PMC:7463108 / 55482-59484 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"Using a primary human brain microvascular endothelial cell (BMEC) and astrocyte co-culture model, Mahajan et al. (2008) were among the first to demonstrate that co-exposure to morphine and HIV-1 Tat resulted in greater increases in TNF-α and IL-8 levels and decreases in barrier tightness (measured by TEER) than either morphine or Tat alone. Morphine and Tat co-exposure also additively increased JAM-2, while zonula occludens-1 (ZO-1) levels were decreased by morphine or by Tat individually, and occludin protein levels were decreased by morphine alone but not Tat (Mahajan et al. 2008). Using the inducible Tat transgenic mouse model, Leibrand et al. (2019), also demonstrated that HIV-1 Tat and morphine act independently to disrupt BBB integrity. In these studies, morphine, and to a lesser extent Tat, exposure increased the leakage of fluorescently labeled dextrans from the circulation into the brain (Leibrand et al. 2017, 2019) (Fig. 3). Morphine exposure decreased the penetration of select ARVs in the brain, in a region-specific manner (Leibrand et al. 2019) (Fig. 3). Morphine exposure also resulted in increased expression and function of the drug efflux transport protein, P-gp, suggesting a mechanism by which morphine decreased the ARV concentrations (Leibrand et al. 2019). This finding suggests that morphine exposure could impact the efficient delivery of any therapeutic drug that is a substrate of P-gp into the CNS. Future research should also investigate morphine’s impact on other drug transport proteins important for ARV delivery to the brain.\nFig. 3 Effects of HIV-1 Tat and morphine on BBB leakiness and on antiretroviral brain concentrations. After 14 days of Tat induction, there was a significant increase in the 10 kDa (Cascade Blue®) tracer leakage into the brain in Tat + placebo as compared to Tat − placebo mice (*p \u003c 0.05) and in Tat − mouse brains upon exposure to morphine as compared to Tat − placebo mice (*p \u003c 0.05) (a). There was a significant main effect of morphine, resulting in reduced integrity of the BBB and increased leakage of the higher molecular weight (40 kDa and 70 kDa) tracers in morphine-exposed groups as compared to the those groups (Tat + and Tat − together) not exposed to morphine (placebo) (#p \u003c 0.05; significant main effect of morphine) (b, c). Data represent the fold change in mean fluorescence intensity ± SEM; n = 8 Tat−/placebo, n = 6 Tat+/placebo, n = 9 Tat−/morphine, and n = 7 Tat+/morphine mice. Additionally, morphine exposure increased horseradish peroxidase (HRP) extravasation from the vasculature into the perivascular space and/or parenchyma in the striatum (d, e). HRP antigenicity was detected by indirect immunofluorescence (red) in tissue sections counterstained with Hoechst 33342 (blue) to reveal cell nuclei and visualized by differential interference contrast (DIC)-enhanced confocal microscopy. HRP extravasation into the striatal perivascular space/parenchyma was especially prevalent in morphine-exposed mice (arrowheads; left-hand panels in e versus d). The dotted lines (············) indicate the approximate edge of the capillaries/post-capillary venules; while intermittent dotted lines (· · · · · · ·) indicate the approximate edge of a partly sectioned blood vessel that appears partially outside the plane of section. The asterisks (*) indicate white matter tracts within the striatum. Representative samples from ≥ n = 4 mice per group. All images are the same magnification. Scale bar = 10 μm. Antiretroviral tissue-to-plasma ratios in striatum (f–g). Irrespective of Tat exposure, morphine significantly reduced the levels of dolutegravir (f) and abacavir (g), but not lamivudine (h), within the striatum, as compared to placebo. (* p \u003c 0.05; main effect for morphine). Data represent the tissue-to-plasma ratios ± SEM sampled from n = 9 Tat−/placebo, n = 9 Tat+/placebo, n = 6 Tat−/morphine, and n = 8 Tat+/morphine mice. (a–h) Modified and reprinted with permission from Leibrand et al. (2019)","divisions":[{"label":"label","span":{"begin":1573,"end":1579}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T541","span":{"begin":22,"end":27},"obj":"Body_part"},{"id":"T542","span":{"begin":42,"end":58},"obj":"Body_part"},{"id":"T543","span":{"begin":54,"end":58},"obj":"Body_part"},{"id":"T544","span":{"begin":70,"end":79},"obj":"Body_part"},{"id":"T545","span":{"begin":189,"end":192},"obj":"Body_part"},{"id":"T546","span":{"begin":411,"end":427},"obj":"Body_part"},{"id":"T547","span":{"begin":508,"end":515},"obj":"Body_part"},{"id":"T548","span":{"begin":686,"end":689},"obj":"Body_part"},{"id":"T549","span":{"begin":904,"end":909},"obj":"Body_part"},{"id":"T550","span":{"begin":1015,"end":1020},"obj":"Body_part"},{"id":"T551","span":{"begin":1181,"end":1188},"obj":"Body_part"},{"id":"T552","span":{"begin":1436,"end":1439},"obj":"Body_part"},{"id":"T553","span":{"begin":1523,"end":1531},"obj":"Body_part"},{"id":"T554","span":{"begin":1566,"end":1571},"obj":"Body_part"},{"id":"T555","span":{"begin":1591,"end":1594},"obj":"Body_part"},{"id":"T556","span":{"begin":1653,"end":1658},"obj":"Body_part"},{"id":"T557","span":{"begin":1794,"end":1799},"obj":"Body_part"},{"id":"T558","span":{"begin":2569,"end":2580},"obj":"Body_part"},{"id":"T559","span":{"begin":2590,"end":2608},"obj":"Body_part"},{"id":"T561","span":{"begin":2616,"end":2626},"obj":"Body_part"},{"id":"T562","span":{"begin":2634,"end":2642},"obj":"Body_part"},{"id":"T563","span":{"begin":2721,"end":2727},"obj":"Body_part"},{"id":"T564","span":{"begin":2788,"end":2792},"obj":"Body_part"},{"id":"T565","span":{"begin":2925,"end":2943},"obj":"Body_part"},{"id":"T567","span":{"begin":2944,"end":2954},"obj":"Body_part"},{"id":"T568","span":{"begin":3018,"end":3027},"obj":"Body_part"},{"id":"T569","span":{"begin":3120,"end":3131},"obj":"Body_part"},{"id":"T570","span":{"begin":3132,"end":3154},"obj":"Body_part"},{"id":"T571","span":{"begin":3137,"end":3146},"obj":"Body_part"},{"id":"T572","span":{"begin":3256,"end":3268},"obj":"Body_part"},{"id":"T573","span":{"begin":3349,"end":3361},"obj":"Body_part"},{"id":"T574","span":{"begin":3380,"end":3388},"obj":"Body_part"},{"id":"T575","span":{"begin":3515,"end":3521},"obj":"Body_part"},{"id":"T576","span":{"begin":3525,"end":3531},"obj":"Body_part"},{"id":"T577","span":{"begin":3542,"end":3550},"obj":"Body_part"},{"id":"T578","span":{"begin":3703,"end":3711},"obj":"Body_part"},{"id":"T579","span":{"begin":3796,"end":3802},"obj":"Body_part"},{"id":"T580","span":{"begin":3806,"end":3812},"obj":"Body_part"}],"attributes":[{"id":"A541","pred":"fma_id","subj":"T541","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A542","pred":"fma_id","subj":"T542","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A543","pred":"fma_id","subj":"T543","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A544","pred":"fma_id","subj":"T544","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A545","pred":"fma_id","subj":"T545","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A546","pred":"fma_id","subj":"T546","obj":"http://purl.org/sig/ont/fma/fma67397"},{"id":"A547","pred":"fma_id","subj":"T547","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A548","pred":"fma_id","subj":"T548","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A549","pred":"fma_id","subj":"T549","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A550","pred":"fma_id","subj":"T550","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A551","pred":"fma_id","subj":"T551","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A552","pred":"fma_id","subj":"T552","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A553","pred":"fma_id","subj":"T553","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A554","pred":"fma_id","subj":"T554","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A555","pred":"fma_id","subj":"T555","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A556","pred":"fma_id","subj":"T556","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A557","pred":"fma_id","subj":"T557","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A558","pred":"fma_id","subj":"T558","obj":"http://purl.org/sig/ont/fma/fma69050"},{"id":"A559","pred":"fma_id","subj":"T559","obj":"http://purl.org/sig/ont/fma/fma323243"},{"id":"A560","pred":"fma_id","subj":"T559","obj":"http://purl.org/sig/ont/fma/fma323272"},{"id":"A561","pred":"fma_id","subj":"T561","obj":"http://purl.org/sig/ont/fma/fma45732"},{"id":"A562","pred":"fma_id","subj":"T562","obj":"http://purl.org/sig/ont/fma/fma77618"},{"id":"A563","pred":"fma_id","subj":"T563","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A564","pred":"fma_id","subj":"T564","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A565","pred":"fma_id","subj":"T565","obj":"http://purl.org/sig/ont/fma/fma323243"},{"id":"A566","pred":"fma_id","subj":"T565","obj":"http://purl.org/sig/ont/fma/fma323272"},{"id":"A567","pred":"fma_id","subj":"T567","obj":"http://purl.org/sig/ont/fma/fma45732"},{"id":"A568","pred":"fma_id","subj":"T568","obj":"http://purl.org/sig/ont/fma/fma9714"},{"id":"A569","pred":"fma_id","subj":"T569","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A570","pred":"fma_id","subj":"T570","obj":"http://purl.org/sig/ont/fma/fma63191"},{"id":"A571","pred":"fma_id","subj":"T571","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A572","pred":"fma_id","subj":"T572","obj":"http://purl.org/sig/ont/fma/fma63183"},{"id":"A573","pred":"fma_id","subj":"T573","obj":"http://purl.org/sig/ont/fma/fma83929"},{"id":"A574","pred":"fma_id","subj":"T574","obj":"http://purl.org/sig/ont/fma/fma77618"},{"id":"A575","pred":"fma_id","subj":"T575","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A576","pred":"fma_id","subj":"T576","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A577","pred":"fma_id","subj":"T577","obj":"http://purl.org/sig/ont/fma/fma77618"},{"id":"A578","pred":"fma_id","subj":"T578","obj":"http://purl.org/sig/ont/fma/fma77618"},{"id":"A579","pred":"fma_id","subj":"T579","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A580","pred":"fma_id","subj":"T580","obj":"http://purl.org/sig/ont/fma/fma62970"},{"subj":"T541","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T542","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T543","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T544","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T545","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T546","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T547","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T548","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T549","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T550","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T551","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T552","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T553","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T554","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T555","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T556","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T557","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T558","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T559","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T561","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T562","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T563","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T564","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T565","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T567","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T568","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T569","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T570","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T571","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T572","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T573","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T574","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T575","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T576","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T577","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T578","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T579","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T580","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T105","span":{"begin":22,"end":27},"obj":"Body_part"},{"id":"T106","span":{"begin":904,"end":909},"obj":"Body_part"},{"id":"T107","span":{"begin":1015,"end":1020},"obj":"Body_part"},{"id":"T108","span":{"begin":1436,"end":1439},"obj":"Body_part"},{"id":"T109","span":{"begin":1566,"end":1571},"obj":"Body_part"},{"id":"T110","span":{"begin":1653,"end":1658},"obj":"Body_part"},{"id":"T111","span":{"begin":1794,"end":1799},"obj":"Body_part"},{"id":"T112","span":{"begin":2569,"end":2580},"obj":"Body_part"},{"id":"T113","span":{"begin":2590,"end":2608},"obj":"Body_part"},{"id":"T114","span":{"begin":2616,"end":2626},"obj":"Body_part"},{"id":"T115","span":{"begin":2634,"end":2642},"obj":"Body_part"},{"id":"T116","span":{"begin":2721,"end":2727},"obj":"Body_part"},{"id":"T117","span":{"begin":2925,"end":2943},"obj":"Body_part"},{"id":"T118","span":{"begin":2944,"end":2954},"obj":"Body_part"},{"id":"T119","span":{"begin":3023,"end":3027},"obj":"Body_part"},{"id":"T120","span":{"begin":3132,"end":3154},"obj":"Body_part"},{"id":"T121","span":{"begin":3137,"end":3146},"obj":"Body_part"},{"id":"T122","span":{"begin":3256,"end":3268},"obj":"Body_part"},{"id":"T123","span":{"begin":3256,"end":3261},"obj":"Body_part"},{"id":"T124","span":{"begin":3262,"end":3268},"obj":"Body_part"},{"id":"T125","span":{"begin":3349,"end":3361},"obj":"Body_part"},{"id":"T126","span":{"begin":3380,"end":3388},"obj":"Body_part"},{"id":"T127","span":{"begin":3481,"end":3486},"obj":"Body_part"},{"id":"T128","span":{"begin":3515,"end":3521},"obj":"Body_part"},{"id":"T129","span":{"begin":3542,"end":3550},"obj":"Body_part"},{"id":"T130","span":{"begin":3703,"end":3711},"obj":"Body_part"},{"id":"T131","span":{"begin":3796,"end":3802},"obj":"Body_part"}],"attributes":[{"id":"A105","pred":"uberon_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A106","pred":"uberon_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A107","pred":"uberon_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A108","pred":"uberon_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A109","pred":"uberon_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A110","pred":"uberon_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A111","pred":"uberon_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A112","pred":"uberon_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/UBERON_0002049"},{"id":"A113","pred":"uberon_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/UBERON_0014930"},{"id":"A114","pred":"uberon_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/UBERON_0000353"},{"id":"A115","pred":"uberon_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/UBERON_0002435"},{"id":"A116","pred":"uberon_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A117","pred":"uberon_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/UBERON_0014930"},{"id":"A118","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0000353"},{"id":"A119","pred":"uberon_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A120","pred":"uberon_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/UBERON_0035428"},{"id":"A121","pred":"uberon_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"},{"id":"A122","pred":"uberon_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/UBERON_0001981"},{"id":"A123","pred":"uberon_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A124","pred":"uberon_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"},{"id":"A125","pred":"uberon_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/UBERON_0002316"},{"id":"A126","pred":"uberon_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/UBERON_0002435"},{"id":"A127","pred":"uberon_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A128","pred":"uberon_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A129","pred":"uberon_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/UBERON_0002435"},{"id":"A130","pred":"uberon_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/UBERON_0002435"},{"id":"A131","pred":"uberon_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T624","span":{"begin":6,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T625","span":{"begin":16,"end":21},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T626","span":{"begin":22,"end":27},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T627","span":{"begin":22,"end":27},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T628","span":{"begin":42,"end":58},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T629","span":{"begin":70,"end":79},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T630","span":{"begin":242,"end":246},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T631","span":{"begin":626,"end":631},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T632","span":{"begin":788,"end":789},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T633","span":{"begin":857,"end":864},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T634","span":{"begin":904,"end":909},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T635","span":{"begin":904,"end":909},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T636","span":{"begin":1015,"end":1020},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T637","span":{"begin":1015,"end":1020},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T638","span":{"begin":1025,"end":1026},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T639","span":{"begin":1207,"end":1208},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T640","span":{"begin":1407,"end":1408},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T641","span":{"begin":1436,"end":1439},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T642","span":{"begin":1436,"end":1439},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T643","span":{"begin":1436,"end":1439},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T644","span":{"begin":1566,"end":1571},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T645","span":{"begin":1566,"end":1571},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T646","span":{"begin":1653,"end":1658},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T647","span":{"begin":1653,"end":1658},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T648","span":{"begin":1717,"end":1718},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T649","span":{"begin":1794,"end":1799},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T650","span":{"begin":1794,"end":1799},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T651","span":{"begin":1876,"end":1881},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T652","span":{"begin":1882,"end":1888},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T653","span":{"begin":1882,"end":1888},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T654","span":{"begin":1962,"end":1963},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T655","span":{"begin":1976,"end":1977},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T656","span":{"begin":2308,"end":2309},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T657","span":{"begin":2788,"end":2792},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T658","span":{"begin":3237,"end":3238},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T659","span":{"begin":3256,"end":3268},"obj":"http://purl.obolibrary.org/obo/UBERON_0001981"},{"id":"T660","span":{"begin":3256,"end":3268},"obj":"http://www.ebi.ac.uk/efo/EFO_0000817"},{"id":"T661","span":{"begin":3525,"end":3531},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T662","span":{"begin":3806,"end":3812},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T663","span":{"begin":3931,"end":3932},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T624","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T625","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T626","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T627","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T628","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T629","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T630","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T631","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T632","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T633","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T634","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T635","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T636","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T637","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T638","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T639","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T640","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T641","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T642","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T643","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T644","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T645","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T646","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T647","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T648","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T649","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T650","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T651","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T652","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T653","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T654","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T655","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T656","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T657","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T658","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T659","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T660","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T661","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T662","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T663","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T97693","span":{"begin":176,"end":184},"obj":"Chemical"},{"id":"T99","span":{"begin":242,"end":244},"obj":"Chemical"},{"id":"T101","span":{"begin":320,"end":328},"obj":"Chemical"},{"id":"T34792","span":{"begin":343,"end":351},"obj":"Chemical"},{"id":"T104","span":{"begin":462,"end":470},"obj":"Chemical"},{"id":"T7399","span":{"begin":508,"end":515},"obj":"Chemical"},{"id":"T80740","span":{"begin":541,"end":549},"obj":"Chemical"},{"id":"T4988","span":{"begin":700,"end":708},"obj":"Chemical"},{"id":"T91450","span":{"begin":771,"end":779},"obj":"Chemical"},{"id":"T19298","span":{"begin":865,"end":873},"obj":"Chemical"},{"id":"T94726","span":{"begin":949,"end":957},"obj":"Chemical"},{"id":"T77966","span":{"begin":1083,"end":1091},"obj":"Chemical"},{"id":"T99250","span":{"begin":1159,"end":1163},"obj":"Chemical"},{"id":"T76004","span":{"begin":1181,"end":1188},"obj":"Chemical"},{"id":"T118","span":{"begin":1228,"end":1236},"obj":"Chemical"},{"id":"T75473","span":{"begin":1321,"end":1329},"obj":"Chemical"},{"id":"T72889","span":{"begin":1394,"end":1398},"obj":"Chemical"},{"id":"T123","span":{"begin":1508,"end":1512},"obj":"Chemical"},{"id":"T54933","span":{"begin":1523,"end":1531},"obj":"Chemical"},{"id":"T125","span":{"begin":1605,"end":1613},"obj":"Chemical"},{"id":"T127","span":{"begin":1770,"end":1776},"obj":"Chemical"},{"id":"T88715","span":{"begin":1906,"end":1914},"obj":"Chemical"},{"id":"T13546","span":{"begin":2005,"end":2013},"obj":"Chemical"},{"id":"T66413","span":{"begin":2141,"end":2149},"obj":"Chemical"},{"id":"T134","span":{"begin":2239,"end":2247},"obj":"Chemical"},{"id":"T136","span":{"begin":2297,"end":2305},"obj":"Chemical"},{"id":"T138","span":{"begin":2435,"end":2443},"obj":"Chemical"},{"id":"T81225","span":{"begin":2460,"end":2468},"obj":"Chemical"},{"id":"T142","span":{"begin":2489,"end":2497},"obj":"Chemical"},{"id":"T37279","span":{"begin":2757,"end":2770},"obj":"Chemical"},{"id":"T79767","span":{"begin":2793,"end":2799},"obj":"Chemical"},{"id":"T42686","span":{"begin":2854,"end":2857},"obj":"Chemical"},{"id":"T5674","span":{"begin":2983,"end":2991},"obj":"Chemical"},{"id":"T61069","span":{"begin":3435,"end":3440},"obj":"Chemical"},{"id":"T21571","span":{"begin":3588,"end":3596},"obj":"Chemical"},{"id":"T2284","span":{"begin":3633,"end":3645},"obj":"Chemical"},{"id":"T19714","span":{"begin":3654,"end":3662},"obj":"Chemical"},{"id":"T29469","span":{"begin":3676,"end":3686},"obj":"Chemical"},{"id":"T20462","span":{"begin":3766,"end":3774},"obj":"Chemical"},{"id":"T49655","span":{"begin":3890,"end":3898},"obj":"Chemical"},{"id":"T84615","span":{"begin":3915,"end":3923},"obj":"Chemical"}],"attributes":[{"id":"A38195","pred":"chebi_id","subj":"T97693","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A53971","pred":"chebi_id","subj":"T97693","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A37373","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A61173","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A96115","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A72202","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A89423","pred":"chebi_id","subj":"T34792","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A69280","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A56490","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A98915","pred":"chebi_id","subj":"T7399","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A21814","pred":"chebi_id","subj":"T80740","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A42116","pred":"chebi_id","subj":"T80740","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A11993","pred":"chebi_id","subj":"T4988","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A5245","pred":"chebi_id","subj":"T4988","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A10802","pred":"chebi_id","subj":"T91450","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A65067","pred":"chebi_id","subj":"T91450","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A73065","pred":"chebi_id","subj":"T19298","obj":"http://purl.obolibrary.org/obo/CHEBI_52071"},{"id":"A61163","pred":"chebi_id","subj":"T94726","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A98559","pred":"chebi_id","subj":"T77966","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A19256","pred":"chebi_id","subj":"T99250","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A77958","pred":"chebi_id","subj":"T76004","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A85570","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A35303","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A34139","pred":"chebi_id","subj":"T75473","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A16899","pred":"chebi_id","subj":"T75473","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A88320","pred":"chebi_id","subj":"T72889","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A38545","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A74094","pred":"chebi_id","subj":"T54933","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A61765","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A18126","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A3144","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_35204"},{"id":"A85374","pred":"chebi_id","subj":"T88715","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A26676","pred":"chebi_id","subj":"T88715","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A70234","pred":"chebi_id","subj":"T13546","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A37139","pred":"chebi_id","subj":"T13546","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A22628","pred":"chebi_id","subj":"T66413","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A17632","pred":"chebi_id","subj":"T66413","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A84844","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A17360","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A56304","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A71082","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A99779","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A84107","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A84725","pred":"chebi_id","subj":"T81225","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A80183","pred":"chebi_id","subj":"T81225","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A98790","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A35227","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A7526","pred":"chebi_id","subj":"T37279","obj":"http://purl.obolibrary.org/obo/CHEBI_51232"},{"id":"A42867","pred":"chebi_id","subj":"T79767","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A87035","pred":"chebi_id","subj":"T42686","obj":"http://purl.obolibrary.org/obo/CHEBI_4305"},{"id":"A5274","pred":"chebi_id","subj":"T42686","obj":"http://purl.obolibrary.org/obo/CHEBI_53092"},{"id":"A60892","pred":"chebi_id","subj":"T5674","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A31272","pred":"chebi_id","subj":"T5674","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A16366","pred":"chebi_id","subj":"T61069","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A29484","pred":"chebi_id","subj":"T21571","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A51910","pred":"chebi_id","subj":"T21571","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A15366","pred":"chebi_id","subj":"T2284","obj":"http://purl.obolibrary.org/obo/CHEBI_76010"},{"id":"A41394","pred":"chebi_id","subj":"T19714","obj":"http://purl.obolibrary.org/obo/CHEBI_421707"},{"id":"A71493","pred":"chebi_id","subj":"T29469","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A86130","pred":"chebi_id","subj":"T20462","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A84077","pred":"chebi_id","subj":"T20462","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A1389","pred":"chebi_id","subj":"T49655","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A10097","pred":"chebi_id","subj":"T49655","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A71289","pred":"chebi_id","subj":"T84615","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A89092","pred":"chebi_id","subj":"T84615","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"subj":"T97693","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34792","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7399","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T80740","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4988","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T91450","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19298","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T94726","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T77966","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T99250","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T76004","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T75473","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T72889","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54933","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T88715","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13546","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T66413","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T81225","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37279","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T79767","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42686","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5674","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T61069","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T21571","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2284","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19714","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T29469","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T20462","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T49655","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T84615","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2041","span":{"begin":1692,"end":1695},"obj":"Gene"},{"id":"2042","span":{"begin":1803,"end":1806},"obj":"Gene"},{"id":"2043","span":{"begin":1832,"end":1835},"obj":"Gene"},{"id":"2044","span":{"begin":1930,"end":1933},"obj":"Gene"},{"id":"2045","span":{"begin":2198,"end":2201},"obj":"Gene"},{"id":"2046","span":{"begin":2208,"end":2211},"obj":"Gene"},{"id":"2047","span":{"begin":2390,"end":2393},"obj":"Gene"},{"id":"2048","span":{"begin":2410,"end":2413},"obj":"Gene"},{"id":"2049","span":{"begin":2430,"end":2433},"obj":"Gene"},{"id":"2050","span":{"begin":2455,"end":2458},"obj":"Gene"},{"id":"2051","span":{"begin":3574,"end":3577},"obj":"Gene"},{"id":"2052","span":{"begin":3845,"end":3848},"obj":"Gene"},{"id":"2053","span":{"begin":3865,"end":3868},"obj":"Gene"},{"id":"2054","span":{"begin":3885,"end":3888},"obj":"Gene"},{"id":"2055","span":{"begin":3910,"end":3913},"obj":"Gene"},{"id":"2056","span":{"begin":1597,"end":1600},"obj":"Gene"},{"id":"2057","span":{"begin":1870,"end":1873},"obj":"Gene"},{"id":"2058","span":{"begin":1591,"end":1596},"obj":"Species"},{"id":"2059","span":{"begin":1846,"end":1850},"obj":"Species"},{"id":"2060","span":{"begin":1876,"end":1881},"obj":"Species"},{"id":"2061","span":{"begin":1944,"end":1948},"obj":"Species"},{"id":"2062","span":{"begin":2469,"end":2473},"obj":"Species"},{"id":"2063","span":{"begin":2517,"end":2528},"obj":"Species"},{"id":"2064","span":{"begin":3000,"end":3004},"obj":"Species"},{"id":"2065","span":{"begin":3426,"end":3430},"obj":"Species"},{"id":"2066","span":{"begin":3924,"end":3928},"obj":"Species"},{"id":"2067","span":{"begin":1605,"end":1613},"obj":"Chemical"},{"id":"2068","span":{"begin":1906,"end":1914},"obj":"Chemical"},{"id":"2069","span":{"begin":2005,"end":2013},"obj":"Chemical"},{"id":"2070","span":{"begin":2141,"end":2149},"obj":"Chemical"},{"id":"2071","span":{"begin":2239,"end":2247},"obj":"Chemical"},{"id":"2072","span":{"begin":2297,"end":2305},"obj":"Chemical"},{"id":"2073","span":{"begin":2435,"end":2443},"obj":"Chemical"},{"id":"2074","span":{"begin":2460,"end":2468},"obj":"Chemical"},{"id":"2075","span":{"begin":2489,"end":2497},"obj":"Chemical"},{"id":"2076","span":{"begin":2757,"end":2770},"obj":"Chemical"},{"id":"2077","span":{"begin":2983,"end":2991},"obj":"Chemical"},{"id":"2078","span":{"begin":3588,"end":3596},"obj":"Chemical"},{"id":"2079","span":{"begin":3633,"end":3645},"obj":"Chemical"},{"id":"2080","span":{"begin":3654,"end":3662},"obj":"Chemical"},{"id":"2081","span":{"begin":3676,"end":3686},"obj":"Chemical"},{"id":"2082","span":{"begin":3766,"end":3774},"obj":"Chemical"},{"id":"2083","span":{"begin":3890,"end":3898},"obj":"Chemical"},{"id":"2084","span":{"begin":3915,"end":3923},"obj":"Chemical"},{"id":"2085","span":{"begin":1621,"end":1630},"obj":"Disease"},{"id":"2121","span":{"begin":195,"end":198},"obj":"Gene"},{"id":"2122","span":{"begin":232,"end":237},"obj":"Gene"},{"id":"2123","span":{"begin":242,"end":246},"obj":"Gene"},{"id":"2124","span":{"begin":332,"end":335},"obj":"Gene"},{"id":"2125","span":{"begin":356,"end":359},"obj":"Gene"},{"id":"2126","span":{"begin":398,"end":403},"obj":"Gene"},{"id":"2127","span":{"begin":431,"end":435},"obj":"Gene"},{"id":"2128","span":{"begin":477,"end":480},"obj":"Gene"},{"id":"2129","span":{"begin":499,"end":507},"obj":"Gene"},{"id":"2130","span":{"begin":564,"end":567},"obj":"Gene"},{"id":"2131","span":{"begin":692,"end":695},"obj":"Gene"},{"id":"2132","span":{"begin":804,"end":807},"obj":"Gene"},{"id":"2133","span":{"begin":1190,"end":1194},"obj":"Gene"},{"id":"2134","span":{"begin":1422,"end":1426},"obj":"Gene"},{"id":"2135","span":{"begin":611,"end":614},"obj":"Gene"},{"id":"2136","span":{"begin":16,"end":21},"obj":"Species"},{"id":"2137","span":{"begin":189,"end":194},"obj":"Species"},{"id":"2138","span":{"begin":626,"end":631},"obj":"Species"},{"id":"2139","span":{"begin":686,"end":691},"obj":"Species"},{"id":"2140","span":{"begin":615,"end":625},"obj":"Species"},{"id":"2141","span":{"begin":176,"end":184},"obj":"Chemical"},{"id":"2142","span":{"begin":320,"end":328},"obj":"Chemical"},{"id":"2143","span":{"begin":343,"end":351},"obj":"Chemical"},{"id":"2144","span":{"begin":462,"end":470},"obj":"Chemical"},{"id":"2145","span":{"begin":541,"end":549},"obj":"Chemical"},{"id":"2146","span":{"begin":700,"end":708},"obj":"Chemical"},{"id":"2147","span":{"begin":771,"end":779},"obj":"Chemical"},{"id":"2148","span":{"begin":865,"end":873},"obj":"Chemical"},{"id":"2149","span":{"begin":949,"end":957},"obj":"Chemical"},{"id":"2150","span":{"begin":1083,"end":1091},"obj":"Chemical"},{"id":"2151","span":{"begin":1228,"end":1236},"obj":"Chemical"},{"id":"2152","span":{"begin":1321,"end":1329},"obj":"Chemical"},{"id":"2153","span":{"begin":1481,"end":1489},"obj":"Chemical"},{"id":"2154","span":{"begin":279,"end":288},"obj":"Disease"},{"id":"2155","span":{"begin":1003,"end":1007},"obj":"Disease"}],"attributes":[{"id":"A2041","pred":"tao:has_database_id","subj":"2041","obj":"Gene:234724"},{"id":"A2042","pred":"tao:has_database_id","subj":"2042","obj":"Gene:234724"},{"id":"A2043","pred":"tao:has_database_id","subj":"2043","obj":"Gene:234724"},{"id":"A2044","pred":"tao:has_database_id","subj":"2044","obj":"Gene:234724"},{"id":"A2045","pred":"tao:has_database_id","subj":"2045","obj":"Gene:234724"},{"id":"A2046","pred":"tao:has_database_id","subj":"2046","obj":"Gene:234724"},{"id":"A2047","pred":"tao:has_database_id","subj":"2047","obj":"Gene:234724"},{"id":"A2048","pred":"tao:has_database_id","subj":"2048","obj":"Gene:234724"},{"id":"A2049","pred":"tao:has_database_id","subj":"2049","obj":"Gene:234724"},{"id":"A2050","pred":"tao:has_database_id","subj":"2050","obj":"Gene:234724"},{"id":"A2051","pred":"tao:has_database_id","subj":"2051","obj":"Gene:234724"},{"id":"A2052","pred":"tao:has_database_id","subj":"2052","obj":"Gene:234724"},{"id":"A2053","pred":"tao:has_database_id","subj":"2053","obj":"Gene:234724"},{"id":"A2054","pred":"tao:has_database_id","subj":"2054","obj":"Gene:234724"},{"id":"A2055","pred":"tao:has_database_id","subj":"2055","obj":"Gene:234724"},{"id":"A2056","pred":"tao:has_database_id","subj":"2056","obj":"Gene:6898"},{"id":"A2057","pred":"tao:has_database_id","subj":"2057","obj":"Gene:234724"},{"id":"A2058","pred":"tao:has_database_id","subj":"2058","obj":"Tax:11676"},{"id":"A2059","pred":"tao:has_database_id","subj":"2059","obj":"Tax:10090"},{"id":"A2060","pred":"tao:has_database_id","subj":"2060","obj":"Tax:10090"},{"id":"A2061","pred":"tao:has_database_id","subj":"2061","obj":"Tax:10090"},{"id":"A2062","pred":"tao:has_database_id","subj":"2062","obj":"Tax:10090"},{"id":"A2063","pred":"tao:has_database_id","subj":"2063","obj":"Tax:3704"},{"id":"A2064","pred":"tao:has_database_id","subj":"2064","obj":"Tax:10090"},{"id":"A2065","pred":"tao:has_database_id","subj":"2065","obj":"Tax:10090"},{"id":"A2066","pred":"tao:has_database_id","subj":"2066","obj":"Tax:10090"},{"id":"A2067","pred":"tao:has_database_id","subj":"2067","obj":"MESH:D009020"},{"id":"A2068","pred":"tao:has_database_id","subj":"2068","obj":"MESH:D009020"},{"id":"A2069","pred":"tao:has_database_id","subj":"2069","obj":"MESH:D009020"},{"id":"A2070","pred":"tao:has_database_id","subj":"2070","obj":"MESH:D009020"},{"id":"A2071","pred":"tao:has_database_id","subj":"2071","obj":"MESH:D009020"},{"id":"A2072","pred":"tao:has_database_id","subj":"2072","obj":"MESH:D009020"},{"id":"A2073","pred":"tao:has_database_id","subj":"2073","obj":"MESH:D009020"},{"id":"A2074","pred":"tao:has_database_id","subj":"2074","obj":"MESH:D009020"},{"id":"A2075","pred":"tao:has_database_id","subj":"2075","obj":"MESH:D009020"},{"id":"A2076","pred":"tao:has_database_id","subj":"2076","obj":"MESH:C017807"},{"id":"A2077","pred":"tao:has_database_id","subj":"2077","obj":"MESH:D009020"},{"id":"A2078","pred":"tao:has_database_id","subj":"2078","obj":"MESH:D009020"},{"id":"A2079","pred":"tao:has_database_id","subj":"2079","obj":"MESH:C562325"},{"id":"A2080","pred":"tao:has_database_id","subj":"2080","obj":"MESH:C106538"},{"id":"A2081","pred":"tao:has_database_id","subj":"2081","obj":"MESH:D019259"},{"id":"A2082","pred":"tao:has_database_id","subj":"2082","obj":"MESH:D009020"},{"id":"A2083","pred":"tao:has_database_id","subj":"2083","obj":"MESH:D009020"},{"id":"A2084","pred":"tao:has_database_id","subj":"2084","obj":"MESH:D009020"},{"id":"A2085","pred":"tao:has_database_id","subj":"2085","obj":"MESH:C535298"},{"id":"A2121","pred":"tao:has_database_id","subj":"2121","obj":"Gene:6898"},{"id":"A2122","pred":"tao:has_database_id","subj":"2122","obj":"Gene:7124"},{"id":"A2123","pred":"tao:has_database_id","subj":"2123","obj":"Gene:3576"},{"id":"A2124","pred":"tao:has_database_id","subj":"2124","obj":"Gene:6898"},{"id":"A2125","pred":"tao:has_database_id","subj":"2125","obj":"Gene:6898"},{"id":"A2126","pred":"tao:has_database_id","subj":"2126","obj":"Gene:58494"},{"id":"A2127","pred":"tao:has_database_id","subj":"2127","obj":"Gene:7082"},{"id":"A2128","pred":"tao:has_database_id","subj":"2128","obj":"Gene:6898"},{"id":"A2129","pred":"tao:has_database_id","subj":"2129","obj":"Gene:100506658"},{"id":"A2130","pred":"tao:has_database_id","subj":"2130","obj":"Gene:6898"},{"id":"A2131","pred":"tao:has_database_id","subj":"2131","obj":"Gene:6898"},{"id":"A2132","pred":"tao:has_database_id","subj":"2132","obj":"Gene:6898"},{"id":"A2133","pred":"tao:has_database_id","subj":"2133","obj":"Gene:5243"},{"id":"A2134","pred":"tao:has_database_id","subj":"2134","obj":"Gene:5243"},{"id":"A2135","pred":"tao:has_database_id","subj":"2135","obj":"Gene:234724"},{"id":"A2136","pred":"tao:has_database_id","subj":"2136","obj":"Tax:9606"},{"id":"A2137","pred":"tao:has_database_id","subj":"2137","obj":"Tax:11676"},{"id":"A2138","pred":"tao:has_database_id","subj":"2138","obj":"Tax:10090"},{"id":"A2139","pred":"tao:has_database_id","subj":"2139","obj":"Tax:11676"},{"id":"A2140","pred":"tao:has_database_id","subj":"2140","obj":"Tax:10090"},{"id":"A2141","pred":"tao:has_database_id","subj":"2141","obj":"MESH:D009020"},{"id":"A2142","pred":"tao:has_database_id","subj":"2142","obj":"MESH:D009020"},{"id":"A2143","pred":"tao:has_database_id","subj":"2143","obj":"MESH:D009020"},{"id":"A2144","pred":"tao:has_database_id","subj":"2144","obj":"MESH:D009020"},{"id":"A2145","pred":"tao:has_database_id","subj":"2145","obj":"MESH:D009020"},{"id":"A2146","pred":"tao:has_database_id","subj":"2146","obj":"MESH:D009020"},{"id":"A2147","pred":"tao:has_database_id","subj":"2147","obj":"MESH:D009020"},{"id":"A2148","pred":"tao:has_database_id","subj":"2148","obj":"MESH:D003911"},{"id":"A2149","pred":"tao:has_database_id","subj":"2149","obj":"MESH:D009020"},{"id":"A2150","pred":"tao:has_database_id","subj":"2150","obj":"MESH:D009020"},{"id":"A2151","pred":"tao:has_database_id","subj":"2151","obj":"MESH:D009020"},{"id":"A2152","pred":"tao:has_database_id","subj":"2152","obj":"MESH:D009020"},{"id":"A2153","pred":"tao:has_database_id","subj":"2153","obj":"MESH:D009020"},{"id":"A2154","pred":"tao:has_database_id","subj":"2154","obj":"MESH:C536920"},{"subj":"2041","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2042","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2043","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2044","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2045","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2046","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2047","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2048","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2049","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2050","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2051","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2052","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2053","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2054","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2055","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2056","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2057","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2058","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2059","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2060","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2061","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2062","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2063","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2064","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2065","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2066","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2067","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2068","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2069","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2070","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2071","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2072","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2073","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2074","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2075","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2076","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2077","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2078","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2079","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2080","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2081","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2082","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2083","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2084","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2085","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2121","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2122","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2123","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2124","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2125","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2126","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2127","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2128","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2129","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2130","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2131","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2132","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2133","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2134","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2135","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2136","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2137","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2138","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2140","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2151","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2152","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2153","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2154","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2155","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T101","span":{"begin":1164,"end":1170},"obj":"http://purl.obolibrary.org/obo/GO_0140352"},{"id":"T102","span":{"begin":1164,"end":1170},"obj":"http://purl.obolibrary.org/obo/GO_0140115"},{"id":"T103","span":{"begin":1171,"end":1180},"obj":"http://purl.obolibrary.org/obo/GO_0006810"},{"id":"T104","span":{"begin":1508,"end":1522},"obj":"http://purl.obolibrary.org/obo/GO_0015893"},{"id":"T105","span":{"begin":1513,"end":1522},"obj":"http://purl.obolibrary.org/obo/GO_0006810"},{"id":"T106","span":{"begin":2517,"end":2545},"obj":"http://purl.obolibrary.org/obo/GO_0004601"}],"attributes":[{"subj":"T101","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T779","span":{"begin":0,"end":342},"obj":"Sentence"},{"id":"T780","span":{"begin":343,"end":583},"obj":"Sentence"},{"id":"T781","span":{"begin":584,"end":590},"obj":"Sentence"},{"id":"T782","span":{"begin":591,"end":752},"obj":"Sentence"},{"id":"T783","span":{"begin":753,"end":926},"obj":"Sentence"},{"id":"T784","span":{"begin":927,"end":948},"obj":"Sentence"},{"id":"T785","span":{"begin":949,"end":1066},"obj":"Sentence"},{"id":"T786","span":{"begin":1067,"end":1082},"obj":"Sentence"},{"id":"T787","span":{"begin":1083,"end":1286},"obj":"Sentence"},{"id":"T788","span":{"begin":1287,"end":1293},"obj":"Sentence"},{"id":"T789","span":{"begin":1294,"end":1440},"obj":"Sentence"},{"id":"T790","span":{"begin":1441,"end":1572},"obj":"Sentence"},{"id":"T791","span":{"begin":1573,"end":1674},"obj":"Sentence"},{"id":"T792","span":{"begin":1675,"end":1965},"obj":"Sentence"},{"id":"T793","span":{"begin":1966,"end":2314},"obj":"Sentence"},{"id":"T794","span":{"begin":2315,"end":2474},"obj":"Sentence"},{"id":"T795","span":{"begin":2475,"end":2650},"obj":"Sentence"},{"id":"T796","span":{"begin":2651,"end":2888},"obj":"Sentence"},{"id":"T797","span":{"begin":2889,"end":3050},"obj":"Sentence"},{"id":"T798","span":{"begin":3051,"end":3321},"obj":"Sentence"},{"id":"T799","span":{"begin":3322,"end":3389},"obj":"Sentence"},{"id":"T800","span":{"begin":3390,"end":3441},"obj":"Sentence"},{"id":"T801","span":{"begin":3442,"end":3480},"obj":"Sentence"},{"id":"T802","span":{"begin":3481,"end":3499},"obj":"Sentence"},{"id":"T803","span":{"begin":3500,"end":3557},"obj":"Sentence"},{"id":"T804","span":{"begin":3558,"end":3776},"obj":"Sentence"},{"id":"T805","span":{"begin":3777,"end":4002},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T779","pred":"source","obj":"LitCovid-sentences"},{"subj":"T780","pred":"source","obj":"LitCovid-sentences"},{"subj":"T781","pred":"source","obj":"LitCovid-sentences"},{"subj":"T782","pred":"source","obj":"LitCovid-sentences"},{"subj":"T783","pred":"source","obj":"LitCovid-sentences"},{"subj":"T784","pred":"source","obj":"LitCovid-sentences"},{"subj":"T785","pred":"source","obj":"LitCovid-sentences"},{"subj":"T786","pred":"source","obj":"LitCovid-sentences"},{"subj":"T787","pred":"source","obj":"LitCovid-sentences"},{"subj":"T788","pred":"source","obj":"LitCovid-sentences"},{"subj":"T789","pred":"source","obj":"LitCovid-sentences"},{"subj":"T790","pred":"source","obj":"LitCovid-sentences"},{"subj":"T791","pred":"source","obj":"LitCovid-sentences"},{"subj":"T792","pred":"source","obj":"LitCovid-sentences"},{"subj":"T793","pred":"source","obj":"LitCovid-sentences"},{"subj":"T794","pred":"source","obj":"LitCovid-sentences"},{"subj":"T795","pred":"source","obj":"LitCovid-sentences"},{"subj":"T796","pred":"source","obj":"LitCovid-sentences"},{"subj":"T797","pred":"source","obj":"LitCovid-sentences"},{"subj":"T798","pred":"source","obj":"LitCovid-sentences"},{"subj":"T799","pred":"source","obj":"LitCovid-sentences"},{"subj":"T800","pred":"source","obj":"LitCovid-sentences"},{"subj":"T801","pred":"source","obj":"LitCovid-sentences"},{"subj":"T802","pred":"source","obj":"LitCovid-sentences"},{"subj":"T803","pred":"source","obj":"LitCovid-sentences"},{"subj":"T804","pred":"source","obj":"LitCovid-sentences"},{"subj":"T805","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T46","span":{"begin":2590,"end":2608},"obj":"Phenotype"},{"id":"T47","span":{"begin":2925,"end":2943},"obj":"Phenotype"}],"attributes":[{"id":"A46","pred":"hp_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/HP_0012520"},{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0012520"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"2_test","denotations":[{"id":"32876803-28057474-62958122","span":{"begin":927,"end":931},"obj":"28057474"}],"attributes":[{"subj":"32876803-28057474-62958122","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9aec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93b4"},{"id":"LitCovid-PD-CLO","color":"#93ceec"},{"id":"LitCovid-PD-CHEBI","color":"#e8ec93"},{"id":"LitCovid-PubTator","color":"#d593ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecbb"},{"id":"LitCovid-sentences","color":"#eca193"},{"id":"LitCovid-PD-HP","color":"#939eec"},{"id":"2_test","color":"#b8ec93"}]}]}}