PMC:7546716 / 14475-15346 JSON TXT

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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T16","span":{"begin":281,"end":286},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Failure of lymphocytes to adequately respond to viral antigens and proapoptotic signals might induce dendritic cells to produce large amounts of the lymphocyte growth factors IL-7 and IL-2, thereby stimulating T-cell survival and expansion. High concentrations of IL-2 and IL-7 in serum are characteristic of severe COVID-19 cases.6, 9 However, IL-2 and IL-7 might amplify ILC2 survival and differentiation induced by IL-33,33 expand γδ T cells, which produce IL-17 through the signal transducer and activator of transcription (STAT)3,34 and enhance IL-33-induced pathologic expansion of T cells expressing GM-CSF through STAT5.35, 36 Patients infected with SARS-CoV-2 show an increase in circulating CD4+ γδ T cells that overexpress the IL-2 receptor CD25 but not PD-1, suggesting that these cells are not exhausted, but are specifically activated in response to IL-2.22"}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T92","span":{"begin":316,"end":324},"obj":"Disease"},{"id":"T93","span":{"begin":658,"end":666},"obj":"Disease"}],"attributes":[{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Failure of lymphocytes to adequately respond to viral antigens and proapoptotic signals might induce dendritic cells to produce large amounts of the lymphocyte growth factors IL-7 and IL-2, thereby stimulating T-cell survival and expansion. High concentrations of IL-2 and IL-7 in serum are characteristic of severe COVID-19 cases.6, 9 However, IL-2 and IL-7 might amplify ILC2 survival and differentiation induced by IL-33,33 expand γδ T cells, which produce IL-17 through the signal transducer and activator of transcription (STAT)3,34 and enhance IL-33-induced pathologic expansion of T cells expressing GM-CSF through STAT5.35, 36 Patients infected with SARS-CoV-2 show an increase in circulating CD4+ γδ T cells that overexpress the IL-2 receptor CD25 but not PD-1, suggesting that these cells are not exhausted, but are specifically activated in response to IL-2.22"}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T198","span":{"begin":80,"end":87},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T199","span":{"begin":101,"end":116},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T200","span":{"begin":184,"end":188},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T201","span":{"begin":210,"end":216},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T202","span":{"begin":264,"end":268},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T203","span":{"begin":345,"end":349},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T204","span":{"begin":437,"end":444},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T205","span":{"begin":478,"end":484},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T206","span":{"begin":500,"end":509},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T207","span":{"begin":588,"end":595},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T208","span":{"begin":632,"end":634},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T209","span":{"begin":701,"end":704},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T210","span":{"begin":709,"end":716},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T211","span":{"begin":738,"end":742},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T212","span":{"begin":752,"end":756},"obj":"http://purl.obolibrary.org/obo/PR_000001380"},{"id":"T213","span":{"begin":793,"end":798},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T214","span":{"begin":839,"end":848},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Failure of lymphocytes to adequately respond to viral antigens and proapoptotic signals might induce dendritic cells to produce large amounts of the lymphocyte growth factors IL-7 and IL-2, thereby stimulating T-cell survival and expansion. High concentrations of IL-2 and IL-7 in serum are characteristic of severe COVID-19 cases.6, 9 However, IL-2 and IL-7 might amplify ILC2 survival and differentiation induced by IL-33,33 expand γδ T cells, which produce IL-17 through the signal transducer and activator of transcription (STAT)3,34 and enhance IL-33-induced pathologic expansion of T cells expressing GM-CSF through STAT5.35, 36 Patients infected with SARS-CoV-2 show an increase in circulating CD4+ γδ T cells that overexpress the IL-2 receptor CD25 but not PD-1, suggesting that these cells are not exhausted, but are specifically activated in response to IL-2.22"}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T36","span":{"begin":160,"end":166},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T37","span":{"begin":513,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"Failure of lymphocytes to adequately respond to viral antigens and proapoptotic signals might induce dendritic cells to produce large amounts of the lymphocyte growth factors IL-7 and IL-2, thereby stimulating T-cell survival and expansion. High concentrations of IL-2 and IL-7 in serum are characteristic of severe COVID-19 cases.6, 9 However, IL-2 and IL-7 might amplify ILC2 survival and differentiation induced by IL-33,33 expand γδ T cells, which produce IL-17 through the signal transducer and activator of transcription (STAT)3,34 and enhance IL-33-induced pathologic expansion of T cells expressing GM-CSF through STAT5.35, 36 Patients infected with SARS-CoV-2 show an increase in circulating CD4+ γδ T cells that overexpress the IL-2 receptor CD25 but not PD-1, suggesting that these cells are not exhausted, but are specifically activated in response to IL-2.22"}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T68","span":{"begin":0,"end":240},"obj":"Sentence"},{"id":"T69","span":{"begin":241,"end":871},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Failure of lymphocytes to adequately respond to viral antigens and proapoptotic signals might induce dendritic cells to produce large amounts of the lymphocyte growth factors IL-7 and IL-2, thereby stimulating T-cell survival and expansion. High concentrations of IL-2 and IL-7 in serum are characteristic of severe COVID-19 cases.6, 9 However, IL-2 and IL-7 might amplify ILC2 survival and differentiation induced by IL-33,33 expand γδ T cells, which produce IL-17 through the signal transducer and activator of transcription (STAT)3,34 and enhance IL-33-induced pathologic expansion of T cells expressing GM-CSF through STAT5.35, 36 Patients infected with SARS-CoV-2 show an increase in circulating CD4+ γδ T cells that overexpress the IL-2 receptor CD25 but not PD-1, suggesting that these cells are not exhausted, but are specifically activated in response to IL-2.22"}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"601","span":{"begin":175,"end":179},"obj":"Gene"},{"id":"602","span":{"begin":184,"end":188},"obj":"Gene"},{"id":"603","span":{"begin":264,"end":268},"obj":"Gene"},{"id":"604","span":{"begin":273,"end":277},"obj":"Gene"},{"id":"605","span":{"begin":345,"end":349},"obj":"Gene"},{"id":"606","span":{"begin":354,"end":358},"obj":"Gene"},{"id":"607","span":{"begin":418,"end":423},"obj":"Gene"},{"id":"608","span":{"begin":460,"end":465},"obj":"Gene"},{"id":"609","span":{"begin":478,"end":534},"obj":"Gene"},{"id":"610","span":{"begin":550,"end":555},"obj":"Gene"},{"id":"611","span":{"begin":607,"end":613},"obj":"Gene"},{"id":"612","span":{"begin":622,"end":627},"obj":"Gene"},{"id":"613","span":{"begin":701,"end":704},"obj":"Gene"},{"id":"614","span":{"begin":738,"end":742},"obj":"Gene"},{"id":"615","span":{"begin":864,"end":868},"obj":"Gene"},{"id":"616","span":{"begin":635,"end":643},"obj":"Species"},{"id":"617","span":{"begin":658,"end":668},"obj":"Species"},{"id":"618","span":{"begin":316,"end":324},"obj":"Disease"},{"id":"619","span":{"begin":644,"end":652},"obj":"Disease"}],"attributes":[{"id":"A601","pred":"tao:has_database_id","subj":"601","obj":"Gene:3574"},{"id":"A602","pred":"tao:has_database_id","subj":"602","obj":"Gene:3558"},{"id":"A603","pred":"tao:has_database_id","subj":"603","obj":"Gene:3558"},{"id":"A604","pred":"tao:has_database_id","subj":"604","obj":"Gene:3574"},{"id":"A605","pred":"tao:has_database_id","subj":"605","obj":"Gene:3558"},{"id":"A606","pred":"tao:has_database_id","subj":"606","obj":"Gene:3574"},{"id":"A607","pred":"tao:has_database_id","subj":"607","obj":"Gene:90865"},{"id":"A608","pred":"tao:has_database_id","subj":"608","obj":"Gene:3605"},{"id":"A609","pred":"tao:has_database_id","subj":"609","obj":"Gene:6774"},{"id":"A610","pred":"tao:has_database_id","subj":"610","obj":"Gene:90865"},{"id":"A611","pred":"tao:has_database_id","subj":"611","obj":"Gene:1437"},{"id":"A612","pred":"tao:has_database_id","subj":"612","obj":"Gene:6776"},{"id":"A613","pred":"tao:has_database_id","subj":"613","obj":"Gene:920"},{"id":"A614","pred":"tao:has_database_id","subj":"614","obj":"Gene:3558"},{"id":"A615","pred":"tao:has_database_id","subj":"615","obj":"Gene:101055066"},{"id":"A616","pred":"tao:has_database_id","subj":"616","obj":"Tax:9606"},{"id":"A617","pred":"tao:has_database_id","subj":"617","obj":"Tax:2697049"},{"id":"A618","pred":"tao:has_database_id","subj":"618","obj":"MESH:C000657245"},{"id":"A619","pred":"tao:has_database_id","subj":"619","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Failure of lymphocytes to adequately respond to viral antigens and proapoptotic signals might induce dendritic cells to produce large amounts of the lymphocyte growth factors IL-7 and IL-2, thereby stimulating T-cell survival and expansion. High concentrations of IL-2 and IL-7 in serum are characteristic of severe COVID-19 cases.6, 9 However, IL-2 and IL-7 might amplify ILC2 survival and differentiation induced by IL-33,33 expand γδ T cells, which produce IL-17 through the signal transducer and activator of transcription (STAT)3,34 and enhance IL-33-induced pathologic expansion of T cells expressing GM-CSF through STAT5.35, 36 Patients infected with SARS-CoV-2 show an increase in circulating CD4+ γδ T cells that overexpress the IL-2 receptor CD25 but not PD-1, suggesting that these cells are not exhausted, but are specifically activated in response to IL-2.22"}

2_test

{"project":"2_test","denotations":[{"id":"33073244-31986264-66244553","span":{"begin":334,"end":335},"obj":"31986264"},{"id":"33073244-22425247-66244554","span":{"begin":424,"end":426},"obj":"22425247"},{"id":"33073244-23047700-66244555","span":{"begin":535,"end":537},"obj":"23047700"},{"id":"33073244-25412660-66244556","span":{"begin":628,"end":630},"obj":"25412660"},{"id":"33073244-30949175-66244557","span":{"begin":632,"end":634},"obj":"30949175"}],"text":"Failure of lymphocytes to adequately respond to viral antigens and proapoptotic signals might induce dendritic cells to produce large amounts of the lymphocyte growth factors IL-7 and IL-2, thereby stimulating T-cell survival and expansion. High concentrations of IL-2 and IL-7 in serum are characteristic of severe COVID-19 cases.6, 9 However, IL-2 and IL-7 might amplify ILC2 survival and differentiation induced by IL-33,33 expand γδ T cells, which produce IL-17 through the signal transducer and activator of transcription (STAT)3,34 and enhance IL-33-induced pathologic expansion of T cells expressing GM-CSF through STAT5.35, 36 Patients infected with SARS-CoV-2 show an increase in circulating CD4+ γδ T cells that overexpress the IL-2 receptor CD25 but not PD-1, suggesting that these cells are not exhausted, but are specifically activated in response to IL-2.22"}

PMC:7546716 / 14475-15346 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7546716 / 14475-15346 JSON TXT