PMC:7556165 / 44952-45781 JSONTXT

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    LitCovid-sample-MedDRA

    {"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T79","span":{"begin":484,"end":494},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A79","pred":"meddra_id","subj":"T79","obj":"http://purl.bioontology.org/ontology/MEDDRA/10069374"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-CHEBI

    {"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T154","span":{"begin":198,"end":205},"obj":"Chemical"},{"id":"T155","span":{"begin":767,"end":775},"obj":"Chemical"}],"attributes":[{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-PD-NCBITaxon

    {"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T200","span":{"begin":6,"end":16},"obj":"Species"},{"id":"T201","span":{"begin":6,"end":10},"obj":"Species"},{"id":"T202","span":{"begin":21,"end":29},"obj":"Species"},{"id":"T203","span":{"begin":21,"end":25},"obj":"Species"},{"id":"T204","span":{"begin":97,"end":107},"obj":"Species"},{"id":"T205","span":{"begin":97,"end":101},"obj":"Species"},{"id":"T206","span":{"begin":138,"end":146},"obj":"Species"},{"id":"T207","span":{"begin":138,"end":142},"obj":"Species"},{"id":"T208","span":{"begin":148,"end":156},"obj":"Species"},{"id":"T209","span":{"begin":148,"end":152},"obj":"Species"},{"id":"T210","span":{"begin":274,"end":284},"obj":"Species"},{"id":"T211","span":{"begin":274,"end":278},"obj":"Species"},{"id":"T212","span":{"begin":331,"end":339},"obj":"Species"},{"id":"T213","span":{"begin":331,"end":335},"obj":"Species"},{"id":"T214","span":{"begin":447,"end":457},"obj":"Species"},{"id":"T215","span":{"begin":447,"end":451},"obj":"Species"},{"id":"T216","span":{"begin":503,"end":513},"obj":"Species"},{"id":"T217","span":{"begin":503,"end":507},"obj":"Species"},{"id":"T218","span":{"begin":684,"end":688},"obj":"Species"}],"attributes":[{"id":"A210","pred":"ncbi_taxonomy_id","subj":"T210","obj":"NCBItxid:2697049"},{"id":"A204","pred":"ncbi_taxonomy_id","subj":"T204","obj":"NCBItxid:2697049"},{"id":"A213","pred":"ncbi_taxonomy_id","subj":"T213","obj":"NCBItxid:694009"},{"id":"A216","pred":"ncbi_taxonomy_id","subj":"T216","obj":"NCBItxid:2697049"},{"id":"A215","pred":"ncbi_taxonomy_id","subj":"T215","obj":"NCBItxid:694009"},{"id":"A200","pred":"ncbi_taxonomy_id","subj":"T200","obj":"NCBItxid:2697049"},{"id":"A211","pred":"ncbi_taxonomy_id","subj":"T211","obj":"NCBItxid:694009"},{"id":"A218","pred":"ncbi_taxonomy_id","subj":"T218","obj":"NCBItxid:1335626"},{"id":"A202","pred":"ncbi_taxonomy_id","subj":"T202","obj":"NCBItxid:694009"},{"id":"A207","pred":"ncbi_taxonomy_id","subj":"T207","obj":"NCBItxid:694009"},{"id":"A201","pred":"ncbi_taxonomy_id","subj":"T201","obj":"NCBItxid:694009"},{"id":"A203","pred":"ncbi_taxonomy_id","subj":"T203","obj":"NCBItxid:694009"},{"id":"A205","pred":"ncbi_taxonomy_id","subj":"T205","obj":"NCBItxid:694009"},{"id":"A214","pred":"ncbi_taxonomy_id","subj":"T214","obj":"NCBItxid:2697049"},{"id":"A217","pred":"ncbi_taxonomy_id","subj":"T217","obj":"NCBItxid:694009"},{"id":"A209","pred":"ncbi_taxonomy_id","subj":"T209","obj":"NCBItxid:694009"},{"id":"A206","pred":"ncbi_taxonomy_id","subj":"T206","obj":"NCBItxid:694009"},{"id":"A208","pred":"ncbi_taxonomy_id","subj":"T208","obj":"NCBItxid:694009"},{"id":"A212","pred":"ncbi_taxonomy_id","subj":"T212","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-sentences

    {"project":"LitCovid-sample-sentences","denotations":[{"id":"T276","span":{"begin":0,"end":147},"obj":"Sentence"},{"id":"T277","span":{"begin":148,"end":224},"obj":"Sentence"},{"id":"T278","span":{"begin":225,"end":364},"obj":"Sentence"},{"id":"T279","span":{"begin":365,"end":495},"obj":"Sentence"},{"id":"T280","span":{"begin":496,"end":699},"obj":"Sentence"},{"id":"T281","span":{"begin":700,"end":829},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-Pubtator

    {"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1217","span":{"begin":569,"end":573},"obj":"Gene"},{"id":"1218","span":{"begin":677,"end":682},"obj":"Gene"},{"id":"1219","span":{"begin":722,"end":726},"obj":"Gene"},{"id":"1220","span":{"begin":780,"end":784},"obj":"Gene"},{"id":"1221","span":{"begin":658,"end":666},"obj":"Gene"},{"id":"1222","span":{"begin":6,"end":16},"obj":"Species"},{"id":"1223","span":{"begin":21,"end":29},"obj":"Species"},{"id":"1224","span":{"begin":97,"end":107},"obj":"Species"},{"id":"1225","span":{"begin":138,"end":146},"obj":"Species"},{"id":"1226","span":{"begin":148,"end":156},"obj":"Species"},{"id":"1227","span":{"begin":274,"end":284},"obj":"Species"},{"id":"1228","span":{"begin":331,"end":339},"obj":"Species"},{"id":"1229","span":{"begin":447,"end":457},"obj":"Species"},{"id":"1230","span":{"begin":503,"end":513},"obj":"Species"},{"id":"1231","span":{"begin":603,"end":606},"obj":"CellLine"}],"attributes":[{"id":"A1222","pred":"pubann:denotes","subj":"1222","obj":"Tax:2697049"},{"id":"A1220","pred":"pubann:denotes","subj":"1220","obj":"Gene:59272"},{"id":"A1225","pred":"pubann:denotes","subj":"1225","obj":"Tax:694009"},{"id":"A1227","pred":"pubann:denotes","subj":"1227","obj":"Tax:2697049"},{"id":"A1228","pred":"pubann:denotes","subj":"1228","obj":"Tax:694009"},{"id":"A1218","pred":"pubann:denotes","subj":"1218","obj":"Gene:1803"},{"id":"A1223","pred":"pubann:denotes","subj":"1223","obj":"Tax:694009"},{"id":"A1230","pred":"pubann:denotes","subj":"1230","obj":"Tax:2697049"},{"id":"A1229","pred":"pubann:denotes","subj":"1229","obj":"Tax:2697049"},{"id":"A1231","pred":"pubann:denotes","subj":"1231","obj":"CVCL:M624"},{"id":"A1219","pred":"pubann:denotes","subj":"1219","obj":"Gene:59272"},{"id":"A1217","pred":"pubann:denotes","subj":"1217","obj":"Gene:59272"},{"id":"A1226","pred":"pubann:denotes","subj":"1226","obj":"Tax:694009"},{"id":"A1221","pred":"pubann:denotes","subj":"1221","obj":"Gene:43740571"},{"id":"A1224","pred":"pubann:denotes","subj":"1224","obj":"Tax:2697049"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-UniProt

    {"project":"LitCovid-sample-UniProt","denotations":[{"id":"T4971","span":{"begin":125,"end":128},"obj":"Protein"},{"id":"T4980","span":{"begin":157,"end":160},"obj":"Protein"},{"id":"T4989","span":{"begin":196,"end":205},"obj":"Protein"},{"id":"T5022","span":{"begin":340,"end":343},"obj":"Protein"},{"id":"T5031","span":{"begin":458,"end":461},"obj":"Protein"},{"id":"T5040","span":{"begin":569,"end":573},"obj":"Protein"},{"id":"T5041","span":{"begin":603,"end":606},"obj":"Protein"},{"id":"T5044","span":{"begin":722,"end":726},"obj":"Protein"},{"id":"T5045","span":{"begin":780,"end":784},"obj":"Protein"}],"attributes":[{"id":"A4971","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A4972","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A4973","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A4974","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A4975","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A4976","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A4977","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A4978","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A4979","pred":"uniprot_id","subj":"T4971","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A4980","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A4981","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A4982","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A4983","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A4984","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A4985","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A4986","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A4987","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A4988","pred":"uniprot_id","subj":"T4980","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A4989","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9UIP0"},{"id":"A4990","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9UIN9"},{"id":"A4991","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9UIN8"},{"id":"A4992","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9UIN7"},{"id":"A4993","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9UIN6"},{"id":"A4994","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9UBH8"},{"id":"A4995","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NRH8"},{"id":"A4996","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NRH7"},{"id":"A4997","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NRH6"},{"id":"A4998","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NRH5"},{"id":"A4999","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NRH4"},{"id":"A5000","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NPG5"},{"id":"A5001","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NPE0"},{"id":"A5002","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q9NP52"},{"id":"A5003","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q95IF9"},{"id":"A5004","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q8N5P3"},{"id":"A5005","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q8IZU6"},{"id":"A5006","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q8IZU5"},{"id":"A5007","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q8IZU4"},{"id":"A5008","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q86Z04"},{"id":"A5009","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q7YR44"},{"id":"A5010","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q7LA71"},{"id":"A5011","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q7LA70"},{"id":"A5012","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q5STD2"},{"id":"A5013","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q5SQ85"},{"id":"A5014","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q1XI16"},{"id":"A5015","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q1XI12"},{"id":"A5016","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/Q15517"},{"id":"A5017","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/O43509"},{"id":"A5018","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/O19084"},{"id":"A5019","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/B0UYZ7"},{"id":"A5020","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/B0S7V2"},{"id":"A5021","pred":"uniprot_id","subj":"T4989","obj":"https://www.uniprot.org/uniprot/A5A6L9"},{"id":"A5022","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5023","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5024","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5025","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5026","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5027","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5028","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5029","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5030","pred":"uniprot_id","subj":"T5022","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5031","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5032","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5033","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5034","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5035","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5036","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5037","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5038","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5039","pred":"uniprot_id","subj":"T5031","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5040","pred":"uniprot_id","subj":"T5040","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5041","pred":"uniprot_id","subj":"T5041","obj":"https://www.uniprot.org/uniprot/Q9H2V4"},{"id":"A5042","pred":"uniprot_id","subj":"T5041","obj":"https://www.uniprot.org/uniprot/Q9H2V3"},{"id":"A5043","pred":"uniprot_id","subj":"T5041","obj":"https://www.uniprot.org/uniprot/P29320"},{"id":"A5044","pred":"uniprot_id","subj":"T5044","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5045","pred":"uniprot_id","subj":"T5045","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-PD-IDO

    {"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T185","span":{"begin":45,"end":49},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T186","span":{"begin":50,"end":54},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T187","span":{"begin":587,"end":591},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T188","span":{"begin":607,"end":612},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T189","span":{"begin":796,"end":801},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-PD-FMA

    {"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T375","span":{"begin":50,"end":54},"obj":"Body_part"},{"id":"T376","span":{"begin":198,"end":205},"obj":"Body_part"},{"id":"T377","span":{"begin":587,"end":599},"obj":"Body_part"},{"id":"T378","span":{"begin":587,"end":591},"obj":"Body_part"},{"id":"T379","span":{"begin":607,"end":612},"obj":"Body_part"},{"id":"T380","span":{"begin":767,"end":775},"obj":"Body_part"},{"id":"T381","span":{"begin":796,"end":801},"obj":"Body_part"}],"attributes":[{"id":"A379","pred":"fma_id","subj":"T379","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A378","pred":"fma_id","subj":"T378","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A380","pred":"fma_id","subj":"T380","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A375","pred":"fma_id","subj":"T375","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A376","pred":"fma_id","subj":"T376","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A377","pred":"fma_id","subj":"T377","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sample-PD-MONDO

    {"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T181","span":{"begin":6,"end":16},"obj":"Disease"},{"id":"T182","span":{"begin":6,"end":10},"obj":"Disease"},{"id":"T183","span":{"begin":21,"end":29},"obj":"Disease"},{"id":"T184","span":{"begin":21,"end":25},"obj":"Disease"},{"id":"T185","span":{"begin":97,"end":107},"obj":"Disease"},{"id":"T186","span":{"begin":97,"end":101},"obj":"Disease"},{"id":"T187","span":{"begin":138,"end":146},"obj":"Disease"},{"id":"T188","span":{"begin":138,"end":142},"obj":"Disease"},{"id":"T189","span":{"begin":148,"end":156},"obj":"Disease"},{"id":"T190","span":{"begin":148,"end":152},"obj":"Disease"},{"id":"T191","span":{"begin":274,"end":284},"obj":"Disease"},{"id":"T192","span":{"begin":274,"end":278},"obj":"Disease"},{"id":"T193","span":{"begin":331,"end":339},"obj":"Disease"},{"id":"T194","span":{"begin":331,"end":335},"obj":"Disease"},{"id":"T195","span":{"begin":447,"end":457},"obj":"Disease"},{"id":"T196","span":{"begin":447,"end":451},"obj":"Disease"},{"id":"T197","span":{"begin":503,"end":513},"obj":"Disease"},{"id":"T198","span":{"begin":503,"end":507},"obj":"Disease"}],"attributes":[{"id":"A188","pred":"mondo_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A184","pred":"mondo_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A181","pred":"mondo_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A186","pred":"mondo_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A198","pred":"mondo_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A185","pred":"mondo_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A195","pred":"mondo_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A187","pred":"mondo_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A193","pred":"mondo_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A182","pred":"mondo_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A183","pred":"mondo_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A192","pred":"mondo_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A189","pred":"mondo_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"1217","span":{"begin":569,"end":573},"obj":"Gene"},{"id":"1218","span":{"begin":677,"end":682},"obj":"Gene"},{"id":"1219","span":{"begin":722,"end":726},"obj":"Gene"},{"id":"1220","span":{"begin":780,"end":784},"obj":"Gene"},{"id":"1221","span":{"begin":658,"end":666},"obj":"Gene"},{"id":"1222","span":{"begin":6,"end":16},"obj":"Species"},{"id":"1223","span":{"begin":21,"end":29},"obj":"Species"},{"id":"1224","span":{"begin":97,"end":107},"obj":"Species"},{"id":"1225","span":{"begin":138,"end":146},"obj":"Species"},{"id":"1226","span":{"begin":148,"end":156},"obj":"Species"},{"id":"1227","span":{"begin":274,"end":284},"obj":"Species"},{"id":"1228","span":{"begin":331,"end":339},"obj":"Species"},{"id":"1229","span":{"begin":447,"end":457},"obj":"Species"},{"id":"1230","span":{"begin":503,"end":513},"obj":"Species"},{"id":"1231","span":{"begin":603,"end":606},"obj":"CellLine"}],"attributes":[{"id":"A1217","pred":"tao:has_database_id","subj":"1217","obj":"Gene:59272"},{"id":"A1218","pred":"tao:has_database_id","subj":"1218","obj":"Gene:1803"},{"id":"A1219","pred":"tao:has_database_id","subj":"1219","obj":"Gene:59272"},{"id":"A1220","pred":"tao:has_database_id","subj":"1220","obj":"Gene:59272"},{"id":"A1221","pred":"tao:has_database_id","subj":"1221","obj":"Gene:43740571"},{"id":"A1222","pred":"tao:has_database_id","subj":"1222","obj":"Tax:2697049"},{"id":"A1223","pred":"tao:has_database_id","subj":"1223","obj":"Tax:694009"},{"id":"A1224","pred":"tao:has_database_id","subj":"1224","obj":"Tax:2697049"},{"id":"A1225","pred":"tao:has_database_id","subj":"1225","obj":"Tax:694009"},{"id":"A1226","pred":"tao:has_database_id","subj":"1226","obj":"Tax:694009"},{"id":"A1227","pred":"tao:has_database_id","subj":"1227","obj":"Tax:2697049"},{"id":"A1228","pred":"tao:has_database_id","subj":"1228","obj":"Tax:694009"},{"id":"A1229","pred":"tao:has_database_id","subj":"1229","obj":"Tax:2697049"},{"id":"A1230","pred":"tao:has_database_id","subj":"1230","obj":"Tax:2697049"},{"id":"A1231","pred":"tao:has_database_id","subj":"1231","obj":"CVCL:M624"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T276","span":{"begin":0,"end":147},"obj":"Sentence"},{"id":"T277","span":{"begin":148,"end":224},"obj":"Sentence"},{"id":"T278","span":{"begin":225,"end":364},"obj":"Sentence"},{"id":"T279","span":{"begin":365,"end":495},"obj":"Sentence"},{"id":"T280","span":{"begin":496,"end":699},"obj":"Sentence"},{"id":"T281","span":{"begin":700,"end":829},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV. SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005). Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020). Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy. Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor). Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner."}