PMC:7601109 / 65133-65485 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T543","span":{"begin":42,"end":46},"obj":"Body_part"},{"id":"T544","span":{"begin":108,"end":115},"obj":"Body_part"}],"attributes":[{"id":"A543","pred":"fma_id","subj":"T543","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A544","pred":"fma_id","subj":"T544","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1045","span":{"begin":42,"end":46},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1046","span":{"begin":73,"end":83},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1047","span":{"begin":98,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1048","span":{"begin":258,"end":259},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T17126","span":{"begin":108,"end":115},"obj":"Chemical"}],"attributes":[{"id":"A87306","pred":"chebi_id","subj":"T17126","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T313","span":{"begin":42,"end":59},"obj":"http://purl.obolibrary.org/obo/GO_0007050"},{"id":"T314","span":{"begin":124,"end":128},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T315","span":{"begin":279,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_1903009"},{"id":"T316","span":{"begin":291,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T68","span":{"begin":173,"end":180},"obj":"Phenotype"}],"attributes":[{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0012418"}],"text":"The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T388","span":{"begin":0,"end":352},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1530","span":{"begin":87,"end":122},"obj":"Gene"},{"id":"1531","span":{"begin":173,"end":206},"obj":"Gene"},{"id":"1532","span":{"begin":306,"end":312},"obj":"Gene"},{"id":"1533","span":{"begin":341,"end":345},"obj":"Gene"},{"id":"1550","span":{"begin":53,"end":59},"obj":"Disease"}],"attributes":[{"id":"A1530","pred":"tao:has_database_id","subj":"1530","obj":"Gene:81649"},{"id":"A1531","pred":"tao:has_database_id","subj":"1531","obj":"Gene:29560"},{"id":"A1532","pred":"tao:has_database_id","subj":"1532","obj":"Gene:29560"},{"id":"A1533","pred":"tao:has_database_id","subj":"1533","obj":"Gene:24451"},{"id":"A1550","pred":"tao:has_database_id","subj":"1550","obj":"MESH:D006323"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The molecular mechanism involved inducing cell-cycle arrest in VSMCs via activation of p38mitogen-activated protein kinase (MAPK), which was associated with accumulation of hypoxia-inducible factor (HIF)-1α—mainly due to inhibition of HIF prolylhydroxylase, a key contributor to proteasomal degradation of HIF-1α—and subsequent induction of HO-1 [155]."}