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PMC:7601109 / 84749-87156 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T164 409-414 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955
T165 1170-1174 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T741 409-414 Body_part denotes Brain http://purl.org/sig/ont/fma/fma50801
T742 662-669 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T743 758-764 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T744 765-774 Body_part denotes threonine http://purl.org/sig/ont/fma/fma82765
T745 792-799 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T746 876-883 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T747 1058-1079 Body_part denotes Endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T748 1129-1136 Body_part denotes Glucose http://purl.org/sig/ont/fma/fma82743
T749 1170-1174 Body_part denotes head http://purl.org/sig/ont/fma/fma7154
T750 1293-1300 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T751 1334-1341 Body_part denotes Insulin http://purl.org/sig/ont/fma/fma83365
T752 1362-1364 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T753 1366-1377 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T754 1420-1427 Body_part denotes Insulin http://purl.org/sig/ont/fma/fma83365
T755 1443-1458 Body_part denotes Lower extremity http://purl.org/sig/ont/fma/fma7184
T756 1468-1474 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T757 1504-1511 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T758 1612-1620 Body_part denotes Monocyte http://purl.org/sig/ont/fma/fma62864
T759 1633-1640 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T760 1668-1676 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T761 1810-1820 Body_part denotes Peroxisome http://purl.org/sig/ont/fma/fma63845
T762 1933-1944 Body_part denotes fatty acids http://purl.org/sig/ont/fma/fma82738
T763 1950-1957 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T764 2166-2175 Body_part denotes ribosomal http://purl.org/sig/ont/fma/fma66867
T765 2176-2184 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T766 2214-2220 Body_part denotes Muscle http://purl.org/sig/ont/fma/fma32558
T767 2379-2407 Body_part denotes Vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T768 2402-2407 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T143 2265-2270 Disease denotes Tumor http://purl.obolibrary.org/obo/MONDO_0005070
T144 2294-2299 Disease denotes Tumor http://purl.obolibrary.org/obo/MONDO_0005070

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1485 409-414 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T1486 409-414 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Brain
T1487 604-609 http://purl.obolibrary.org/obo/CLO_0053406 denotes 4eBP1
T1488 617-627 http://purl.obolibrary.org/obo/NCBITaxon_2759 denotes Eukaryotic
T1489 756-757 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1490 866-875 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T1491 931-941 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activating
T1492 1170-1174 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
T1493 1170-1174 http://www.ebi.ac.uk/efo/EFO_0000964 denotes head
T1494 1190-1193 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T1495 1257-1259 http://purl.obolibrary.org/obo/PR_000009064 denotes IR
T1496 1293-1300 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T1497 1319-1320 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T1498 1334-1341 http://purl.obolibrary.org/obo/PR_000009054 denotes Insulin
T1499 1416-1418 http://purl.obolibrary.org/obo/PR_000009064 denotes IR
T1500 1420-1436 http://purl.obolibrary.org/obo/PR_000009064 denotes Insulin receptor
T1501 1449-1458 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremity
T1502 1459-1474 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1503 1459-1474 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1504 1459-1474 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1505 1494-1503 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T1506 1612-1620 http://purl.obolibrary.org/obo/CL_0000576 denotes Monocyte
T1507 1713-1715 http://purl.obolibrary.org/obo/CLO_0007074 denotes kB
T1508 1713-1715 http://purl.obolibrary.org/obo/CLO_0051988 denotes kB
T1509 1738-1739 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T1510 1834-1843 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T1511 2214-2220 http://purl.obolibrary.org/obo/UBERON_0001630 denotes Muscle
T1512 2214-2220 http://purl.obolibrary.org/obo/UBERON_0005090 denotes Muscle
T1513 2214-2220 http://www.ebi.ac.uk/efo/EFO_0000801 denotes Muscle
T1514 2214-2220 http://www.ebi.ac.uk/efo/EFO_0001949 denotes Muscle
T1515 2332-2333 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1516 2370-2371 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1517 2388-2407 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T90243 662-669 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15524 675-678 Chemical denotes HDA http://purl.obolibrary.org/obo/CHEBI_17314
T63647 689-696 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T25144 697-712 Chemical denotes 2-decenoic acid http://purl.obolibrary.org/obo/CHEBI_50465
T367 699-712 Chemical denotes decenoic acid http://purl.obolibrary.org/obo/CHEBI_36003
T47429 708-712 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T44186 713-717 Chemical denotes AGEs http://purl.obolibrary.org/obo/CHEBI_84123
T10601 758-764 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T30027 765-774 Chemical denotes threonine http://purl.obolibrary.org/obo/CHEBI_26986
T45653 775-783 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T96786 792-799 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33445 807-810 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T54092 812-821 Chemical denotes Adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T6019 842-851 Chemical denotes Adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T14673 876-883 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T4132 965-968 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T66822 970-979 Chemical denotes Adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T53115 984-993 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T4904 1032-1044 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T6654 1039-1044 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T84904 1101-1103 Chemical denotes GI http://purl.obolibrary.org/obo/CHEBI_73907
T71170 1129-1136 Chemical denotes Glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_42758
T79657 1235-1239 Chemical denotes Heme http://purl.obolibrary.org/obo/CHEBI_17627
T38997 1257-1259 Chemical denotes IR http://purl.obolibrary.org/obo/CHEBI_74061
T396 1293-1300 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T43255 1334-1341 Chemical denotes Insulin http://purl.obolibrary.org/obo/CHEBI_5931
T75814 1362-1364 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T400 1394-1406 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T72415 1401-1406 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T61693 1416-1418 Chemical denotes IR http://purl.obolibrary.org/obo/CHEBI_74061
T22005 1420-1427 Chemical denotes Insulin http://purl.obolibrary.org/obo/CHEBI_5931
T405 1504-1511 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79024 1519-1522 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T91425 1524-1539 Chemical denotes Malondialdehyde http://purl.obolibrary.org/obo/CHEBI_566274
T408 1566-1575 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T58536 1576-1579 Chemical denotes MMP http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761
T94640 1605-1608 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T54751 1633-1640 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T26510 1656-1667 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T66177 1668-1676 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T3889 1710-1712 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T14830 1802-1805 Chemical denotes PGC http://purl.obolibrary.org/obo/CHEBI_26336
T80830 1853-1858 Chemical denotes gamma http://purl.obolibrary.org/obo/CHEBI_30212
T49190 1873-1878 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T44561 1911-1915 Chemical denotes PUFA http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567
T80126 1917-1944 Chemical denotes Polyunsaturated fatty acids http://purl.obolibrary.org/obo/CHEBI_26208
T67854 1933-1944 Chemical denotes fatty acids http://purl.obolibrary.org/obo/CHEBI_35366
T33771 1939-1944 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T98175 1950-1957 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T46462 1989-2000 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T4655 2103-2106 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T83718 2108-2131 Chemical denotes Reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T68566 2117-2123 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T19829 2176-2184 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T433 2363-2371 Chemical denotes factor A http://purl.obolibrary.org/obo/CHEBI_79381

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T395 628-650 http://purl.obolibrary.org/obo/GO_0006413 denotes translation initiation
T396 628-639 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T397 775-791 http://purl.obolibrary.org/obo/GO_0009594 denotes nutrient sensing
T398 836-840 http://purl.obolibrary.org/obo/GO_0050405 denotes AMPK
T399 836-840 http://purl.obolibrary.org/obo/GO_0047322 denotes AMPK
T400 836-840 http://purl.obolibrary.org/obo/GO_0004691 denotes AMPK
T401 942-962 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T402 942-955 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T403 1129-1148 http://purl.obolibrary.org/obo/GO_1904659 denotes Glucose transporter
T404 1347-1353 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T405 1480-1484 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T406 1810-1833 http://purl.obolibrary.org/obo/GO_0016559 denotes Peroxisome proliferator
T407 1879-1883 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3k
T408 2214-2228 http://purl.obolibrary.org/obo/GO_0014889 denotes Muscle Atrophy
T409 2246-2259 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T410 2271-2279 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T411 2271-2279 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T412 2271-2279 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T413 2271-2279 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T414 2300-2308 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T415 2300-2308 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T416 2300-2308 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T417 2300-2308 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T418 2356-2362 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T87 1204-1211 Phenotype denotes Hypoxia http://purl.obolibrary.org/obo/HP_0012418
T88 1293-1311 Phenotype denotes insulin resistance http://purl.obolibrary.org/obo/HP_0000855
T89 2214-2228 Phenotype denotes Muscle Atrophy http://purl.obolibrary.org/obo/HP_0003202
T90 2265-2270 Phenotype denotes Tumor http://purl.obolibrary.org/obo/HP_0002664
T91 2294-2299 Phenotype denotes Tumor http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T499 0-20 Sentence denotes Author Contributions
T500 21-259 Sentence denotes Conceptualization, A.M.A.; methodology, A.M.A.; software, A.M.A.; validation, A.M.A.; writing—original draft preparation, A.M.A.; writing—review and editing, H.K.; supervision, H.K.; project administration, H.K.; funding acquisition, H.K.
T501 260-336 Sentence denotes All authors have read and agreed to the published version of the manuscript.
T502 338-345 Sentence denotes Funding
T503 346-502 Sentence denotes This study was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED, Japan (Grant No.
T504 503-521 Sentence denotes 18dm0107100h0003).
T505 523-544 Sentence denotes Conflicts of Interest
T506 545-589 Sentence denotes The authors declare no conflict of interest.
T507 590-603 Sentence denotes Abbreviations
T508 604-671 Sentence denotes 4eBP1/eIF4E Eukaryotic translation initiation 4E-binding protein 1
T509 672-712 Sentence denotes 10-HDA trans-10-hydroxy-2-decenoic acid
T510 713-750 Sentence denotes AGEs Advanced glycation end products
T511 751-806 Sentence denotes AKT A serine/threonine nutrient sensing protein kinase
T512 807-835 Sentence denotes AMP Adenosine monophosphate
T513 836-890 Sentence denotes AMPK Adenosine monophosphate activated protein kinase
T514 891-924 Sentence denotes ARE Antioxidant response element
T515 925-964 Sentence denotes ATF4 Activating transcription factor-4
T516 965-993 Sentence denotes ATP Adenosine tri-phosphate
T517 994-1013 Sentence denotes COX Cyclooxygenase
T518 1014-1053 Sentence denotes eNOs Endothelial nitric oxide synthase
T519 1054-1079 Sentence denotes ER Endoplasmic reticulum
T520 1080-1100 Sentence denotes FOXO Forkhead box O
T521 1101-1121 Sentence denotes GI Gastrointestinal
T522 1122-1150 Sentence denotes GLUT4 Glucose transporter 4
T523 1151-1179 Sentence denotes HET Heterogeneous head tilt
T524 1180-1198 Sentence denotes HFD High fat diet
T525 1199-1228 Sentence denotes HIF Hypoxia-inducible factor
T526 1229-1251 Sentence denotes HO-1 Heme oxygenase 1
T527 1252-1311 Sentence denotes HOMA-IR Homeostatic model assessment of insulin resistance
T528 1312-1327 Sentence denotes IKK IκB kinase
T529 1328-1361 Sentence denotes IGFs Insulin-like growth factors
T530 1362-1377 Sentence denotes IL Interleukin
T531 1378-1415 Sentence denotes iNOS Inducible nitric oxide synthase
T532 1416-1436 Sentence denotes IR Insulin receptor
T533 1437-1479 Sentence denotes LESM Lower extremity skeletal muscle mass
T534 1480-1518 Sentence denotes MAPK Mitogen-activated protein kinase
T535 1519-1539 Sentence denotes MDA Malondialdehyde
T536 1540-1575 Sentence denotes mTOR Mammalian target of rapamycin
T537 1576-1604 Sentence denotes MMP-12 Metalloproteinase-12
T538 1605-1642 Sentence denotes MCP-1 Monocyte chemotactic protein 1
T539 1643-1676 Sentence denotes MRJPs Major royal jelly proteins
T540 1677-1709 Sentence denotes MyoD Myogenic differentiation 1
T541 1710-1739 Sentence denotes NF-kB Nuclear factor kappa-B
T542 1740-1801 Sentence denotes NRF2 Nuclear factor erythroid 2/Nuclear respiratory factor 2
T543 1802-1878 Sentence denotes PGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1 alpha
T544 1879-1910 Sentence denotes PI3k Phosphoinositide-3 kinase
T545 1911-1944 Sentence denotes PUFA Polyunsaturated fatty acids
T546 1945-1966 Sentence denotes PKC Protein kinase C
T547 1967-2000 Sentence denotes pRJ Protease-treated royal jelly
T548 2001-2021 Sentence denotes QOL Quality of life
T549 2022-2072 Sentence denotes RAGE Receptor for Advanced Glycation End products
T550 2073-2102 Sentence denotes RCT Randomized control trial
T551 2103-2131 Sentence denotes ROS Reactive oxygen species
T552 2132-2156 Sentence denotes SDs Standard deviations
T553 2157-2194 Sentence denotes S6K P70 ribosomal proteins S6 kinase
T554 2195-2259 Sentence denotes SMART Specific of Muscle Atrophy and Regulated by Transcription
T555 2260-2286 Sentence denotes TNF Tumor necrosis factor
T556 2287-2326 Sentence denotes TNFR1 Tumor necrosis factor receptor 1
T557 2327-2371 Sentence denotes VEGF-A Vascular endothelial growth factor A
T558 2372-2407 Sentence denotes VSMCs Vascular smooth muscle cells

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1895 604-609 Gene denotes 4eBP1 Gene:1978
1896 610-615 Gene denotes eIF4E Gene:1977
1897 751-754 Gene denotes AKT Gene:207
1898 1122-1127 Gene denotes GLUT4 Gene:6517
1899 1229-1233 Gene denotes HO-1 Gene:3162
1900 1293-1300 Gene denotes insulin Gene:3630
1901 1334-1341 Gene denotes Insulin Gene:3630
1902 1420-1436 Gene denotes Insulin receptor Gene:3643
1903 1773-1801 Gene denotes Nuclear respiratory factor 2 Gene:2553
1904 2022-2026 Gene denotes RAGE Gene:177
1905 2185-2194 Gene denotes S6 kinase Gene:83840
1906 2287-2292 Gene denotes TNFR1 Gene:7132
1907 1129-1150 Gene denotes Glucose transporter 4 Gene:20528
1908 1677-1681 Gene denotes MyoD Gene:4654
1909 1190-1193 Gene denotes fat Gene:2195
1910 1170-1179 Gene denotes head tilt Gene:224480
1911 1576-1582 Gene denotes MMP-12 Gene:17381
1912 1546-1575 Gene denotes Mammalian target of rapamycin Gene:2475
1913 2294-2326 Gene denotes Tumor necrosis factor receptor 1 Gene:21937
1914 1683-1709 Gene denotes Myogenic differentiation 1 Gene:17927
1915 2157-2160 Gene denotes S6K Gene:83840
1916 1710-1715 Gene denotes NF-kB Gene:309165
1917 2028-2072 Gene denotes Receptor for Advanced Glycation End products Gene:81722
1918 1540-1544 Gene denotes mTOR Gene:56717
1919 758-764 Chemical denotes serine MESH:D012694
1920 812-821 Chemical denotes Adenosine MESH:D000241
1921 842-851 Chemical denotes Adenosine MESH:D000241
1922 970-979 Chemical denotes Adenosine MESH:D000241
1923 1199-1211 Disease denotes HIF Hypoxia MESH:D000860
1924 2214-2228 Disease denotes Muscle Atrophy MESH:D009133
1925 2260-2279 Disease denotes TNF Tumor necrosis MESH:C536657