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PMC:7463108 / 55482-59484 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T541 22-27 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T542 42-58 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T543 54-58 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T544 70-79 Body_part denotes astrocyte http://purl.org/sig/ont/fma/fma54537
T545 189-192 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T546 411-427 Body_part denotes zonula occludens http://purl.org/sig/ont/fma/fma67397
T547 508-515 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T548 686-689 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T549 904-909 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T550 1015-1020 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T551 1181-1188 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T552 1436-1439 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T553 1523-1531 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T554 1566-1571 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T555 1591-1594 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T556 1653-1658 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T557 1794-1799 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T558 2569-2580 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T559 2590-2608 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T561 2616-2626 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T562 2634-2642 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T563 2721-2727 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T564 2788-2792 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T565 2925-2943 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T567 2944-2954 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T568 3018-3027 Body_part denotes left-hand http://purl.org/sig/ont/fma/fma9714
T569 3120-3131 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T570 3132-3154 Body_part denotes post-capillary venules http://purl.org/sig/ont/fma/fma63191
T571 3137-3146 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T572 3256-3268 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T573 3349-3361 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T574 3380-3388 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T575 3515-3521 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T576 3525-3531 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T577 3542-3550 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T578 3703-3711 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T579 3796-3802 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T580 3806-3812 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T105 22-27 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T106 904-909 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T107 1015-1020 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T108 1436-1439 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T109 1566-1571 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T110 1653-1658 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T111 1794-1799 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T112 2569-2580 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T113 2590-2608 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T114 2616-2626 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T115 2634-2642 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T116 2721-2727 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T117 2925-2943 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T118 2944-2954 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T119 3023-3027 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T120 3132-3154 Body_part denotes post-capillary venules http://purl.obolibrary.org/obo/UBERON_0035428
T121 3137-3146 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T122 3256-3268 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T123 3256-3261 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 3262-3268 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T125 3349-3361 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T126 3380-3388 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T127 3481-3486 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542
T128 3515-3521 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T129 3542-3550 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T130 3703-3711 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T131 3796-3802 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T624 6-7 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T625 16-21 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T626 22-27 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T627 22-27 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T628 42-58 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T629 70-79 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocyte
T630 242-246 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T631 626-631 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T632 788-789 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T633 857-864 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T634 904-909 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T635 904-909 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T636 1015-1020 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T637 1015-1020 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T638 1025-1026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T639 1207-1208 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T640 1407-1408 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T641 1436-1439 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T642 1436-1439 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T643 1436-1439 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T644 1566-1571 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T645 1566-1571 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T646 1653-1658 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T647 1653-1658 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T648 1717-1718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T649 1794-1799 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T650 1794-1799 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T651 1876-1881 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T652 1882-1888 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brains
T653 1882-1888 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brains
T654 1962-1963 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T655 1976-1977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T656 2308-2309 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T657 2788-2792 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T658 3237-3238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T659 3256-3268 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessel
T660 3256-3268 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessel
T661 3525-3531 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T662 3806-3812 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T663 3931-3932 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T97693 176-184 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T99 242-244 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T101 320-328 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T34792 343-351 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T104 462-470 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T7399 508-515 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T80740 541-549 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T4988 700-708 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T91450 771-779 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T19298 865-873 Chemical denotes dextrans http://purl.obolibrary.org/obo/CHEBI_52071
T94726 949-957 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T77966 1083-1091 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T99250 1159-1163 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T76004 1181-1188 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T118 1228-1236 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T75473 1321-1329 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T72889 1394-1398 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T123 1508-1512 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T54933 1523-1531 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T125 1605-1613 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T127 1770-1776 Chemical denotes tracer http://purl.obolibrary.org/obo/CHEBI_35204
T88715 1906-1914 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13546 2005-2013 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T66413 2141-2149 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T134 2239-2247 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T136 2297-2305 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T138 2435-2443 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T81225 2460-2468 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T142 2489-2497 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37279 2757-2770 Chemical denotes Hoechst 33342 http://purl.obolibrary.org/obo/CHEBI_51232
T79767 2793-2799 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T42686 2854-2857 Chemical denotes DIC http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092
T5674 2983-2991 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61069 3435-3440 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T21571 3588-3596 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T2284 3633-3645 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T19714 3654-3662 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T29469 3676-3686 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T20462 3766-3774 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49655 3890-3898 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T84615 3915-3923 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2041 1692-1695 Gene denotes Tat Gene:234724
2042 1803-1806 Gene denotes Tat Gene:234724
2043 1832-1835 Gene denotes Tat Gene:234724
2044 1930-1933 Gene denotes Tat Gene:234724
2045 2198-2201 Gene denotes Tat Gene:234724
2046 2208-2211 Gene denotes Tat Gene:234724
2047 2390-2393 Gene denotes Tat Gene:234724
2048 2410-2413 Gene denotes Tat Gene:234724
2049 2430-2433 Gene denotes Tat Gene:234724
2050 2455-2458 Gene denotes Tat Gene:234724
2051 3574-3577 Gene denotes Tat Gene:234724
2052 3845-3848 Gene denotes Tat Gene:234724
2053 3865-3868 Gene denotes Tat Gene:234724
2054 3885-3888 Gene denotes Tat Gene:234724
2055 3910-3913 Gene denotes Tat Gene:234724
2056 1597-1600 Gene denotes Tat Gene:6898
2057 1870-1873 Gene denotes Tat Gene:234724
2058 1591-1596 Species denotes HIV-1 Tax:11676
2059 1846-1850 Species denotes mice Tax:10090
2060 1876-1881 Species denotes mouse Tax:10090
2061 1944-1948 Species denotes mice Tax:10090
2062 2469-2473 Species denotes mice Tax:10090
2063 2517-2528 Species denotes horseradish Tax:3704
2064 3000-3004 Species denotes mice Tax:10090
2065 3426-3430 Species denotes mice Tax:10090
2066 3924-3928 Species denotes mice Tax:10090
2067 1605-1613 Chemical denotes morphine MESH:D009020
2068 1906-1914 Chemical denotes morphine MESH:D009020
2069 2005-2013 Chemical denotes morphine MESH:D009020
2070 2141-2149 Chemical denotes morphine MESH:D009020
2071 2239-2247 Chemical denotes morphine MESH:D009020
2072 2297-2305 Chemical denotes morphine MESH:D009020
2073 2435-2443 Chemical denotes morphine MESH:D009020
2074 2460-2468 Chemical denotes morphine MESH:D009020
2075 2489-2497 Chemical denotes morphine MESH:D009020
2076 2757-2770 Chemical denotes Hoechst 33342 MESH:C017807
2077 2983-2991 Chemical denotes morphine MESH:D009020
2078 3588-3596 Chemical denotes morphine MESH:D009020
2079 3633-3645 Chemical denotes dolutegravir MESH:C562325
2080 3654-3662 Chemical denotes abacavir MESH:C106538
2081 3676-3686 Chemical denotes lamivudine MESH:D019259
2082 3766-3774 Chemical denotes morphine MESH:D009020
2083 3890-3898 Chemical denotes morphine MESH:D009020
2084 3915-3923 Chemical denotes morphine MESH:D009020
2085 1621-1630 Disease denotes leakiness MESH:C535298
2121 195-198 Gene denotes Tat Gene:6898
2122 232-237 Gene denotes TNF-α Gene:7124
2123 242-246 Gene denotes IL-8 Gene:3576
2124 332-335 Gene denotes Tat Gene:6898
2125 356-359 Gene denotes Tat Gene:6898
2126 398-403 Gene denotes JAM-2 Gene:58494
2127 431-435 Gene denotes ZO-1 Gene:7082
2128 477-480 Gene denotes Tat Gene:6898
2129 499-507 Gene denotes occludin Gene:100506658
2130 564-567 Gene denotes Tat Gene:6898
2131 692-695 Gene denotes Tat Gene:6898
2132 804-807 Gene denotes Tat Gene:6898
2133 1190-1194 Gene denotes P-gp Gene:5243
2134 1422-1426 Gene denotes P-gp Gene:5243
2135 611-614 Gene denotes Tat Gene:234724
2136 16-21 Species denotes human Tax:9606
2137 189-194 Species denotes HIV-1 Tax:11676
2138 626-631 Species denotes mouse Tax:10090
2139 686-691 Species denotes HIV-1 Tax:11676
2140 615-625 Species denotes transgenic Tax:10090
2141 176-184 Chemical denotes morphine MESH:D009020
2142 320-328 Chemical denotes morphine MESH:D009020
2143 343-351 Chemical denotes Morphine MESH:D009020
2144 462-470 Chemical denotes morphine MESH:D009020
2145 541-549 Chemical denotes morphine MESH:D009020
2146 700-708 Chemical denotes morphine MESH:D009020
2147 771-779 Chemical denotes morphine MESH:D009020
2148 865-873 Chemical denotes dextrans MESH:D003911
2149 949-957 Chemical denotes Morphine MESH:D009020
2150 1083-1091 Chemical denotes Morphine MESH:D009020
2151 1228-1236 Chemical denotes morphine MESH:D009020
2152 1321-1329 Chemical denotes morphine MESH:D009020
2153 1481-1489 Chemical denotes morphine MESH:D009020
2154 279-288 Disease denotes tightness MESH:C536920
2155 1003-1007 Disease denotes ARVs

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T101 1164-1170 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T102 1164-1170 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T103 1171-1180 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T104 1508-1522 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T105 1513-1522 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T106 2517-2545 http://purl.obolibrary.org/obo/GO_0004601 denotes horseradish peroxidase (HRP)

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T779 0-342 Sentence denotes Using a primary human brain microvascular endothelial cell (BMEC) and astrocyte co-culture model, Mahajan et al. (2008) were among the first to demonstrate that co-exposure to morphine and HIV-1 Tat resulted in greater increases in TNF-α and IL-8 levels and decreases in barrier tightness (measured by TEER) than either morphine or Tat alone.
T780 343-583 Sentence denotes Morphine and Tat co-exposure also additively increased JAM-2, while zonula occludens-1 (ZO-1) levels were decreased by morphine or by Tat individually, and occludin protein levels were decreased by morphine alone but not Tat (Mahajan et al.
T781 584-590 Sentence denotes 2008).
T782 591-752 Sentence denotes Using the inducible Tat transgenic mouse model, Leibrand et al. (2019), also demonstrated that HIV-1 Tat and morphine act independently to disrupt BBB integrity.
T783 753-926 Sentence denotes In these studies, morphine, and to a lesser extent Tat, exposure increased the leakage of fluorescently labeled dextrans from the circulation into the brain (Leibrand et al.
T784 927-948 Sentence denotes 2017, 2019) (Fig. 3).
T785 949-1066 Sentence denotes Morphine exposure decreased the penetration of select ARVs in the brain, in a region-specific manner (Leibrand et al.
T786 1067-1082 Sentence denotes 2019) (Fig. 3).
T787 1083-1286 Sentence denotes Morphine exposure also resulted in increased expression and function of the drug efflux transport protein, P-gp, suggesting a mechanism by which morphine decreased the ARV concentrations (Leibrand et al.
T788 1287-1293 Sentence denotes 2019).
T789 1294-1440 Sentence denotes This finding suggests that morphine exposure could impact the efficient delivery of any therapeutic drug that is a substrate of P-gp into the CNS.
T790 1441-1572 Sentence denotes Future research should also investigate morphine’s impact on other drug transport proteins important for ARV delivery to the brain.
T791 1573-1674 Sentence denotes Fig. 3 Effects of HIV-1 Tat and morphine on BBB leakiness and on antiretroviral brain concentrations.
T792 1675-1965 Sentence denotes After 14 days of Tat induction, there was a significant increase in the 10 kDa (Cascade Blue®) tracer leakage into the brain in Tat + placebo as compared to Tat − placebo mice (*p < 0.05) and in Tat − mouse brains upon exposure to morphine as compared to Tat − placebo mice (*p < 0.05) (a).
T793 1966-2314 Sentence denotes There was a significant main effect of morphine, resulting in reduced integrity of the BBB and increased leakage of the higher molecular weight (40 kDa and 70 kDa) tracers in morphine-exposed groups as compared to the those groups (Tat + and Tat − together) not exposed to morphine (placebo) (#p < 0.05; significant main effect of morphine) (b, c).
T794 2315-2474 Sentence denotes Data represent the fold change in mean fluorescence intensity ± SEM; n = 8 Tat−/placebo, n = 6 Tat+/placebo, n = 9 Tat−/morphine, and n = 7 Tat+/morphine mice.
T795 2475-2650 Sentence denotes Additionally, morphine exposure increased horseradish peroxidase (HRP) extravasation from the vasculature into the perivascular space and/or parenchyma in the striatum (d, e).
T796 2651-2888 Sentence denotes HRP antigenicity was detected by indirect immunofluorescence (red) in tissue sections counterstained with Hoechst 33342 (blue) to reveal cell nuclei and visualized by differential interference contrast (DIC)-enhanced confocal microscopy.
T797 2889-3050 Sentence denotes HRP extravasation into the striatal perivascular space/parenchyma was especially prevalent in morphine-exposed mice (arrowheads; left-hand panels in e versus d).
T798 3051-3321 Sentence denotes The dotted lines (············) indicate the approximate edge of the capillaries/post-capillary venules; while intermittent dotted lines (· · · · · · ·) indicate the approximate edge of a partly sectioned blood vessel that appears partially outside the plane of section.
T799 3322-3389 Sentence denotes The asterisks (*) indicate white matter tracts within the striatum.
T800 3390-3441 Sentence denotes Representative samples from ≥ n = 4 mice per group.
T801 3442-3480 Sentence denotes All images are the same magnification.
T802 3481-3499 Sentence denotes Scale bar = 10 μm.
T803 3500-3557 Sentence denotes Antiretroviral tissue-to-plasma ratios in striatum (f–g).
T804 3558-3776 Sentence denotes Irrespective of Tat exposure, morphine significantly reduced the levels of dolutegravir (f) and abacavir (g), but not lamivudine (h), within the striatum, as compared to placebo. (* p < 0.05; main effect for morphine).
T805 3777-4002 Sentence denotes Data represent the tissue-to-plasma ratios ± SEM sampled from n = 9 Tat−/placebo, n = 9 Tat+/placebo, n = 6 Tat−/morphine, and n = 8 Tat+/morphine mice. (a–h) Modified and reprinted with permission from Leibrand et al. (2019)

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T46 2590-2608 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520
T47 2925-2943 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520

2_test

Id Subject Object Predicate Lexical cue
32876803-28057474-62958122 927-931 28057474 denotes 2017