":1612,"end":1620},"obj":"Body_part"},{"id":"T759","span":{"begin":1633,"end":1640},"obj":"Body_part"},{"id":"T760","span":{"begin":1668,"end":1676},"obj":"Body_part"},{"id":"T761","span":{"begin":1810,"end":1820},"obj":"Body_part"},{"id":"T762","span":{"begin":1933,"end":1944},"obj":"Body_part"},{"id":"T763","span":{"begin":1950,"end":1957},"obj":"Body_part"},{"id":"T764","span":{"begin":2166,"end":2175},"obj":"Body_part"},{"id":"T765","span":{"begin":2176,"end":2184},"obj":"Body_part"},{"id":"T766","span":{"begin":2214,"end":2220},"obj":"Body_part"},{"id":"T767","span":{"begin":2379,"end":2407},"obj":"Body_part"},{"id":"T768","span":{"begin":2402,"end":2407},"obj":"Body_part"}],"attributes":[{"id":"A741","pred":"fma_id","subj":"T741","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A742","pred":"fma_id","subj":"T742","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A743","pred":"fma_id","subj":"T743","obj":"http://purl.org/sig/ont/fma/fma82764"},{"id":"A744","pred":"fma_id","subj":"T744","obj":"http://purl.org/sig/ont/fma/fma82765"},{"id":"A745","pred":"fma_id","subj":"T745","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A746","pred":"fma_id","subj":"T746","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A747","pred":"fma_id","subj":"T747","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A748","pred":"fma_id","subj":"T748","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A749","pred":"fma_id","subj":"T749","obj":"http://purl.org/sig/ont/fma/fma7154"},{"id":"A750","pred":"fma_id","subj":"T750","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A751","pred":"fma_id","subj":"T751","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A752","pred":"fma_id","subj":"T752","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A753","pred":"fma_id","subj":"T753","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A754","pred":"fma_id","subj":"T754","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A755","pred":"fma_id","subj":"T755","obj":"http://purl.org/sig/ont/fma/fma7184"},{"id":"A756","pred":"fma_id","subj":"T756","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A757","pred":"fma_id","subj":"T757","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A758","pred":"fma_id","subj":"T758","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A759","pred":"fma_id","subj":"T759","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A760","pred":"fma_id","subj":"T760","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A761","pred":"fma_id","subj":"T761","obj":"http://purl.org/sig/ont/fma/fma63845"},{"id":"A762","pred":"fma_id","subj":"T762","obj":"http://purl.org/sig/ont/fma/fma82738"},{"id":"A763","pred":"fma_id","subj":"T763","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A764","pred":"fma_id","subj":"T764","obj":"http://purl.org/sig/ont/fma/fma66867"},{"id":"A765","pred":"fma_id","subj":"T765","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A766","pred":"fma_id","subj":"T766","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A767","pred":"fma_id","subj":"T767","obj":"http://purl.org/sig/ont/fma/fma284560"},{"id":"A768","pred":"fma_id","subj":"T768","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T143","span":{"begin":2265,"end":2270},"obj":"Disease"},{"id":"T144","span":{"begin":2294,"end":2299},"obj":"Disease"}],"attributes":[{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1485","span":{"begin":409,"end":414},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T1486","span":{"begin":409,"end":414},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T1487","span":{"begin":604,"end":609},"obj":"http://purl.obolibrary.org/obo/CLO_0053406"},{"id":"T1488","span":{"begin":617,"end":627},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2759"},{"id":"T1489","span":{"begin":756,"end":757},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1490","span":{"begin":866,"end":875},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1491","span":{"begin":931,"end":941},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1492","span":{"begin":1170,"end":1174},"obj":"http://purl.obolibrary.org/obo/UBERON_0000033"},{"id":"T1493","span":{"begin":1170,"end":1174},"obj":"http://www.ebi.ac.uk/efo/EFO_0000964"},{"id":"T1494","span":{"begin":1190,"end":1193},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T1495","span":{"begin":1257,"end":1259},"obj":"http://purl.obolibrary.org/obo/PR_000009064"},{"id":"T1496","span":{"begin":1293,"end":1300},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T1497","span":{"begin":1319,"end":1320},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T1498","span":{"begin":1334,"end":1341},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T1499","span":{"begin":1416,"end":1418},"obj":"http://purl.obolibrary.org/obo/PR_000009064"},{"id":"T1500","span":{"begin":1420,"end":1436},"obj":"http://purl.obolibrary.org/obo/PR_000009064"},{"id":"T1501","span":{"begin":1449,"end":1458},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T1502","span":{"begin":1459,"end":1474},"obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"T1503","span":{"begin":1459,"end":1474},"obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"T1504","span":{"begin":1459,"end":1474},"obj":"http://www.ebi.ac.uk/efo/EFO_0000888"},{"id":"T1505","span":{"begin":1494,"end":1503},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1506","span":{"begin":1612,"end":1620},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T1507","span":{"begin":1713,"end":1715},"obj":"http://purl.obolibrary.org/obo/CLO_0007074"},{"id":"T1508","span":{"begin":1713,"end":1715},"obj":"http://purl.obolibrary.org/obo/CLO_0051988"},{"id":"T1509","span":{"begin":1738,"end":1739},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T1510","span":{"begin":1834,"end":1843},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1511","span":{"begin":2214,"end":2220},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1512","span":{"begin":2214,"end":2220},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1513","span":{"begin":2214,"end":2220},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1514","span":{"begin":2214,"end":2220},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1515","span":{"begin":2332,"end":2333},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1516","span":{"begin":2370,"end":2371},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1517","span":{"begin":2388,"end":2407},"obj":"http://purl.obolibrary.org/obo/CL_0000192"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-PD-CHEBI
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ebi_id","subj":"T33771","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A84931","pred":"chebi_id","subj":"T98175","obj":"http://purl.obolibrary.org/obo/CHEBI_16541"},{"id":"A65220","pred":"chebi_id","subj":"T46462","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A31994","pred":"chebi_id","subj":"T4655","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A96627","pred":"chebi_id","subj":"T83718","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A89067","pred":"chebi_id","subj":"T68566","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A6429","pred":"chebi_id","subj":"T19829","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A66895","pred":"chebi_id","subj":"T433","obj":"http://purl.obolibrary.org/obo/CHEBI_79381"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-PD-GO-BP
{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T395","span":{"begin":628,"end":650},"obj":"http://purl.obolibrary.org/obo/GO_0006413"},{"id":"T396","span":{"begin":628,"end":639},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T397","span":{"begin":775,"end":791},"obj":"http://purl.obolibrary.org/obo/GO_0009594"},{"id":"T398","span":{"begin":836,"end":840},"obj":"http://purl.obolibrary.org/obo/GO_0050405"},{"id":"T399","span":{"begin":836,"end":840},"obj":"http://purl.obolibrary.org/obo/GO_0047322"},{"id":"T400","span":{"begin":836,"end":840},"obj":"http://purl.obolibrary.org/obo/GO_0004691"},{"id":"T401","span":{"begin":942,"end":962},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T402","span":{"begin":942,"end":955},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T403","span":{"begin":1129,"end":1148},"obj":"http://purl.obolibrary.org/obo/GO_1904659"},{"id":"T404","span":{"begin":1347,"end":1353},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T405","span":{"begin":1480,"end":1484},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T406","span":{"begin":1810,"end":1833},"obj":"http://purl.obolibrary.org/obo/GO_0016559"},{"id":"T407","span":{"begin":1879,"end":1883},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T408","span":{"begin":2214,"end":2228},"obj":"http://purl.obolibrary.org/obo/GO_0014889"},{"id":"T409","span":{"begin":2246,"end":2259},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T410","span":{"begin":2271,"end":2279},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T411","span":{"begin":2271,"end":2279},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T412","span":{"begin":2271,"end":2279},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T413","span":{"begin":2271,"end":2279},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T414","span":{"begin":2300,"end":2308},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T415","span":{"begin":2300,"end":2308},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T416","span":{"begin":2300,"end":2308},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T417","span":{"begin":2300,"end":2308},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T418","span":{"begin":2356,"end":2362},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T87","span":{"begin":1204,"end":1211},"obj":"Phenotype"},{"id":"T88","span":{"begin":1293,"end":1311},"obj":"Phenotype"},{"id":"T89","span":{"begin":2214,"end":2228},"obj":"Phenotype"},{"id":"T90","span":{"begin":2265,"end":2270},"obj":"Phenotype"},{"id":"T91","span":{"begin":2294,"end":2299},"obj":"Phenotype"}],"attributes":[{"id":"A87","pred":"hp_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A88","pred":"hp_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A89","pred":"hp_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/HP_0003202"},{"id":"A90","pred":"hp_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A91","pred":"hp_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T499","span":{"begin":0,"end":20},"obj":"Sentence"},{"id":"T500","span":{"begin":21,"end":259},"obj":"Sentence"},{"id":"T501","span":{"begin":260,"end":336},"obj":"Sentence"},{"id":"T502","span":{"begin":338,"end":345},"obj":"Sentence"},{"id":"T503","span":{"begin":346,"end":502},"obj":"Sentence"},{"id":"T504","span":{"begin":503,"end":521},"obj":"Sentence"},{"id":"T505","span":{"begin":523,"end":544},"obj":"Sentence"},{"id":"T506","span":{"begin":545,"end":589},"obj":"Sentence"},{"id":"T507","span":{"begin":590,"end":603},"obj":"Sentence"},{"id":"T508","span":{"begin":604,"end":671},"obj":"Sentence"},{"id":"T509","span":{"begin":672,"end":712},"obj":"Sentence"},{"id":"T510","span":{"begin":713,"end":750},"obj":"Sentence"},{"id":"T511","span":{"begin":751,"end":806},"obj":"Sentence"},{"id":"T512","span":{"begin":807,"end":835},"obj":"Sentence"},{"id":"T513","span":{"begin":836,"end":890},"obj":"Sentence"},{"id":"T514","span":{"begin":891,"end":924},"obj":"Sentence"},{"id":"T515","span":{"begin":925,"end":964},"obj":"Sentence"},{"id":"T516","span":{"begin":965,"end":993},"obj":"Sentence"},{"id":"T517","span":{"begin":994,"end":1013},"obj":"Sentence"},{"id":"T518","span":{"begin":1014,"end":1053},"obj":"Sentence"},{"id":"T519","span":{"begin":1054,"end":1079},"obj":"Sentence"},{"id":"T520","span":{"begin":1080,"end":1100},"obj":"Sentence"},{"id":"T521","span":{"begin":1101,"end":1121},"obj":"Sentence"},{"id":"T522","span":{"begin":1122,"end":1150},"obj":"Sentence"},{"id":"T523","span":{"begin":1151,"end":1179},"obj":"Sentence"},{"id":"T524","span":{"begin":1180,"end":1198},"obj":"Sentence"},{"id":"T525","span":{"begin":1199,"end":1228},"obj":"Sentence"},{"id":"T526","span":{"begin":1229,"end":1251},"obj":"Sentence"},{"id":"T527","span":{"begin":1252,"end":1311},"obj":"Sentence"},{"id":"T528","span":{"begin":1312,"end":1327},"obj":"Sentence"},{"id":"T529","span":{"begin":1328,"end":1361},"obj":"Sentence"},{"id":"T530","span":{"begin":1362,"end":1377},"obj":"Sentence"},{"id":"T531","span":{"begin":1378,"end":1415},"obj":"Sentence"},{"id":"T532","span":{"begin":1416,"end":1436},"obj":"Sentence"},{"id":"T533","span":{"begin":1437,"end":1479},"obj":"Sentence"},{"id":"T534","span":{"begin":1480,"end":1518},"obj":"Sentence"},{"id":"T535","span":{"begin":1519,"end":1539},"obj":"Sentence"},{"id":"T536","span":{"begin":1540,"end":1575},"obj":"Sentence"},{"id":"T537","span":{"begin":1576,"end":1604},"obj":"Sentence"},{"id":"T538","span":{"begin":1605,"end":1642},"obj":"Sentence"},{"id":"T539","span":{"begin":1643,"end":1676},"obj":"Sentence"},{"id":"T540","span":{"begin":1677,"end":1709},"obj":"Sentence"},{"id":"T541","span":{"begin":1710,"end":1739},"obj":"Sentence"},{"id":"T542","span":{"begin":1740,"end":1801},"obj":"Sentence"},{"id":"T543","span":{"begin":1802,"end":1878},"obj":"Sentence"},{"id":"T544","span":{"begin":1879,"end":1910},"obj":"Sentence"},{"id":"T545","span":{"begin":1911,"end":1944},"obj":"Sentence"},{"id":"T546","span":{"begin":1945,"end":1966},"obj":"Sentence"},{"id":"T547","span":{"begin":1967,"end":2000},"obj":"Sentence"},{"id":"T548","span":{"begin":2001,"end":2021},"obj":"Sentence"},{"id":"T549","span":{"begin":2022,"end":2072},"obj":"Sentence"},{"id":"T550","span":{"begin":2073,"end":2102},"obj":"Sentence"},{"id":"T551","span":{"begin":2103,"end":2131},"obj":"Sentence"},{"id":"T552","span":{"begin":2132,"end":2156},"obj":"Sentence"},{"id":"T553","span":{"begin":2157,"end":2194},"obj":"Sentence"},{"id":"T554","span":{"begin":2195,"end":2259},"obj":"Sentence"},{"id":"T555","span":{"begin":2260,"end":2286},"obj":"Sentence"},{"id":"T556","span":{"begin":2287,"end":2326},"obj":"Sentence"},{"id":"T557","span":{"begin":2327,"end":2371},"obj":"Sentence"},{"id":"T558","span":{"begin":2372,"end":2407},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"1895","span":{"begin":604,"end":609},"obj":"Gene"},{"id":"1896","span":{"begin":610,"end":615},"obj":"Gene"},{"id":"1897","span":{"begin":751,"end":754},"obj":"Gene"},{"id":"1898","span":{"begin":1122,"end":1127},"obj":"Gene"},{"id":"1899","span":{"begin":1229,"end":1233},"obj":"Gene"},{"id":"1900","span":{"begin":1293,"end":1300},"obj":"Gene"},{"id":"1901","span":{"begin":1334,"end":1341},"obj":"Gene"},{"id":"1902","span":{"begin":1420,"end":1436},"obj":"Gene"},{"id":"1903","span":{"begin":1773,"end":1801},"obj":"Gene"},{"id":"1904","span":{"begin":2022,"end":2026},"obj":"Gene"},{"id":"1905","span":{"begin":2185,"end":2194},"obj":"Gene"},{"id":"1906","span":{"begin":2287,"end":2292},"obj":"Gene"},{"id":"1907","span":{"begin":1129,"end":1150},"obj":"Gene"},{"id":"1908","span":{"begin":1677,"end":1681},"obj":"Gene"},{"id":"1909","span":{"begin":1190,"end":1193},"obj":"Gene"},{"id":"1910","span":{"begin":1170,"end":1179},"obj":"Gene"},{"id":"1911","span":{"begin":1576,"end":1582},"obj":"Gene"},{"id":"1912","span":{"begin":1546,"end":1575},"obj":"Gene"},{"id":"1913","span":{"begin":2294,"end":2326},"obj":"Gene"},{"id":"1914","span":{"begin":1683,"end":1709},"obj":"Gene"},{"id":"1915","span":{"begin":2157,"end":2160},"obj":"Gene"},{"id":"1916","span":{"begin":1710,"end":1715},"obj":"Gene"},{"id":"1917","span":{"begin":2028,"end":2072},"obj":"Gene"},{"id":"1918","span":{"begin":1540,"end":1544},"obj":"Gene"},{"id":"1919","span":{"begin":758,"end":764},"obj":"Chemical"},{"id":"1920","span":{"begin":812,"end":821},"obj":"Chemical"},{"id":"1921","span":{"begin":842,"end":851},"obj":"Chemical"},{"id":"1922","span":{"begin":970,"end":979},"obj":"Chemical"},{"id":"1923","span":{"begin":1199,"end":1211},"obj":"Disease"},{"id":"1924","span":{"begin":2214,"end":2228},"obj":"Disease"},{"id":"1925","span":{"begin":2260,"end":2279},"obj":"Disease"}],"attributes":[{"id":"A1895","pred":"tao:has_database_id","subj":"1895","obj":"Gene:1978"},{"id":"A1896","pred":"tao:has_database_id","subj":"1896","obj":"Gene:1977"},{"id":"A1897","pred":"tao:has_database_id","subj":"1897","obj":"Gene:207"},{"id":"A1898","pred":"tao:has_database_id","subj":"1898","obj":"Gene:6517"},{"id":"A1899","pred":"tao:has_database_id","subj":"1899","obj":"Gene:3162"},{"id":"A1900","pred":"tao:has_database_id","subj":"1900","obj":"Gene:3630"},{"id":"A1901","pred":"tao:has_database_id","subj":"1901","obj":"Gene:3630"},{"id":"A1902","pred":"tao:has_database_id","subj":"1902","obj":"Gene:3643"},{"id":"A1903","pred":"tao:has_database_id","subj":"1903","obj":"Gene:2553"},{"id":"A1904","pred":"tao:has_database_id","subj":"1904","obj":"Gene:177"},{"id":"A1905","pred":"tao:has_database_id","subj":"1905","obj":"Gene:83840"},{"id":"A1906","pred":"tao:has_database_id","subj":"1906","obj":"Gene:7132"},{"id":"A1907","pred":"tao:has_database_id","subj":"1907","obj":"Gene:20528"},{"id":"A1908","pred":"tao:has_database_id","subj":"1908","obj":"Gene:4654"},{"id":"A1909","pred":"tao:has_database_id","subj":"1909","obj":"Gene:2195"},{"id":"A1910","pred":"tao:has_database_id","subj":"1910","obj":"Gene:224480"},{"id":"A1911","pred":"tao:has_database_id","subj":"1911","obj":"Gene:17381"},{"id":"A1912","pred":"tao:has_database_id","subj":"1912","obj":"Gene:2475"},{"id":"A1913","pred":"tao:has_database_id","subj":"1913","obj":"Gene:21937"},{"id":"A1914","pred":"tao:has_database_id","subj":"1914","obj":"Gene:17927"},{"id":"A1915","pred":"tao:has_database_id","subj":"1915","obj":"Gene:83840"},{"id":"A1916","pred":"tao:has_database_id","subj":"1916","obj":"Gene:309165"},{"id":"A1917","pred":"tao:has_database_id","subj":"1917","obj":"Gene:81722"},{"id":"A1918","pred":"tao:has_database_id","subj":"1918","obj":"Gene:56717"},{"id":"A1919","pred":"tao:has_database_id","subj":"1919","obj":"MESH:D012694"},{"id":"A1920","pred":"tao:has_database_id","subj":"1920","obj":"MESH:D000241"},{"id":"A1921","pred":"tao:has_database_id","subj":"1921","obj":"MESH:D000241"},{"id":"A1922","pred":"tao:has_database_id","subj":"1922","obj":"MESH:D000241"},{"id":"A1923","pred":"tao:has_database_id","subj":"1923","obj":"MESH:D000860"},{"id":"A1924","pred":"tao:has_database_id","subj":"1924","obj":"MESH:D009133"},{"id":"A1925","pred":"tao:has_database_id","subj":"1925","obj":"MESH:C536657"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Author Contributions\nConceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K. All authors have read and agreed to the published version of the manuscript.\n\nFunding\nThis study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No. 18dm0107100h0003).\n\nConflicts of Interest\nThe authors declare no conflict of interest. Abbreviations\n4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1\n10-HDA trans-10-hydroxy-2-decenoic acid\nAGEs Advanced glycation end products\nAKT A serine/threonine nutrient sensing protein kinase\nAMP Adenosine monophosphate\nAMPK Adenosine monophosphate activated protein kinase\nARE Antioxidant response element\nATF4 Activating transcription factor-4\nATP Adenosine tri-phosphate\nCOX Cyclooxygenase\neNOs Endothelial nitric oxide synthase\nER Endoplasmic reticulum\nFOXO Forkhead box O\nGI Gastrointestinal\nGLUT4 Glucose transporter 4\nHET Heterogeneous head tilt\nHFD High fat diet\nHIF Hypoxia-inducible factor\nHO-1 Heme oxygenase 1\nHOMA-IR Homeostatic model assessment of insulin resistance\nIKK IκB kinase\nIGFs Insulin-like growth factors\nIL Interleukin\niNOS Inducible nitric oxide synthase\nIR Insulin receptor\nLESM Lower extremity skeletal muscle mass\nMAPK Mitogen-activated protein kinase\nMDA Malondialdehyde\nmTOR Mammalian target of rapamycin\nMMP-12 Metalloproteinase-12\nMCP-1 Monocyte chemotactic protein 1\nMRJPs Major royal jelly proteins\nMyoD Myogenic differentiation 1\nNF-kB Nuclear factor kappa-B\nNRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2\nPGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha\nPI3k Phosphoinositide-3 kinase\nPUFA Polyunsaturated fatty acids\nPKC Protein kinase C\npRJ Protease-treated royal jelly\nQOL Quality of life\nRAGE Receptor for Advanced Glycation End products\nRCT Randomized control trial\nROS Reactive oxygen species\nSDs Standard deviations\nS6K P70 ribosomal proteins S6 kinase\nSMART Specific of Muscle Atrophy and Regulated by Transcription\nTNF Tumor necrosis factor\nTNFR1 Tumor necrosis factor receptor 1\nVEGF-A Vascular endothelial growth factor A\nVSMCs Vascular smooth muscle cells"}