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PMC:7534795 / 4703-8036 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T26828 319-328 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T62683 458-463 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T69623 527-540 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T2300 673-681 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T70564 996-1001 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T71556 1344-1357 Body_part denotes interleukin-1 http://purl.org/sig/ont/fma/fma86583
T41271 1381-1385 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T45585 1406-1413 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T90573 1461-1469 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T84940 1586-1597 Body_part denotes Granulocyte http://purl.org/sig/ont/fma/fma62854
T2963 1598-1608 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T89453 1639-1642 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T80835 1660-1663 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T16035 1710-1721 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T75061 1785-1788 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T35610 1836-1839 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T79976 1865-1874 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T70672 1914-1922 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T41412 2012-2021 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T31184 2645-2650 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T42589 3038-3059 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T72751 3061-3063 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T4655 3245-3256 Body_part denotes fatty acids http://purl.org/sig/ont/fma/fma82738

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 458-463 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T16 996-1001 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T17 2645-2650 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T44 94-102 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T45 274-282 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T46 373-387 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T47 406-427 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T48 429-443 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T49 445-472 Disease denotes hypertensive heart diseases http://purl.obolibrary.org/obo/MONDO_0001302
T50 478-500 Disease denotes pulmonary hypertension http://purl.obolibrary.org/obo/MONDO_0005149
T51 488-500 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T52 942-950 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T53 1033-1039 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T54 1724-1732 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T55 2038-2046 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T56 2341-2349 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T57 2490-2498 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T58 2584-2596 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T59 2598-2613 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T60 2625-2637 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T61 2645-2658 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T62 2668-2680 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T63 2686-2705 Disease denotes myocardial ischemia http://purl.obolibrary.org/obo/MONDO_0024644
T64 2697-2705 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T65 3124-3136 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T20269 390-393 http://purl.obolibrary.org/obo/CLO_0051582 denotes Has
T32303 458-463 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T86034 458-463 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T68915 458-463 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T41295 458-463 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T78016 527-540 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T85990 996-1001 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T15304 1196-1205 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T98618 1344-1357 http://purl.obolibrary.org/obo/PR_000001091 denotes interleukin-1
T66694 1370-1371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23727 1673-1674 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5199 1697-1706 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T73249 2645-2650 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T2074 2645-2650 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T35465 2645-2650 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T11230 2645-2650 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T35 186-195 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T38 186-193 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T39 319-328 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T40 561-563 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T42 594-596 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T44 621-623 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T46 701-703 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T48 841-851 Chemical denotes etanercept http://purl.obolibrary.org/obo/CHEBI_4875
T49 1085-1095 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T50 1111-1122 Chemical denotes tofacitinib http://purl.obolibrary.org/obo/CHEBI_71200
T51 1191-1193 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T53 1381-1383 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T55 1395-1405 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T56 1406-1413 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T57 1636-1638 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T58 1657-1659 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T59 1782-1784 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T60 1833-1835 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T61 2228-2239 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T62 2376-2392 Chemical denotes N-acetylcysteine http://purl.obolibrary.org/obo/CHEBI_28939
T63 2378-2392 Chemical denotes acetylcysteine http://purl.obolibrary.org/obo/CHEBI_22198
T64 2394-2397 Chemical denotes NAC http://purl.obolibrary.org/obo/CHEBI_28939|http://purl.obolibrary.org/obo/CHEBI_7421
T66 2406-2413 Chemical denotes oxidant http://purl.obolibrary.org/obo/CHEBI_63248
T67 2450-2453 Chemical denotes NAC http://purl.obolibrary.org/obo/CHEBI_28939|http://purl.obolibrary.org/obo/CHEBI_7421
T69 2469-2477 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T70 2563-2566 Chemical denotes NAC http://purl.obolibrary.org/obo/CHEBI_28939|http://purl.obolibrary.org/obo/CHEBI_7421
T72 2729-2731 Chemical denotes La http://purl.obolibrary.org/obo/CHEBI_33336
T73 2798-2805 Chemical denotes epoxide http://purl.obolibrary.org/obo/CHEBI_32955
T74 2822-2832 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T75 2835-2860 Chemical denotes Epoxyeicosatrienoic acids http://purl.obolibrary.org/obo/CHEBI_64007
T76 2855-2860 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T77 2862-2866 Chemical denotes EETs http://purl.obolibrary.org/obo/CHEBI_64007
T78 3007-3017 Chemical denotes eicosanoid http://purl.obolibrary.org/obo/CHEBI_23899
T79 3200-3202 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T80 3222-3232 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T81 3237-3256 Chemical denotes omega-3 fatty acids http://purl.obolibrary.org/obo/CHEBI_25681
T82 3245-3256 Chemical denotes fatty acids http://purl.obolibrary.org/obo/CHEBI_35366
T83 3251-3256 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4456 1196-1205 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T38785 1697-1706 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T79378 2625-2637 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T50858 2668-2680 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T54320 2817-2820 http://purl.obolibrary.org/obo/GO_0033885 denotes sEH
T86858 2969-2972 http://purl.obolibrary.org/obo/GO_0033885 denotes sEH
T99650 3124-3136 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T10292 3218-3221 http://purl.obolibrary.org/obo/GO_0033885 denotes sEH

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T25 0-112 Sentence denotes Table 1 Overview of some proposed pharmacological agents with potential beneficial effects in COVID-19 patients.
T26 113-162 Sentence denotes Pharmacological intervention Conclusion Reference
T27 163-318 Sentence denotes Antioxidants including Vitamin C and E • Antioxidant effects may ameliorate cardiac injuries of critically ill COVID-19 patients (Wang, Zhang, & Bai, 2020)
T28 319-387 Sentence denotes Melatonin • May have preventive effect against septic cardiomyopathy
T29 388-521 Sentence denotes • Has benefits in myocardial infarction, cardiomyopathy, hypertensive heart diseases, and pulmonary hypertension (Zhang et al., 2020)
T30 522-804 Sentence denotes Anti-interleukin-6 • Tocilizumab (anti-IL-6 receptor), siltuximab (anti-IL-6), and sirukumab (anti-IL-6) are proposed as possible treatments to manage cytokine storm and elevated IL-6 levels (Akhmerov & Marban, 2020; Hendren, Drazner, Bozkurt, & Cooper Jr., 2020; Rizk et al., 2020)
T31 805-1065 Sentence denotes Anti-TNFα • Infliximab, adalimumab, etanercept, golimumab, certolizumab as TNFα neutralizing therapies suggested as potential agents for COVID-19 hyperinflammatory state which may ameliorate organ damage including acute cardiac injury (Convertino et al., 2020)
T32 1066-1338 Sentence denotes Janus kinase (JAK) inhibitors • Ruxolitinib, tofacitinib, baricitinib are proposed to be beneficial in controlling excessive IL-6 signaling through STAT-1 and STAT-3 pathways (Alijotas-Reig et al., 2020; Convertino et al., 2020; Richardson et al., 2020; Rizk et al., 2020)
T33 1339-1585 Sentence denotes Anti-interleukin-1 • Anakinra, a modified IL-1 receptor antagonist protein, is suggested to have therapeutic potential in cytokine storm, given its effectiveness on patient survival in severe sepsis (Alijotas-Reig et al., 2020; Rizk et al., 2020)
T34 1586-1721 Sentence denotes Granulocyte-macrophage-colony stimulating factor (GM-CSF) inhibition • GM-CSF can play a pro-inflammatory role signaling to macrophages
T35 1722-1795 Sentence denotes • COVID-19 patients have been demonstrated to have elevated GM-CSF levels
T36 1796-1948 Sentence denotes • Literature proposes that targeting GM-CSF upstream of inflammatory cytokines ex. gimsilumab, may be useful to blunt cytokine storm (Rizk et al., 2020)
T37 1949-2181 Sentence denotes Statins • Anti-inflammatory properties, including reduction in cytokines, may benefit in COVID-19 hyperinflammatory states in addition to their conventional cardioprotective properties (Alijotas-Reig et al., 2020; Rizk et al., 2020)
T38 2182-2375 Sentence denotes ACEi/ARBs • Proposed that treatment with RAAS antagonists may theoretically be beneficial by upregulating ACE2 and compensating for ACE2 receptors lost due to COVID-19 (Akhmerov & Marban, 2020)
T39 2376-2541 Sentence denotes N-acetylcysteine (NAC) • Anti-oxidant and anti-inflammatory properties of NAC proposed as an adjuvant therapy for COVID-19 and secondary cardiovascular complications
T40 2542-2773 Sentence denotes • Suggested role for NAC in prevention of hypertension, atherosclerosis-associated inflammation, acute heart failure, thrombo-inflammation, and myocardial ischemia (De Flora, Balansky, & La Maestra, 2020; Guglielmetti et al., 2020)
T41 2774-2925 Sentence denotes Eicosanoids and soluble epoxide hydrolase (sEH) inhibitors • Epoxyeicosatrienoic acids (EETs) are cardioprotective, anti-inflammatory and pro-resolving
T42 2926-3071 Sentence denotes • Inhibition of their metabolizing enzyme, sEH, may be beneficial by maintaining eicosanoid levels and reducing endoplasmic reticulum (ER) stress
T43 3072-3197 Sentence denotes • Potential to limit inflammatory storm and resolve inflammation in addition to their established cardioprotective properties
T44 3198-3333 Sentence denotes • Co-treatment with sEH inhibitors and omega-3 fatty acids may provide synergistic effects (Hammock, Wang, Gilligan, & Panigrahy, 2020)

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T18 373-387 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T19 406-427 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T20 429-443 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T21 488-500 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T22 673-687 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T23 1461-1475 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T24 1531-1537 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T25 1914-1928 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T26 2584-2596 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T27 2598-2613 Phenotype denotes atherosclerosis http://purl.obolibrary.org/obo/HP_0002621
T28 2645-2658 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635

2_test

Id Subject Object Predicate Lexical cue
33031856-32321655-84038801 313-317 32321655 denotes 2020
33031856-32252591-84038802 733-737 32252591 denotes 2020
33031856-32297796-84038803 780-784 32297796 denotes 2020
33031856-32696108-84038804 799-803 32696108 denotes 2020
33031856-32527304-84038805 1060-1064 32527304 denotes 2020
33031856-32527304-84038806 1289-1293 32527304 denotes 2020
33031856-32032529-84038807 1314-1318 32032529 denotes 2020
33031856-32696108-84038808 1333-1337 32696108 denotes 2020
33031856-32696108-84038809 1580-1584 32696108 denotes 2020
33031856-32696108-84038810 1943-1947 32696108 denotes 2020
33031856-32696108-84038811 1580-1584 32696108 denotes 2020
33031856-32252591-84038812 2370-2374 32252591 denotes 2020
33031856-32560665-84038813 2768-2772 32560665 denotes 2020
33031856-32650004-84038814 3328-3332 32650004 denotes 2020

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
156 527-540 Gene denotes interleukin-6 Gene:3569
157 594-598 Gene denotes IL-6 Gene:3569
158 621-625 Gene denotes IL-6 Gene:3569
159 701-705 Gene denotes IL-6 Gene:3569
160 810-814 Gene denotes TNFα Gene:7124
161 880-884 Gene denotes TNFα Gene:7124
162 1191-1195 Gene denotes IL-6 Gene:3569
163 1214-1220 Gene denotes STAT-1 Gene:6772
164 1225-1231 Gene denotes STAT-3 Gene:6774
165 1381-1405 Gene denotes IL-1 receptor antagonist Gene:3557
166 1586-1634 Gene denotes Granulocyte-macrophage-colony stimulating factor Gene:1437
167 1636-1642 Gene denotes GM-CSF Gene:1437
168 1782-1788 Gene denotes GM-CSF Gene:1437
169 1833-1839 Gene denotes GM-CSF Gene:1437
176 1344-1357 Gene denotes interleukin-1 Gene:3552
177 283-291 Species denotes patients Tax:9606
178 1504-1511 Species denotes patient Tax:9606
179 1733-1741 Species denotes patients Tax:9606
180 1657-1663 Gene denotes GM-CSF Gene:1437
181 186-195 Chemical denotes Vitamin C MESH:D001205
182 319-328 Chemical denotes Melatonin MESH:D008550
183 239-255 Disease denotes cardiac injuries MESH:D006331
184 259-273 Disease denotes critically ill MESH:D016638
185 274-282 Disease denotes COVID-19 MESH:C000657245
186 366-387 Disease denotes septic cardiomyopathy MESH:D009202
187 406-427 Disease denotes myocardial infarction MESH:D009203
188 429-443 Disease denotes cardiomyopathy MESH:D009202
189 445-472 Disease denotes hypertensive heart diseases MESH:D006973
190 478-500 Disease denotes pulmonary hypertension MESH:D006976
191 942-950 Disease denotes COVID-19 MESH:C000657245
192 1025-1071 Disease denotes cardiac injury (Convertino et al., 2020) Janus MESH:D006331
193 1531-1537 Disease denotes sepsis MESH:D018805
194 1710-1732 Disease denotes macrophages • COVID-19 MESH:C000657245
195 1879-1889 Disease denotes gimsilumab
208 103-111 Species denotes patients Tax:9606
209 94-102 Disease denotes COVID-19 MESH:C000657245