PMC:7463108 / 23139-23597 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T171","span":{"begin":289,"end":296},"obj":"Body_part"},{"id":"T172","span":{"begin":317,"end":321},"obj":"Body_part"},{"id":"T173","span":{"begin":379,"end":384},"obj":"Body_part"},{"id":"T174","span":{"begin":417,"end":429},"obj":"Body_part"}],"attributes":[{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma83929"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T42","span":{"begin":417,"end":429},"obj":"Body_part"}],"attributes":[{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0002316"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T62","span":{"begin":274,"end":277},"obj":"Disease"},{"id":"T63","span":{"begin":365,"end":378},"obj":"Disease"}],"attributes":[{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0010029"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005072"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T206","span":{"begin":93,"end":98},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T207","span":{"begin":100,"end":104},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T208","span":{"begin":100,"end":104},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T209","span":{"begin":109,"end":115},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T210","span":{"begin":333,"end":348},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9544"},{"id":"T211","span":{"begin":350,"end":355},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T212","span":{"begin":357,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0009015"},{"id":"T213","span":{"begin":357,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0051795"},{"id":"T214","span":{"begin":357,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0052135"},{"id":"T215","span":{"begin":357,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0052139"},{"id":"T216","span":{"begin":357,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0052141"},{"id":"T217","span":{"begin":379,"end":393},"obj":"http://purl.obolibrary.org/obo/CL_0001034"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T150","span":{"begin":39,"end":47},"obj":"Chemical"},{"id":"T151","span":{"begin":100,"end":104},"obj":"Chemical"},{"id":"T152","span":{"begin":117,"end":120},"obj":"Chemical"},{"id":"T153","span":{"begin":187,"end":195},"obj":"Chemical"},{"id":"T154","span":{"begin":254,"end":262},"obj":"Chemical"},{"id":"T155","span":{"begin":289,"end":296},"obj":"Chemical"},{"id":"T156","span":{"begin":357,"end":359},"obj":"Chemical"}],"attributes":[{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_134091"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_29312"},{"id":"A157","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_73651"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-PubTator","denotations":[{"id":"561","span":{"begin":28,"end":32},"obj":"Gene"},{"id":"562","span":{"begin":297,"end":302},"obj":"Gene"},{"id":"563","span":{"begin":311,"end":316},"obj":"Gene"},{"id":"649","span":{"begin":93,"end":98},"obj":"Species"},{"id":"650","span":{"begin":333,"end":348},"obj":"Species"},{"id":"651","span":{"begin":350,"end":355},"obj":"Species"},{"id":"714","span":{"begin":274,"end":277},"obj":"Gene"},{"id":"737","span":{"begin":305,"end":308},"obj":"Gene"},{"id":"776","span":{"begin":365,"end":378},"obj":"Disease"},{"id":"777","span":{"begin":395,"end":403},"obj":"Disease"},{"id":"785","span":{"begin":357,"end":364},"obj":"CellLine"}],"attributes":[{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"Gene:72472"},{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"Gene:14828"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"Gene:14828"},{"id":"A649","pred":"tao:has_database_id","subj":"649","obj":"Tax:10090"},{"id":"A650","pred":"tao:has_database_id","subj":"650","obj":"Tax:9544"},{"id":"A651","pred":"tao:has_database_id","subj":"651","obj":"Tax:9606"},{"id":"A714","pred":"tao:has_database_id","subj":"714","obj":"Gene:8114"},{"id":"A737","pred":"tao:has_database_id","subj":"737","obj":"Gene:6898"},{"id":"A776","pred":"tao:has_database_id","subj":"776","obj":"MESH:D009447"},{"id":"A785","pred":"tao:has_database_id","subj":"785","obj":"CVCL:0019"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1026","span":{"begin":6,"end":27},"obj":"http://purl.obolibrary.org/obo/GO_0007268"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-sentences","denotations":[{"id":"T346","span":{"begin":0,"end":5},"obj":"Sentence"},{"id":"T347","span":{"begin":6,"end":158},"obj":"Sentence"},{"id":"T348","span":{"begin":159,"end":172},"obj":"Sentence"},{"id":"T349","span":{"begin":173,"end":251},"obj":"Sentence"},{"id":"T350","span":{"begin":252,"end":302},"obj":"Sentence"},{"id":"T351","span":{"begin":303,"end":349},"obj":"Sentence"},{"id":"T352","span":{"begin":350,"end":356},"obj":"Sentence"},{"id":"T353","span":{"begin":357,"end":410},"obj":"Sentence"},{"id":"T354","span":{"begin":411,"end":416},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T31","span":{"begin":365,"end":378},"obj":"Phenotype"}],"attributes":[{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0003006"}],"text":"2012)\nSynaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)\nSIVmacR71/17E\nTat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)\n• Morphine in vitro • SIV ↑ Synaptic protein HSPA5\n• Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;\nHuman,\nSH-SY5Y neuroblastoma cells in vitro (Pendyala et al. 2015)\nWhite matter effects SIVmacR71/17E No Mor"}