PMC:7594251 / 72191-73084 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T509","span":{"begin":32,"end":33},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T510","span":{"begin":158,"end":165},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T511","span":{"begin":158,"end":165},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T512","span":{"begin":181,"end":182},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T513","span":{"begin":323,"end":324},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T514","span":{"begin":583,"end":584},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T515","span":{"begin":626,"end":627},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T516","span":{"begin":782,"end":783},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"PNMR depends on the presence of a group (called the paramagnetic center) with an unpaired electron [343], and since many naturally occurring biomolecules and organic compounds lack a paramagnetic center, one such as caged lanthanide (CLaNP) [344], must be introduced artificially [341]. Once the paramagnetic center (often a metal ion) is present, paramagnetic effects can be used to measure the distance and the relative orientation (i.e., angle) between molecules [345]. This information is crucial when it comes to determining how ligands and substrates bind. Thus, PNMR is quite a useful technique for drug discovery when a paramagnetic center is present. The most relevant consequence of PNMR for drug discovery is paramagnetic relaxation enhancement (PRE), although there are a number of studies demonstrating the use of pseudocontact shift (PCS) effect in drug discovery research [341]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T82904","span":{"begin":34,"end":39},"obj":"Chemical"},{"id":"T68158","span":{"begin":90,"end":98},"obj":"Chemical"},{"id":"T245","span":{"begin":158,"end":175},"obj":"Chemical"},{"id":"T85584","span":{"begin":222,"end":232},"obj":"Chemical"},{"id":"T42562","span":{"begin":331,"end":334},"obj":"Chemical"},{"id":"T60918","span":{"begin":456,"end":465},"obj":"Chemical"},{"id":"T47900","span":{"begin":534,"end":541},"obj":"Chemical"},{"id":"T99644","span":{"begin":606,"end":610},"obj":"Chemical"},{"id":"T64740","span":{"begin":702,"end":706},"obj":"Chemical"},{"id":"T92435","span":{"begin":863,"end":867},"obj":"Chemical"}],"attributes":[{"id":"A60225","pred":"chebi_id","subj":"T82904","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A83968","pred":"chebi_id","subj":"T68158","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A83059","pred":"chebi_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/CHEBI_50860"},{"id":"A31271","pred":"chebi_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/CHEBI_72695"},{"id":"A16606","pred":"chebi_id","subj":"T85584","obj":"http://purl.obolibrary.org/obo/CHEBI_33319"},{"id":"A51324","pred":"chebi_id","subj":"T42562","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A69265","pred":"chebi_id","subj":"T60918","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A25675","pred":"chebi_id","subj":"T47900","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A23042","pred":"chebi_id","subj":"T99644","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A36127","pred":"chebi_id","subj":"T64740","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A28756","pred":"chebi_id","subj":"T92435","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"PNMR depends on the presence of a group (called the paramagnetic center) with an unpaired electron [343], and since many naturally occurring biomolecules and organic compounds lack a paramagnetic center, one such as caged lanthanide (CLaNP) [344], must be introduced artificially [341]. Once the paramagnetic center (often a metal ion) is present, paramagnetic effects can be used to measure the distance and the relative orientation (i.e., angle) between molecules [345]. This information is crucial when it comes to determining how ligands and substrates bind. Thus, PNMR is quite a useful technique for drug discovery when a paramagnetic center is present. The most relevant consequence of PNMR for drug discovery is paramagnetic relaxation enhancement (PRE), although there are a number of studies demonstrating the use of pseudocontact shift (PCS) effect in drug discovery research [341]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"704","span":{"begin":222,"end":232},"obj":"Chemical"},{"id":"705","span":{"begin":325,"end":330},"obj":"Chemical"}],"attributes":[{"id":"A704","pred":"tao:has_database_id","subj":"704","obj":"MESH:D028581"},{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"MESH:D008670"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"PNMR depends on the presence of a group (called the paramagnetic center) with an unpaired electron [343], and since many naturally occurring biomolecules and organic compounds lack a paramagnetic center, one such as caged lanthanide (CLaNP) [344], must be introduced artificially [341]. Once the paramagnetic center (often a metal ion) is present, paramagnetic effects can be used to measure the distance and the relative orientation (i.e., angle) between molecules [345]. This information is crucial when it comes to determining how ligands and substrates bind. Thus, PNMR is quite a useful technique for drug discovery when a paramagnetic center is present. The most relevant consequence of PNMR for drug discovery is paramagnetic relaxation enhancement (PRE), although there are a number of studies demonstrating the use of pseudocontact shift (PCS) effect in drug discovery research [341]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T483","span":{"begin":0,"end":286},"obj":"Sentence"},{"id":"T484","span":{"begin":287,"end":472},"obj":"Sentence"},{"id":"T485","span":{"begin":473,"end":562},"obj":"Sentence"},{"id":"T486","span":{"begin":563,"end":659},"obj":"Sentence"},{"id":"T487","span":{"begin":660,"end":893},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"PNMR depends on the presence of a group (called the paramagnetic center) with an unpaired electron [343], and since many naturally occurring biomolecules and organic compounds lack a paramagnetic center, one such as caged lanthanide (CLaNP) [344], must be introduced artificially [341]. Once the paramagnetic center (often a metal ion) is present, paramagnetic effects can be used to measure the distance and the relative orientation (i.e., angle) between molecules [345]. This information is crucial when it comes to determining how ligands and substrates bind. Thus, PNMR is quite a useful technique for drug discovery when a paramagnetic center is present. The most relevant consequence of PNMR for drug discovery is paramagnetic relaxation enhancement (PRE), although there are a number of studies demonstrating the use of pseudocontact shift (PCS) effect in drug discovery research [341]."}