PMC:7556165 / 44952-45781
Annnotations
LitCovid-sample-MedDRA
Id | Subject | Object | Predicate | Lexical cue | meddra_id |
---|---|---|---|---|---|
T79 | 484-494 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | microscopy | http://purl.bioontology.org/ontology/MEDDRA/10069374 |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T154 | 198-205 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T155 | 767-775 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T200 | 6-16 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T201 | 6-10 | Species | denotes | SARS | NCBItxid:694009 |
T202 | 21-29 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T203 | 21-25 | Species | denotes | SARS | NCBItxid:694009 |
T204 | 97-107 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T205 | 97-101 | Species | denotes | SARS | NCBItxid:694009 |
T206 | 138-146 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T207 | 138-142 | Species | denotes | SARS | NCBItxid:694009 |
T208 | 148-156 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T209 | 148-152 | Species | denotes | SARS | NCBItxid:694009 |
T210 | 274-284 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T211 | 274-278 | Species | denotes | SARS | NCBItxid:694009 |
T212 | 331-339 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T213 | 331-335 | Species | denotes | SARS | NCBItxid:694009 |
T214 | 447-457 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T215 | 447-451 | Species | denotes | SARS | NCBItxid:694009 |
T216 | 503-513 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T217 | 503-507 | Species | denotes | SARS | NCBItxid:694009 |
T218 | 684-688 | Species | denotes | MERS | NCBItxid:1335626 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T276 | 0-147 | Sentence | denotes | Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. |
T277 | 148-224 | Sentence | denotes | SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). |
T278 | 225-364 | Sentence | denotes | Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). |
T279 | 365-495 | Sentence | denotes | Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. |
T280 | 496-699 | Sentence | denotes | Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). |
T281 | 700-829 | Sentence | denotes | Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner. |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
1217 | 569-573 | Gene | denotes | ACE2 | Gene:59272 |
1218 | 677-682 | Gene | denotes | hDPP4 | Gene:1803 |
1219 | 722-726 | Gene | denotes | ACE2 | Gene:59272 |
1220 | 780-784 | Gene | denotes | ACE2 | Gene:59272 |
1221 | 658-666 | Gene | denotes | membrane | Gene:43740571 |
1222 | 6-16 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1223 | 21-29 | Species | denotes | SARS-CoV | Tax:694009 |
1224 | 97-107 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1225 | 138-146 | Species | denotes | SARS-CoV | Tax:694009 |
1226 | 148-156 | Species | denotes | SARS-CoV | Tax:694009 |
1227 | 274-284 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1228 | 331-339 | Species | denotes | SARS-CoV | Tax:694009 |
1229 | 447-457 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1230 | 503-513 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1231 | 603-606 | CellLine | denotes | HEK | CVCL:M624 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T4971 | 125-128 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T4980 | 157-160 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T4989 | 196-205 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T5022 | 340-343 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5031 | 458-461 | Protein | denotes | RBD | https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022 |
T5040 | 569-573 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5041 | 603-606 | Protein | denotes | HEK | https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320 |
T5044 | 722-726 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T5045 | 780-784 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T185 | 45-49 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
T186 | 50-54 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T187 | 587-591 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T188 | 607-612 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T189 | 796-801 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T375 | 50-54 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T376 | 198-205 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T377 | 587-599 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
T378 | 587-591 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T379 | 607-612 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T380 | 767-775 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T381 | 796-801 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T181 | 6-16 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T182 | 6-10 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T183 | 21-29 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T184 | 21-25 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T185 | 97-107 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T186 | 97-101 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T187 | 138-146 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T188 | 138-142 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T189 | 148-156 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T190 | 148-152 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T191 | 274-284 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T192 | 274-278 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T193 | 331-339 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T194 | 331-335 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T195 | 447-457 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T196 | 447-451 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T197 | 503-513 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T198 | 503-507 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1217 | 569-573 | Gene | denotes | ACE2 | Gene:59272 |
1218 | 677-682 | Gene | denotes | hDPP4 | Gene:1803 |
1219 | 722-726 | Gene | denotes | ACE2 | Gene:59272 |
1220 | 780-784 | Gene | denotes | ACE2 | Gene:59272 |
1221 | 658-666 | Gene | denotes | membrane | Gene:43740571 |
1222 | 6-16 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1223 | 21-29 | Species | denotes | SARS-CoV | Tax:694009 |
1224 | 97-107 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1225 | 138-146 | Species | denotes | SARS-CoV | Tax:694009 |
1226 | 148-156 | Species | denotes | SARS-CoV | Tax:694009 |
1227 | 274-284 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1228 | 331-339 | Species | denotes | SARS-CoV | Tax:694009 |
1229 | 447-457 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1230 | 503-513 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1231 | 603-606 | CellLine | denotes | HEK | CVCL:M624 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T276 | 0-147 | Sentence | denotes | Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. |
T277 | 148-224 | Sentence | denotes | SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). |
T278 | 225-364 | Sentence | denotes | Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). |
T279 | 365-495 | Sentence | denotes | Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. |
T280 | 496-699 | Sentence | denotes | Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). |
T281 | 700-829 | Sentence | denotes | Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner. |